Efficient reduction of loco-regional recurrences but no effect on mortality twenty years after postmastectomy radiation in premenopausal women with stage II breast cancer - A randomized trial from the South Sweden Breast Cancer Group

Breast

Volumn 18, Issue 5, 2009, Pages 309-315

  Killander, Fredrika ^a   Anderson, Harald ^b   Rydén, Stefan ^c   Möller, Torgil ^b   Hafstrom L O ^d   Malmström, Per ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c Region Skåne ^*  (Sweden)

^d SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Breast cancer; Local recurrence; Mastectomy; Mortality; Radiotherapy; Randomized

Indexed keywords

CYCLOPHOSPHAMIDE;

ADULT; ARTICLE; BRACHIAL PLEXUS INJURY; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER LOCALIZATION; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISTANT METASTASIS; FEMALE; HUMAN; LYMPHEDEMA; MAJOR CLINICAL STUDY; MASTECTOMY; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; PHASE 3 CLINICAL TRIAL; PREMENOPAUSE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; RISK REDUCTION; SWEDEN; SYSTEMIC DISEASE; TUMOR VOLUME;

EID: 71049194712     PISSN: 09609776     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.breast.2009.09.006     Document Type: Article

References (28)

1. Overgaard M., Hansen P.S., Overgaard J., Rose C., Andersson M., Bach F., et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med 337 14 (1997) 949-955
2. Overgaard M., Jensen M.B., Overgaard J., Hansen P.S., Rose C., Andersson M., et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomized trial. Lancet 353 9165 (1999) 1641-1648
3. Ragaz J., Olivotto I.A., Spinelli J.J., Phillips N., Jackson S.M., Wilson K.S., et al. Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial. J Natl Cancer Inst 97 2 (2005) 116-126
4. Clarke M., Collins R., Darby S., Davies C., Elphinstone P., Evans E., et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomized trials. Lancet 366 9503 (2005) 2087-2106
5. Whelan T.J., Julian J., Wright J., Jadad A.R., and Levine M.L. Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis. J Clin Oncol 18 6 (2000) 1220-1229
6. Bonadonna G., Brusamolino E., Valagussa P., Rossi A., Brugnatelli L., Brambilla C., et al. Combination chemotherapy as an adjuvant treatment in operable breast cancer. N Engl J Med 294 8 (1976) 405-410
7. Nissen-Meyer R., Kjellgren K., Malmio K., Mansson B., and Norin T. Surgical adjuvant chemotherapy: results with one short course with cyclophosphamide after mastectomy for breast cancer. Cancer 41 6 (1978) 2088-2098
8. Ryden S., Moller T., Hafstrom L., Ranstam J., Westrup C., and Wiklander O. Adjuvant therapy of breast cancer: compliance and data validity in a multicenter trial. Control Clin Trials 7 4 (1986) 290-305
9. Ryden S., Ferno M., Borg A., Hafstrom L., Moller T., and Norgren A. Prognostic significance of estrogen and progesterone receptors in stage II breast cancer. J Surg Oncol 37 4 (1988) 221-226
10. Tennvall-Nittby L., Tengrup I., and Landberg T. The total incidence of loco-regional recurrence in a randomized trial of breast cancer TNM stage II. The South Sweden Breast Cancer Trial. Acta Oncol 32 6 (1993) 641-646
11. Gustavsson A., Bendahl P.O., Cwikiel M., Eskilsson J., Thapper K.L., and Pahlm O. No serious late cardiac effects after adjuvant radiotherapy following mastectomy in premenopausal women with early breast cancer. Int J Radiat Oncol Biol Phys 43 4 (1999) 745-754
12. Killander F., Anderson H., Ryden S., Moller T., Aspegren K., Ceberg J., et al. Radiotherapy and tamoxifen after mastectomy in postmenopausal women - 20 year follow-up of the South Sweden Breast Cancer Group randomised trial SSBCG II: I. Eur J Cancer 43 14 (2007) 2100-2108
