MDSCs mediate angiogenesis and predispose canine mammary tumor cells for metastasis via IL-28/IL-28RA (IFN-λ) signaling

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Mucha, Joanna ^a   Majchrzak, Kinga ^a   Taciak, Bartłomiej ^a   Hellmén, Eva ^b   Król, Magdalena ^a  

^a WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; GAMMA INTERFERON; INTERLEUKIN 28; INTERLEUKIN 28A; SMALL INTERFERING RNA; STAT3 PROTEIN; CYTOKINE RECEPTOR; INTERLEUKIN 28ALPHA RECEPTOR; KERATIN; VIMENTIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; BREAST TUMOR; CANCER CELL; CANCER STAGING; CELL INVASION; CELL MIGRATION; COCULTURE; CONTROLLED STUDY; DOG; DRUG TARGETING; ENDOTHELIUM CELL; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; IN VITRO STUDY; METASTASIS; MICROARRAY ANALYSIS; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPPRESSOR CELL; T LYMPHOCYTE; TUMOR CELL; WESTERN BLOTTING; ANIMAL; BONE MARROW CELL; CELL COUNT; CELL MOTION; EXPERIMENTAL MAMMARY NEOPLASM; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; CELL COUNT; CELL LINE, TUMOR; CELL MOVEMENT; COCULTURE TECHNIQUES; DOGS; EPITHELIAL-MESENCHYMAL TRANSITION; IMMUNOPHENOTYPING; INTERFERON-GAMMA; KERATINS; MAMMARY NEOPLASMS, ANIMAL; MYELOID CELLS; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; VIMENTIN;

EID: 84904991801     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103249     Document Type: Article

References (38)

