Antioxidative effects of Panax notoginseng saponins in brain cells

Phytomedicine

Volumn 21, Issue 10, 2014, Pages 1189-1195

  Zhou, Ningna ^a,b   Tang, Yang ^a   Keep, Richard F ^a,c   Ma, Xiaoxia ^b   Xiang, Jianming ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b YUNNAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Astrocytes; Oxidative stress; SH SY5Y cells; Total saponins of Panax notoginseng leaves

Indexed keywords

ANTIOXIDANT; GLUCOSE; GLUTATHIONE TRANSFERASE P1; HEME OXYGENASE 1; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; OXYGEN; REACTIVE OXYGEN METABOLITE; SAPONIN; TRANSCRIPTION FACTOR NRF2; GINSENOSIDE; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; ASTROCYTE; BRAIN CELL; BRAIN CORTEX; CELL DAMAGE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROBLASTOMA CELL LINE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PANAX NOTOGINSENG; PLANT LEAF; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; REOXYGENATION; ANIMAL; BRAIN; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; UPREGULATION;

PANAX NOTOGINSENG; RATTUS;

ANIMALS; ANTIOXIDANTS; ASTROCYTES; BRAIN; CELL DEATH; CELL LINE, TUMOR; CELLS, CULTURED; GENE EXPRESSION REGULATION; GINSENOSIDES; HUMANS; HYDROGEN PEROXIDE; L-LACTATE DEHYDROGENASE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; OXYGEN; PANAX NOTOGINSENG; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SAPONINS; UP-REGULATION;

EID: 84904973535     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.05.004     Document Type: Article

References (48)

