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Volumn 68, Issue 5, 2014, Pages 611-617

Inhibition of phosphoinositide 3-kinase is associated with reduced angiogenesis and an altered expression of angiogenic markers in endothelioma cells

Author keywords

002; Akt; Angiogenesis; Endothelioma; LY294; PI3k

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CRYSTAL VIOLET; EOTAXIN; FAS LIGAND; FIBROBLAST GROWTH FACTOR 2; PROTEIN KINASE B; THROMBOCYTE FACTOR 4; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANGIOGENIC FACTOR; CASPASE; CHROMONE DERIVATIVE; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; TUMOR MARKER;

EID: 84905114229     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2014.03.017     Document Type: Article
Times cited : (5)

References (29)
  • 1
    • 84884824282 scopus 로고    scopus 로고
    • Vascular tumors have increased p70 S6-Kinase activation and are inhibited by topical Rapamycin
    • Du W., Gerald D., Carole A., Perruzzi C.A., Rodriguez-Waitkus P., Enayati L., et al. Vascular tumors have increased p70 S6-Kinase activation and are inhibited by topical Rapamycin. Lab Invest 2013, 93:1115-1127.
    • (2013) Lab Invest , vol.93 , pp. 1115-1127
    • Du, W.1    Gerald, D.2    Carole, A.3    Perruzzi, C.A.4    Rodriguez-Waitkus, P.5    Enayati, L.6
  • 2
    • 0034652392 scopus 로고    scopus 로고
    • Phosphotidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
    • Jiang B.H., Zheng J.Z., Aoki M., Vogt P.K. Phosphotidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. PNAS 2000, 97:1749-1753.
    • (2000) PNAS , vol.97 , pp. 1749-1753
    • Jiang, B.H.1    Zheng, J.Z.2    Aoki, M.3    Vogt, P.K.4
  • 3
    • 84861558883 scopus 로고    scopus 로고
    • Inhibition of hemangioma development in a syngeneic mouse model correlates with Bcl-2 suppression and the inhibition of Akt kinase activity
    • Mabeta P., Pepper M.S. Inhibition of hemangioma development in a syngeneic mouse model correlates with Bcl-2 suppression and the inhibition of Akt kinase activity. Angiogenesis 2012, 15:131-139.
    • (2012) Angiogenesis , vol.15 , pp. 131-139
    • Mabeta, P.1    Pepper, M.S.2
  • 4
    • 0036632368 scopus 로고    scopus 로고
    • The Phosphotidylinositol 3-Kinase-Akt pathway in human cancer
    • Vivanco I., Sawyers C.S. The Phosphotidylinositol 3-Kinase-Akt pathway in human cancer. Nat Rev Cancer 2002, 2:489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.S.2
  • 6
    • 84855171780 scopus 로고    scopus 로고
    • PI3K functions in cancer progression, anticancer immunity and immune evasion by tumors
    • Dituri F., Mazzocca A., Giannelli G., Antonaci S. PI3K functions in cancer progression, anticancer immunity and immune evasion by tumors. Clin Dev Immunol 2011, 2011:947858-947958.
    • (2011) Clin Dev Immunol , vol.2011 , pp. 947858-947958
    • Dituri, F.1    Mazzocca, A.2    Giannelli, G.3    Antonaci, S.4
  • 8
    • 38049069829 scopus 로고    scopus 로고
    • Melittin induces Bcl-2 and Caspase-3-dependent apoptosis through downregulation of Akt phosphorylation in human leukemic U937 cells
    • Moon D.-O., Park S.-Y., Choi Y.H., Kim N.D., Lee C., Kim G.-Y. Melittin induces Bcl-2 and Caspase-3-dependent apoptosis through downregulation of Akt phosphorylation in human leukemic U937 cells. Toxicon 2008, 51:112-120.
    • (2008) Toxicon , vol.51 , pp. 112-120
    • Moon, D.-O.1    Park, S.-Y.2    Choi, Y.H.3    Kim, N.D.4    Lee, C.5    Kim, G.-Y.6
  • 9
    • 0344142396 scopus 로고    scopus 로고
    • Emerging roles of Caspase-3 in apoptosis
    • Porter A.G., Janicke R.U. Emerging roles of Caspase-3 in apoptosis. Cell Death Differ 1999, 6:99-104.
    • (1999) Cell Death Differ , vol.6 , pp. 99-104
    • Porter, A.G.1    Janicke, R.U.2
  • 11
    • 0025063772 scopus 로고
    • Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the Middle T Oncogene
    • Montesano R., Pepper M.S., Möhle-Steinlein U., Risau W., Wagner E.F., Orci L. Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the Middle T Oncogene. Cell 1990, 62:435-445.
    • (1990) Cell , vol.62 , pp. 435-445
    • Montesano, R.1    Pepper, M.S.2    Möhle-Steinlein, U.3    Risau, W.4    Wagner, E.F.5    Orci, L.6
  • 12
    • 0035190026 scopus 로고    scopus 로고
    • Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
    • Katso R., Okkenhaug K., Ahmadi K., White S., Timms J., Waterfield M.D. Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001, 17:615-675.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 615-675
    • Katso, R.1    Okkenhaug, K.2    Ahmadi, K.3    White, S.4    Timms, J.5    Waterfield, M.D.6
  • 13
    • 84877141136 scopus 로고    scopus 로고
    • Regulation of angiogenesis by PI3k signaling networks
    • Graupera M., Potente M. Regulation of angiogenesis by PI3k signaling networks. Exp Cell Res 2013, 319:1348-1355.
