Determination of chrysotoxine in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 967, Issue , 2014, Pages 57-62

  Fan, Jingjing ^a   Guan, Li ^a   Kou, Zeqi ^a   Feng, Feng ^a   Zhang, Yanbo ^b   Liu, Wenyuan ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b THE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Bioavailability; Chrysotoxine; HPLC MS MS; Method validation; Pharmacokinetics

Indexed keywords

BIOCHEMISTRY; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; RATS; BODY FLUIDS; EXTRACTION; LIQUIDS; MASS SPECTROMETERS; PLASMA STABILITY; SPECTROMETRY;

BIOAVAILABILITY; CHROMATOGRAPHIC SEPARATIONS; CHRYSOTOXINE; HPLC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; METHOD VALIDATIONS; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC PROFILES; TANDEM MASS SPECTROMETRIC;

BODY FLUIDS; LIQUID CHROMATOGRAPHY;

BIBENZYL DERIVATIVE; CHRYSOTOXINE; UNCLASSIFIED DRUG; WOGONIN; ACETIC ACID ETHYL ESTER; ACETONITRILE; ACETIC ACID DERIVATIVE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG STABILITY; FREEZE THAWING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ANALYTIC METHOD; BLOOD SAMPLING; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MEASUREMENT ACCURACY; NEUROPROTECTION; PHASE SEPARATION; ROOM TEMPERATURE; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; VALIDATION STUDY; ANIMAL; BIOAVAILABILITY; BLOOD; CHEMISTRY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; STATISTICAL MODEL;

DENDROBIUM; RATTUS;

ACETATES; ANIMALS; BIBENZYLS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84904906249     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.07.011     Document Type: Article

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