TRPM1

Handbook of Experimental Pharmacology

Volumn 222, Issue , 2014, Pages 387-402

  Irie, Shoichi ^a,b   Furukawa, Takahisa ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Autoantigen; Cation channel; Congenital stationary night blindness; MGluR6; ON bipolar cell; Paraneoplastic retinopathy; Retina; TRP channel

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR 4; MESSENGER RNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR OTX2; TRANSIENT RECEPTOR POTENTIAL CHANNEL M1; UNCLASSIFIED DRUG; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM1 PROTEIN, HUMAN; TRPM1 PROTEIN, MOUSE;

AMINO TERMINAL SEQUENCE; ARHGAP11B GENE; ARTICLE; BINDING SITE; CABP4 GENE; CACNA1F GENE; CACNA2D4 GENE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL MEMBRANE PERMEABILITY; CHANNEL GATING; CHRNA7 GENE; CONGENITAL STATIONARY NIGHT BLINDNESS; DNA SPLICING; GENE; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE MUTATION; GPR179 GENE; GRM6 GENE; HEREDITY; HUMAN; INTRACELLULAR SIGNALING; KLF13 GENE; LRIT3 GENE; MTMR10 GENE; MTMR15 GENE; NONHUMAN; NYX GENE; OTUD7A GENE; PARANEOPLASTIC RETINOPATHY; PARANEOPLASTIC SYNDROME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RETINOPATHY; TRPM1 GENE; VISUAL DISORDER; ANIMAL; CHEMISTRY; GENETIC PREDISPOSITION; GENETICS; KNOCKOUT MOUSE; MEMBRANE POTENTIAL; METABOLISM; MOUSE; PHENOTYPE; PROTEIN CONFORMATION; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL MEMBRANE PERMEABILITY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; PHENOTYPE; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

EID: 84904891943     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-54215-2_15     Document Type: Article

References (84)

1. Adamus G (2009) Autoantibody targets and their cancer relationship in the pathogenicity of paraneoplastic retinopathy. Autoimmun Rev 8:410–414
2. Arshavsky VY, Lamb TD, Pugh EN (2002) G proteins and phototransduction. Annu Rev Physiol 64:153–187
3. Audo I, Robson AG, Holder GE, Moore AT (2008) The negative ERG: clinical phenotypes and disease mechanisms of inner retinal dysfunction. Surv Ophthalmol 53:16–40
4. Audo I, Kohl S, Leroy BP, Munier FL, Guillonneau X, Mohand-Saïd S, Bujakowska K, Nandrot EF, Lorenz B, PreisingM KU, Renner AB, Bernd A, Antonio A, Moskova-Doumanova-V LME, Poloschek CM, Drumare I, Defoort-Dhellemmes S (2009) TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet 85:720–729
5. Audo I, Bujakowska K, Orhan E, Poloschek CM, Defoort-Dhellemmes S, Drumare I, Kohl S, Luu TD, Lecompte O, Zrenner E, Lancelot ME, Antonio A, Germain A, Michiels C, Audier C, Letexier M, Saraiva JP, Leroy BP, Munier FL, Mohand-Saïd S (2012) Whole-exome sequencing identifies mutations in GPR179 leading to autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet 90:321–330
6. Bech-Hansen NT, Naylor MJ, Maybaum TA, Pearce WG, Koop B, Fishman GA, Mets M, Musarella MA, Boycott KM (1998) Loss-of-function mutations in a calcium-channel alpha1- subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness. Nat Genet 19:264–267
7. Bellone RR, Brooks SA, Sandmeyer L, Murphy BA, Forsyth G, Archer S, Bailey E, Grahn B (2008) Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus). Genetics 179:1861–1870
8. Boyle GM, Woods SL, Bonazzi VF, Stark MS, Hacker E, Aoude LG, Dutton-Regester K, Cook AL, Sturm RA, Hayward NK (2011) Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. Pigment Cell Melanoma Res 24:525–537