13. ICRU report 29. Dose specification for reporting external beam therapy with photons and electrons (1978)
14. Arwidi A., Aspegren K., Augustsson N.E., Hafstrom L., Norgren A., and Svahn-Tapper G. Postoperative radiation therapy in mammary carcinoma stage II. Target volume, organs at risk, absorbed dose, time-dose schedule, and dose to organs at risk in a prospective investigation. Acta Radiol Oncol Radiat Phys Biol 18 4 (1979) 273-281
15. Kalbfleisch J., and Prentice R. The statistical analysis of failure time data (1980), John Wiley, New York
16. Marubini E.V.M. Analysing survival data from clinical trials and observational studies (1995), Wiley
17. Schulgen G., Schmoor C., Sauerbrei W., and Schumacher M. A note on estimating local recurrence rates in clinical trials on the treatment of breast cancer. Breast Cancer Res Treat 49 1 (1998) 87-91
18. Veronesi U., Marubini E., Del Vecchio M., Manzari A., Andreola S., Greco M., et al. Local recurrences and distant metastases after conservative breast cancer treatments: partly independent events. J Natl Cancer Inst 87 1 (1995) 19-27
19. Schemper M., and Smith T.L. A note on quantifying follow-up in studies of failure time. Control Clin Trials 17 4 (1996) 343-346
20. Altman D.G., Schulz K.F., Moher D., Egger M., Davidoff F., Elbourne D., et al. The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 134 8 (2001) 663-694
21. Fisher B., Carbone P., Economou S.G., Frelick R., Glass A., Lerner H., et al. 1-Phenylalanine mustard (L-PAM) in the management of primary breast cancer. A report of early findings. N Engl J Med 292 3 (1975) 117-122
22. Taghian A., Jeong J.H., Mamounas E., Anderson S., Bryant J., Deutsch M., et al. Patterns of locoregional failure in patients with operable breast cancer treated by mastectomy and adjuvant chemotherapy with or without tamoxifen and without radiotherapy: results from five National Surgical Adjuvant Breast and Bowel Project randomized clinical trials. J Clin Oncol 22 21 (2004) 4247-4254
23. Karlsson P., Cole B.F., Price K.N., Coates A.S., Castiglione-Gertsch M., Gusterson B.A., et al. The role of the number of uninvolved lymph nodes in predicting locoregional recurrence in breast cancer. J Clin Oncol 25 15 (2007) 2019-2026
24. Recht A., Gray R., Davidson N.E., Fowble B.L., Solin L.J., Cummings F.J., et al. Locoregional failure 10 years after mastectomy and adjuvant chemotherapy with or without tamoxifen without irradiation: experience of the Eastern Cooperative Oncology Group. J Clin Oncol 17 6 (1999) 1689-1700
25. Katz A., Strom E.A., Buchholz T.A., Thames H.D., Smith C.D., Jhingran A., et al. Locoregional recurrence patterns after mastectomy and doxorubicin-based chemotherapy: implications for postoperative irradiation. J Clin Oncol 18 15 (2000) 2817-2827
26. Recht A., Edge S.B., Solin L.J., Robinson D.S., Estabrook A., Fine R.E., et al. Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol 19 5 (2001) 1539-1569
27. Hojris I., Overgaard M., Christensen J.J., and Overgaard J. Morbidity and mortality of ischaemic heart disease in high-risk breast-cancer patients after adjuvant postmastectomy systemic treatment with or without radiotherapy: analysis of DBCG 82b and 82c randomised trials. Radiotherapy Committee of the Danish Breast Cancer Cooperative Group. Lancet 354 9188 (1999) 1425-1430
28. Nimeus-Malmstrom E., Krogh M., Malmstrom P., Strand C., Fredriksson I., Karlsson P., et al. Gene expression profiling in primary breast cancer distinguishes patients developing local recurrence after breast-conservation surgery, with or without postoperative radiotherapy. Breast Cancer Res 10 2 (2008) R34