Convenient access to 1,3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation

European Journal of Medicinal Chemistry

Volumn 43, Issue 8, 2008, Pages 1715-1720

  Satheesha Rai, N ^a   Kalluraya, Balakrishna ^a   Lingappa, B ^a   Shenoy, Shaliny ^b   Puranic, Vedavati G ^c  

^a MANGALORE UNIVERSITY   (India)

^b KASTURBA MEDICAL COLLEGE   (India)

^c NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

1,3 Dipolar cycloaddition; 5 Nitrothiophene; Acetylenic ketone; Antibacterial; Antifungal; Pyrazole; Sydnone

Indexed keywords

1 PHENYL 3 (5 NITRO 2 THIENYL) 4 (4 METHYLBENZOYL)PYRAZOLE; 1 PHENYL 3 (5 NITRO 2 THIENYL) 4 4 (METHOXYBENZOYL)PYRAZOLE; 1 PHENYL 3 (5 NITRO 2 THIENYL) 4 BENZOYL PYRAZOLE; 1,4 ANISYL 3 (5 NITRO 2 THIENYL) 4 (4 CHLOROBENZOYL)PYRAZOLE; 1,4 TOLYL 3 (5 NITRO 2 THIENYL) 4 (4 CHLOROBENZOYL)PYRAZOLE; 1,4 TOLYL 3 (5 NITRO 2 THIENYL) 4 (4 METHYLBENZOYL)PYRAZOLE; 1,4 TOLYL 3 (5 NITRO 2 THIENYL) 4 BENZOYL PYRAZOLE; 5 NITROTHIOPHENE; ANTIINFECTIVE AGENT; KETONE DERIVATIVE; PYRAZOLE DERIVATIVE; SYDNONE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLOADDITION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ACETYLENE; ANTI-BACTERIAL AGENTS; CYCLIZATION; KETONES; MICROBIAL VIABILITY; MOLECULAR STRUCTURE; NITROGEN COMPOUNDS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; SYDNONES; THIOPHENES;

EID: 48149103866     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.08.002     Document Type: Article

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