9. Cao Y, Posokhova E, Martemyanov KA (2011) TRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner. J Neurosci 31:11521–11526
10. Chan JW (2003) Paraneoplastic retinopathies and optic neuropathies. Surv Ophthalmol 48:12–38
11. de la Villa P, Kurahashi T, Kaneko A (1995) L-glutamate-induced responses and cGMP-activated channels in three subtypes of retinal bipolar cells dissociated from the cat. J Neurosci 15:3571-3582
12. Devi S, Kedlaya R, Maddodi N, Bhat KM, Weber CS, Valdivia H, Setaluri V (2009) Calcium homeostasis in human melanocytes: role of transient receptor potential melastatin 1 (TRPM1) and its regulation by ultraviolet light. Am J Physiol Cell Physiol 297:C679–C687
13. Devi S, Markandeya Y, Maddodi N, Dhingra A, Vardi N, Balijepalli RC, Setaluri V (2013) Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes. Pigment Cell Melanoma Res 26(3):348–356
14. DeVries SH, Baylor DA (1993) Synaptic circuitry of the retina and olfactory bulb. Cell 72 (Suppl):139–149
15. Dhingra A, Lyubarsky A, Jiang M, Pugh EN, Birnbaumer L, Sterling P, Vardi N (2000) The light response of ON bipolar neurons requires G[alpha]o. J Neurosci 20:9053–9058
16. Dhingra A, Jiang M, Wang TL, Lyubarsky A, Savchenko A, Bar-Yehuda T, Sterling P, Birnbaumer L, Vardi N (2002) Light response of retinal ON bipolar cells requires a specific splice variant of Galpha(o). J Neurosci 22:4878–4884
17. Dhingra A, Faurobert E, Dascal N, Sterling P, Vardi N (2004) A retinal-specific regulator of G-protein signaling interacts with Galpha(o) and accelerates an expressed metabotropic glutamate receptor 6 cascade. J Neurosci 24:5684–5693
18. Dhingra A, Fina ME, Neinstein A, Ramsey DJ, Xu Y, Fishman GA, Alexander KR, Qian H, Peachey NS, Gregg RG, Vardi N (2011) Autoantibodies in Melanoma-Associated Retinopathy Target TRPM1 Cation Channels of Retinal ON Bipolar Cells. J Neurosci 31:3962–3967
19. Dhingra A, Ramakrishnan H, Neinstein A, Fina ME, Xu Y, Li J, Chung DC, Lyubarsky A, Vardi N (2012) Gβ3 is required for normal light ON responses and synaptic maintenance. J Neurosci 32:11343–11355
20. Dowling JE (1978) How the retina "sees". Invest Ophthalmol Vis Sci 17:832–834
21. Dryja TP, McGee TL, Berson EL, Fishman GA, Sandberg MA, Alexander KR, Derlacki DJ, Rajagopalan AS (2005) Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. Proc Natl Acad Sci USA 102:4884–4889
22. Duncan LM, Deeds J, Hunter J, Shao J, Holmgren LM, Woolf EA, Tepper RI, Shyjan AW (1998) Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res 58:1515–1520
23. Erler I, Al-Ansary DM, Wissenbach U, Wagner TF, Flockerzi V, Niemeyer BA (2006) Trafficking and assembly of the cold-sensitive TRPM8 channel. J Biol Chem 281:38396–38404
24. Euler T, Schneider H, Wässle H (1996) Glutamate responses of bipolar cells in a slice preparation of the rat retina. J Neurosci 16:2934–2944
25. Fang D, Setaluri V (2000) Expression and Up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells. Biochem Biophys Res Commun 279:53–61
26. Fujiwara Y, Minor DL (2008) X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil. J Mol Biol 383:854–870
27. Gregg RG, Kamermans M, Klooster J, Lukasiewicz PD, Peachey NS, Vessey KA, McCall MA (2007) Nyctalopin expression in retinal bipolar cells restores visual function in a mouse model of complete X-linked congenital stationary night blindness. J Neurophysiol 98:3023–3033
