Increased cardio and cerebrovascular mortality in breast cancer patients treated with postmastectomy radiotherapy - 25 year follow-up of a randomised trial from the South Sweden Breast Cancer Group

European Journal of Cancer

Volumn 50, Issue 13, 2014, Pages 2201-2210

  Killander, Fredrika ^a,b   Anderson, Harald ^b   Kjellén, Elisabeth ^a,b   Malmström, Per ^a,b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Breast cancer; Cause of death; Cerebrovascular disease; Heart disease; Radiotherapy; Side effect

Indexed keywords

ALKYLATING AGENT; CYCLOPHOSPHAMIDE;

BREAST NEOPLASMS; CANCER STAGING; CARDIOVASCULAR DISEASES; CEREBROVASCULAR DISORDERS; CLINICAL TRIAL; CONTROLLED STUDY; EPIDEMIOLOGY; FEMALE; HUMAN; MASTECTOMY; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; NEOPLASM RECURRENCE, LOCAL; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; SWEDEN;

ANTINEOPLASTIC AGENTS, ALKYLATING; BREAST NEOPLASMS; CARDIOVASCULAR DISEASES; CEREBROVASCULAR DISORDERS; COMBINED MODALITY THERAPY; CYCLOPHOSPHAMIDE; FEMALE; HUMANS; MASTECTOMY; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; POSTMENOPAUSE; SWEDEN;

EID: 84905099823     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2014.04.033     Document Type: Article

References (42)

