Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo

Biochemical and Biophysical Research Communications

Volumn 450, Issue 2, 2014, Pages 1063-1069

  Larsson, Mikael ^a   Caraballo, Rémi ^a   Ericsson, Madelene ^a   Lookene, Aivar ^a,b   Enquist, Per Anders ^a   Elofsson, Mikael ^a   Nilsson, Stefan K ^a   Olivecrona, Gunilla ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b TALLINN UNIVERSITY OF TECHNOLOGY   (Estonia)

Author keywords

Angiopoietin like protein 4; Cardiovascular disease; Hypertriglyceridemia; Lipoprotein lipase; Lipoprotein metabolism; Small molecule screening

Indexed keywords

50F10; AGENTS AFFECTING LIPID METABOLISM; ANGIOPOIETIN LIKE PROTEIN 4; APOLIPOPROTEIN A5; CHYLOMICRON; HYPNORM; LIPOPROTEIN LIPASE; OLIVE OIL; PROTEIN; TRIACYLGLYCEROL; TYLOXAPOL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DOSE RESPONSE; DYSLIPIDEMIA; ENZYME ACTIVITY; HYDROLYSIS; HYPERTRIGLYCERIDEMIA; IN VITRO STUDY; IN VIVO STUDY; LIPID METABOLISM; LIPOPROTEIN METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; RADIOACTIVITY; STRUCTURE ACTIVITY RELATION; TRIACYLGLYCEROL BLOOD LEVEL;

ANGIOPOIETIN-LIKE PROTEIN 4; CARDIOVASCULAR DISEASE; HYPERTRIGLYCERIDEMIA; LIPOPROTEIN LIPASE; LIPOPROTEIN METABOLISM; SMALL MOLECULE SCREENING;

ANGIOPOIETINS; ANIMALS; APOLIPOPROTEINS; ENZYME STABILITY; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HYPERTRIGLYCERIDEMIA; HYPOLIPIDEMIC AGENTS; LIPOPROTEIN LIPASE; MICE, INBRED C57BL; MICE, KNOCKOUT; POSTPRANDIAL PERIOD; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PYRIDINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

EID: 84905109095     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.06.114     Document Type: Article

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