Attenuated TLRs in middle ear mucosa contributes to susceptibility of chronic suppurative otitis media

Human Immunology

Volumn 75, Issue 8, 2014, Pages 771-776

  Si, Yu ^a   Zhang, Zhi Gang ^a   Chen, Sui Jun ^a   Zheng, Yi Qing ^a   Chen, Yu Bin ^a   Liu, Yi ^a   Jiang, Huaili ^a   Feng, Lian Qiang ^a,b   Huang, Xi ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Otitis media; Recovery; TLR

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; IL6 PROTEIN, HUMAN; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TLR5 PROTEIN, HUMAN; TLR9 PROTEIN, HUMAN;

ADULT; ARTICLE; CELL INFILTRATION; CHRONIC INFLAMMATION; CHRONIC OTITIS MEDIA; CHRONIC SUPPURATIVE OTITIS MEDIA; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; HUMAN; HUMAN TISSUE; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MIDDLE EAR MUCOSA; MONOCYTE; MUCOSAL IMMUNITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STROMA; UPREGULATION; ADOLESCENT; AGED; CASE CONTROL STUDY; CHILD; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MIDDLE AGED; MIDDLE EAR; MUCOSA; PATHOLOGY; SUPPURATIVE OTITIS MEDIA;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CHILD; DISEASE SUSCEPTIBILITY; EAR, MIDDLE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; INTERLEUKIN-6; MACROPHAGES; MALE; MIDDLE AGED; MONOCYTES; MUCOUS MEMBRANE; OTITIS MEDIA, SUPPURATIVE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 5; TOLL-LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84905125833     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2014.05.009     Document Type: Article

References (33)

1. Lalwani Anil K. Current diagnosis and treatment in otolaryngology - head and neck surgery; 2004. p. 701-3.
2. Herberts G., Jeppsson P., Nylén O., Branefors-Helander P. Acute otitis media. ORL 2010, 33:191-202.
3. Sale M.M., Chen W.M., Weeks D.E., Mychaleckyj J.C., Hou X., et al. Evaluation of 15 functional candidate genes for association with chronic otitis media with effusion and/or recurrent otitis media (COME/ROM). PLoS One 2011, 6:e22297.
4. The otolaryngologic clinics of North America 1999, Saunders, 372-3. M.M. Paparella (Ed.).
5. Paparella M.M., Schachern P. New developments in treating otitis media. Ann Otol Rhinol Laryngol Suppl 1994, 163:7-10.
6. Lee S.Y., Ryu E.W., Kim J.B., Yeo S.G. Clinical approaches for understanding the expression levels of pattern recognition receptors in otitis media with effusion. Clin Exp Otorhinolaryngol 2011, 4:163-167.
7. Trunea Dennis R., Zheng Qing Yin Mouse models for human otitis media. Brain Res 2009, 1277:90-103.
8. Leibovitz E. The challenge of recalcitrant acute otitis media: pathogens, resistance, and treatment strategy. Pediatr Infect Dis J 2007, 26:S8-S11.
9. Leichtle A., Lai Y., Wollenberg B., Wasserman S.I., Ryan A.F. Innate signaling in otitis media: pathogenesis and recovery. Curr Allergy Asthma Rep 2011, 11:78-84.
10. Tlaskalova-Hogenova H., Tuckova L., Lodinova-Zadnikova R., Stepankova R., Cukrowska B., et al. Mucosal immunity: its role in defense and allergy. Int Arch Allergy Immunol 2002, 128:77-89.
11. Wu M., Peng A., Sun M., et al. TREM-1 amplifies corneal inflammation after Pseudomonas aeruginosa infection by modulating Toll-like receptor signaling and Th1/Th2-type immune responses. Infect Immun 2011, 79:2709-2716.
12. Drexler S.K., Foxwell B.M. The role of toll-like receptors in chronic inflammation. Int J Biochem Cell Biol 2010, 42:506-518.
13. Lien E., Sellati T.J., Yoshimura A., et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 1999, 274:33419-33425.
14. Beutler B., Du X., Poltorak A. Identification of Toll-like receptor 4 (TLR4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies. J Endotoxin Res 2001, 7:277-280.
15. Akira S., Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004, 4:499-511.
16. Han F., Yu H., Tian C., Li S., Jacobs M.R., et al. Role for Toll-like receptor 2 in the immune response to Streptococcus pneumoniae infection in mouse otitis media. Infect Immun 2009, 77:3100-3108.
17. MacArthur C.J., Hefeneider S.H., Kempton J.B., Trune D.R. C3H/HeJ mouse model for spontaneous chronic otitis media. Laryngoscope 2006, 116:1071-1079.
18. Leichtle A., Hernandez M., Lee J., Pak K., Webster N.J., et al. The role of DNA sensing and innate immune receptor TLR9 in otitis media. Innate Immun 2012, 18:3-13.
19. Brook I. Chronic otitis media in children: microbiological studies. Arch Pediatr Adolesc Med 1980, 134:564.
20. Ryan A.F., Catanzaro A., Wasserman S.I., et al. Complement depletion reduces immunologically mediated middle ear effusion and inflammation. Clin Immunol Immunopathol 1986, 40:410-421.
21. Creagh E.M., O'Neill L.A. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 2006, 27:352.
22. Schröder Nicolas W.J., Schumann Ralf R. Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis 2005, 5:156-164.
23. Jones D.B., Jerry D.R., Khatkar M.S. A high-density SNP genetic linkage map for the silver-lipped pearl oyster, Pinctada maxima: a valuable resource for gene localisation and marker-assisted selection. BMC Genomics 2013, 14(1):810.
24. Vuononvirta J., Peltola V., Mertsola J. Risk of repeated Moraxella catarrhalis colonization is increased in children with Toll-like receptor 4 Asp299Gly polymorphism. Pediatr Infect Dis J 2013, 32(11):1185-1188.
25. Hussein Y.M., Awad H.A., Shalaby S.M. Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and susceptibility to asthma and allergic rhinitis: a case-control analysis. Cell Immunol 2012, 274(1-2):34-38.
26. Chen J., Hu S., Liang S. Associations between the four toll-like receptor polymorphisms and the risk of gastric cancer: a meta-analysis. Cancer Biother Radiopharm 2013, 28(9):674-681.
27. Hernandez M., Leichtle A., Pak K., Ebmeyer J., Euteneuer S., et al. Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. J Infect Dis 2008, 198:1862-1869.
28. Leichtle A., Hernandez M., Pak K., Webster N.J., Wasserman S.I., et al. The toll-like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery. BMC Immunol 2009, 10:45.
29. Kariya S., Okano M., Hattori H., et al. TH1/TH2 and regulatory cytokines in adults with otitis media with effusion. Otol Neurotol 2006, 27:1089-1093.
30. Kuczkowski J., Sakowicz-Burkiewicz M., Izycka-Swieszewska E., et al. Expression of tumor necrosis factor-alpha, interleukin-1alpha, interleukin-6 and interleukin-10 in chronic otitis media with bone osteolysis. ORL J Otorhinolaryngol Relat Spec 2011, 73:93-99.
31. Ukai T., Yumoto H., Gibson F.R., Genco C.A. Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-alpha production. Infect Immun 2008, 76:812-819.
32. Sakagami M., Maeda A., Node M., et al. Long-term observation on hearing change in patients with chronic otitis media. Auris Nasus Larynx 2000, 27:117-120.
33. Latz E., Schoenemeyer A., Visintin A., et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol 2004, 5:190-198.