28. Haverkamp S, Grünert U, Wässle H (2001) The synaptic architecture of AMPA receptors at the cone pedicle of the primate retina. J Neurosci 21:2488–2500
29. Heckenlively JR, Ferreyra HA (2008) Autoimmune retinopathy: a review and summary. Semin Immunopathol 30:127–134
30. Hunter JJ, Shao J, Smutko JS, Dussault BJ, Nagle DL, Woolf EA, Holmgren LM, Moore KJ, Shyjan AW (1998) Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1). Genomics 54:116–123
31. Iwakabe H, Katsuura G, Ishibashi C, Nakanishi S (1997) Impairment of pupillary responses and optokinetic nystagmus in the mGluR6-deficient mouse. Neuropharmacology 36:135–143
32. Kim DS, Ross SE, Trimarchi JM, Aach J, Greenberg ME, Cepko CL (2008) Identification of molecular markers of bipolar cells in the murine retina. J Comp Neurol 507:1795–1810
33. Koike C, Sanuki R, Miyata K, Koyasu T, Miyoshi T, Sawai H, Kondo M, Usukura J, Furukawa T (2007) The functional analysis of TRPM1 in retinal bipolar cells. Neurosci Res 58:S41
34. Koike C, Numata T, Ueda H, Mori Y, Furukawa T (2010a) TRPM1: a vertebrate TRP channel responsible for retinal ON bipolar function. Cell Calcium 48:95–101
35. Koike C, Obara T, Uriu Y, Numata T, Sanuki R, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M, Furukawa T (2010b) TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci USA 107:332–337
36. Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T (2011) Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction. PLoS One 6:e19911
37. Lambert S, Drews A, Rizun O, Wagner TF, Lis A, Mannebach S, Plant S, Portz M, Meissner M, Philipp SE, Oberwinkler J (2011) Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions. J Biol Chem 286:12221–12233
38. Lepichon JB, Bittel DC, Graf WD, Yu S (2010) A 15q13.3 homozygous microdeletion associated with a severe neurodevelopmental disorder suggests putative functions of the TRPM1, CHRNA7, and other homozygously deleted genes. Am J Med Genet A 152A:1300–1304
39. Li Z, Sergouniotis PI, Michaelides M, Mackay DS, Wright GA, Devery S, Moore AT, Holder GE, Robson AG, Webster AR (2009) Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans. Am J Hum Genet 85:711–719
40. Masu M, Iwakabe H, Tagawa Y, Miyoshi T, Yamashita M, Fukuda Y, Sasaki H, Hiroi K, Nakamura Y, Shigemoto R (1995) Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell 80:757–765
41. McGillem GS, Dacheux RF (2001) Rabbit cone bipolar cells: correlation of their morphologies with whole-cell recordings. Vis Neurosci 18:675–685
42. Miyake Y, Yagasaki K, Horiguchi M, Kawase Y, Kanda T (1986) Congenital stationary night blindness with negative electroretinogram. A new classification. Arch Ophthalmol 104:1013–1020
43. Morgans CW, Ren G, Akileswaran L (2006) Localization of nyctalopin in the mammalian retina. Eur J Neurosci 23:1163–1171
44. Morgans CW, Brown RL, Duvoisin RM (2010) TRPM1: the endpoint of the mGluR6 signal transduction cascade in retinal ON-bipolar cells. Bioessays 32:609–614
45. Morigiwa K, Vardi N (1999) Differential expression of ionotropic glutamate receptor subunits in the outer retina. J Comp Neurol 405:173–184
46. Nakamura M, Sanuki R, Yasuma TR, Onishi A, Nishiguchi KM, Koike C, Kadowaki M, Kondo M, Miyake Y, Furukawa T (2010) TRPM1 mutations are associated with the complete form of congenital stationary night blindness. Mol Vis 16:425–437
