Impairment of pupillary responses and optokinetic nystagmus in the mGluR6-deficient mouse

Neuropharmacology

Volumn 36, Issue 2, 1997, Pages 135-143

  Iwakabe, H ^a   Katsuura, G ^b   Ishibashi, C ^b   Nakanishi, S ^a  

^a KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

Author keywords

gene targeting; metabotropic glutamate receptor; optokinetic nystagmus; pupillary response; visual contrast; visual ON OFF segregation

Indexed keywords

GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR; RECEPTOR SUBTYPE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTRAST; CONTROLLED STUDY; GENE TARGETING; INFORMATION PROCESSING; LIGHT DARK CYCLE; LOCOMOTION; MALE; MOUSE; NEUROTRANSMISSION; NONHUMAN; ONCOGENE C FOS; OPTOKINETIC NYSTAGMUS; PHOTOSTIMULATION; PRIORITY JOURNAL; PUPIL REFLEX; RETINA BIPOLAR GANGLION CELL; SUPRACHIASMATIC NUCLEUS; VISUAL DISCRIMINATION; VISUAL INFORMATION;

ANIMALS; MALE; MICE; MOTOR ACTIVITY; MUTATION; NYSTAGMUS, OPTOKINETIC; PHOTIC STIMULATION; PROTO-ONCOGENE PROTEINS C-FOS; PUPIL; RECEPTORS, METABOTROPIC GLUTAMATE; SUPRACHIASMATIC NUCLEUS;

EID: 0030941005     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00167-0     Document Type: Article

References (35)

