G-Protein beta3 subunit C825T polymorphism in patients with overlap syndrome of functional dyspepsia and irritable bowel syndrome

Journal of Neurogastroenterology and Motility

Volumn 18, Issue 2, 2012, Pages 205-210

  Kim, Han Gyeol ^a   Lee, Kwang Jae ^a   Lim, Sun Gyo ^a   Jung, Jae Yeon ^a   Cho, Sung Won ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Functional dyspepsia; G protein beta3 subunit; Irritable bowel syndrome; Syndrome

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN BETA POLYPEPTIDE 3; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DNA POLYMORPHISM; DYSPEPSIA; ENTEROPATHY; FEMALE; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; IRRITABLE COLON; KOREA; MAJOR CLINICAL STUDY; MALE; OVERLAP SYNDROME; PHENOTYPE;

EID: 84865078310     PISSN: 20930879     EISSN: 20930887     Source Type: Journal    
DOI: 10.5056/jnm.2012.18.2.205     Document Type: Article

References (24)

1. Locke GR 3rd, Zinsmeister AR, Talley NJ, Fett SL, Melton LJ 3rd. Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc 2000;75:907-912.
2. Bengtson MB, Rønning T, Vatn MH, Harris JR. Irritable bowel syndrome in twins: genes and environment. Gut 2006;55:1754-1759.
3. Holtmann G, Siffert W, Haag S, et al. G-protein ß3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia. Gastroenterology 2004;126:971-979.
4. Camilleri CE, Carlson PJ, Camilleri M, et al. A study of candidate genotypes associated with dyspepsia in a U.S. community. Am J Gastroenterol 2006;101:581-592.
5. van Lelyveld N, Linde JT, Schipper M, Samsom M. Candidate genotypes associated with functional dyspepsia. Neurogastroenterol Motil 2008;20:767-773.
6. Tahara T, Arisawa T, Shibata T, et al. Homozygous 825T allele of the GNB3 protein influences the susceptibility of Japanese to dyspepsia. Dig Dis Sci 2008;53:642-646.
7. Andresen V, Camilleri M, Kim HJ, et al. Is there an association between GNB3-C825T genotype and lower functional gastrointestinal disorders? Gastroenterology 2006;130:1985-1994.
8. Baumgart D, Naber C, Haude M, et al. Protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha2-adrenoceptor activation. Circ Res 1999;85:965-969.
9. Zill P, Baghai TC, Zwanzger P, et al. Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment. Neuroreport 2000;11:1893-1897.
10. Lindemaann M, Virchow S, Ramann F, et al. The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response. FEBS Lett 2001;495:82-86.
11. Holtmann G, Gschossmann J, Neufang-Hüber J, Gerken G, Talley NJ. Differences in gastric mechnosensory function after repeated ramp distensions in non-consulters with dyspepsia and healthy controls. Gut 2000;47:332-336.
12. Locke GR 3rd. The epidemiology of functional gastrointestinal disorders in North America. Gastroenterol Clin North Am 1996;25:1-19.
13. Agréus L, Svärdsudd K, Nyrén O, Tibblin G. Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology 1995;109:671-680.
14. Caballero-Plasencia AM, Sofos-Kontoyannis S, Valenzuela-Barraco M, Martín-Ruiz JL, Casado-Caballero FJ, López-Mañas JG. Irritable bowel syndrome in patients with dyspepsia: a community-based study in southern Europe. Eur J Gastroenterol Hepatol 1999;11:517-522.
15. Stanghellini V, Tosetti C, Paternico A, et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 1996;110:1036-1042.
16. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998;115:1346-1352.
17. Holtmann G, Goebell H, Jockenhovel F, Talley NJ. Altered vagal and intestinal mechano-sensory function in chronic unexplained dyspepsia. Gut 1998;42:501-506.
18. Coffin B, Azpiroz F, Guarner F, Malagelada JR. Selective gastric hypersensitivity and reflex hyporeactivity in functional dyspepsia. Gastroenterology 1994;107:1345-1351.
19. Corsetti M, Caenepeel P, Fischler B, Janssens J, Tack J. Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia. Am J Gastroenterol 2004;99:1152-1159.
20. Tack J, Talley NJ, Camilleri M, et al. Functional gastroduodenal disorders. Gastroenterology 2006;130:1466-1479.
21. Park HY, Jahng JH, Lee YJ, Park H, Lee SI. Serotonin Transporter Gene and G-protein ß3 C825T Gene Polymorphism in Patients with Functional Dyspepsia and Irritable Bowel Syndrome. Kor J Neurogastroenterol Motil 2009;15:58-64.
22. Oshima T, Nakajima S, Yokoyama T, et al. The G-protein beta3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia. BMC Med Genet 2010;11:13.
23. Lee HJ, Lee SY, Choi JE, et al. G protein beta3 subunit, interleukin- 10, and tumor necrosis factor-alpha gene polymorphisms in Koreans with irritable bowel syndrome. Neurogastroenterol Motil 2010;22:758-763.
24. Siffert W, Rosskopf D, Siffert G, et al. Association of a human Gprotein beta3 subunit variant with hypertension. Nat Genet 1998;18: 45-48