ε-poly-L-lysine peptide chain length regulated by the linkers connecting the transmembrane domains of ε-poly-L-lysine synthetase

Applied and Environmental Microbiology

Volumn 80, Issue 16, 2014, Pages 4993-5000

  Hamano, Yoshimitsu ^a   Kito, Naoko ^a   Kita, Akihiro ^a   Imokawa, Yuuki ^a   Yamanaka, Kazuya ^b   Maruyama, Chitose ^a   Katano, Hajime ^a  

^a FUKUI PREFECTURAL UNIVERSITY   (Japan)

^b CHISSO CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; BIOLOGICAL MEMBRANES; CHAINS; ENZYMES; POLYMERIZATION; POLYPEPTIDES;

ADENYLATION DOMAINS; AMINO ACID RESIDUES; CATALYTIC MECHANISMS; NONRIBOSOMAL PEPTIDE SYNTHETASES; POLYMERIZATION REACTION; RANDOM MUTAGENESIS; STREPTOMYCES ALBULUS; TRANS-MEMBRANE DOMAINS;

CHAIN LENGTH;

BACTERIAL PROTEIN; NONRIBOSOMAL PEPTIDE SYNTHETASE; PEPTIDE SYNTHASE; POLYLYSINE;

AMINO ACID SEQUENCE; CELL MEMBRANE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; STREPTOMYCES;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CELL MEMBRANE; MOLECULAR SEQUENCE DATA; PEPTIDE SYNTHASES; POLYLYSINE; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STREPTOMYCES;

EID: 84904893255     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.01201-14     Document Type: Article

References (26)

