Grape seed pro-anthocyanidins ameliorates radiation-induced lung injury

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 7, 2014, Pages 1267-1277

  Huang, Yijuan ^a   Liu, Wen ^a   Liu, Hu ^a   Yang, Yanyong ^a   Cui, Jianguo ^a   Zhang, Pei ^a   Zhao, Hainan ^a   He, Feng ^a   Cheng, Ying ^a   Ni, Jin ^a   Cai, Jianming ^a   Li, Bailong ^a   Gao, Fu ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Epithelial mesenchymal transition; Grape seed pro anthocyanidins; Radiation induced lung injury; Reactive oxygen species

Indexed keywords

CYTOKINE; MESSENGER RNA; PLANT EXTRACT; RADIOPROTECTIVE AGENT;

ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CHEMISTRY; ELECTRON SPIN RESONANCE; ENZYME IMMUNOASSAY; FEMALE; GAMMA RADIATION; GENETICS; HUMAN; LUNG INJURY; METABOLISM; MOUSE; PLANT SEED; RADIATION INJURIES, EXPERIMENTAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VITIS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CYTOKINES; ELECTRON SPIN RESONANCE SPECTROSCOPY; FEMALE; GAMMA RAYS; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG INJURY; MICE; MICE, INBRED C57BL; PLANT EXTRACTS; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEEDS; VITIS;

EID: 84904958092     PISSN: 15821838     EISSN: 15824934     Source Type: Journal    
DOI: 10.1111/jcmm.12276     Document Type: Article

References (51)

