Structural effects of PrP polymorphisms on intra- and interspecies prion transmission

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 30, 2014, Pages 11169-11174

  Angers, Rachel ^a,e   Christiansen, Jeffrey ^b   Nalls, Amy V ^b   Kang, Hae Eun ^b   Hunter, Nora ^c   Hoover, Edward ^b   Mathiason, Candace K ^b   Sheetz, Michael ^d   Telling, Glenn C ^a,b  

^a Veterinary Dentistry and Oral Surgery   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF KENTUCKY   (United States)

^e N30 Pharmaceuticals   (United States)

Author keywords

Prion replication; Protective polymorphisms; Protein structure; Structural plasticity

Indexed keywords

AMINO ACID; EPITOPE; GLUTAMIC ACID; GLUTAMINE; PHENYLALANINE; PRION PROTEIN; SERINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHRONIC WASTING DISEASE; DEER; DISEASE PREDISPOSITION; DISEASE TRANSMISSION; EPIDEMIC; NONHUMAN; PATHOGENESIS; PLASTICITY; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SHEEP; SPECIES;

PRION REPLICATION; PROTECTIVE POLYMORPHISMS; PROTEIN STRUCTURE; STRUCTURAL PLASTICITY;

AMINO ACID SUBSTITUTION; ANIMALS; DEER; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; POLYMORPHISM, GENETIC; PROTEIN STRUCTURE, SECONDARY; PRPSC PROTEINS; SHEEP; SHEEP DISEASES; WASTING DISEASE, CHRONIC;

EID: 84904961687     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1404739111     Document Type: Article

References (37)

1. Will RG, et al. (1996) A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 347(9006):921-925. (Pubitemid 26102546)
2. Prusiner SB, et al. (1990) Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication. Cell 63(4):673 -686.
3. Bessen RA, Marsh RF (1994) Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy. J Virol 68(12):7859-7868. (Pubitemid 24362673)
4. Telling GC, et al. (1996) Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity. Science 274(5295):2079-2082. (Pubitemid 27020700)
5. Angers RC, et al. (2010) Prion strain mutation determined by prion protein conformational compatibility and primary structure. Science 328(5982):1154-1158.
6. Bian J, Kang HE, Telling GC (2014) Quinacrine promotes replication and conformational mutation of chronic wasting disease prions. Proc Natl Acad Sci USA 111(16):6028-6033.
7. Jewell JE, Conner MM, Wolfe LL, Miller MW, Williams ES (2005) Low frequency of PrP genotype 225SF among free-ranging mule deer (Odocoileus hemionus) with chronic wasting disease. J Gen Virol 86(Pt 8):2127-2134. (Pubitemid 41057516)
8. Gossert AD, Bonjour S, Lysek DA, Fiorito F, Wüthrich K (2005) Prion protein NMR structures of elk and of mouse/elk hybrids. Proc Natl Acad Sci USA 102(3):646-650. (Pubitemid 40282719)
9. Kurt TD, et al. (2014) Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC. J Neurosci 34(3):1022-1027.
10. Groschup MH, Gretzschel A, Kuczius T (2006) Prion Strains (Walter de Gruyter, Berlin).
11. Green KM, et al. (2008) The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation. J Gen Virol 89(Pt 2):598-608. (Pubitemid 351622458)
12. Saijo E, et al. (2013) Epigenetic dominance of prion conformers. PLoS Pathog 9(10):e1003692.
13. Tamgüney G, et al. (2009) Transmission of scrapie and sheep-passaged bovine spongiform encephalopathy prions to transgenic mice expressing elk prion protein. J Gen Virol 90(Pt 4):1035-1047.
14. Castilla J, Saá P, Hetz C, Soto C (2005) In vitro generation of infectious scrapie prions. Cell 121(2):195-206. (Pubitemid 40546388)
15. Browning SR, et al. (2004) Transmission of prions from mule deer and elk with chronic wasting disease to transgenic mice expressing cervid PrP. J Virol 78(23):13345-13350. (Pubitemid 39507839)
16. Wadsworth JD, et al. (2004) Human prion protein with valine 129 prevents expression of variant CJD phenotype. Science 306(5702):1793-1796. (Pubitemid 39601400)
17. Pérez DR, Damberger FF, Wüthrich K (2010) Horse prion protein NMR structure and comparisons with related variants of the mouse prion protein. J Mol Biol 400(2):121-128.
18. Angers RC, et al. (2009) Chronic wasting disease prions in elk antler velvet. Emerg Infect Dis 15(5):696-703.
19. Christen B, Hornemann S, Damberger FF, Wüthrich K (2009) Prion protein NMR structure from tammar wallaby (Macropus eugenii) shows that the beta2-alpha2 loop is modulated by long-range sequence effects. J Mol Biol 389(5):833-845.
20. Zhang J, Zhang Y (2014) Molecular dynamics studies on the NMR and X-ray structures of rabbit prion proteins. J Theor Biol 342:70-82.
21. Khan MQ, et al. (2010) Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP. Proc Natl Acad Sci USA 107(46):19808-19813.
22. Mathiason CK, et al. (2006) Infectious prions in the saliva and blood of deer with chronic wasting disease. Science 314(5796):133-136. (Pubitemid 44547758)
23. Johnson CJ, et al. (2011) Prion protein polymorphisms affect chronic wasting disease progression. PLoS ONE 6(3):e17450.
24. Greenlee JJ, Smith JD, Kunkle RA (2011) White-tailed deer are susceptible to the agent of sheep scrapie by intracerebral inoculation. Vet Res 42:107.
25. Korth C, et al. (2003) Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene. Proc Natl Acad Sci USA 100(8):4784-4789. (Pubitemid 36457806)
26. Meade-White K, et al. (2007) Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein. J Virol 81(9):4533-4539. (Pubitemid 46668651)
27. Race B, Meade-White K, Miller MW, Fox KA, Chesebro B (2011) In vivo comparison of chronic wasting disease infectivity from deer with variation at prion protein residue 96. J Virol 85(17):9235-9238.
28. Keane DP, et al. (2008) Chronic wasting disease in a Wisconsin white-tailed deer farm. J Vet Diagn Invest 20(5):698-703.
29. Hamir AN, et al. (2004) Transmission of sheep scrapie to elk (Cervus elaphus nelsoni) by intracerebral inoculation: Final outcome of the experiment. J Vet Diagn Invest 16(4):316-321. (Pubitemid 39098395)
30. Borchelt DR, et al. (1996) A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal 13(6):159-163. (Pubitemid 27063321)
31. Green KM, et al. (2008) Accelerated high fidelity prion amplification within and across prion species barriers. PLoS Pathog 4(8):e1000139.
32. Kang HE, et al. (2012) Characterization of conformation-dependent prion protein epitopes. J Biol Chem 287(44):37219-37232.
33. Essmann U, et al. (1995) A smooth particle mesh Ewald method. J Chem Phys 103(19):8577-8593.
34. Case DA, et al. (2012) AMBER 12 (University of California, San Francisco).
35. Ryckaert JP, Ciccotti G, Berendsen HJC (1977) Numerical integration of Cartesian equations of motion of a system with constraints: Molecular dynamics of n-alkanes. J Comput Phys 23(3):327-341.
36. Brunger A, Brooks CL, Karplus M (1984) Stochastic boundary conditions for molecular dynamics simulations of St2 water. Chem Phys Lett 105(5):495-500.
37. Humphrey W, Dalke A, Schulten K (1996) VMD: Visual molecular dynamics. J Mol Graph 14(1):33-38, 27-28.