Comparative gene identification 58/α/β hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activity

Journal of Lipid Research

Volumn 55, Issue 8, 2014, Pages 1750-1761

  McMahon, Derek ^a   Dinh, Anna ^a   Kurz, Daniel ^a   Shah, Dharika ^a   Han, Gil Soo ^a   Carman, George M ^a   Brasaemle, Dawn L ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Adipose triglyceride lipase; Chanarin Dorfman syndrome; Neutral lipid storage disorder; Phosphatidylinositol 3 phosphate; Phosphatidylinositol 5 phosphate

Indexed keywords

1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; ACYL[ACYL CARRIER PROTEIN] PHOSPHOLIPID ACYLTRANSFERASE; ADIPOSE TRIGLYCERIDE LIPASE; GLUTATHIONE TRANSFERASE; GLYCEROPHOSPHOLIPID; LYSOPHOSPHATIDIC ACID; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHATIDYLINOSITOL 5 PHOSPHATE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; 2-ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; ABHD5 PROTEIN, HUMAN; ABHD5 PROTEIN, MOUSE; ACYLTRANSFERASE; LYSOPHOSPHOLIPID; RECOMBINANT PROTEIN;

ALPHA BETA HYDROLASE DOMAIN 5 GENE; ANIMAL CELL; ARTICLE; CATALYSIS; COMPARATIVE GENE IDENTIFICATION 58 GENE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PURIFICATION; ANIMAL; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOUSE; PROTEIN DOMAIN;

1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; ACYLTRANSFERASES; ANIMALS; HUMANS; LYSOPHOSPHOLIPIDS; MICE; PROTEIN DOMAINS; RECOMBINANT PROTEINS;

EID: 84905040517     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M051151     Document Type: Article

References (49)