    • (2013) Exp Cell Res , vol.319 , pp. 1348-1355
    • Graupera, M.1    Potente, M.2
  • 14
    • 84979851956 scopus 로고    scopus 로고
    • PI3K/PTEN signaling in angiogenesis and tumorigenesis
    • Jiang B.H., Liu L.Z. PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res 2008, 102:150-158.
    • (2008) Adv Cancer Res , vol.102 , pp. 150-158
    • Jiang, B.H.1    Liu, L.Z.2
  • 15
    • 0037188941 scopus 로고    scopus 로고
    • Role of Akt signaling in vascular homeostasis and angiogenesis
    • Shiojima I., Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 2002, 90:1243-1250.
    • (2002) Circ Res , vol.90 , pp. 1243-1250
    • Shiojima, I.1    Walsh, K.2
  • 16
    • 61449133020 scopus 로고    scopus 로고
    • A comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents
    • Mabeta P., Pepper M.S. A comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents. Angiogenesis 2009, 12:18-90.
    • (2009) Angiogenesis , vol.12 , pp. 18-90
    • Mabeta, P.1    Pepper, M.S.2
  • 17
    • 0032978139 scopus 로고    scopus 로고
    • Fas Ligand (CD95 Ligand) controls angiogenesis beneath the retina
    • Kaplan H.J., Leibole M.A., Tezel T., Ferguson T.A. Fas Ligand (CD95 Ligand) controls angiogenesis beneath the retina. Nat Med 1999, 5:292-297.
    • (1999) Nat Med , vol.5 , pp. 292-297
    • Kaplan, H.J.1    Leibole, M.A.2    Tezel, T.3    Ferguson, T.A.4
  • 19
    • 3843136173 scopus 로고    scopus 로고
    • Platelet Factor 4: an inhibitor of angiogenesis
    • Bikfalvi A. Platelet Factor 4: an inhibitor of angiogenesis. Semin Thromb Hemost 2004, 30:379-385.
    • (2004) Semin Thromb Hemost , vol.30 , pp. 379-385
    • Bikfalvi, A.1
  • 20
    • 4143051554 scopus 로고    scopus 로고
    • Recent developments in the inhibition of angiogenesis: examples from studies on Platelet Factor-4 and the VEGF/VEGFR system
    • Bikfalvi A. Recent developments in the inhibition of angiogenesis: examples from studies on Platelet Factor-4 and the VEGF/VEGFR system. Biochem Pharmacol 2004, 68:1017-1021.
    • (2004) Biochem Pharmacol , vol.68 , pp. 1017-1021
    • Bikfalvi, A.1
  • 21
    • 78149479992 scopus 로고    scopus 로고
    • Interaction of PF4 (CXCL4) with the vasculature: role in atherosclerosis and angiogenesis
    • Aidoudi S.B.A. Interaction of PF4 (CXCL4) with the vasculature: role in atherosclerosis and angiogenesis. Thromb Hemost 2010, 104:941-948.
    • (2010) Thromb Hemost , vol.104 , pp. 941-948
    • Aidoudi, S.B.A.1
  • 22
    • 0035313488 scopus 로고    scopus 로고
    • FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition
    • Cross M.J.C.L. FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition. Trends Pharmacol Sci 2001, 22:201-207.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 201-207
    • Cross, M.J.C.L.1
  • 23
    • 65249126938 scopus 로고    scopus 로고
    • Role of Eotaxin-1 signaling in ovarian cancer
    • Levina V., Nolen B.M., Marrangoni A.M., et al. Role of Eotaxin-1 signaling in ovarian cancer. Clin Cancer Res 2009, 15:2647-2656.
    • (2009) Clin Cancer Res , vol.15 , pp. 2647-2656
    • Levina, V.1    Nolen, B.M.2    Marrangoni, A.M.3
  • 24
    • 0035877258 scopus 로고    scopus 로고
    • Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells
    • Salcedo R., Young H.A., Ponce M.L., Ward J.M., Kleinman H.K., Murphy W.J., et al. Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells. J Immunol 2001, 166:7571-7578.
    • (2001) J Immunol , vol.166 , pp. 7571-7578
    • Salcedo, R.1    Young, H.A.2    Ponce, M.L.3    Ward, J.M.4    Kleinman, H.K.5    Murphy, W.J.6
  • 26
    • 0036866913 scopus 로고    scopus 로고
    • Leptin: a review of its peripheral actions and interactions
    • Margetic S., Gazzola C., Pegg G.G., Hill R.A. Leptin: a review of its peripheral actions and interactions. Int J Obesity 2002, 26:1407-1410.
    • (2002) Int J Obesity , vol.26 , pp. 1407-1410
    • Margetic, S.1    Gazzola, C.2    Pegg, G.G.3    Hill, R.A.4
  • 27
    • 84884232245 scopus 로고    scopus 로고
    • Leptin's pro-angiogenic signature in breast cancer
    • Gonzalez-Perez R.R., Lanier V., Newman G. Leptin's pro-angiogenic signature in breast cancer. Cancers 2013, 5:1140-1150.
    • (2013) Cancers , vol.5 , pp. 1140-1150
    • Gonzalez-Perez, R.R.1    Lanier, V.2    Newman, G.3
  • 29
    • 74949143243 scopus 로고    scopus 로고
    • Narrative review: the role of leptin in human physiology: emerging clinical applications
    • Kelesidis T., Kelesidis I., Chou S., Mantzoros C.S. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Int Med 2010, 152:93-100.
    • (2010) Ann Int Med , vol.152 , pp. 93-100
    • Kelesidis, T.1    Kelesidis, I.2    Chou, S.3    Mantzoros, C.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.