Pregnancy complicated by obesity induces global transcript expression alterations in visceral and subcutaneous fat

Molecular Genetics and Genomics

Volumn 289, Issue 4, 2014, Pages 695-705

  Bashiri, Asher ^a,b   Heo, Hye J ^c   Ben Avraham, Danny ^c   Mazor, Moshe ^a,b   Budagov, Temuri ^c   Einstein, Francine H ^c   Atzmon, Gil ^c  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Gene expression; Obesity; Omental; Pregnancy; Subcutaneous

Indexed keywords

BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC LOCI; HUMANS; INFANT, NEWBORN; INTRA-ABDOMINAL FAT; MALE; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREGNANCY; PREGNANCY COMPLICATIONS; REAL-TIME POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT;

EID: 84905094442     PISSN: 16174615     EISSN: 16174623     Source Type: Journal    
DOI: 10.1007/s00438-014-0841-5     Document Type: Article

References (43)

1. Atzmon G, Yang XM, Muzumdar R, Ma XH, Gabriely I, Barzilai N (2002) Differential gene expression between visceral and subcutaneous fat depots. Horm Metab Res 34:622-628 (Pubitemid 36398696)
2. Barau G, Robillard PY, Hulsey TC, Dedecker F, Laffite A, Gerardin P, Kauffmann E (2006) Linear association between maternal prepregnancy body mass index and risk of caesarean section in term deliveries. BJOG 113:1173-1177 (Pubitemid 44401211)
3. Bjorntorp P (1991) Metabolic implications of body fat distribution. Diabetes Care 14:1132-1143
4. Boney CM, Verma A, Tucker R, Vohr BR (2005) Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 115:e290-e296 (Pubitemid 43373011)
5. Callaway LK, Prins JB, Chang AM, McIntyre HD (2006) The prevalence and impact of overweight and obesity in an Australian obstetric population. Med J Aust 184:56-59 (Pubitemid 43174192)
6. Cartwright MJ, Schlauch K, Lenburg ME, Tchkonia T, Pirtskhalava T, Cartwright A, Thomou T, Kirkland JL (2010) Aging, depot origin, and preadipocyte gene expression. J Gerontol A Biol Sci Med Sci 65:242-251
7. Catalano PM (2003) Obesity and pregnancy - the propagation of a viscous cycle? J Clin Endocrinol Metab 88:3505-3506
8. Catalano PM, Ehrenberg HM (2006) The short- and long-term implications of maternal obesity on the mother and her offspring. BJOG 113:1126-1133
9. Catalano PM, McIntyre HD, Cruickshank JK, McCance DR, Dyer AR, Metzger BE, Lowe LP, Trimble ER, Coustan DR, Hadden DR, Persson B, Hod M, Oats JJ, HSCRG (2012) The hyperglycemia and adverse pregnancy outcome study: associations of GDM and obesity with pregnancy outcomes. Diabetes care 35:780-786
10. Djelantik A, Kunst AE, van der Wal MF, Smit HA, Vrijkotte TG (2012) Contribution of overweight and obesity to the occurrence of adverse pregnancy outcomes in a multi-ethnic cohort: population attributive fractions for Amsterdam. BJOG 119:283-290
11. Ehrmann DA, Liljenquist DR, Kasza K, Azziz R, Legro RS, Ghazzi MN, Group PCTS (2006) Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 91:48-53 (Pubitemid 43069116)
12. Einstein FH, Atzmon G, Yang XM, Ma XH, Rincon M, Rudin E, Muzumdar R, Barzilai N (2005) Differential responses of visceral and subcutaneous fat depots to nutrients. Diabetes 54:672-678 (Pubitemid 40322069)
13. Einstein F, Thompson RF, Bhagat TD, Fazzari MJ, Verma A, Barzilai N, Greally JM (2010) Cytosine methylation dysregulation in neonates following intrauterine growth restriction. PLoS ONE 5:e8887
14. Fox BP, Kandpal RP (2009) EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells. Oncogene 28:1706-1713
15. Frederick IO, Rudra CB, Miller RS, Foster JC, Williams MA (2006) Adult weight change, weight cycling, and prepregnancy obesity in relation to risk of preeclampsia. Epidemiology 17:428-434 (Pubitemid 44305516)
16. Guelinckx I, Devlieger R, Beckers K, Vansant G (2008) Maternal obesity: pregnancy complications, gestational weight gain and nutrition. Obes Rev 9:140-150 (Pubitemid 351197441)
17. Hafner C, Schmitz G, Meyer S, Bataille F, Hau P, Langmann T, Dietmaier W, Landthaler M, Vogt T (2004) Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. Clin Chem 50:490-499 (Pubitemid 38297297)
18. Han JC, Lawlor DA, Kimm SY (2010) Childhood obesity. Lancet 375:1737-1748
19. Jacob MS, Presti DE (2005) Endogenous psychoactive tryptamines reconsidered: an anxiolytic role for dimethyltryptamine. Med Hypotheses 64:930-937 (Pubitemid 40385946)
20. Kelly T, Yang W, Chen CS, Reynolds K, He J (2008) Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 32:1431-1437
21. Kissebah AH (1991) Insulin resistance in visceral obesity. Int J Obes 15(Suppl 2):109-115