1. Akazawa C., Ohishi H., Nakajima Y., Okamoto N., Shigemoto R., Nakanishi S., Mizuno N. Expression of mRNAs of L-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neurosci. Lett. 171:1994;52-54.
2. Ariel M. (1992) Neurotransmitter drugs that affect vertebrate eye movements. In: The Visual System (Lent R., Ed.), pp. 158-172. Birkhäuser Boston, Cambridge.
3. Clarke R.J., Ikeda H. Luminance and darkness detectors in the olivary and posterior pretectal nuclei and their relationship to the pupillary light reflex in the rat. I. Studies with steady luminance levels Exp. Brain Res. 57:1985;224-232.
4. Collewijn H. (1991) The optokinetic contribution. In: Vision and Visual Dysfunction: Eye Movements (Carpenter R.H.S., Ed.), Vol. 8, pp. 45-70. Macmillan Press, London.
5. Colwell C.S., Foster R.G. Photic regulation of Fos-like immunoreactivity in the suprachiasmatic nucleus of the mouse. J. Comp. Neurol. 324:1992;135-142.
6. DeVries S.H. and Baylor D.A. (1993) Synaptic circuitry of the retina and olfactory bulb. Cell 72/Neuron 10 (suppl.): 139-149.
7. Duvoisin R.M., Zhang C., Ramonell K. A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J. Neurosci. 15:1995;3075-3083.
8. Euler T., Wässle H. Immunocytochemical identification of cone bipolar cells in the rat retina. J. Comp. Neurol. 361:1995;461-478.
9. Horton J.C., Sherk H. Receptive field properties in the cat's lateral geniculate nucleus in the absence of on-center retinal input. J. Neurosci. 4:1984;374-380.
10. Knapp A.G., Mistler L.A. Response properties of cells in rabbit's lateral geniculate nucleus during reversible blockade of retinal on-center channel. J. Neurophysiol. 50:1983;1236-1245.
11. Knapp A.G., Ariel M., Robinson F.R. Analysis of vertebrate eye movements following intravitreal drug injections. I. Blockade of retinal on-cells by 2-amino-4-phosphonobutyrate eliminates optokinetic nystagmus J. Neurophysiol. 60:1988;1010-1021.
12. Mangini N.J., Vanable J.W. Jr., Williams M.A., Pinto L.H. The optokinetic nystagmus and ocular pigmentation of hypopigmented mouse mutants. J. Comp. Neurol. 241:1985;191-209.
13. Massey S.C., Redburn D.A., Crawford M.L.J. The effects of 2-amino-4-phosphonobutyric acid (APB) on the ERG and ganglion cell discharge of rabbit retina. Vision Res. 23:1983;1607-1613.
14. Masu M., Iwakabe H., Tagawa Y., Miyoshi T., Yamashita M., Fukuda Y., Sasaki H., Hiroi K., Nakamura Y., Shigemoto R., Takada M., Nakamura K., Nakao K., Katsuki M., Nakanishi S. Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell. 80:1995;757-765.
15. Miller R.F., Slaughter M.M. Excitatory amino acid receptors of the retina: diversity of subtypes and conductance mechanisms. Trends Neurosci. 9:1986;211-218.
16. Nakajima Y., Iwakabe H., Akazawa C., Nawa H., Shigemoto R., Mizuno N., Nakanishi S. Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. J. Biol. Chem. 268:1993;11868-11873.
17. Nakanishi S. Metabotropic glutamate receptors: synaptic transmission, modulation and plasticity. Neuron. 13:1994;1031-1037.
18. Nakanishi S. Second-order neurones and receptor mechanisms in visual- and olfactory-information processing. Trends Neurosci. 18:1995;359-364.
19. Nawy S., Jahr C.E. Suppression by glutamate of cGMP-activated conductance in retinal bipolar cells. Nature. 346:1990;269-271.
20. Nawy S., Jahr C.E. cGMP-gated conductance in retinal bipolar cells is suppressed by the photoreceptor transmitter. Neuron. 7:1991;677-683.
21. Nomura A., Shigemoto R., Nakamura Y., Okamoto N., Mizuno N., Nakanishi S. Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell. 77:1994;361-369.
22. Pin J.P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
23. Rea M.A. Light increases Fos-related protein immunoreactivity in the rat suprachiasmatic nuclei. Brain Res. Bull. 23:1989;577-581.
24. Rusak B., Zucker I. Neural regulation of circadian rhythms. Physiol. Rev. 59:1979;449-526.
25. Schiller P.H., Central connections of the retinal ON and OFF pathways Nature. 297:1982;580-583.
26. Schiller P.H. The ON and OFF channels of the visual system. Trends Neurosci. 15:1992;86-92.
27. Schiller P.H., Sandell J.H., Maunsell J.H.R. Functions of the ON and OFF channels of the visual system. Nature. 322:1986;824-825.
28. Shiells R.A., Falk G. Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein. Proc. Royal Soc. Lond. (B). 242:1990;91-94.
29. Shiells R. Glutamate receptors for signal amplification. Curr. Biol. 4:1994;917-918.
30. Slaughter M.M., Miller R.F. 2-Amino-4-phosphonobutyric acid: a new pharmacological tool for retina research. Science. 211:1981;182-185.
31. Ticher A., Ashkenazi I.E. Compound structure of rodents activity rhythm. Physiol. Behav. 57:1995;37-40.
32. Trejo L.J., Cicerone C.M. Cells in the pretectal olivary nucleus are in the pathway for the direct light reflex of the pupil in the rat. Brain Res. 300:1984;49-62.
33. de la Villa P., Kurahashi T., Kaneko A. L-Glutamate-induced responses and cGMP-activated channels in three subtypes of retinal bipolar cells dissociated from the cat. J. Neurosci. 15:1995;3571-3582.
34. Wässle H., Yamashita M., Greferath U., Grünert U., Müller F. The rod bipolar cell of the mammalian retina. Vis. Neurosci. 7:1991;99-112.
35. Yücel Y.H., Jardon B., Bonaventure N. Involvement of ON and OFF retinal channels in the eye and head horizontal optokinetic nystagmus of the frog. Vis. Neurosci. 2:1989;357-365.