1. G.P. Bienert, J.K. Schjoerring, and T.P. Jahn Membrane transport of hydrogen peroxide Biochim. Biophys. Acta 1758 2006 994 1003
2. J.M. Braughler, and E.D. Hall Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation Free Radic. Biol. Med. 6 1989 289 301
3. M.J. Calkins, R.J. Jakel, D.A. Johnson, K. Chan, Y.W. Kan, and J.A. Johnson Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription Proc. Natl. Acad. Sci. U. S. A. 102 2005 244 249
4. P. Chan, G.N. Thomas, and B. Tomlinson Protective effects of trilinolein extracted from panax notoginseng against cardiovascular disease Acta Pharmacol. Sin. 23 2002 1157 1162
5. S. Chen, J. Liu, X. Liu, Y. Fu, M. Zhang, Q. Lin, J. Zhu, L. Mai, Z. Shan, X. Yu, M. Yang, and S. Lin Panax notoginseng saponins inhibit ischemia-induced apoptosis by activating PI3K/Akt pathway in cardiomyocytes J. Ethnopharmacol. 137 2011 263 270
6. X. Chen, M. Zhou, Q. Li, J. Yang, Y. Zhang, D. Zhang, S. Kong, D. Zhou, and L. He Sanchi for acute ischaemic stroke Cochrane Database Syst. Rev. 2008 CD006305
7. 2-induced cytotoxicity in cultured PC12 cells Chin. Med. 5 2010 38
8. C.G. Cochrane Cellular injury by oxidants Am. J. Med. 91 1991 23S 30S
9. J.C. Copin, Y. Gasche, Y. Li, and P.H. Chan Prolonged hypoxia during cell development protects mature manganese superoxide dismutase-deficient astrocytes from damage by oxidative stress FASEB J. 15 2001 525 534
10. P.J. Crack, and J.M. Taylor Reactive oxygen species and the modulation of stroke Free Radic. Biol. Med. 38 2005 1433 1444
11. L.M. de Almeida, M.C. Leite, A.P. Thomazi, C. Battu, P. Nardin, L.S. Tortorelli, C. Zanotto, T. Posser, S.T. Wofchuk, R.B. Leal, C.A. Goncalves, and C. Gottfried Resveratrol protects against oxidative injury induced by H2O2 in acute hippocampal slice preparations from Wistar rats Arch. Biochem. Biophys. 480 2008 27 32
12. G.M. DeNicola, F.A. Karreth, T.J. Humpton, A. Gopinathan, C. Wei, K. Frese, D. Mangal, K.H. Yu, C.J. Yeo, E.S. Calhoun, F. Scrimieri, J.M. Winter, R.H. Hruban, C. Iacobuzio-Donahue, S.E. Kern, I.A. Blair, and D.A. Tuveson Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis Nature 475 2011 106 109
13. R. Dringen, and J. Hirrlinger Glutathione pathways in the brain Biol. Chem. 384 2003 505 516
14. J.H. Fu, X.Z. Li, X.H. Shang, and J.X. Liu Protective effects of saponines of stem and leaf of Panax notoginseng on acute myocardial ischemia in anaesthetic dogs Zhongguo Zhong Yao Za Zhi 31 2006 62 65
15. R.G. Giffard, and R.A. Swanson Ischemia-induced programmed cell death in astrocytes Glia 50 2005 299 306
16. M.P. Goldberg, and D.W. Choi Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury J. Neurosci. 13 1993 3510 3524
17. S. Guo, M. Miyake, K.J. Liu, and H. Shi Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment J. Neurochem. 108 2009 1309 1321
18. A.V. Gyulkhandanyan, C.J. Feeney, and P.S. Pennefather Modulation of mitochondrial membrane potential and reactive oxygen species production by copper in astrocytes J. Neurochem. 87 2003 448 460
19. Y. Hamdi, O. Masmoudi-Kouki, H. Kaddour, F. Belhadj, P. Gandolfo, D. Vaudry, M. Mokni, J. Leprince, R. Hachem, H. Vaudry, M.C. Tonon, and M. Amri Protective effect of the octadecaneuropeptide on hydrogen peroxide-induced oxidative stress and cell death in cultured rat astrocytes J. Neurochem. 118 2011 416 428
20. L. He, X. Chen, M. Zhou, D. Zhang, J. Yang, M. Yang, and D. Zhou Radix/rhizoma notoginseng extract (sanchitongtshu) for ischemic stroke: a randomized controlled study Phytomedicine 18 2011 437 442
21. A.K. Jaiswal Nrf2 signaling in coordinated activation of antioxidant gene expression Free Radic. Biol. Med. 36 2004 1199 1207
22. M.J. Jou, T.I. Peng, R.J. Reiter, S.B. Jou, H.Y. Wu, and S.T. Wen Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes J. Pineal Res. 37 2004 55 70
23. 2 availability to ARPE-19 cultures in models of oxidative stress Free Radic. Biol. Med. 48 2010 1064 1070
24. N.P. Kedar Can we prevent Parkinson's and Alzheimer's disease? J. Postgrad. Med. 49 2003 236 245