1. Early Breast Cancer Trialists' Collaborative Group Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials Lancet 355 9217 2000 1757 1770
2. J. Cuzick, H. Stewart, R. Peto, M. Baum, B. Fisher, and H. Host et al. Overview of randomized trials of postoperative adjuvant radiotherapy in breast cancer Cancer Treat Rep 71 1 1987 15 29
3. J.L. Haybittle, D. Brinkley, J. Houghton, R.P. A'Hern, and M. Baum Postoperative radiotherapy and late mortality: evidence from the Cancer Research Campaign trial for early breast cancer BMJ 298 6688 1989 1611 1614
4. H. Host, I.O. Brennhovd, and M. Loeb Postoperative radiotherapy in breast cancer - long-term results from the Oslo study Int J Radiat Oncol Biol Phys 12 5 1986 727 732
5. J.M. Jones, and G.G. Ribeiro Mortality patterns over 34 years of breast cancer patients in a clinical trial of post-operative radiotherapy Clin Radiol 40 2 1989 204 208
6. L.E. Rutqvist, I. Lax, T. Fornander, and H. Johansson Cardiovascular mortality in a randomized trial of adjuvant radiation therapy versus surgery alone in primary breast cancer Int J Radiat Oncol Biol Phys 22 5 1992 887 896
7. M. Overgaard, P.S. Hansen, J. Overgaard, C. Rose, M. Andersson, and F. Bach et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial N Engl J Med 337 14 1997 949 955 Epub 1998/02/12
8. M. Overgaard, M.B. Jensen, J. Overgaard, P.S. Hansen, C. Rose, and M. Andersson et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial Lancet 353 9165 1999 1641 1648 Epub 1999/05/21
9. Ragaz Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer N Engl J Med 337 14 1997 956 962
10. J. Ragaz, I.A. Olivotto, J.J. Spinelli, N. Phillips, S.M. Jackson, and K.S. Wilson et al. Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial J Natl Cancer Inst 97 2 2005 116 126
11. M. Clarke, R. Collins, S. Darby, C. Davies, P. Elphinstone, and E. Evans et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials Lancet 366 9503 2005 2087 2106
12. T.J. Whelan, J. Julian, J. Wright, A.R. Jadad, and M.L. Levine Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis J Clin Oncol 18 6 2000 1220 1229
13. F. Killander, H. Anderson, S. Ryden, T. Moller, K. Aspegren, and J. Ceberg et al. Radiotherapy and tamoxifen after mastectomy in postmenopausal women - 20 year follow-up of the South Sweden Breast Cancer Group randomised trial SSBCG II:I Eur J Cancer 43 14 2007 2100 2108
14. F. Killander, H. Anderson, S. Ryden, T. Moller, L.O. Hafstrom, and P. Malmstrom Efficient reduction of loco-regional recurrences but no effect on mortality twenty years after postmastectomy radiation in premenopausal women with stage II breast cancer - a randomized trial from the South Sweden Breast Cancer Group Breast 18 5 2009 309 315 Epub 2009/10/09
15. http://www.cancerstaging.org/products/csmanual1ed.pdf; 1977.
16. A. Arwidi, K. Aspegren, N.E. Augustsson, L. Hafstrom, A. Norgren, and G. Svahn-Tapper Postoperative radiation therapy in mammary carcinoma stage II. Target volume, organs at risk, absorbed dose, time-dose schedule, and dose to organs at risk in a prospective investigation Acta Radiol Oncol Radiat Phys Biol 18 4 1979 273 281
17. Causes of death 2008. National Board of Health and Welfare; 2010.
18. Inpatient diseases in Sweden 1987-2008. National Board of Health and Welfare; 2009.
19. J. Kalbfleisch, and R. Prentice The statistical analysis of failure time data 1980 John Wiley New York
20. D. Moher, K.F. Schulz, and D.G. Altman The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials Lancet. 357 9263 2001 1191 1194
21. G. Gyenes Radiation-induced ischemic heart disease in breast cancer-a review Acta Oncol 37 3 1998 241 246
22. L.F. Paszat, W.J. Mackillop, P.A. Groome, C. Boyd, K. Schulze, and E. Holowaty Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries J Clin Oncol 16 8 1998 2625 2631
23. L.F. Paszat, W.J. Mackillop, P.A. Groome, K. Schulze, and E. Holowaty Mortality from myocardial infarction following postlumpectomy radiotherapy for breast cancer: a population-based study in Ontario, Canada Int J Radiat Oncol Biol Phys 43 4 1999 755 762
24. L.F. Paszat, K.A. Vallis, V.M. Benk, P.A. Groome, W.J. Mackillop, and A. Wielgosz A population-based case-cohort study of the risk of myocardial infarction following radiation therapy for breast cancer Radiother Oncol 82 3 2007 294 300 Epub 2007/02/06
25. S. Taddei Blood pressure through aging and menopause Climacteric 12 Suppl. 1 2009 36 40 Epub 2009/10/16
26. F.C. Brosius 3rd, B.F. Waller, and W.C. Roberts Radiation heart disease. Analysis of 16 young (aged 15 to 33 years) necropsy patients who received over 3500 rads to the heart Am J Med 70 3 1981 519 530 Epub 1981/03/01
27. L.D. Dorresteijn, A.C. Kappelle, N.M. Scholz, M. Munneke, J.T. Scholma, and A.J. Balm et al. Increased carotid wall thickening after radiotherapy on the neck Eur J Cancer 41 7 2005 1026 1030 Epub 2005/05/03
28. M. Halle, A. Gabrielsen, G. Paulsson-Berne, C. Gahm, H.E. Agardh, and F. Farnebo et al. Sustained inflammation due to nuclear factor-kappa B activation in irradiated human arteries J Am Coll Cardiol 55 12 2010 1227 1236 Epub 2010/03/20
29. E.E. Harris Cardiac mortality and morbidity after breast cancer treatment Cancer Control 15 2 2008 120 129 Epub 2008/04/01
30. P.A. Lind, R. Pagnanelli, L.B. Marks, S. Borges-Neto, C. Hu, and S.M. Zhou et al. Myocardial perfusion changes in patients irradiated for left-sided breast cancer and correlation with coronary artery distribution Int J Radiat Oncol Biol Phys 55 4 2003 914 920 Epub 2003/02/28
31. J.R. Stewart, L.F. Fajardo, S.M. Gillette, and L.S. Constine Radiation injury to the heart Int J Radiat Oncol Biol Phys 31 5 1995 1205 1211 Epub 1995/03/30
32. G.A. Tanteles, J. Whitworth, J. Mills, I. Peat, A. Osman, and G.P. McCann et al. Can cutaneous telangiectasiae as late normal-tissue injury predict cardiovascular disease in women receiving radiotherapy for breast cancer? Br J Cancer 101 3 2009 403 409 Epub 2009/07/16
33. I. Hojris, M. Overgaard, J.J. Christensen, and J. Overgaard Morbidity and mortality of ischaemic heart disease in high-risk breast-cancer patients after adjuvant postmastectomy systemic treatment with or without radiotherapy: analysis of DBCG 82b and 82c randomised trials. Radiotherapy Committee of the Danish Breast Cancer Cooperative Group Lancet 354 9188 1999 1425 1430
34. S.C. Darby, M. Ewertz, P. McGale, A.M. Bennet, U. Blom-Goldman, and D. Bronnum et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer N Engl J Med 368 11 2013 987 998 Epub 2013/03/15
35. M.J. Hooning, A. Botma, B.M. Aleman, M.H. Baaijens, H. Bartelink, and J.G. Klijn et al. Long-term risk of cardiovascular disease in 10-year survivors of breast cancer J Natl Cancer Inst 99 5 2007 365 375
36. P. McGale, S.C. Darby, P. Hall, J. Adolfsson, N.O. Bengtsson, and A.M. Bennet et al. Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden Radiother Oncol 100 2 2011 167 175 Epub 2011/07/15
37. G. Nilsson, L. Holmberg, H. Garmo, O. Duvernoy, I. Sjogren, and B. Lagerqvist et al. Distribution of coronary artery stenosis after radiation for breast cancer J Clin Oncol 30 4 2012 380 386 Epub 2011/12/29
38. C.W. Taylor, A. Nisbet, P. McGale, and S.C. Darby Cardiac exposures in breast cancer radiotherapy: 1950s-1990s Int J Radiat Oncol Biol Phys 69 5 2007 1484 1495 Epub 2007/11/24
39. O. Matzinger, I. Heimsoth, P. Poortmans, L. Collette, H. Struikmans, and W. Van Den Bogaert et al. Toxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage I to III breast cancer (EORTC trial 22922/10925) Acta Oncol 49 1 2010 24 34 Epub 2010/01/27
40. G. Nilsson, L. Holmberg, H. Garmo, A. Terent, and C. Blomqvist Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke Br J Cancer 100 5 2009 811 816 Epub 2009/03/05
41. S. Ryden, T. Moller, L. Hafstrom, J. Ranstam, C. Westrup, and O. Wiklander Adjuvant therapy of breast cancer: compliance and data validity in a multicenter trial Control Clin Trials 7 4 1986 290 305
42. Myocardial infarctions in Sweden 1987-2007. Statistics-health and medical care; 2009.