1. Lefèvre, C., F. Jobard, F. Caux, B. Bouadjar, A. Karaduman, R. Heilig, H. Lakhdar, A. Wollenberg, J. L. Verret, J. Weissenbach, et al. 2001. Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/ thioesterase subfamily, in Chanarin-Dorfman syndrome. Am. J. Hum. Genet. 69: 1002-1012. (Pubitemid 33015815)
2. Bruno, C., E. Bertini, M. Di Rocco, D. Cassandrini, G. Ruffa, T. De Toni, M. Seri, M. Spada, V. G. Li, A. D'Amico, et al. 2008. Clinical and genetic characterization of Chanarin-Dorfman syndrome. Biochem. Biophys. Res. Commun. 369: 1125-1128.
3. Chanarin, I., A. Patel, G. Slavin, E. J. Wills, T. M. Andrews, and G. Stewart. 1975. Neutral-lipid storage disease: a new disorder of lipid metabolism. Br. Med. J. 1: 553-555.
4. Dorfman, M. L., C. Hershko, S. Eisenberg, and F. Sagher. 1974. Ichthyosiform dermatosis with systemic lipidosis. Arch. Dermatol. 110: 261-266.
5. Igal, R. A., J. M. Rhoads, and R. A. Coleman. 1997. Neutral lipid storage disease with fatty liver and cholestasis. J. Pediatr. Gastroenterol. Nutr. 25: 541-547. (Pubitemid 27463293)
6. Schleinitz, N., J. Fischer, A. Sanchez, V. Veit, J. R. Harle, and J. F. Pelissier. 2005. Two new mutations of the ABHD5 gene in a new adult case of Chanarin Dorfman syndrome: an uncommon lipid storage disease. Arch. Dermatol. 141: 798-800. (Pubitemid 41001097)
7. Slavin, G., E. J. Wills, J. E. Richmond, I. Chanarin, T. Andrews, and G. Stewart. 1975. Morphological features in a neutral lipid storage disease. J. Clin. Pathol. 28: 701-710.
8. Lass, A., R. Zimmermann, G. Haemmerle, M. Riederer, G. Schoiswohl, M. Schweiger, P. Kienesberger, J. G. Strauss, G. Gorkiewicz, and R. Zechner. 2006. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman syndrome. Cell Metab. 3: 309-319.
9. Fischer, J., C. Lefevre, E. Morava, J. M. Mussini, P. Laforet, A. Negre-Salvayre, M. Lathrop, and R. Salvayre. 2007. The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat. Genet. 39: 28-30. (Pubitemid 46026498)
10. Ghosh, A. K., G. Ramakrishnan, C. Chandramohan, and R. Rajasekharan. 2008. CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid. J. Biol. Chem. 283: 24525-24533.
11. Montero-Moran, G., J. M. Caviglia, D. McMahon, A. Rothenberg, V. Subramanian, Z. Xu, S. Lara-Gonzalez, J. Storch, G. M. Carman, and D. L. Brasaemle. 2010. CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase. J. Lipid Res. 51: 709-719.
12. Brown, J. M., J. L. Betters, C. Lord, Y. Ma, X. Han, K. Yang, H. M. Alger, J. Melchior, J. Sawyer, R. Shah, et al. 2010. CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance. J. Lipid Res. 51: 3306-3315.
13. Lord, C. C., J. L. Betters, P. T. Ivanova, S. B. Milne, D. S. Myers, J. Madenspacher, G. Thomas, S. Chung, M. Liu, M. A. Davis, et al. 2012. CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action. Diabetes. 61: 355-363.
14. Subramanian, V., A. Rothenberg, C. Gomez, A. W. Cohen, A. Garcia, S. Bhattacharyya, L. Shapiro, G. Dolios, R. Wang, M. P. Lisanti, et al. 2004. Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J. Biol. Chem. 279: 42062-42071. (Pubitemid 39313657)
15. Kelley, L. A., and M. J. Sternberg. 2009. Protein structure prediction on the Web: a case study using the Phyre server. Nat. Protoc. 4: 363-371.
16. Laskowski, R. A., D. S. Moss, and J. M. Thornton. 1993. Main-chain bond lengths and bond angles in protein structures. J. Mol. Biol. 231: 1049-1067. (Pubitemid 23209879)
17. Hooft, R. W., G. Vriend, C. Sander, and E. E. Abola. 1996. Errors in protein structures. Nature. 381: 272.
18. Colovos, C., and T. O. Yeates. 1993. Verification of protein structures: patterns of nonbonded atomic interactions. Protein Sci. 2: 1511-1519. (Pubitemid 23262844)
19. Lüthy, R., J. U. Bowie, and D. Eisenberg. 1992. Assessment of protein models with three-dimensional profiles. Nature. 356: 83-85.
20. Pontius, J., J. Richelle, and S. J. Wodak. 1996. Deviations from standard atomic volumes as a quality measure for protein crystal structures. J. Mol. Biol. 264: 121-136. (Pubitemid 26399998)
21. Han, G. S., L. O'Hara, G. M. Carman, and S. Siniossoglou. 2008. An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth. J. Biol. Chem. 283: 20433-20442.
22. Brachmann, C. B., A. Davies, G. J. Cost, E. Caputo, J. Li, P. Hieter, and J. D. Boeke. 1998. Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast. 14: 115-132. (Pubitemid 28062863)
23. Holm, C., and T. Osterlund. 1999. Hormone-sensitive lipase and neutral cholesteryl ester lipase. Methods Mol. Biol. 109: 109-121.
24. Yamashita, A., H. Nakanishi, H. Suzuki, R. Kamata, K. Tanaka, K. Waku, and T. Sugiura. 2007. Topology of acyltransferase motifs and substrate specificity and accessibility in 1-acyl-sn-glycero-3-phosphate acyltransferase 1. Biochim. Biophys. Acta. 1771: 1202-1215. (Pubitemid 47404973)
25. Golczak, M., P. D. Kiser, A. E. Sears, D. T. Lodowski, W. S. Blaner, and K. Palczewski. 2012. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J. Biol. Chem. 287: 23790-23807.
