MicroRNAs in acute myeloid leukemia: Expression patterns, correlations with genetic and clinical parameters, and prognostic significance

Genes Chromosomes and Cancer

Volumn 49, Issue 3, 2010, Pages 193-203

  Wieser, Rotraud ^a   Scheideler, Marcel ^b   Hackl, Hubert ^b   Engelmann, Maria ^a   Schneckenleithner, Christine ^a   Hiden, Karin ^c   Papak, Christine ^b   Trajanoski, Zlatko ^b   Sill, Heinz ^c   Fonatsch, Christa ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; BONE MARROW; CANCER SURVIVAL; CHROMOSOME REARRANGEMENT; CYTOGENETICS; GENE CONTROL; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HOX GENE; HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW;

GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICRORNAS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; RNA, NEOPLASM; SURVIVAL ANALYSIS; TRANSCRIPTION, GENETIC;

EID: 76649121200     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20740     Document Type: Review

References (71)

1. Ach R, Wang H, Curry B. 2008. Measuring microRNAs: Comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods. BMC Biotechnol 8:69.
2. Baek D, Villen J, Shin C, Camargo F, Gygi S, Bartel D. 2008. The impact of microRNAs on protein output. Nature 455:64-71.
3. Bousquet M, Quelen C, Rosati R, Mansat-De Mas V, La Starza R, Bastard C, Lippert E, Talmant P, Lafage-Pochitaloff M, Leroux D, Gervais C, Viguie F, Lai J, Terre C, Beverlo B, Sambani C, Hagemeijer A, Marynen P, Delsol G, Dastugue N, Mecucci C, Brousset P. 2008. Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. J Exp Med 205:2499-2506.
4. Bryant A, Lutherborrow M, Ma D. 2009. The clinicopathological relevance of microRNA in normal and malignant haematopoiesis. Pathology 41:204-213.
5. Calin G, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik S, Iorio M, Visone R, Sever N, Fabbri M, Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C, Rassenti L, Alder H, Volinia S, Liu C, Kipps T, Negrini M, Croce C. 2005. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 353:1793-1801.
6. Chan J, Krichevsky A, Kosik K. 2005. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65:6029-6033.
7. Chen C, Li L, Lodish H, Bartel D. 2004. MicroRNAs modulate hematopoietic lineage differentiation. Science 303:83-86.
8. Chen C, Ridzon D, Broomer A, Zhou Z, Lee D, Nguyen J, Barbisin M, Xu N, Mahuvakar V, Andersen M, Lao K, Livak K, Guegler K. 2005. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33:e179.
9. Corsten M, Miranda R, Kasmieh R, Krichevsky A, Weissleder R, Shah K. 2007. MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res 67:8994-9000.
10. Costinean S, Zanesi N, Pekarsky Y, Tili E, Volinia S, Heerema N, Croce C. 2006. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA 103:7024-7029.
11. Davis B, Hilyard A, Lagna G, Hata A. 2008. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454:56-61.
12. Debernardi S, Skoulakis S, Molloy G, Chaplin T, Dixon-McIver A, Young B. 2007. MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis. Leukemia 21:912-916.
13. Dixon-McIver A, East P, Mein C, Cazier J, Molloy G, Chaplin T, Andrew Lister T, Young B, Debernardi S. 2008. Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia. PLoS ONE 3:e2141.
14. Fatica A, Rosa A, Ballarino M, De Marchis M, Rasmussen K, Bozzoni I. 2008. Role of microRNAs in myeloid differentiation. Biochem Soc Trans 36:1201-1205.
15. Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis M, Nervi C, Bozzoni. 2005. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell 123:819-831.
16. Fazi F, Racanicchi S, Zardo G, Starnes L, Mancini M, Travaglini L, Diverio D, Ammatuna E, Cimino G, Lo-Coco F, Grignani F, Nervi C. 2007. Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein. Cancer Cell 12:457-466.
