Downregulation of miRNA-134 protects neural cells against ischemic injury in N2A cells and mouse brain with ischemic stroke by targeting HSPA12B

Neuroscience

Volumn 277, Issue , 2014, Pages 111-122

  Chi, W ^a   Meng, F ^b   Li, Y ^b   Wang, Q ^b   Wang, G ^a   Han, S ^c   Wang, P ^c   Li, J ^c  

^a WEIFANG MEDICAL UNIVERSITY   (China)

^b JINAN CENTRAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^c BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

Author keywords

Heat shock protein A12B (HSPA12B); Ischemic stroke; MicroRNA 134 (miR 134); Middle cerebral artery occlusion (MCAO); Oxygen glucose deprivation (OGD)

Indexed keywords

HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN A12B; HEAT SHOCK PROTEIN A5; MESSENGER RNA; MICRORNA; MICRORNA 134; UNCLASSIFIED DRUG; GLUCOSE; HEAT SHOCK PROTEIN 70; HSPA12B PROTEIN, MOUSE; MIRN134 MICRORNA, MOUSE; MOLECULAR CHAPERONE GRP78;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOINFORMATICS; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL VIABILITY ASSAY; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; N2A CELL LINE; NEUROBLASTOMA CELL; NEUROLOGICAL AND SENSORIAL PROCEDURES; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OXYGEN GLUCOSE DEPRIVATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BRAIN; C57BL MOUSE; CELL DEATH; CELL HYPOXIA; CEREBRAL ARTERY DISEASE; CEREBROVASCULAR ACCIDENT; DEFICIENCY; DISEASE MODEL; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CELL DEATH; CELL HYPOXIA; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GLUCOSE; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; NEURONS; STROKE;

EID: 84904902310     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.06.062     Document Type: Article

References (49)

