A genetic association study of single nucleotide polymorphisms in GNβ3 and COMT in elderly patients with irritable bowel syndrome

Medical Science Monitor

Volumn 20, Issue , 2014, Pages 1246-1254

  Wang, Yuezhi ^a   Wu, Zhengyu ^a   Qiao, Hui ^b   Zhang, Yu ^a  

^a FUDAN UNIVERSITY   (China)

^b EYE AND ENT HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Dental care for elderly; Irritable bowel syndrome; Single nucleotide polymorphisms

Indexed keywords

CATECHOL METHYLTRANSFERASE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; COMT PROTEIN, HUMAN; G-PROTEIN BETA3 SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PRIMER DNA;

AGED; ARTICLE; CATECHOL METHYLTRANSFERASE GENE; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DISEASE DURATION; FEMALE; GENE; GENE FREQUENCY; GENE INTERACTION; GENE MUTATION; GENETIC ASSOCIATION; GENOTYPE; GERIATRIC DEPRESSION SCALE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT GENE; HUMAN; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PREVALENCE; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; ASIAN CONTINENTAL ANCESTRY GROUP; GENETICS; PATHOLOGY; POLYMERASE CHAIN REACTION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; CATECHOL O-METHYLTRANSFERASE; DNA PRIMERS; GENE FREQUENCY; GENOTYPE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; IRRITABLE BOWEL SYNDROME; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84904962285     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.890315     Document Type: Article

References (25)

1. Chang FY, Lu CL, Chen TS: The current prevalence of irritable bowel syndrome in Asia. J Neurogastroenterol Motil, 2010; 16: 389-400
2. Masud MA, Hasan M, Khan AK: Irritable bowel syndrome in a rural community in Bangladesh: prevalence, symptoms pattern, and health care seeking behavior. Am J Gastroenterol, 2001; 96: 1547-52
3. Feng XW, Xu S: Epidemiological analysis of Hong Kong SAR older people with irritable bowel syndrome. Chengde Medical Science, 2009; 26: 43-45
4. Feng S, Reading J, Huiqing Z: Epidemiological investigations of irritable bowel syndrome patients in Songjiang community. Chinese Journal of Digestion, 2010; 31: 663-8
5. Saito YA, Zimmerman JM, Harmsen WS et al: Irritable bowel syndrome aggregates strongly in families: a family-based case-control study. Neurogastroenterol Motil, 2008; 20: 790-97
6. Saito YA: The role of genetics in IBS. Gastroenterol Clin North Am, 2011; 40: 45-67
7. Camilleri M, Katzka DA: Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol, 2012; 302: G1075-84
8. Yeo A, Boyd P, Lumsden S et al: Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut, 2004; 53: 1452-58
9. Colucci R, Gambaccini D, Ghisu N et al: Influence of the serotonin transporter 5HTTLPR polymorphism on symptom severity in irritable bowel syndrome. PLoS One, 2013; 8: e54831
10. Oshima T, Toyoshima F, Nakajima S et al: Genetic factors for functional dyspepsia. J Gastroenterol Hepatol, 2011; 26(3): 83-87
11. Siffert W, Rosskopf D, Siffert G et al: Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet, 1998; 18: 45-48
12. Kim HG, Lee KJ, Lim SG et al: G-Protein Beta3 Subunit C825T Polymorphism in Patients With Overlap Syndrome of Functional Dyspepsia and Irritable Bowel Syndrome. J Neurogastroenterol Motil, 2012; 18: 205-10
13. Markoutsaki T, Karantanos T, Gazouli M et al: Serotonin transporter and G protein beta 3 subunit gene polymorphisms in Greeks with irritable bowel syndrome. Dig Dis Sci, 2011; 56: 3276-80
14. Lee HJ, Lee SY, Choi JE et al: G protein beta3 subunit, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms in Koreans with irritable bowel syndrome. Neurogastroenterol Motil, 2010; 22: 758-63
15. Saito YA, Locke GR III, Zimmerman JM et al: A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome.Neurogastroenterol Motil, 2007; 19: 465-70
16. Park CS, Uhm JH: Polymorphisms of the Serotonin Transporter Gene and G-Protein beta3 Subunit Gene in Korean Children with Irritable Bowel Syndrome and Functional Dyspepsia. Gut Liver, 2012; 6: 223-28
17. Evans A, Jun SE, Heitkemper M: IBS symptoms: It's in the genes. Am J Gastroenterol, 2010; 105: S491-S2
18. Syvanen AC, Tilgmann C, Rinne J, Ulmanen I: Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland. Pharmacogenetics, 1997; 7: 65-71
19. Hall KT, Lembo AJ, Kirsch I et al: Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS One, 2012; 7: e48135
20. Karling P, Danielsson A, Adolfsson R, Norrback KF: No difference in symptoms of irritable bowel syndrome between healthy subjects and patients with recurrent depression in remission. Neurogastroenterol Motil, 2007; 19: 896-904 1253
21. Lotta T, Vidgren J, Tilgmann C et al: Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry, 1995; 34: 4202-10
22. Lachman HM, Papolos DF, Saito T et al: Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 1996; 6: 243-50
23. Choung RS, Locke GR III, Zinsmeister AR et al: Psychosocial distress and somatic symptoms in community subjects with irritable bowel syndrome: a psychological component is the rule. Am J Gastroenterol, 2009; 104: 1772-79
24. Drossman DA: Rome III: the new criteria. Chin J Dig Dis, 2006; 7: 181-85
25. Talley NJ, Howell S, Poulton R: The irritable bowel syndrome and psychiatric disorders in the community: is there a link? Am J Gastroenterol, 2001; 96: 1072-79 1254