1. Shima S, Sakai H. 1981. Poly-L-lysine produced by Streptomyces. Part II. Taxonomy and fermentation studies. Agric. Biol. Chem. 45:2497-2502.
2. Oppermann-Sanio FB, Steinbüchel A. 2002. Occurrence, functions and biosynthesis of polyamides in microorganisms and biotechnological production. Naturwissenschaften 89:11-22. http://dx.doi.org/10.1007/s00114-001-0280-0.
3. Shima S, Sakai H. 1977. Polylysine produced by Streptomyces. Agric. Biol. Chem. 41:1807-1809. http://dx.doi.org/10.1271/bbb1961.41.1807.
4. Shima S, Sakai H. 1981. Poly-L-lysine produced by Streptomyces. Part III. Chemical studies. Agric. Biol. Chem. 45:2503-2508.
5. Shima S, Fukuhara Y, Sakai H. 1982. Inactivation of bacteriophages by e-poly-L-lysine produced by Streptomyces. Agric. Biol. Chem. 46:1917-1919.
6. Takehara M, Hirohara H. 2010. Occurrence and biosynthesis of polyepsilon-L-lysine in microorganisms, p 1-22. In Hamano Y (ed), Aminoacid homopolymers occurring in nature. Microbiology monographs, vol. 15. Springer, New York, NY.
7. Hirohara H, Takehara M, Saimura M, Ikezaki A, Miyamoto M. 2006. Biosynthesis of poly(e-L-lysine)s in two newly isolated strains of Streptomyces sp. Appl. Microbiol. Biotechnol. 73:321-331. http://dx.doi.org/10.1007/s00253-006-0479-2.
8. Hirohara H, Saimura M, Takehara M, Miyamoto M, Ikezaki A. 2007. Substantially monodispersed poly(e-L-lysine)s frequently occurred in newly isolated strains of Streptomyces sp. Appl. Microbiol. Biotechnol. 76:1009-1016. http://dx.doi.org/10.1007/s00253-007-1082-x.
9. Shima S, Matsuoka H, Iwamoto T, Sakai H. 1984. Antimicrobial action of e-poly-L-lysine. J. Antibiot. (Tokyo) 37:1449-1455. http://dx.doi.org/10.7164/antibiotics.37.1449.
10. Yamanaka K, Maruyama C, Takagi H, Hamano Y. 2008. e-Poly-L-lysine dispersity is controlled by a highly unusual nonribosomal peptide synthetase. Nat. Chem. Biol. 4:766-772. http://dx.doi.org/10.1038/nchembio.125.
11. Hamano Y. 2010. Biochemistry and enzymology of poly-epsilon-L-lysine biosynthesis, p 23-44. In Hamano Y (ed), Amino-acid homopolymers occurring in nature. Microbiology monographs, vol 15. Springer, New York, NY.
12. Hamano Y, Arai T, Ashiuchi M, Kino K. 2013. NRPSs and amide ligases producing homopoly(amino acid)s and homooligo(amino acid)s. Nat. Prod. Rep. 30:1087-1097. http://dx.doi.org/10.1039/c3np70025a.
13. Marahiel MA, Stachelhaus T, Mootz HD. 1997. Modular peptide synthetases involved in nonribosomal peptide synthesis. Chem. Rev. 97: 2651-2674. http://dx.doi.org/10.1021/cr960029e.
14. Schwarzer D, Finking R, Marahiel MA. 2003. Nonribosomal peptides: from genes to products. Nat. Prod. Rep. 20:275-287. http://dx.doi.org/10.1039/b111145k.
15. Mootz HD, Schwarzer D, Marahiel MA. 2002. Ways of assembling complex natural products on modular nonribosomal peptide synthetases. Chembiochem 3:490-504. http://dx.doi.org/10.1002/1439-7633(200206 03)3:6<490::AID-CBIC490>3.0.CO;2-N.
16. Yamanaka K, Kito N, Kita A, Imokawa Y, Maruyama C, Utagawa T, Hamano Y. 2011. Development of a recombinant e-poly-L-lysine synthetase expression system to perform mutational analysis. J. Biosci. Bioeng. 111:646-649. http://dx.doi.org/10.1016/j.jbiosc.2011.01.020.
17. Kito N, Maruyama C, Yamanaka K, Imokawa Y, Utagawa T, Hamano Y. 2013. Mutational analysis of the three tandem domains of e-poly-Llysine synthetase catalyzing the L-lysine polymerization reaction. J. Biosci. Bioeng. 115:523-526. http://dx.doi.org/10.1016/j.jbiosc.2012.11.020.
18. Yamanaka K, Kito N, Imokawa Y, Maruyama C, Utagawa T, Hamano Y. 2010. Mechanism of e-poly-L-lysine production and accumulation revealed by identification and analysis of an e-poly-L-lysine-degrading enzyme. Appl. Environ. Microbiol. 76:5669-5675. http://dx.doi.org/10.1128/AEM.00853-10.
19. Hamano Y, Nicchu I, Hoshino Y, Kawai T, Nakamori S, Takagi H. 2005. Development of gene delivery systems for the e-poly-L-lysine producer, Streptomyces albulus. J. Biosci. Bioeng. 99:636-641. http://dx.doi.org/10.1263/jbb.99.636.
20. Maruyama C, Toyoda J, Kato Y, Izumikawa M, Takagi M, Shin-ya K, Katano KH, Utagawa T, Hamano Y. 2012. A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis. Nat. Chem. Biol. 8:791-797. http://dx.doi.org/10.1038/nchembio.1040.
21. Sambrook J, Russell DW. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
22. Kieser T, Bibb MJ, Buttner MJ, Chater KF, Hopwood DA. 2000. Practical Streptomyces genetics. John Innes Foundation, Norwich, United Kingdom.
23. Itzhaki RF. 1972. Colorimetric method for estimating polylysine and polyarginine. Anal. Biochem. 50:569-574. http://dx.doi.org/10.1016/0003-2697(72)90067-X.
24. Katano H, Yoneoka T, Kito N, Maruyama C, Hamano Y. 2012. Separation and purification of e-poly-L-lysine from the culture broth based on precipitation with the tetraphenylborate anion. Anal. Sci. 28:1153-1157. http://dx.doi.org/10.2116/analsci.28.1153.
25. Hirokawa T, Boon-Chieng S, Mitaku S. 1998. SOSUI: classification and secondary structure prediction system for membrane proteins. Bioinformatics 14:378-379. http://dx.doi.org/10.1093/bioinformatics/14.4.378.
26. Nishikawa M, Ogawa K. 2006. Inhibition of epsilon-poly-L-lysine biosynthesis in Streptomycetaceae bacteria by short-chain polyols. Appl. Environ. Microbiol. 72:2306-2312. http://dx.doi.org/10.1128/AEM.72.4.2306-2312.2006.