26. Coleman, J. 1992. Characterization of the Escherichia coli gene for 1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC). Mol. Gen. Genet. 232: 295-303.
27. Coleman, J. 1990. Characterization of Escherichia coli cells deficient in 1-acyl-sn-glycerol-3- phosphate acyltransferase activity. J. Biol. Chem. 265: 17215-17221.
28. Modregger, J., A. A. Schmidt, B. Ritter, W. B. Huttner, and M. Plomann. 2003. Characterization of endophilin B1b, a brainspecific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1. J. Biol. Chem. 278: 4160-4167. (Pubitemid 36801153)
29. Schmidt, A., M. Wolde, C. Thiele, W. Fest, H. Kratzin, A. V. Podtelejnikov, W. Witke, W. B. Huttner, and H. D. Soling. 1999. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. Nature. 401: 133-141. (Pubitemid 29436310)
30. Weigert, R., M. G. Silletta, S. Spano, G. Turacchio, C. Cericola, A. Colanzi, S. Senatore, R. Mancini, E. V. Polishchuk, M. Salmona, et al. 1999. CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid. Nature. 402: 429-433. (Pubitemid 129544833)
31. Bonazzi, M., S. Spano, G. Turacchio, C. Cericola, C. Valente, A. Colanzi, H. S. Kweon, V. W. Hsu, E. V. Polishchuck, R. S. Polishchuck, et al. 2005. CtBP3/BARS drives membrane fission in dynamin-independent transport pathways. Nat. Cell Biol. 7: 570-580. (Pubitemid 40796980)
32. Guichet, A., T. Wucherpfennig, V. Dudu, S. Etter, M. Wilsch-Brauniger, A. Hellwig, M. Gonzalez-Gaitan, W. B. Huttner, and A. A. Schmidt. 2002. Essential role of endophilin A in synaptic vesicle budding at the Drosophila neuromuscular junction. EMBO J. 21: 1661-1672. (Pubitemid 34614622)
33. Hidalgo Carcedo, C., M. Bonazzi, S. Spano, G. Turacchio, A. Colanzi, A. Luini, and D. Corda. 2004. Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS. Science. 305: 93-96. (Pubitemid 38869379)
34. Schuske, K. R., J. E. Richmond, D. S. Matthies, W. S. Davis, S. Runz, D. A. Rube, A. M. van der Bliek, and E. M. Jorgensen. 2003. Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin. Neuron. 40: 749-762. (Pubitemid 37431035)
35. Kooijman, E. E., V. Chupin, N. L. Fuller, M. M. Kozlov, B. de Kruijff, K. N. Burger, and P. R. Rand. 2005. Spontaneous curvature of phosphatidic acid and lysophosphatidic acid. Biochemistry. 44: 2097-2102. (Pubitemid 40223637)
36. Shemesh, T., A. Luini, V. Malhotra, K. N. Burger, and M. M. Kozlov. 2003. Prefission constriction of Golgi tubular carriers driven by local lipid metabolism: a theoretical model. Biophys. J. 85: 3813-3827. (Pubitemid 37490291)
37. Gallop, J. L., P. J. Butler, and H. T. McMahon. 2005. Endophilin and CtBP/BARS are not acyl transferases in endocytosis or Golgi fission. Nature. 438: 675-678. (Pubitemid 41740578)
38. Ankem, G., S. Mitra, F. Sun, A. C. Moreno, B. Chutvirasakul, H. F. Azurmendi, L. Li, and D. G. Capelluto. 2011. The C2 domain of Tollip, a Toll-like receptor signalling regulator, exhibits broad preference for phosphoinositides. Biochem. J. 435: 597-608.
39. Kachel, N., K. S. Erdmann, W. Kremer, P. Wolff, W. Gronwald, R. Heumann, and H. R. Kalbitzer. 2003. Structure determination and ligand interactions of the PDZ2b domain of PTP-Bas (hPTP1E): splicing-induced modulation of ligand specificity. J. Mol. Biol. 334: 143-155. (Pubitemid 37330106)
40. Kuerschner, L., C. Moessinger, and C. Thiele. 2008. Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets. Traffic. 9: 338-352. (Pubitemid 351188994)
41. van den Bogaart, G., K. Meyenberg, U. Diederichsen, and R. Jahn. 2012. Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold. J. Biol. Chem. 287: 16447-16453.
42. Bridges, D., and A. R. Saltiel. 2012. Phosphoinositides in insulin action and diabetes. Curr. Top. Microbiol. Immunol. 362: 61-85.
43. Cullen, P. J., and H. C. Korswagen. 2012. Sorting nexins provide diversity for retromer-dependent trafficking events. Nat. Cell Biol. 14: 29-37.
44. Mayinger, P. 2012. Phosphoinositides and vesicular membrane traffic. Biochim. Biophys. Acta. 1821: 1104-1113.
45. Yamaguchi, T., N. Omatsu, S. Matsushita, and T. Osumi. 2004. CGI-58 interacts with perilipin and is localized to lipid droplets: possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. J. Biol. Chem. 279: 30490-30497. (Pubitemid 38937979)
46. Wang, H., M. Bell, U. Sreenevasan, H. Hu, J. Liu, K. Dalen, C. Londos, T. Yamaguchi, M. A. Rizzo, R. Coleman, et al. 2011. Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. J. Biol. Chem. 286: 15707-15715. [Erratum. 2013. J. Biol. Chem. 288: 10952.]
47. Bartz, R., W. H. Li, B. Venables, J. K. Zehmer, M. R. Roth, R. Welti, R. G. Anderson, P. Liu, and K. D. Chapman. 2007. Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. J. Lipid Res. 48: 837-847. (Pubitemid 46557888)
48. Tauchi-Sato, K., S. Ozeki, T. Houjou, R. Taguchi, and T. Fujimoto. 2002. The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J. Biol. Chem. 277: 44507-44512. (Pubitemid 36157885)
49. Yu, W., J. Cassara, and P. F. Weller. 2000. Phosphatidylinositide 3-kinase localizes to cytoplasmic lipid bodies in human polymorphonuclear leukocytes and other myeloid-derived cells. Blood. 95: 1078-1085. (Pubitemid 30062734)