17. Felli N, Fontana L, Pelosi E, Botta R, Bonci D, Facchiano F, Liuzzi F, Lulli V, Morsilli O, Santoro S, Valtieri M, Calin G, Liu C, Sorrentino A, Croce C, Peschle C. 2005. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc Natl Acad Sci USA 102:18081-18086.
18. Fontana L, Fiori M, Albini S, Cifaldi L, Giovinazzi S, Forloni M, Boldrini R, Donfrancesco A, Federici V, Giacomini P, Peschle C, Fruci D. 2008. Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS ONE 3:e2236.
19. Fornari F, Gramantieri L, Giovannini C, Veronese A, Ferracin M, Sabbioni S, Calin G, Grazi G, Croce C, Tavolari S, Chieco P, Negrini M, Bolondi L. 2009. MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res 69:5761-5767.
20. Garzon R, Garofalo M, Martelli M, Briesewitz R, Wang L, Fernandez-Cymering C, Volinia S, Liu C, Schnittger S, Haferlach T, Liso A, Diverio D, Mancini M, Meloni G, Foa R, Martelli M, Mecucci C, Croce C, Falini B. 2008a. Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci USA 105:3945-3950.
21. Garzon R, Volinia S, Liu C, Fernandez-Cymering C, Palumbo T, Pichiorri F, Fabbri M, Coombes K, Alder H, Nakamura T, Flomenberg N, Marcucci G, Calin G, Kornblau S, Kantarjian H, Bloomfield C, Andreeff M, Croce C. 2008b. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 111:3183-3189.
22. Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K, Sekido Y, Takahashi T. 2005. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res 65:9628-9632.
23. HeL, Thomson J, Hemann M, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe S, Hannon G, Hammond S. 2005. A microRNA polycistron as a potential human oncogene. Nature 435:828-833.
24. He L, He X, Lim L, de Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson A, Linsley P, Chen C, Lowe S, Cleary M, Hannon G. 2007. A microRNA component of the p53 tumour suppressor network. Nature 447:1130-1134.
25. Iorio M, Ferracin M, Liu C, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Menard S, Palazzo J, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin G, Querzoli P, Negrini M, Croce C. 2005. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 65:7065-7070.
26. Isken F, Steffen B, Merk S, Dugas M, Markus B, Tidow N, Zuhlsdorf M, Illmer T, Thiede C, Berdel W, Serve H, Muller-Tidow C. 2008. Identification of acute myeloid leukaemia associated microRNA expression patterns. Br J Haematol 140:153-161.
27. Jongen-Lavrencic M, Sun S, Dijkstra M, Valk P, Lowenberg B. 2008. MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. Blood 111:5078-5085.
28. KimV, Nam J. 2006. Genomics of microRNA. Trends Genet 22:165-173.
29. KrekA, Gruen D, Poy M, Wolf R, Rosenberg L, Epstein E, Mac-Menamin P, da Piedade I, Gunsalus K, Stoffel M, Rajewsky N. 2005. Combinatorial microRNA target predictions. Nat Genet 37:495-500.
30. Kruetzfeldt J, Rajewsky N, Braich R, Rajeev K, Tuschl T, Manoharan M, Stoffel M. 2005. Silencing of microRNAs in vivo with 'antagomirs'. Nature 438:685-689.
31. Kuchenbauer F, Morin R, Argiropoulos B, Petriv O, Griffith M, Heuser M, Yung E, Piper J, Delaney A, Prabhu A, Zhao Y, McDonald H, Zeng T, Hirst M, Hansen C, Marra M, Humphries R. 2008. In-depth characterization of the microRNA transcriptome in a leukemia progression model. Genome Res 18:1787-1797.
32. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst A, Landthaler M, Lin C, Socci N, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller R, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir D, Choksi R, De Vita G, Frezzetti D, Trompeter H, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler C, Nagle J, Ju J, Papavasiliou F, Benzing T, Lichter P, Tam W, Brownstein M, Bosio A, Borkhardt A, Russo J, Sander C, Zavolan M, Tuschl T. 2007. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129:1401-1414.
