Mesoscopic structures of triglyceride nanosuspensions studied by small-angle X-ray and neutron scattering and computer simulations

Journal of Physical Chemistry B

Volumn 118, Issue 29, 2014, Pages 8808-8818

  Schmiele, Martin ^a   Schindler, Torben ^a   Westermann, Martin ^b   Steiniger, Frank ^b   Radulescu, Aurel ^c   Kriele, Armin ^d   Gilles, Ralph ^e   Unruh, Tobias ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

^d INSTITUTE OF MATERIALS RESEARCH   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; EMULSIONS; LECITHIN; NANOCRYSTALS; NEUTRON SCATTERING; PLATELETS; VOLUME FRACTION;

AQUEOUS SUSPENSIONS; CRYSTALLIZATION TEMPERATURE; MESOSCOPIC STRUCTURE; MOLECULAR RESOLUTION; PHASE TRANSFORMATION TEMPERATURE; SMALL-ANGLE X-RAYS; STABILIZED SUSPENSION; THICKNESS DISTRIBUTIONS;

SUSPENSIONS (FLUIDS);

NANOPARTICLE; SUSPENSION; TRIACYLGLYCEROL; TRIPALMITIN;

CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; FREEZING; NEUTRON DIFFRACTION; SMALL ANGLE SCATTERING; SUSPENSION; X RAY DIFFRACTION;

FREEZING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NANOPARTICLES; NEUTRON DIFFRACTION; SCATTERING, SMALL ANGLE; SUSPENSIONS; TRIGLYCERIDES; X-RAY DIFFRACTION;

EID: 84905046573     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp502580a     Document Type: Article

References (31)

