Sustained Inflammation Due to Nuclear Factor-Kappa B Activation in Irradiated Human Arteries

Journal of the American College of Cardiology

Volumn 55, Issue 12, 2010, Pages 1227-1236

  Halle, Martin ^a   Gabrielsen, Anders ^a   Paulsson Berne, Gabrielle ^a   Gahm, Caroline ^a   Agardh, Hanna E ^a   Farnebo, Filip ^a   Tornvall, Per ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

gene expression; human arteries; inflammation; irradiation

Indexed keywords

CXCL2 CHEMOKINE; DNA; DUAL SPECIFICITY PHOSPHATASE 5; FIBROBLAST GROWTH FACTOR RECEPTOR 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MANGANESE SUPEROXIDE DISMUTASE; MONOCYTE CHEMOTACTIC PROTEIN 2; PENTRAXIN 3; TRANSCRIPTION FACTOR HOXA9; UNCLASSIFIED DRUG;

ADULT; AGED; ARTERY; ARTICLE; BLOOD VESSEL BIOPSY; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; FREE TISSUE GRAFT; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; HUMAN; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; RADIATION INJURY; SIGNAL TRANSDUCTION;

AGED; ARTERIES; CARDIOVASCULAR DISEASES; FEMALE; GENE EXPRESSION; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; NF-KAPPA B; RADIATION INJURIES;

EID: 77949303825     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2009.10.047     Document Type: Article

References (38)