33. Langer C, Radmacher M, Ruppert A, Whitman S, Paschka P, Mrozek K, Baldus C, Vukosavljevic T, Liu C, Ross M, Powell B, de la Chapelle A, Kolitz J, Larson R, Marcucci G, Bloomfield C. 2008. High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct geneexpression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: A Cancer and Leukemia Group B (CALGB) study. Blood 111:5371-5379.
34. Langer C, Marcucci G, Holland K, Radmacher M, Maharry K, Paschka P, Whitman S, Mrozek K, Baldus C, Vij R, Powell B, Carroll A, Kolitz J, Caligiuri M, Larson R, Bloomfield C. 2009. Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 27:3198-3204.
35. Lee K, Chen Y, Yeh S, Hsiao M, Lin J, Goan Y, Lu P. 2009. Micro-RNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Oncogene 28:3360-3370.
36. Lewis B, Shih I, Jones-Rhoades M, Bartel D, Burge C. 2003. Prediction of mammalian microRNA targets. Cell 115:787-798.
37. Lewis B, Burge C, Bartel D. 2005. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15-20.
38. Li Z, Lu J, Sun M, Mi S, Zhang H, Luo R, Chen P, Wang Y, Yan M, Qian Z, Neilly M, Jin J, Zhang Y, Bohlander S, Zhang D, Larson R, Le Beau M, Thirman M, Golub T, Rowley J, Chen J. 2008. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci USA 105:15535-15540.
39. Liu C, Calin G, Meloon B, Gamliel N, Sevignani C, Ferracin M, Dumitru C, Shimizu M, Zupo S, Dono M, Alder H, Bullrich F, Negrini M, Croce C. 2004. An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci USA 101:9740-9744.
40. Löwenberg B. 2008. Acute myeloid leukemia: the challenge of capturing disease variety. Hematol Am Soc Hematol Educ Program 1-11.
41. Lu J, Getz G, Miska E, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert B, Mak R, Ferrando A, Downing J, Jacks T, Horvitz H, Golub T. 2005. MicroRNA expression profiles classify human cancers. Nature 435:834-838.
42. Marcucci G, Maharry K, Radmacher M, Mrozek K, Vukosavljevic T, Paschka P, Whitman S, Langer C, Baldus C, Liu C, Ruppert A, Powell B, Carroll A, Caligiuri M, Kolitz J, Larson R, Bloom-field C. 2008a. Prognostic significance of, and gene and micro-RNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with highrisk molecular features: A Cancer and Leukemia Group B Study. J Clin Oncol 26:5078-5087.
43. Marcucci G, Radmacher M, Maharry K, Mrozek K, Ruppert A, Paschka P, Vukosavljevic T, Whitman S, Baldus C, Langer C, Liu C, Carroll A, Powell B, Garzon R, Croce C, Kolitz J, Caligiuri M, Larson R, Bloomfield C. 2008b. MicroRNA expression in cytogenetically normal acute myeloid leukemia. N Engl J Med 358:1919-1928.
44. Mercatelli N, Coppola V, Bonci D, Miele F, Costantini A, Guadagnoli M, Bonanno E, Muto G, Frajese G, De Maria R, Spagnoli L, Farace M, Ciafre S. 2008. The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. PLoS One 3:e4029.
45. Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly M, Wang Y, Qian Z, Jin J, Zhang Y, Bohlander S, Le Beau M, Larson R, Golub T, Rowley J, Chen J. 2007. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci USA 104:19971-19976.
46. Michael M, SM OC, van Holst Pellekaan N, Young G, James R. 2003. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res 1:882-891.
47. Morin R, O'Connor M, Griffith M, Kuchenbauer F, Delaney A, Prabhu A, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves C, Marra M. 2008. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res 18:610-621.