1. Abnosi M.H., Jafari Y.Z. Low dose and long term toxicity of sodium arsenite caused caspase dependent apoptosis based on morphology and biochemical character. Cell J 2012, 14:161-170.
2. Avci C.B., Baran Y. Use of microRNAs in personalized medicine. Methods Mol Biol 2014, 1107:311-325.
3. Baczynska D., Michalowska D., Witkiewicz W. The role of microRNA in ischemic diseases-impact on the regulation of inflammatory, apoptosis and angiogenesis processes. Przegl Lek 2013, 70:135-142.
4. Barca-Mayo O., De Pietri T.D. Convergent microRNA actions coordinate neocortical development. Cell Mol Life Sci 2014, 10.1007/s00018-014-1576-5.
5. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
6. Buller B., Liu X., Wang X., Zhang R.L., Zhang L., Hozeska-Solgot A., Chopp M., Zhang Z.G. MicroRNA-21 protects neurons from ischemic death. FEBS J 2010, 277:4299-4307.
7. Cui Z., Wang P., Sun L., Liu H., Yang J., Li X., Kang L., Huang Y., Shen A., Cheng C. Lipopolysaccharide-evoked HSPA12B expression by activation of MAPK cascade in microglial cells of the spinal cord. J Neurol Sci 2010, 294:29-37.
8. Dharap A., Bowen K., Place R., Li L.C., Vemuganti R. Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J Cereb Blood Flow Metab 2009, 29:675-687.
9. Dirnagl U., Iadecola C., Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 1999, 22:391-397.
10. Endres M., Engelhardt B., Koistinaho J., Lindvall O., Meairs S., Mohr J.P., Planas A., Rothwell N., Schwaninger M., Schwab M.E., Vivien D., Wieloch T., Dirnagl U. Improving outcome after stroke: overcoming the translational roadblock. Cerebrovasc Dis 2008, 25:268-278.
11. Giffard R.G., Yenari M.A. Many mechanisms for hsp70 protection from cerebral ischemia. J Neurosurg Anesthesiol 2004, 16:53-61.
12. Hacioglu A., Algin C., Pasaoglu O., Pasaoglu E., Kanbak G. Protective effect of leptin against ischemia-reperfusion injury in the rat small intestine. BMC Gastroenterol 2005, 5:37.
13. Han Z., Truong Q.A., Park S., Breslow J.L. Two Hsp70 family members expressed in atherosclerotic lesions. Proc Natl Acad Sci U S A 2003, 100:1256-1261.
14. He Q., Wu C., Luo H., Wang Z.Y., Ma X.Q., Zhao Y.F., Lu J., Xiang C., Qin Y.Y., Wu S.Q., Yu F.F., He J. Trends in in-hospital mortality among patients with stroke in China. PLoS One 2014, 9:e92763.
15. Hu G., Tang J., Zhang B., Lin Y., Hanai J., Galloway J., Bedell V., Bahary N., Han Z., Ramchandran R., Thisse B., Thisse C., Zon L.I., Sukhatme V.P. A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro. J Cell Sci 2006, 119:4117-4126.
16. Jeyaseelan K., Lim K.Y., Armugam A. MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke 2008, 39:959-966.
17. Jimenez-Mateos E.M., Engel T., Merino-Serrais P., McKiernan R.C., Tanaka K., Mouri G., Sano T., O'Tuathaigh C., Waddington J.L., Prenter S., Delanty N., Farrell M.A., O'Brien D.F., Conroy R.M., Stallings R.L., DeFelipe J., Henshall D.C. Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nat Med 2012, 18:1087-1094.
18. Kang L., Zhang G., Yan Y., Ke K., Wu X., Gao Y., Li J., Zhu L., Wu Q., Zhou Z. The role of HSPA12B in regulating neuronal apoptosis. Neurochem Res 2013, 38:311-320.
19. Kim M.G., Jung C.E., Won L.J., Sook K.Y., Young L.H., Jo S.K., Cho W.Y., Kim H.K. The heat-shock protein-70-induced renoprotective effect is partially mediated by CD4+ CD25+ Foxp3+regulatory T cells in ischemia/reperfusion-induced acute kidney injury. Kidney Int 2014, 85:62-71.
20. Lakhan S.E., Kirchgessner A., Hofer M. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med 2009, 7:97.
21. Li J., Wang Y., Luo J., Fu Z., Ying J., Yu Y., Yu W. MiR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells. FEBS Lett 2012, 586:3761-3765.
22. Li J., Zhang Y., Li C., Xie J., Liu Y., Zhu W., Zhang X., Jiang S., Liu L., Ding Z. HSPA12B attenuates cardiac dysfunction and remodelling after myocardial infarction through an eNOS-dependent mechanism. Cardiovasc Res 2013, 99:674-684.
23. Liu C., Peng Z., Zhang N., Yu L., Han S., Li D., Li J. Identification of differentially expressed microRNAs and their PKC-isoform specific gene network prediction during hypoxic pre-conditioning and focal cerebral ischemia of mice. J Neurochem 2012, 120:830-841.
24. Liu D.Z., Tian Y., Ander B.P., Xu H., Stamova B.S., Zhan X., Turner R.J., Jickling G., Sharp F.R. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab 2010, 30:92-101.
25. Liu J., Githinji J., Mclaughlin B., Wilczek K., Nolta J. Role of miRNAs in neuronal differentiation from human embryonic stem cell-derived neural stem cells. Stem Cell Rev 2012, 8:1129-1137.
26. Liu X., Li F., Zhao S., Luo Y., Kang J., Zhao H., Yan F., Li S., Ji X. MicroRNA-124-mediated regulation of inhibitory member of apoptosis-stimulating protein of p53 family in experimental stroke. Stroke 2013, 44:1973-1980.