1. Balwit JM, Hwu P, Urba WJ, Marincola FM (2011) The iSBTc/SITC primer on tumor immunology and biological therapy of cancer: a summary of the 2010 program. J Transl Med; 9:18.
2. Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, et al. (2004) Expansion of myeloid immune suppressor Gr+ CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Canc Cell; 6:409-21. (Pubitemid 39361441)
3. Vincent J, Mignot G, Chalmin F, Ladoire S, Bruchard M, et al. (2010) 5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell- dependent antitumor immunity. Cancer Res; 70:3052-61.
4. Pekarek LA, Starr BA, Toledano AY, Schreiber H (1995) Inhibition of tumor growth by elimination of granulocytes. J Exp Med; 181:435-40.
5. Li H, Han Y, Guo Q, Zhang M, Cao X (2009) Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. J Immunol; 182:240-49.
6. Zhang Y, Liu Q, Zhang M, Yu Y, Liu X, et al. (2009) Fas signal promotes lung cancer growth by recruiting myeloid-derived suppressor cells via cancer cell-derived PGE2. J Immunol; 182:3801-08.
7. Abastado JP, Zhi L (2012) Myeloid Derived Suppressor Cells: Subsets, Expansion, and Role in Cancer Progression, Tumor Microenvironment and Myelomonocytic Cells, Dr. Subhra Biswas (Ed.); ISBN: 978-953-51-0439-1, InTech.
8. Zetter BR (1998) Angiogenesis and tumor metastasis. Annu Rev Med; 49:407-24.
9. Kujawski M, Kortylewski M, Lee H, Herrmann A, Kay H, et al. (2008) Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J Clin Invest; 118:3367-77.
10. Kusmartsev S, Cheng F, Yu B, Nefedova Y, Sotomayor E, et al. (2003) All-transretinoic acid eliminates immature myeloid cells from tumor- bearing mice and improves the effect of vaccination. Cancer Res; 63:4441-49. (Pubitemid 36951016)
11. Serafini P, Meckel K, Kelso M, Noonan K, Califano J, et al. (2006) Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med; 203:2691-2702. (Pubitemid 44833345)
12. Suzuki E, Kapoor V, Jassar AS, Kaiser LR, Albelda SM (2005) Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res; 11:6713-21. (Pubitemid 41339014)
13. Sinha P, Clements VK, Ostrand-Rosenberg S (2005) Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease. J Immunol; 174:636-45. (Pubitemid 40094255)
14. Tamburini BA, Trapp S, Phang TL, Schappa JT, Hunter LE, et al. (2009) Gene Expression Profiles of Sporadic Canine Hemangiosarcoma Are Uniquely Associated with Breed. PLoS ONE; 4:e5549.
15. Rowell JL, McCarthy DO, Alvarez CE (2011) Dog models of naturally occurring cancer. Trends Mol Med; 17:380-88.
16. Gordon I, Paoloni M, Mazcko C, Khanna C (2009) The Comparative Oncology Trials Consortium: Using Spontaneously Occurring Cancers in Dogs to Inform the Cancer Drug Development Pathway. PLoS Med; 6:e1000161.
17. Paoloni M, Khanna C (2008) Translation of new cancer treatments from pet dogs to humans. Nat Rev Cancer; 8:147-56. (Pubitemid 351161319)
18. Król M, Mucha J, Majchrzak K, Homa A, Bulkowska M, et al. (2014) Macrophages mediate a 'switch' between canonical and non-canonical Wnt pathways in canine mammary tumors. PLoS ONE; DOI. 10.1371/journal.pone.0083995.
19. Król M, Majchrzak K, Jakubowska A, Karwicka M, Pawłowski K, et al. (2013) CSF-1R as an inhibitor of apoptosis and promotor of proliferation, migration and invasion of canine mammary cancer cells. BMC Vet Res; 9:65.
20. Owen LM (1980) The TNM classification of tumours in domestic animals. Geneva: World Health Organization.
21. Numasaki M, Tagawa M, Iwata F, Suzuki T, Nakamura A, et al. (2007) IL-28 Elicits Antitumor Responses against Murine Fibrosarcoma. J Immunol; 178:5086-98. (Pubitemid 46595292)
22. Mi H, Lazareva-Ulitsky B, Loo R, Kejariwal A, Vandergriff J, et al. (2005) The PANTHER database of protein families, subfamilies, functions and pathways. Nucleic Acids Res; 33:D284-288. (Pubitemid 40207879)
23. Brinkhof B, Spee B, Rothuizen J, Penning LC (2006) Development and evaluation of canine reference genes for accurate quantification of gene expression. Anal Biochem; 356:36-43. (Pubitemid 44232736)
24. Etschmann B, Wilcken B, Stoevesand K, von der Schulenburg A, Sterner-Kock A (2006) Selection of reference genes for quantitative real-time PCR analysis in canine mammary tumors using the GeNorm algorithm. Vet Pathol; 43:934-42. (Pubitemid 44785966)
25. Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative Ct method. Nat Prot; 3:1101-08. (Pubitemid 351818697)
26. Kosaka N, Iguchi H, Hagiwara K, Yoshioka Y, Takeshita F, et al. (2013) Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis. J Biol Chem; 288:10849-59.
27. Dumoutier L, Tounsi A, Michiels T, Sommereyns C, Kotenko SV, et al. (2004) Role of the Interleukin (IL)-28 Receptor Tyrosine Residues for Antiviral and Antiproliferative Activity of IL-29/Interferon-l1. Similarities with type I interferon signaling. J Biol Chem; 279:32269-74. (Pubitemid 39014676)
28. Vasquez-Dunddel D, Pan F, Zeng Q, Gorbounov M, Albesiano E, et al. (2013) STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. J Clin Invest; 123:1580-89.
29. Diaz-Montero CM, Salem ML, Nishimura MI, Garrett-Mayer E, Cole DJ, et al. (2009) Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother; 58:49-59.
30. Zhang B, Wang Z, Wu L, Zhang M, Li W, et al. (2013) Circulating and Tumor-Infiltrating Myeloid-Derived Suppressor Cells in Patients with Colorectal Carcinoma. PLoS ONE; 8:e57114.
31. Król M, Pawłowski KM, Dolka I, Musielak O, Majchrzak K, et al. (2011) Denisty of Gr-1 positive myeloid precursor cells, p-STAT3 expression and gene expression pattern in canine mammary cancer metastasis. Vet Res Commun 2011; 35:409-23.
32. Melani C, Chiodoni C, Forni G, Colombo MP (2003) Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity. Blood; 102:2138.
33. Wang M, Zhang W, Crisostomo P, Markel T, Meldrum KK, et al. (2007) STAT3 mediates bone marrow mesenchymal stem cell VEGF production. J Mol Cell Cardiol; 42:1009-15. (Pubitemid 46829204)
34. Rivat C, De Wever O, Bruyneel E, Mareel M, Gespach C, et al. (2004) Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes. Oncogene; 23:3317-27. (Pubitemid 38669821)
35. Vidal-Vanaclocha F, Mendoza L, Telleria N, Salado C, Valcárcel M, et al. (2006) Clinical and experimental approaches to the pathophysiology of interleukin-18 in cancer progression. Canc Met Rev; 25:417-34. (Pubitemid 44922359)
36. Petersen OW, Nielsen HL, Gudjonsson T, Villadsen R, Rønnov-Jessen L, et al. (2001) The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion. Breast Canc Res; 3:213-17. (Pubitemid 32631699)
37. Doble BW, Woodhett JR (2007) Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cell Tissues Organs; 185:73-84. (Pubitemid 46956846)
38. Shaw AK, Novitskiy S, Moses HL (2012) Myeloid-derived suppressor cells promote cancer-associated fibroblast migration and carcinoma cell invasion. Canc Res; 72 doi: 10.1158/1538-7445.AM2012-LB-495.