48. Mrozek K, Marcucci G, Paschka P, Whitman S, Bloomfield C. 2007. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classification? Blood 109:431-448.
49. O'Donnell K, Wentzel E, Zeller K, Dang C, Mendell J. 2005. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435:839-843.
50. Obernosterer G, Leuschner P, Alenius M, Martinez J. 2006. Posttranscriptional regulation of microRNA expression. Rna 12:1161-1167.
51. Pelosi E, Labbaye C, Testa U. 2009. MicroRNAs in normal and malignant myelopoiesis. Leuk Res 33:1584-1593.
52. Schratt G, Tuebing F, Nigh E, Kane C, Sabatini M, Kiebler M, Greenberg M. 2006. A brain-specific microRNA regulates dendritic spine development. Nature 439:283-289.
53. Selbach M, Schwanhausser B, Thierfelder N, Fang Z, Khanin R, Rajewsky N. 2008. Widespread changes in protein synthesis induced by microRNAs. Nature 455:58-63.
54. Storey J, Tibshirani R. 2003. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100:9440-9445.
55. Sturn A, Quackenbush J, Trajanoski Z. 2002. Genesis: Cluster analysis of microarray data. Bioinformatics 18:207-208.
56. SuzukiH, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K. 2009. Modulation of microRNA processing by p53. Nature 460:529-533.
57. Takada S, Berezikov E, Yamashita Y, Lagos-Quintana M, Kloosterman W, Enomoto M, Hatanaka H, Fujiwara S, Watanabe H, Soda M, Choi Y, Plasterk R, Cuppen E, Mano H. 2006. Mouse microRNA profiles determined with a new and sensitive cloning method. Nucleic Acids Res 34:e115.
58. Takada S, Yamashita Y, Berezikov E, Hatanaka H, Fujiwara S, Kurashina K, Watanabe H, Enomoto M, Soda M, Choi Y, Mano H. 2008. MicroRNA expression profiles of human leukemias. Leukemia 22:1274-1278.
59. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, Mitsudomi T, Takahashi T. 2004. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 64:3753-3756.
60. Tallman M. 2005. New strategies for the treatment of acute myeloid leukemia including antibodies and other novel agents. Hematology (Am Soc Hematol Educ Program) 143-150.
61. Tallman M, Gilliland D, Rowe J. 2005. Drug therapy for acute myeloid leukemia. Blood 106:1154-1163.
62. Tanaka M, Oikawa K, Takanashi M, Kudo M, Ohyashiki J, Ohyashiki K, Kuroda M. 2009. Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients. PLoS One 4:e5532.
63. Tang G. 2005. siRNA and miRNA: An insight into RISCs. Trends Biochem Sci 30:106-114.
64. Thomson J, Newman M, Parker J, Morin-Kensicki E, Wright T, Hammond S. 2006. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev 20:2202-2207.
65. Tibshirani R, Hastie T, Narasimhan B, Chu G. 2002. Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc Natl Acad Sci USA 99:6567-6572.
66. Tusher V, Tibshirani R, Chu G. 2001. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 98:5116-5121.
67. Velu C, Baktula A, Grimes H. 2009. Gfi1 regulates miR-21 and miR-196b to control myelopoiesis. Blood 113:4720-4728.
68. Vo N, Klein M, Varlamova O, Keller D, Yamamoto T, Goodman R, Impey S. 2005. A cAMP-response element binding proteininduced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci USA 102:16426-16431.
69. Voorhoeve P, le Sage C, Schrier M, Gillis A, Stoop H, Nagel R, Liu Y, van Duijse J, Drost J, Griekspoor A, Zlotorynski E, Yabuta N, De Vita G, Nojima H, Looijenga L, Agami R. 2006. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 124:1169-1181.
70. Winter J, Jung S, Keller S, Gregory R, Diederichs S. 2009. Many roads to maturity: MicroRNA biogenesis pathways and their regulation. Nat Cell Biol 11:228-234.
71. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens R, Okamoto A, Yokota J, Tanaka T, Calin G, Liu C, Croce C, Harris C. 2006. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9:189-198.