27. Lloyd-Jones D., Adams R.J., Brown T.M., Carnethon M., Dai S., De S.G., Ferguson T.B., Ford E., Furie K., Gillespie C., Go A., Greenlund K., Haase N., Hailpern S., Ho P.M., Howard V., Kissela B., Kittner S., Lackland D., Lisabeth L., Marelli A., McDermott M.M., Meigs J., Mozaffarian D., Mussolino M., Nichol G., Roger V.L., Rosamond W., Sacco R., Sorlie P., Roger V.L., Thom T., Wasserthiel-Smoller S., Wong N.D., Wylie-Rosett J. Heart disease and stroke statistics - 2010 update: a report from the American Heart Association. Circulation 2010, 121:e46-e215.
28. Ma Y., Lu C., Li C., Li R., Zhang Y., Ma H., Zhang X., Ding Z., Liu L. Overexpression of HSPA12B protects against cerebral ischemia/reperfusion injury via a PI3K/Akt-dependent mechanism. Biochim Biophys Acta 2013, 1832:57-66.
29. Nazari Q.A., Mizuno K., Kume T., Takada-Takatori Y., Izumi Y., Akaike A. In vivo brain oxidative stress model induced by microinjection of sodium nitroprusside in mice. J Pharmacol Sci 2012, 120:105-111.
30. Niu C.S., Yang Y., Cheng C.D. MiR-134 regulates the proliferation and invasion of glioblastoma cells by reducing Nanog expression. Int J Oncol 2013, 42:1533-1540.
31. Ouyang Y.B., Lu Y., Yue S., Xu L.J., Xiong X.X., White R.E., Sun X., Giffard R.G. MiR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo. Neurobiol Dis 2012, 45:555-563.
32. Palmer G.C., Peeling J., Corbett D., Del Bigio M.R., Hudzik T.J. T2-weighted MRI correlates with long-term histopathology, neurology scores, and skilled motor behavior in a rat stroke model. Ann N Y Acad Sci 2001, 939:283-296.
33. Papadakis M., Hadley G., Xilouri M., Hoyte L.C., Nagel S., McMenamin M.M., Tsaknakis G., Watt S.M., Drakesmith C.W., Chen R., Wood M.J., Zhao Z., Kessler B., Vekrellis K., Buchan A.M. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat Med 2013, 19:351-357.
34. Peng Z., Li J., Li Y., Yang X., Feng S., Han S., Li J. Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1. J Neurosci Res 2013, 91:1349-1362.
35. Poitz D.M., Stolzel F., Arabanian L., Friedrichs J., Docheva D., Schieker M., Fierro F.A., Platzbecker U., Ordemann R., Werner C., Bornhauser M., Strasser R.H., Ehninger G., Illmer T. MiR-134-mediated beta1 integrin expression and function in mesenchymal stem cells. Biochim Biophys Acta 2013, 1833:3396-3404.
36. Reglodi D., Tamas A., Lengvari I. Examination of sensorimotor performance following middle cerebral artery occlusion in rats. Brain Res Bull 2003, 59:459-466.
37. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008, 3:1101-1108.
38. Schratt G.M., Tuebing F., Nigh E.A., Kane C.G., Sabatini M.E., Kiebler M., Greenberg M.E. A brain-specific microRNA regulates dendritic spine development. Nature 2006, 439:283-289.
39. Sheinerman K.S., Tsivinsky V.G., Abdullah L., Crawford F., Umansky S.R. Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study. Aging (Albany, NY) 2013, 5:925-938.
40. Shwetha S., Gouthamchandra K., Chandra M., Ravishankar B., Khaja M.N., Das S. Circulating miRNA profile in HCV infected serum: novel insight into pathogenesis. Sci Rep 2013, 3:1555.
41. Steagall R.J., Rusinol A.E., Truong Q.A., Han Z. HSPA12B is predominantly expressed in endothelial cells and required for angiogenesis. Arterioscler Thromb Vasc Biol 2006, 26:2012-2018.
42. Tan K.S., Armugam A., Sepramaniam S., Lim K.Y., Setyowati K.D., Wang C.W., Jeyaseelan K. Expression profile of MicroRNAs in young stroke patients. PLoS One 2009, 4:e7689.
43. Tsai P.C., Liao Y.C., Wang Y.S., Lin H.F., Lin R.T., Juo S.H. Serum microRNA-21 and microRNA-221 as potential biomarkers for cerebrovascular disease. J Vasc Res 2013, 50:346-354.
44. van der W.L., Lythgoe M.F., Badin R.A., Valentim L.M., Akbar M.T., de Belleroche J.S., Latchman D.S., Gadian D.G. Neuroprotective effects of HSP70 overexpression after cerebral ischaemia - an MRI study. Exp Neurol 2005, 195:257-266.
45. varez-Erviti L., Seow Y., Schapira A.H., Rodriguez-Oroz M.C., Obeso J.A., Cooper J.M. Influence of microRNA deregulation on chaperone-mediated autophagy and alpha-synuclein pathology in Parkinson' s disease. Cell Death Dis 2013, 4:e545.
46. Wang D., Yuan X., Liu T., Liu L., Hu Y., Wang Z., Zheng Q. Neuroprotective activity of lavender oil on transient focal cerebral ischemia in mice. Molecules 2012, 17:9803-9817.
47. Yin K.J., Deng Z., Huang H., Hamblin M., Xie C., Zhang J., Chen Y.E. MiR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. Neurobiol Dis 2010, 38:17-26.
48. Yuan Y., Wang J.Y., Xu L.Y., Cai R., Chen Z., Luo B.Y. MicroRNA expression changes in the hippocampi of rats subjected to global ischemia. J Clin Neurosci 2010, 17:774-778.
49. Zhou L., Li F., Xu H.B., Luo C.X., Wu H.Y., Zhu M.M., Lu W., Ji X., Zhou Q.G., Zhu D.Y. Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med 2010, 16:1439-1443.