47. Nakanishi S, Nakajima Y, Masu M, Ueda Y, Nakahara K, Watanabe D, Yamaguchi S, Kawabata S, Okada M (1998) Glutamate receptors: brain function and signal transduction. Brain Res Brain Res Rev 26:230–235
48. Nawy S (1999) The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells. J Neurosci 19:2938–2944
49. Nawy S, Jahr CE (1990) Suppression by glutamate of cGMP-activated conductance in retinal bipolar cells. Nature 346:269–271
50. Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S (1994) Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell 77:361–369
51. Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE (2009) TRPM1 forms ion channels associated with melanin content in melanocytes. Science signaling 2:ra21
52. Peachey NS, Pearring JN, Bojang P, Hirschtritt ME, Sturgill-Short G, Ray TA, Furukawa T, Koike C, Goldberg AF, Shen Y, McCall MA, Nawy S, Nishina PM, Gregg RG (2012a) Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation. J Neurophysiol 108 (9):2442–2451
53. Peachey NS, Ray TA, Florijn R, Rowe LB, Sjoerdsma T, Contreras-Alcantara S, Baba K, Tosini G, Pozdeyev N, Iuvone PM, Bojang P, Pearring JN, Simonsz HJ, van Genderen M, Birch DG, Traboulsi EI, Dorfman A, Lopez I, Ren H, Goldberg AF, Nishina PM (2012b) GPR179 is required for depolarizing bipolar cell function and is mutated in autosomalrecessive complete congenital stationary night blindness. Am J Hum Genet 90:331–339
54. Perraud AL, Schmitz C, Scharenberg AM (2003) TRPM2 Ca2+ permeable cation channels: from gene to biological function. Cell Calcium 33:519–531
55. Pusch CM, Zeitz C, Brandau O, Pesch K, Achatz H, Feil S, Scharfe C, Maurer J, Jacobi FK, Pinckers A, Andreasson S, Hardcastle A, Wissinger B, Berger W, Meindl A (2000) The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein. Nat Genet 26:324–327
56. Rampino MA, Nawy SA (2011) Relief of Mg2+-dependent inhibition of TRPM1 by PKCα at the rod bipolar cell synapse. J Neurosci 31:13596–13603
57. Redenti S, Chappell RL (2005) Neuroimaging of zinc released by depolarization of rat retinal cells. Vision Res 45:3520–3525
58. Redenti S, Ripps H, Chappell RL (2007) Zinc release at the synaptic terminals of rod photoreceptors. Exp Eye Res 85:580–584
59. Rohrer B, Blanco R, Marc RE, Lloyd MB, Bok D, Schneeweis DM, Reichardt LF (2004) Functionally intact glutamate-mediated signaling in bipolar cells of the TRKB knockout mouse retina. Vis Neurosci 21:703–713
60. Shen Y, Heimel JA, Kamermans M, Peachey NS, Gregg RG, Nawy S (2009) A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells. J Neurosci 29:6088–6093
61. Shiells RA, Falk G (1990) Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein. Proc Biol Sci 242:91–94
62. Shiells R, Falk G (1992a) Retinal on-bipolar cells contain a nitric oxide-sensitive guanylate cyclase. Neuroreport 3:845–848
63. Shiells RA, Falk G (1992b) The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive. Proc Biol Sci 247:17–20
64. Shiells RA, Falk G (1992c) Properties of the cGMP-activated channel of retinal on-bipolar cells. Proc Biol Sci 247:21–25
65. Shiells RA, Falk G, Naghshineh S (1981) Action of glutamate and aspartate analogues on rod horizontal and bipolar cells. Nature 294:592–594
66. Slaughter MM, Miller RF (1981) 2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research. Science 211:182–185
67. Slaughter MM, Miller RF (1985) Characterization of an extended glutamate receptor of the on bipolar neuron in the vertebrate retina. J Neurosci 5:224–233