1. Vujaskovic Z, Marks LB, Anscher MS. The physical parameters and molecular events associated with radiation-induced lung toxicity. Semin Radiat Oncol. 2000; 10: 296-307.
2. Carruthers SA, Wallington MM. Total body irradiation and pneumonitis risk: a review of outcomes. Br J Cancer. 2004; 90: 2080-4.
3. Marks LB, Yu X, Vujaskovic Z, et al. Radiation-induced lung injury. Semin Radiat Oncol. 2003; 13: 333-45.
4. Hill RP. Radiation effects on the respiratory system. BJR Suppl. 2005; 27: 75-81.
5. Kwok E, Chan CK. Corticosteroids and azathioprine do not prevent radiation-induced lung injury. Can Respir J. 1998; 5: 211-4.
6. Rube CE, Wilfert F, Palm J, et al. Irradiation induces a biphasic expression of pro-inflammatory cytokines in the lung. Strahlenther Onkol. 2004; 180: 442-8.
7. Khan MA, Van Dyk J, Yeung IW, et al. Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiother Oncol. 2003; 66: 95-102.
8. Johnston CJ, Williams JP, Elder A, et al. Inflammatory cell recruitment following thoracic irradiation. Exp Lung Res. 2004; 30: 369-82.
9. Travis EL. Organizational response of normal tissues to irradiation. Semin Radiat Oncol. 2001; 11: 184-96.
10. Dudek SM, Garcia JG. Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol. 2001; 91: 1487-500.
11. Undas A, Brozek J, Musial J. Anti-inflammatory and antithrombotic effects of statins in the management of coronary artery disease. Clin Lab. 2002; 48: 287-96.
12. Riley PA. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol. 1994; 65: 27-33.
13. Araya J, Nishimura SL. Fibrogenic reactions in lung disease. Annu Rev Pathol. 2010; 5: 77-98.
14. Salah N, Miller NJ, Paganga G, et al. Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants. Arch Biochem Biophys. 1995; 322: 339-46.
15. Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med. 1996; 20: 933-56.
16. Bagchi D, Bagchi M, Stohs SJ, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000; 148: 187-97.
17. Mantena SK, Baliga MS, Katiyar SK. Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis. 2006; 27: 1682-91.
18. Mahmood J, Jelveh S, Calveley V, et al. Mitigation of radiation-induced lung injury by genistein and EUK-207. Int J Radiat Biol. 2011; 87: 889-901.
19. Abdollahi A, Li M, Ping G, et al. Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis. J Exp Med. 2005; 201: 925-35.
20. Ashcroft T, Simpson JM, Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol. 1988; 41: 467-70.
21. Wynn TA. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat Rev Immunol. 2004; 4: 583-94.
22. Roberts AB, Tian F, Byfield SD, et al. Smad3 is key to TGF-beta-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis. Cytokine Growth Factor Rev. 2006; 17: 19-27.
23. Thiery JP, Acloque H, Huang RY, et al. Epithelial-mesenchymal transitions in development and disease. Cell. 2009; 139: 871-90.
24. du Bois RM. Strategies for treating idiopathic pulmonary fibrosis. Nat Rev Drug Discov. 2010; 9: 129-40.
25. King TE Jr, Pardo A, Selman M. Idiopathic pulmonary fibrosis. Lancet. 2011; 378: 1949-61.
26. Selman M, Pardo A. Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers. Proc Am Thorac Soc. 2006; 3: 364-72.
27. Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol. 1998; 16: 137-61.
28. Khalil N, Corne S, Whitman C, et al. Plasmin regulates the activation of cell-associated latent TGF-beta 1 secreted by rat alveolar macrophages after in vivo bleomycin injury. Am J Respir Cell Mol Biol. 1996; 15: 252-9.
29. Annes JP, Munger JS, Rifkin DB. Making sense of latent TGFbeta activation. J Cell Sci. 2003; 116: 217-24.
30. Roberts AB, Russo A, Felici A, et al. Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta. Ann N Y Acad Sci. 2003; 995: 1-10.
31. Lee CG, Homer RJ, Zhu Z, et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med. 2001; 194: 809-21.
32. Kitani A, Fuss I, Nakamura K, et al. Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis. J Exp Med. 2003; 198: 1179-88.
33. Puthawala K, Hadjiangelis N, Jacoby SC, et al. Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med. 2008; 177: 82-90.
34. Miyauchi T, Masaki T. Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol. 1999; 61: 391-415.
35. Lee SD, Lee DS, Chun YG, et al. Transforming growth factor-beta1 induces endothelin-1 in a bovine pulmonary artery endothelial cell line and rat lungs via cAMP. Pulm Pharmacol Ther. 2000; 13: 257-65.
36. Castanares C, Redondo-Horcajo M, Magan-Marchal N, et al. Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation. J Cell Sci. 2007; 120: 1256-66.
37. Xu SW, Howat SL, Renzoni EA, et al. Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem. 2004; 279: 23098-103.
38. Shi-wen X, Kennedy L, Renzoni EA, et al. Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. Arthritis Rheum. 2007; 56: 4189-94.
39. King TE Jr, Behr J, Brown KK, et al. BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2008; 177: 75-81.
40. Gordon S. Alternative activation of macrophages. Nat Rev Immunol. 2003; 3: 23-35.
41. Munder M, Eichmann K, Modolell M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol. 1998; 160: 5347-54.
42. Ma LJ, Yang H, Gaspert A, et al. Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol. 2003; 163: 1261-73.
43. Kaviratne M, Hesse M, Leusink M, et al. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol. 2004; 173: 4020-9.
44. Hu X, Ivashkiv LB. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity. 2009; 31: 539-50.
45. Ulloa L, Doody J, Massague J. Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature. 1999; 397: 710-3.
46. Ghosh AK, Yuan W, Mori Y, et al. Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators. J Biol Chem. 2001; 276: 11041-8.
47. Gauldie J, Kolb M, Sime PJ. A new direction in the pathogenesis of idiopathic pulmonary fibrosis? Respir Res. 2002; 3: 1.
48. Vancheri C, Mastruzzo C, Sortino MA, et al. The lung as a privileged site for the beneficial actions of PGE2. Trends Immunol. 2004; 25: 40-6.
49. Olman MA. Epithelial cell modulation of airway fibrosis in asthma. Am J Respir Cell Mol Biol. 2003; 28: 125-8.
50. Fleckenstein K, Zgonjanin L, Chen L, et al. Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. Int J Radiat Oncol Biol Phys. 2007; 68: 196-204.
51. Zhao W, Diz DI, Robbins ME. Oxidative damage pathways in relation to normal tissue injury. Br J Radiol. 2007; 80: 23-31.