25. M. Kobayashi, and M. Yamamoto Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation Antioxid. Redox Signal. 7 2005 385 394
26. X.L. Lei, and G.C. Chiou Cardiovascular pharmacology of Panax notoginseng (Burk) F.H. Chen and Salvia miltiorrhiza Am. J. Chin. Med. 14 1986 145 152
27. J. Lotharius, J. Falsig, J. van Beek, S. Payne, R. Dringen, P. Brundin, and M. Leist Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway J. Neurosci. 25 2005 6329 6342
28. J. Mathers, J.A. Fraser, M. McMahon, R.D. Saunders, J.D. Hayes, and L.I. McLellan Antioxidant and cytoprotective responses to redox stress Biochem. Soc. Symp. 2004 157 176
29. K.D. McCarthy, and J. de Vellis Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue J. Cell Biol. 85 1980 890 902
30. T.B. Ng Pharmacological activity of sanchi ginseng (Panax notoginseng) J. Pharm. Pharmacol. 58 2006 1007 1019
31. M.C. Papadopoulos, I.L. Koumenis, T.Y. Yuan, and R.G. Giffard Increasing vulnerability of astrocytes to oxidative injury with age despite constant antioxidant defenses Neuroscience 82 1998 915 925
32. J.S. Park, J.S. Jung, Y.H. Jeong, J.W. Hyun, T.K. Le, D.H. Kim, E.C. Choi, and H.S. Kim Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression J. Neurochem. 119 2011 909 919
33. 2 in Saccharomyces cerevisiae Free Radic. Biol. Med. 46 2009 289 298
34. S. Peuchen, J.P. Bolanos, S.J. Heales, A. Almeida, M.R. Duchen, and J.B. Clark Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system Prog. Neurobiol. 52 1997 261 281
35. R. Resende, P.I. Moreira, T. Proenca, A. Deshpande, J. Busciglio, C. Pereira, and C.R. Oliveira Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease Free Radic. Biol. Med. 44 2008 2051 2057
36. I.B. Sabirzhanova, B.E. Sabirzhanov, J. Keifer, and T.G. Clark Activation of mammalian Tolloid-like 1 expression by hypoxia in human neuroblastoma SH-SY5Y cells Biochem. Biophys. Res. Commun. 389 2009 338 342
37. H.M. Schipper, A. Liberman, and E.G. Stopa Neural heme oxygenase-1 expression in idiopathic Parkinson's disease Exp. Neurol. 150 1998 60 68
38. L.H. Shen, Y. Li, Q. Gao, S. Savant-Bhonsale, and M. Chopp Down-regulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain Glia 56 2008 1747 1754
39. K. Takuma, A. Baba, and T. Matsuda Astrocyte apoptosis: implications for neuroprotection Prog. Neurobiol. 72 2004 111 127
40. R.K. Thimmulappa, K.H. Mai, S. Srisuma, T.W. Kensler, M. Yamamoto, and S. Biswal Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray Cancer Res. 62 2002 5196 5203
41. H. Wagner, R. Bauer, D. Melchart, X. Pei-Gen, and A. Staudinger The analytical monograph (TLC and HPLC) of Radix and Rhizoma Notoginseng (Sanqi) H. Wagner, R. Bauer, D. Melchart, X. Pei-Gen, A. Staudinger, Chromatographic Fingerprint Analysis of Herbal Medicines 2011 Springer Wien-New York 843 855
42. J.X. Wilson Antioxidant defense of the brain: a role for astrocytes Can. J. Physiol. Pharmacol. 75 1997 1149 1163
43. C.C. Winterbourn Hydroxyl radical production in body fluids. Roles of metal ions, ascorbate and superoxide Biochem. J. 198 1981 125 131
44. H. Xiang, Y. Liu, B. Zhang, J. Huang, Y. Li, B. Yang, Z. Huang, F. Xiang, and H. Zhang The antidepressant effects and mechanism of action of total saponins from the caudexes and leaves of Panax notoginseng in animal models of depression Phytomedicine 18 2011 731 738
45. X.H. Yao, and X.J. Li Protective effects and its mechanism of panaxatriol saponins isolated from Panax notoginseng on cerebral ischemia Zhongguo Zhong Yao Za Zhi 27 2002 371 373
46. M.S. Yoo, H.S. Chun, J.J. Son, L.A. DeGiorgio, D.J. Kim, C. Peng, and J.H. Son Oxidative stress regulated genes in nigral dopaminergic neuronal cells: correlation with the known pathology in Parkinson's disease Brain Res. Mol. Brain Res. 110 2003 76 84
47. D. Zhu, K.S. Tan, X. Zhang, A.Y. Sun, G.Y. Sun, and J.C. Lee Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes J. Cell Sci. 118 2005 3695 3703
48. J.R. Zhu, Y.F. Tao, S. Lou, and Z.M. Wu Protective effects of ginsenoside Rb(3) on oxygen and glucose deprivation-induced ischemic injury in PC12 cells Acta Pharmacol. Sin. 31 2010 273 280