22. Kopantzev EP, Monastyrskaya GS, Vinogradova TV, Zinovyeva MV, Kostina MB, Filyukova OB, Tonevitsky AG, Sukhikh GT, Sverdlov ED (2008) Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma. Lung Cancer 62:23-34
23. Kristensen J, Vestergaard M, Wisborg K, Kesmodel U, Secher NJ (2005) Pre-pregnancy weight and the risk of stillbirth and neonatal death. BJOG 112:403-408 (Pubitemid 40516551)
24. Larkin SE, Holmes S, Cree IA, Walker T, Basketter V, Bickers B, Harris S, Garbis SD, Townsend PA, Aukim-Hastie C (2012) Identification of markers of prostate cancer progression using candidate gene expression. Br J Cancer 106:157-165
25. Larsen TB, Sorensen HT, Gislum M, Johnsen SP (2007) Maternal smoking, obesity, and risk of venous thromboembolism during pregnancy and the puerperium: a population-based nested casecontrol study. Thromb Res 120:505-509 (Pubitemid 47094915)
26. Lockstone HE (2011) Exon array data analysis using Affymetrix power tools and R statistical software. Brief Bioinform 12:634-644
27. Matsuoka H, Iwata N, Ito M, Shimoyama M, Nagata A, Chihara K, Takai S, Matsui T (1997) Expression of a kinase-defective Ephlike receptor in the normal human brain. Biochem Biophys Res Commun 235:487-492 (Pubitemid 27326506)
28. McIntyre HD, Gibbons KS, Flenady VJ, Callaway LK (2012) Overweight and obesity in Australian mothers: epidemic or endemic? Med J Aust 196:184-188
29. Moore LL, Singer MR, Bradlee ML, Rothman KJ, Milunsky A (2000) A prospective study of the risk of congenital defects associated with maternal obesity and diabetes mellitus. Epidemiology 11:689-694
30. Muller-Tidow C, Diederichs S, Bulk E, Pohle T, Steffen B, Schwable J, Plewka S, Thomas M, Metzger R, Schneider PM, Brandts CH, Berdel WE, Serve H (2005) Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancer. Cancer Res 65:1778-1782 (Pubitemid 40478604)
31. Nuno-Ayala M, Guillen N, Arnal C, Lou-Bonafonte JM, de Martino A, Garcia-de-Jalon JA, Gascon S, Osaba L, Osada J, Navarro MA (2012) Cystathionine beta-synthase deficiency causes infertility by impairing decidualization and gene expression networks in uterus implantation sites. Physiol Genomics 44:702-716
32. Okoniewski MJ, Hey Y, Pepper SD, Miller CJ (2007a) High correspondence between Affymetrix exon and standard expression arrays. Biotechniques 42:181-185
33. Okoniewski MJ, Yates T, Dibben S, Miller CJ (2007b) An annotation infrastructure for the analysis and interpretation of Affymetrix exon array data. Genome Biol 8:R79
34. Pou J, Rebollo A, Piera L, Merlos M, Roglans N, Laguna JC, Alegret M (2011) Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages. Biochim Biophys Acta 1813:1254-1260
35. Rexrode KM, Carey VJ, Hennekens CH, Walters E, Colditz GA, Stampfer MJ, Willett WC, Manson JE (1998) Abdominal adiposity and coronary heart disease in women. JAMA 280:1843-1848 (Pubitemid 28544425)
36. Tang XX, Zhao H, Robinson ME, Cohen B, Cnaan A, London W, Cohn SL, Cheung NK, Brodeur GM, Evans AE, Ikegaki N (2000) Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma. Proc Natl Acad Sci USA 97:10936-10941
37. Tchkonia T, Tchoukalova YD, Giorgadze N, Pirtskhalava T, Karagiannides I, Forse RA, Koo A, Stevenson M, Chinnappan D, Cartwright A, Jensen MD, Kirkland JL (2005) Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots. Am J Physiol Endocrinol Metab 288:E267-E277 (Pubitemid 40023816)
38. Truitt L, Freywald A (2011) Dancing with the dead: Eph receptors and their kinase-null partners. Biochem Cell Biol 89:115-129
39. Truitt L, Freywald T, DeCoteau J, Sharfe N, Freywald A (2010) The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells. Cancer Res 70:1141-1153
40. Wang JX, Davies MJ, Norman RJ (2002) Obesity increases the risk of spontaneous abortion during infertility treatment. Obes Res 10:551-554 (Pubitemid 135686648)
41. Xiong Y, Zhou Q, Jiang F, Zhou S, Lou Y, Guo Q, Liang W, Kong D, Ma D, Li X (2010) Changes of plasma and placental tissue factor pathway inhibitor-2 in women with preeclampsia and normal pregnancy. Thromb Res 125:e317-e322
42. Zawadzki C, Chatelain N, Delestre M, Susen S, Quesnel B, Juthier F, Jeanpierre E, Azzaoui R, Corseaux D, Breyne J, Torpier G, Staels B, Van Belle E, Jude B (2009) Tissue factor pathway inhibitor-2 gene methylation is associated with low expression in carotid atherosclerotic plaques. Atherosclerosis 204:e4-e14
43. Zhang Q, Zhang Y, Wang SZ, Wang N, Jiang WG, Ji YH, Zhang SL (2012) Reduced expression of tissue factor pathway inhibitor-2 contributes to apoptosis and angiogenesis in cervical cancer. J Exp Clin Cancer Res 31:1