Electroencephalographic Properties of Zaleplon, A Non-Benzodiazepine Sedative/Hypnotic, in Rats

Journal of Pharmacological Sciences

Volumn 94, Issue 3, 2004, Pages 246-251

  Noguchi, Hideaki ^a   Kitazumi, Kazuhiro ^a   Mori, Megumi ^a   Shiba, Toshiharu ^a  

^a Wyeth Lederle Japan Ltd   (Japan)

Author keywords

1 receptor; EEG; Hypnotic; Spectra analysis; Zaleplon

Indexed keywords

BROTIZOLAM; HYPNOTIC SEDATIVE AGENT; NERBON; NITRAZEPAM; TRIAZOLAM; ZALEPLON; ZOPICLONE;

ANIMAL EXPERIMENT; ARTICLE; CONSCIOUSNESS; CONTROLLED STUDY; DELTA RHYTHM; DENSITY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG SCREENING; ELECTRODE; ELECTROENCEPHALOGRAPHY; MALE; NONHUMAN; RAT; REM SLEEP; SLEEP; SLEEP TIME; SLEEP WAKING CYCLE; SLOW BRAIN WAVE; SPECTROSCOPY;

ACETAMIDES; ADMINISTRATION, ORAL; ANIMALS; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; HYPNOTICS AND SEDATIVES; MALE; NITRAZEPAM; PIPERAZINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SLEEP INITIATION AND MAINTENANCE DISORDERS; SLEEP STAGES; TRIAZOLAM; UPPER EXTREMITY;

EID: 1842783143     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.94.246     Document Type: Article

References (22)

1. Bixler EO, Kales A, Soldatos CR, Kales JD, Healy S. Prevalence of sleep disorders in the Los Angeles metropolitan area. Am J Psychiatry. 1979;136:1257-1262.
2. Karacan I, Thornby JI, Anch M, et al. Prevalence of sleep disturbance in a primarily urban Florida county. Soc Sci Med. 1976;10:239-244.
3. Noguchi H, Kitazumi K, Mori M, Shiba T. Binding and neuropharmacological profile of zaleplon, a novel nonbenzodiazepine sedative/hypnotic. Eur J Pharmacol. 2002;434:21-28.
4. Day IP, Clody DE, Monaghan MM, Abel MS, Dusza JP, Beer B. Pharmacology of CL284,846, a non-benzodiazepine sedative with reduced amnesic liability. Soc Neurosci Abstr. 1992;18:725.
5. Gaudreault J, Varin F, Pollack GM. Pharmacokinetics and anticonvulsant effect of new hypnotics, CL284,846, in rats. Pharm Res. 1995;12:1592-1597.
6. 1) selective, benzodiazepine receptor ligands. Psychopharmacology (Berl). 1996;124:245-254.
7. Noguchi H, Kitazumi K, Mori M, Shiba T. Effect of zaleplon on learning and memory in rats. Naunyn Schmidebergs Arch Pharmacol. 2003;366:183-188.
8. Noguchi H, Kitazumi K, Mori M, Shiobara Y, Shiba T. Effect of zaleplon on melatonin secretion in rabbits. J Pharmacol Sci. 2003;93:204-209.
9. Beer B, Ieni JR, Wu W-H, et al. A placebo-controlled evaluation of single, escalating doses of CL284,846, a non-benzodiazepine hypnotic. J Clin Pharmacol. 1994;34:335-344.
10. Paxios G, Watson C. The rat brain in stereotaxic coordinates. 2nd ed. San Diego, CA: Academic Press; 1986.
11. Depoortere H. Some aspects of the polygraphic studies on sleep-wakefulness cycle in rat. Waking and Sleeping. 1980;4:47-62.
12. Van Luijtelaar ELJM, Coenen AML. An EEG averaging technique for automated sleep-wake stage identification in the rat. Physiol Behav. 1984;33:837-841.
13. A receptor subtypes. J Pharmacol Exp Ther. 1995;275:761-767.
14. Depoortere H, Zivikovic B, Lloyd KG, et al. Zolpidem, a novel nonbenzidiazepine hypnotic I. Neuropharmacological and biobehavioral effect. J Pharmacol Exp Ther. 1986;237:649-658.
15. Patat A, Trocherie S, Thebault JJ, et al. EEG profile of intravenous zolpidem in healthy volunteers. Psychopharmacology (Berl). 1994;114:138-146.
16. Sakamoto T, Uchimura N, Mukai M, Mizuma H, Shirakawa S, Nakazawa Y. Efficacy of L-846 in patients with insomnia: evaluation by polysomnography. Psychiatry Clin Neurosci. 1998;52:156-157.
17. Nakajima T, Sasaki T, Nakagome K, et al. Comparison of the effects of zolpidem and zopiclone on nocturnal sleep and sleep latency in the morning. A cross-over study in healthy young volunteers. Life Sci. 2000;67:81-90.
18. Borbély AA. Principales sleep regulation; implications for the effect of hypnotic on sleep. In: Kales A, editor. Handbook of experimental pharmacology, Vol. 116, Pharmacology of sleep. Springer-Verlag: Berlin/Heiddberg; 1995. p. 29-45.
19. Parrino L, Terzano MG. Polysomnographic effects of hypnotic drugs. Psychopharmacology (Berl). 1996;126:1-16.
20. Aeschbach D, Dijk DJ, Borbély AA. Dynamics of EEG spindle frequency activity during extended sleep in humans. Brain Res. 1997;748:131-136.
21. Feinberg I, Carlson V. Sleep variable as a function of age in man. Arch Gen Psychiatry. 1975;18:329-350.
22. Kales A, Wilson T, Kales JD, et al. Measurement of all-night sleep in normal elderly persons: effects of aging. J Am Geriatr Soc. 1967;15:405-414.