68. Strom TM, Nyakatura G, Apfelstedt-Sylla E, Hellebrand H, Lorenz B, Weber BH, Wutz K, Gutwillinger N, Rüther K, Drescher B, Sauer C, Zrenner E, Meitinger T, Rosenthal A, Meindl A (1998) An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness. Nat Genet 19:260–263
69. Thirkill CE, FitzGerald P, Sergott RC, Roth AM, Tyler NK, Keltner JL (1989) Cancer-associated retinopathy (CAR syndrome) with antibodies reacting with retinal, optic-nerve, and cancer cells. N Engl J Med 321:1589–1594
70. Tsuruda PR, Julius D, Minor DL (2006) Coiled coils direct assembly of a cold-activated TRP channel. Neuron 51:201–212
71. van Genderen MM, Bijveld MM, Claassen YB, Florijn RJ, Pearring JN, Meire FM, McCall MA, Riemslag FC, Gregg RG, Bergen AA, Kamermans M (2009) Mutations in TRPM1 are a common cause of complete congenital stationary night blindness. Am J Hum Genet 85: 730–736
72. Vardi N (1998) Alpha subunit of Go localizes in the dendritic tips of ON bipolar cells. J Comp Neurol 395:43–52
73. Vardi N, Morigiwa K (1997) ON cone bipolar cells in rat express the metabotropic receptor mGluR6. Vis Neurosci 14:789–794
74. Vardi N, Duvoisin R, Wu G, Sterling P (2000) Localization of mGluR6 to dendrites of ON bipolar cells in primate retina. J Comp Neurol 423:402–412
75. Venkatachalam K, Montell C (2007) TRP channels. Annu Rev Biochem 76:387–417
76. Wang Y, Abu-Asab MS, Li W, Aronow ME, Singh AD, Chan CC (2012) Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy. BMC Ophthalmol 12:56
77. Weng K, Lu C, Daggett LP, Kuhn R, Flor PJ, Johnson EC, Robinson PR (1997) Functional coupling of a human retinal metabotropic glutamate receptor (hmGluR6) to bovine rod transducin and rat Go in an in vitro reconstitution system. J Biol Chem 272:33100–33104
78. Won J, Shi LY, Hicks W, Wang J, Hurd R, Naggert JK, Chang B, Nishina PM (2011) Mouse model resources for vision research. J Ophthalmol 2011:391384
79. Xiong WH, Duvoisin RM, Adamus G, Jeffrey BG, Gellman C, Morgans CW (2013) Serum TRPM1 autoantibodies from melanoma associated retinopathy patients enter retinal ON-bipolar cells and attenuate the electroretinogram in mice. PLoS One 8:e69506
80. Xu XZ, Moebius F, Gill DL, Montell C (2001) Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc Natl Acad Sci USA 98:10692–10697
81. Zeitz C, van Genderen M, Neidhardt J, Luhmann UF, Hoeben F, Forster U, Wycisk K, Mátyás G, Hoyng CB, Riemslag F, Meire F, Cremers FP, Berger W (2005) Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram. Invest Ophthalmol Vis Sci 46:4328–4335
82. Zeitz C, Kloeckener-Gruissem B, Forster U, Kohl S, Magyar I, Wissinger B, Mátyás G, Borruat FX, Schorderet DF, Zrenner E, Munier FL, Berger W (2006) Mutations in CABP4, the gene encoding the Ca2+-binding protein 4, cause autosomal recessive night blindness. Am J Hum Genet 79:657–667
83. Zeitz C, Jacobson SG, Hamel CP, Bujakowska K, Neuille´ M, Orhan E, Zanlonghi X, Lancelot ME, Michiels C, Schwartz SB, Bocquet B, Antonio A, Audier C, Letexier M, Saraiva JP, Luu TD, Sennlaub F, Nguyen H, Poch O, Dollfus H, Lecompte O (2013) Whole-exome sequencing identifies LRIT3 mutations as a cause of autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet 92:67–75
84. Zhiqi S, Soltani MH, Bhat KM, Sangha N, Fang D, Hunter JJ, Setaluri V (2004) Human melastatin 1 (TRPM1) is regulated by MITF and produces multiple polypeptide isoforms in melanocytes and melanoma. Melanoma Res 14:509–516