1. Siekmann, B.; Westesen, K. Submicron-Sized Parenteral Carrier Systems Based on Solid Lipids Pharm. Pharmacol. Lett. 1992, 1, 123-126
2. Bunjes, H. Structural Properties of Solid Lipid Based Colloidal Drug Delivery Systems Curr. Opin. Colloid Interface Sci. 2011, 16, 405-411
3. Unruh, T. Interpretation of Small-Angle X-ray Scattering Patterns of Crystalline Triglyceride Nanoparticles in Dispersion J. Appl. Crystallogr. 2007, 40, 1008-1018
4. Schmiele, M.; Schindler, T.; Unruh, T.; Busch, S.; Morhenn, H.; Westermann, M.; Steiniger, F.; Radulescu, A.; Lindner, P.; Schweins, R. Structural Characterization of the Phospholipid Stabilizer Layer at the Solid-Liquid Interface of Dispersed Triglyceride Nanocrystals with Small-Angle X-ray and Neutron Scattering Phys. Rev. E 2013, 87, 062316
5. Unruh, T.; Westesen, K.; Bösecke, P.; Lindner, P.; Koch, M. H. J. Self-Assembly of Triglyceride Nanocrystals in Suspension Langmuir 2002, 18, 1796-1800
6. Illing, A.; Unruh, T.; Koch, M. Investigation on Particle Self-Assembly in Solid Lipid-Based Colloidal Drug Carrier Systems Pharm. Res. 2004, 21, 592-597
7. Bunjes, H.; Westesen, K.; Koch, M. H. Crystallization Tendency and Polymorphic Transitions in Triglyceride Nanoparticles Int. J. Pharm. 1996, 129, 159-173
8. Bunjes, H.; Koch, M. H. J. Saturated Phospholipids Promote Crystallization but Slow Down Polymorphic Transitions in Triglyceride Nanoparticles J. Controlled Release 2005, 107, 229-243
9. Bunjes, H.; Steiniger, F.; Richter, W. Visualizing the Structure of Triglyceride Nanoparticles in Different Crystal Modifications Langmuir 2007, 23, 4005-4011
10. Seetapan, N.; Bejrapha, P.; Srinuanchai, W.; Puttipipatkhachorn, S.; Ruktanonchai, U. Nondestructive Rheological Measurement of Aqueous Dispersions of Solid Lipid Nanoparticles: Effects of Lipid Types and Concentrations on Dispersion Consistency Drug Dev. Ind. Pharm. 2010, 36, 1005-1015
11. Gilles, R.; Keiderling, U.; Wiedenmann, A. Silver Behenate Powder as a Possible Low-Angle Calibration Standard for Small-Angle Neutron Scattering J. Appl. Crystallogr. 1998, 31, 957-959
12. Fan, L.; Degen, M.; Bendle, S.; Grupido, N.; Ilavsky, J. The Absolute Calibration of a Small-Angle Scattering Instrument with a Laboratory X-ray Source J. Phys.: Conf. Ser. 2010, 247, 012005
13. Zhang, F.; Ilavsky, J.; Long, G.; Quintana, J.; Allen, A.; Jemian, P. Glassy Carbon as an Absolute Intensity Calibration Standard for Small-Angle Scattering Metall. Mater. Trans. A 2010, 41, 1151-1158
14. Dreiss, C. A.; Jack, K. S.; Parker, A. P. On the Absolute Calibration of Bench-Top Small-Angle X-ray Scattering Instruments: A Comparison of Different Standard Methods J. Appl. Crystallogr. 2006, 39, 32-38
15. Hammersley, A. P.; Svensson, S. O.; Hanfland, M.; Fitch, A. N.; Hausermann, D. Two-Dimensional Detector Software: From Real Detector to Idealised Image or Two-Theta Scan High Pressure Res. 1996, 14, 235-248
16. Radulescu, A.; Pipich, V.; Frielinghaus, H.; Appavou, M. S. KWS-2, the High Intensity/Wide Q-Range Small-Angle Neutron Diffractometer for Soft-Matter and Biology at FRM II J. Phys.: Conf. Ser. 2012, 351, 012026
17. van Langevelde, A.; van Malssen, K.; Hollander, F.; Peschar, R.; Schenk, H. Structure of Mono-Acid Even-Numbered β-Triacylglycerols Acta Crystallogr., Sect. B 1999, 55, 114-122
18. XNDiff. https://sourceforge.net/projects/xndiff/.
19. Nagle, J. F.; Tristram-Nagle, S. Structure of Lipid Bilayers Biochim. Biophys. Acta, Rev. Biomembr. 2000, 1469, 159-195
20. Pencer, J.; Mills, T.; Anghel, V.; Krueger, S.; Epand, R. M.; Katsaras, J. Detection of Submicron-Sized Raft-like Domains in Membranes by Small-Angle Neutron Scattering Eur. Phys. J. E: Soft Matter Biol. Phys. 2005, 18, 447-458
21. Heberle, F.; Pan, J.; Standaert, R.; Drazba, P.; Kučerka, N.; Katsaras, J. Model-Based Approaches for the Determination of Lipid Bilayer Structure from Small-Angle Neutron and X-ray Scattering Data Eur. Biophys. J. 2012, 41, 875-890
22. Bunjes, H.; Koch, M. H. J.; Westesen, K. Effect of Particle Size on Colloidal Solid Triglycerides Langmuir 2000, 16, 5234-5241
23. Schubert, M.; Schicke, B.; Müller-Goymann, C. Thermal Analysis of the Crystallization and Melting Behavior of Lipid Matrices and Lipid Nanoparticles Containing High Amounts of Lecithin Int. J. Pharm. 2005, 298, 242-254
24. Unruh, T.; Bunjes, H.; Westesen, K.; Koch, M. H. J. Observation of Size-Dependent Melting in Lipid Nanoparticles J. Phys. Chem. B 1999, 103, 10373-10377
25. Unruh, T.; Bunjes, H.; Westesen, K.; Koch, M. H. J. Investigations on the Melting Behaviour of Triglyceride Nanoparticles Colloid Polym. Sci. 2001, 279, 398-403
26. Chapman, D. The Polymorphism of Glycerides Chem. Rev. 1962, 62, 433-456
27. Kellens, M.; Meeussen, W.; Riekel, C.; Reynaers, H. Time Resolved X-ray Diffraction Studies of the Polymorphic Behaviour of Tripalmitin Using Synchrotron Radiation Chem. Phys. Lipids 1990, 52, 79-98
28. van Miltenburg, J. C.; ten Grotenhuis, E. A Thermodynamic Investigation of Tripalmitin. Molar Heat Capacities of the α- and β-Form between 10 and 350 K J. Chem. Eng. Data 1999, 44, 721-726
29. Segad, M.; Jönsson, B.; Cabane, B. Tactoid Formation in Montmorillonite J. Phys. Chem. C 2012, 116, 25425-25433
30. Segad, M. Microstructure Determination of IQ-WB Clays: A Direct Procedure by Small-Angle X-ray Scattering J. Appl. Crystallogr. 2013, 46, 1316-1322
31. Gaspar, A. M.; Busch, S.; Appavou, M.-S.; Haeussler, W.; Georgii, R.; Su, Y.; Doster, W. Using Polarization Analysis To Separate the Coherent and Incoherent Scattering from Protein Samples Biochim. Biophys. Acta, Proteins Proteomics 2010, 1804, 76-82