New thiophene-1,2,4-triazole-5(3)-ones: Highly bioactive thiosemicarbazides, structures of Schiff bases and triazole-thiols

European Journal of Medicinal Chemistry

Volumn 84, Issue , 2014, Pages 639-650

  Ünver, Yasemin ^a   Sancak, Kemal ^a   Çelik, Fatih ^a   Birinci, Emrah ^a   Küçük, Murat ^a   Soylu, Serkan ^b   Burnaz, Nesibe Arslan ^c  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

^b GIRESUN UNIVERSITY   (Turkey)

^c GUMUSHANE UNIVERSITY   (Turkey)

Author keywords

1,2,4 Triazole thiol; Antimicrobial; Antioxidant; Schiff base; Thiosemicarbazide

Indexed keywords

1 [2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETYL] 4 (4 BROMOPHENYL)THIOSEMICARDAZIDE; 1 [2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETYL] 4 (4 FLUOROPHENYL)THIOSEMICARDAZIDE; 1 [2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETYL] 4 P TOLYLTHIOSEMICARDAZIDE; 1 [2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETYL] 4 PHENYLTHIOSEMICARBAZIDE; 1,2,4 TRIAZOLE DERIVATIVE; 2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TIAZOLE 1 YL] N' (PYRIDIN 3 YLMETHYLENE) ACETOHYDRAZIDE; 2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TIAZOLE 1 YL] N' BENZYLIDENE ACETOHYDRAZIDE; 2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETO HYDRAZIDE; 2 [5 OXO 3 (THIOPHENE 2 YLMETHYL) 4 (THIOPHENE 2 YLMETHYLENEAMINO) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL] N' (THIOPHENE 2 YLMETHYLENE)ACETOHYDRAZIDE; 2 [5 OXO 4 (PYRIDIN 3 YLMETHYLENEAMINO) 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL) N' PYRIDIN 3 YLMETHYLENE[ACETOHYDRAZIDE; 4 AMINO 2 [(5 MERCAPTO 4 P TOLYL 4H 1,2,4 TRIAZOLE 3 YL) METHYL] 5 (THIOPHENE 2 YL METHYL) 2H 1,2,4 TRIAZOLE 3(4H) ONE; 4 AMINO 2 [(5 MERCAPTO 4 PHENYL 4H 1,2,4 TRIAZOLE 3 YL) METHYL] 5 (THIOPHENE 2 YL METHYL) 2H 1,2,4 TRIAZOLE 3(4H) ONE; 4 AMINO 2 [[4 (4 BROMOPHENYL) 5 MERCAPTO 4 PHENYL 4H 1,2,4 TRIAZOLE 3 YL] METHYL] 5 (THIOPHENE 2 YL METHYL) 2H 1,2,4 TRIAZOLE 3(4H) ONE; 4 AMINO 2 [[4 (4 FLUOROPHENYL) 5 MERCAPTO 4 PHENYL 4H 1,2,4 TRIAZOLE 3 YL] METHYL] 5 (THIOPHENE 2 YL METHYL) 2H 1,2,4 TRIAZOLE 3(4H) ONE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIOXIDANT; ETHYL 2 (4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL) ACETATE; N' (4 METHOXYBENZYLIDENE) 2 [4 (4 METHOXYBENZYLIDENEAMINO) 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETOHYDRAZIDE; N' (4 METHOXYBENZYLIDENE) 2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETOHYDRAZIDE; N' (FURAN 2 YLMETHYLENE) 2 [4 (FURAN 2 YLMETHYLENEAMINO) 5 OXO 3 (THIOPENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETOHYDRAZIDE; N' BENZYLIDEN 2 [4 (BENZYLIDENEAMINO) 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETOHYDRAZIDE; SCHIFF BASE; THIOPHENE DERIVATIVE; THIOSEMICARBAZIDE DERIVATIVE; UNCLASSIFIED DRUG; 1 [2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETYL] 4 (4 BROMOPHENYL)THIOSEMICARBAZIDE; 1 [2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETYL] 4 (4 FLUOROPHENYL)THIOSEMICARBAZIDE; 1 [2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETYL] 4 PARA TOLYLTHIOSEMICARBAZIDE; 2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL)ACETOHYDRAZIDE; 2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL] N' (PYRIDIN 3 YLMETHYLENE)ACETOHYDRAZIDE; 2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL] N' BENZYLIDENE ACETOHYDRAZIDE; 2 [5 OXO 3 (THIOPHENE 2 YLMETHYL) 4 (THIOPHENE 2 YLMETHYLENEAMINO) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL] N' (THIOPHEN 2 YLMETHYLENE)ACETOHYDRAZIDE; 2 [5 OXO 4 (PYRIDIN 3 YLMETHYLENEAMINO) 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL] N' (PYRIDIN 3 YLMETHYLENE)ACETOHYDRAZIDE; 4 AMINO 2 [(5 MERCAPTO 4 PARA TOLYL 4H 1,2,4 TRIAZOLE 3 YL)METHYL] 5 (THIOPHENE 2 YLMETHYL) 2H 1,2,4 TRIAZOLE 3(4H) ONE; 4 AMINO 2 [(5 MERCAPTO 4 PHENYL 4H 1,2,4 TRIAZOLE 3 YL)METHYL] 5 (THIOPHENE 2 YLMETHYL) 2H 1,2,4 TRIAZOLE 3(4H) ONE; 4 AMINO 2 [[4 (4 BROMOPHENYL) 5 MERCAPTO 4H 1,2,4 TRIAZOLE 3 YL]METHYL] 5 (THIOPHENE 2 YLMETHYL) 2H 1,2,4 TRIAZOLE 3(4H) ONE; 4 AMINO 2 [[4 (4 FLUOROPHENYL) 5 MERCAPTO 4H 1,2,4 TRIAZOLE 3 YL]METHYL] 5 (THIOPHENE 2 YLMETHYL) 2H 1,2,4 TRIAZOLE 3(4H) ONE; ANTIBIOTIC AGENT; ETHYL 2 [4 AMINO 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1YL]ACETATE; HYDRAZINE; N' (FURAN 2 YMETHYLENE) 2 [4 (FURAN 2 YLMETHYLENEAMINO) 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETOHYDRAZIDE; N' BENZYLIDENE 2 [4 (BENZYLIDENEAMINO) 5 OXO 3 (THIOPHENE 2 YLMETHYL) 4,5 DIHYDRO 1,2,4 TRIAZOLE 1 YL]ACETOHYDRAZIDE; SEMICARBAZIDE DERIVATIVE; THIOL DERIVATIVE; THIOSEMICARBAZIDE; TRIAZOLE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BACILLUS CEREUS; CANDIDA ALBICANS; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HYDROGEN BOND; LISTERIA MONOCYTOGENES; MYCOBACTERIUM SMEGMATIS; NONHUMAN; OXIDATIVE STRESS; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; SACCHAROMYCES CEREVISIAE; STAPHYLOCOCCUS AUREUS; YERSINIA PSEUDOTUBERCULOSIS; BACTERIAL CELL WALL; DPPH RADICAL SCAVENGING ASSAY; INFRARED SPECTROSCOPY; MINIMUM INHIBITORY CONCENTRATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; ANTIOXIDANTS; BACILLUS CEREUS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM SMEGMATIS; SCHIFF BASES; SEMICARBAZIDES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; THIOPHENES; TRIAZOLES;

EID: 84904958088     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.01.014     Document Type: Article

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