1. Darby S., McGale P., Peto R., Granath F., Hall P., and Ekbom A. Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer: nationwide cohort study of 90 000 Swedish women. BMJ 326 (2003) 256-257
2. Smith G.L., Smith B.D., Buchholz T.A., et al. Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy. J Clin Oncol 26 (2008) 5119-5125
3. Ferrero V., Ribichini F., Piessens M., et al. Intracoronary beta-irradiation for the treatment of de novo lesions: 5-year clinical follow-up of the BetAce randomized trial. Am Heart J 153 (2007) 398-402
4. Halle M., Bodin I., Tornvall P., Wickman M., Farnebo F., and Arnander C. Timing of radiotherapy in head and neck free flap reconstruction-a study of postoperative complications. J Plast Reconstr Aesthet Surg 62 (2009) 889-895
5. Stone H.B., Coleman C.N., Anscher M.S., and McBride W.H. Effects of radiation on normal tissue: consequences and mechanisms. Lancet Oncol 4 (2003) 529-536
6. Fischer-Dzoga K., Dimitrievich G.S., and Griem M.L. Radiosensitivity of vascular tissue. II. Differential radiosensitivity of aortic cells in vitro. Radiat Res 99 (1984) 536-546
7. Gaugler M.H., Squiban C., Claraz M., et al. Characterization of the response of human bone marrow endothelial cells to in vitro irradiation. Br J Haematol 103 (1998) 980-989
8. Gaugler M.H., Squiban C., Mouthon M.A., Gourmelon P., and van der Meeren A. Irradiation enhances the support of haemopoietic cell transmigration, proliferation and differentiation by endothelial cells. Br J Haematol 113 (2001) 940-950
9. van Kleef E., Verheij M., te Poele H., Oussoren Y., Dewit L., and Stewart F. In vitro and in vivo expression of endothelial von Willebrand factor and leukocyte accumulation after fractionated irradiation. Radiat Res 154 (2000) 375-381
10. Wang J., Zheng H., Ou X., Fink L.M., and Hauer-Jensen M. Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis. Am J Pathol 160 (2002) 2063-2072
11. Paris F., Fuks Z., Kang A., et al. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293 (2001) 293-297
12. Molla M., Gironella M., Miquel R., et al. Relative roles of ICAM-1 and VCAM-1 in the pathogenesis of experimental radiation-induced intestinal inflammation. Int J Radiat Oncol Biol Phys 57 (2003) 264-273
13. Panes J., Molla M., Casadevall M., et al. Tepoxalin inhibits inflammation and microvascular dysfunction induced by abdominal irradiation in rats. Aliment Pharmacol Ther 14 (2000) 841-850
14. Qi F., Sugihara T., Hattori Y., Yamamoto Y., Kanno M., and Abe K. Functional and morphological damage of endothelium in rabbit ear artery following irradiation with cobalt60. Br J Pharmacol 123 (1998) 653-660
15. Bonetti P.O., Lerman L.O., and Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 23 (2003) 168-175
16. Hallahan D., Clark E.T., Kuchibhotla J., Gewertz B.L., and Collins T. E-selectin gene induction by ionizing radiation is independent of cytokine induction. Biochem Biophys Res Commun 217 (1995) 784-795
17. Gaugler M.H., Squiban C., van der Meeren A., Bertho J.M., Vandamme M., and Mouthon M.A. Late and persistent up-regulation of intercellular adhesion molecule-1 (ICAM-1) expression by ionizing radiation in human endothelial cells in vitro. Int J Radiat Biol 72 (1997) 201-209
18. Panes J., Anderson D.C., Miyasaka M., and Granger D.N. Role of leukocyte-endothelial cell adhesion in radiation-induced microvascular dysfunction in rats. Gastroenterology 108 (1995) 1761-1769
19. Basavaraju S.R., and Easterly C.E. Pathophysiological effects of radiation on atherosclerosis development and progression, and the incidence of cardiovascular complications. Med Phys 29 (2002) 2391-2403
20. Vereycken-Holler V., Aigueperse J., and Gaugler M.H. Radiation effects on circulating and endothelial cell interactions studied by quantitative real-time videomicroscopy. Int J Radiat Biol 78 (2002) 923-930
21. Quarmby S., Kumar P., and Kumar S. Radiation-induced normal tissue injury: role of adhesion molecules in leukocyte-endothelial cell interactions. Int J Cancer 82 (1999) 385-395
22. Salame M.Y., Verheye S., Mulkey S.P., et al. The effect of endovascular irradiation on platelet recruitment at sites of balloon angioplasty in pig coronary arteries. Circulation 101 (2000) 1087-1090
23. Sugihara T., Hattori Y., Yamamoto Y., et al. Preferential impairment of nitric oxide-mediated endothelium-dependent relaxation in human cervical arteries after irradiation. Circulation 100 (1999) 635-641
24. Zhang B., Schmoyer D., Kirov S., and Snoddy J. GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies. BMC Bioinformatics 5 (2004) 16
25. Irizarry R.A., Hobbs B., Collin F., et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4 (2003) 249-264
26. Dorresteijn L.D., Kappelle A.C., Scholz N.M., et al. Increased carotid wall thickening after radiotherapy on the neck. Eur J Cancer 41 (2005) 1026-1030
27. Witzke C.F., MacNeill B.D., Lowe H.C., Houser S.L., and Palacios I.F. Coronary in-stent restenosis following beta brachytherapy: a histopathological examination. Cardiovasc Pathol 13 (2004) 85-90
28. Deiner C., Shagdarsuren E., Schwimmbeck P.L., et al. Nf-kappaB and AP-1 activation is associated with late lumen loss after porcine coronary angioplasty and antiproliferative beta-irradiation. Cardiovasc Res 75 (2007) 195-204
29. Chase A.J., Bond M., Crook M.F., and Newby A.C. Role of nuclear factor-kappa B activation in metalloproteinase-1, -3, and -9 secretion by human macrophages in vitro and rabbit foam cells produced in vivo. Arterioscler Thromb Vasc Biol 22 (2002) 765-771
30. Bond M., Chase A.J., Baker A.H., and Newby A.C. Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells. Cardiovasc Res 50 (2001) 556-565
31. Libby P. Inflammation in atherosclerosis. Nature 420 (2002) 868-874
32. Hallahan D., Kuchibhotla J., and Wyble C. Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium. Cancer Res 56 (1996) 5150-5155
33. Acker J.C., Marks L.B., Spencer D.P., et al. Serial in vivo observations of cerebral vasculature after treatment with a large single fraction of radiation. Radiat Res 149 (1998) 350-359
34. Zhou D., Brown S.A., Yu T., et al. A high dose of ionizing radiation induces tissue-specific activation of nuclear factor-kappaB in vivo. Radiat Res 151 (1999) 703-709
35. Magne N., Toillon R.A., Bottero V., et al. NF-kappaB modulation and ionizing radiation: mechanisms and future directions for cancer treatment. Cancer Lett 231 (2006) 158-168
36. Bandyopadhyay S., Ashraf M.Z., Daher P., Howe P.H., and DiCorleto P.E. HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells. Mol Cell Biol 27 (2007) 4207-4216
37. Trivedi C.M., Patel R.C., and Patel C.V. Homeobox gene HOXA9 inhibits nuclear factor-kappa B dependent activation of endothelium. Atherosclerosis 195 (2007) e50-e60
38. Trivedi C.M., Patel R.C., and Patel C.V. Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-kappaB) and HOXA9. Gene 408 (2008) 187-195