Dna methylation of human telomerase reverse transcriptase associated with leukocyte telomere length shortening in hyperhomocysteinemia-type hypertension in humans and in a rat model

Circulation Journal

Volumn 78, Issue 8, 2014, Pages 1915-1923

  Zhang, Dong Hong ^a   Wen, Xue Mei ^a   Zhang, Lin ^a   Cui, Wei ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

DNA methylation; Homocysteine; Human telomerase reverse transcriptase (hTERT); Hypertension; Leukocyte telomere length

Indexed keywords

MESSENGER RNA; TELOMERASE; TERT PROTEIN, HUMAN;

AGE; AGED; ANIMAL; BIOSYNTHESIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE MODEL; DNA METHYLATION; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HYPERHOMOCYSTEINEMIA; HYPERTENSION; LEUKOCYTE; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; RAT; SEX DIFFERENCE; SPRAGUE DAWLEY RAT; TELOMERE; TELOMERE HOMEOSTASIS;

AGE FACTORS; AGED; ANIMALS; CROSS-SECTIONAL STUDIES; DISEASE MODELS, ANIMAL; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYPERHOMOCYSTEINEMIA; HYPERTENSION; LEUKOCYTES; MALE; MIDDLE AGED; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEX FACTORS; TELOMERASE; TELOMERE; TELOMERE HOMEOSTASIS;

EID: 84905036236     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-14-0233     Document Type: Article

References (32)

1. Svetkey LP, Harris EL, Martin E, Vollmer WM, Meltesen GT, Ricchiuti V, et al. Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system. Am J Hypertens 2011; 24: 209-217.
2. Ohira T, Iso H. Cardiovascular disease epidemiology in Asia: An overview. Circ J 2013; 77: 1646-1652.
3. Binder A. A review of the genetics of essential hypertension. Curr Opin Cardiol 2007; 22: 176-184.
4. Banos-Gonzalez MA, Angles-Cano E, Cardoso-Saldana G, Pena-Duque MA, Martinez-Rios MA, Valente-Acosta B, et al. Lipoprotein(a) and homocysteine potentiate the risk of coronary artery disease in male subjects. Circ J 2012; 76: 1953-1957.
5. Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, et al. Total plasma homocysteine and cardiovascular risk profile: The Hordaland Homocysteine Study. JAMA 1995; 274: 1526-1533.
6. Perez-Rivero G, Ruiz-Torres MP, Rivas-Elena JV, Jerkic M, Diez-Marques ML, Lopez-Novoa JM, et al. Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Circulation 2006; 114: 309-317.
7. Hansson GK, Libby P. The immune response in atherosclerosis: A double-edged sword. Nat Rev Immunol 2006; 6: 508-519.
8. Zhang D, Xie X, Chen Y, Hammock BD, Kong W, Zhu Y. Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Circ Res 2012; 110: 808-817.
9. Zhang D, Chen Y, Xie X, Liu J, Wang Q, Kong W, et al. Homocysteine activates vascular smooth muscle cells by DNA demethylation of platelet-derived growth factor in endothelial cells. J Mol Cell Cardiol 2012; 53: 487-496.
10. Choi JH, Min NY, Park J, Kim JH, Park SH, Ko YJ, et al. TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT in HCT116. Biochem Biophys Res Commun 2010; 391: 449-454.
11. Guilleret I, Benhattar J. Demethylation of the human telomerase catalytic subunit (hTERT) gene promoter reduced hTERT expression and telomerase activity and shortened telomeres. Exp Cell Res 2003; 289: 326-334.
12. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2013; 31: 1281-1357.
13. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002; 30: e47, doi:10.1093/nar/30.10.e47.
14. Zhang D, Ai D, Tanaka H, Hammock BD, Zhu Y. DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism. Biochim Biophys Acta 2010; 1799: 659-667.
15. Zhang D, Wen X, Wu W, Xu E, Zhang Y, Cui W. Homocysteinerelated hTERT DNA demethylation contributes to shortened leukocyte telomere length in atherosclerosis. Atherosclerosis 2013; 231: 173-179.
16. Da LP, Tanaka L, Brum PC, Dourado PM, Favarato D, Krieger JE, et al. Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats. Atherosclerosis 2012; 224: 136-142.
17. Qu Y, Duan Z, Zhao F, Wei D, Zhang J, Tang B, et al. Telomerase reverse transcriptase upregulation attenuates astrocyte proliferation and promotes neuronal survival in the hypoxic-ischemic rat brain. Stroke 2011; 42: 3542-3550.
18. Bhupatiraju C, Saini D, Patkar S, Deepak P, Das B, Padma T. Association of shorter telomere length with essential hypertension in Indian population. Am J Hum Biol 2012; 24: 573-578.
19. Yang Z, Huang X, Jiang H, Zhang Y, Liu H, Qin C, et al. Short telomeres and prognosis of hypertension in a Chinese population. Hypertension 2009; 53: 639-645.
20. Castro R, Rivera I, Martins C, Struys EA, Jansen EE, Clode N, et al. Intracellular S-adenosylhomocysteine increased levels are associated with DNA hypomethylation in HUVEC. J Mol Med (Berl) 2005; 83: 831-836.
21. Nilsson PM, Tufvesson H, Leosdottir M, Melander O. Telomeres and cardiovascular disease risk: An update 2013. Transl Res 2013; 162: 371-380.
22. Sen U, Tyagi SC. Homocysteine and Hypertension in Diabetes: Does PPARgamma Have a Regulatory Role? PPAR Res 2010; 2010: 806538.
23. Vermeulen EG, Niessen HW, Bogels M, Stehouwer CD, Rauwerda JA, van Hinsbergh VW. Decreased smooth muscle cell/extracellular matrix ratio of media of femoral artery in patients with atherosclerosis and hyperhomocysteinemia. Arterioscler Thromb Vasc Biol 2001; 21: 573-577.
24. Demissie S, Levy D, Benjamin EJ, Cupples LA, Gardner JP, Herbert A, et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell 2006; 5: 325-330.
25. Aviv A. Telomeres and human aging: Facts and fibs. Sci Aging Knowledge Environ 2004; 51: pe43, doi:10.1126/sageke.2004.51.pe43.
26. Weischer M, Nordestgaard BG, Cawthon RM, Freiberg JJ, Tybjaerg-Hansen A, Bojesen SE. Short telomere length, cancer survival, and cancer risk in 47102 individuals. J Natl Cancer Inst 2013; 105: 459-468.
27. Butt HZ, Atturu G, London NJ, Sayers RD, Bown MJ. Telomere length dynamics in vascular disease: A review. Eur J Vasc Endovasc Surg 2010; 40: 17-26.
28. Daly C, Fitzgerald AP, O'Callaghan P, Collins P, Cooney MT, Graham IM. Homocysteine increases the risk associated with hyperlipidaemia. Eur J Cardiovasc Prev Rehabil 2009; 16: 150-155.
29. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993; 270: 2693-2698.
30. Huo Y, Qin X, Wang J, Sun N, Zeng Q, Xu X, et al. Efficacy of folic acid supplementation in stroke prevention: New insight from a metaanalysis. Int J Clin Pract 2012; 66: 544-551.
31. Richards JB, Valdes AM, Gardner JP, Kato BS, Siva A, Kimura M, et al. Homocysteine levels and leukocyte telomere length. Atherosclerosis 2008; 200: 271-277.
32. Kyo S, Takakura M, Fujiwara T, Inoue M. Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers. Cancer Sci 2008; 99: 1528-1538.