Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status

Reproduction

Volumn 148, Issue 3, 2014, Pages 295-302

  Cao, Chang ^a   Pressman, Eva K ^b   Cooper, Elizabeth M ^b   Guillet, Ronnie ^b   Westerman, Mark ^c   O'Brien, Kimberly O ^a  

^a Division of Nutritional Sciences Cornell University 230 Savage Hall ^*  (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c Intrinsic Life Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FELINE LEUKEMIA VIRUS C RECEPTOR 1; FERRITIN; HEMOPEXIN; HEPCIDIN; INDICATOR; IRON; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; RECEPTOR PROTEIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CARRIER PROTEIN; FLVCR1 PROTEIN, HUMAN; HEMOGLOBIN; LRP1 PROTEIN, HUMAN; VIRUS RECEPTOR;

ADOLESCENT; ADOLESCENT PREGNANCY; ADULT; ARTICLE; CORRELATIONAL STUDY; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; IRON DEFICIENCY; MATERNAL BLOOD; NEWBORN; PLACENTAL TRANSFER; PREGNANT WOMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; UMBILICAL CORD BLOOD; BLOOD; FETUS BLOOD; GENETICS; HOMEOSTASIS; METABOLISM; PLACENTA; PREGNANCY;

ADOLESCENT; BIOLOGICAL MARKERS; FEMALE; FERRITINS; FETAL BLOOD; HEMOGLOBINS; HEMOPEXIN; HEPCIDINS; HOMEOSTASIS; HUMANS; IRON; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1; MEMBRANE TRANSPORT PROTEINS; PLACENTA; PREGNANCY; PROSPECTIVE STUDIES; RECEPTORS, TRANSFERRIN; RECEPTORS, VIRUS;

EID: 84904889066     PISSN: 14701626     EISSN: 17417899     Source Type: Journal    
DOI: 10.1530/REP-14-0053     Document Type: Article

References (44)

1. Akesson A, Bjellerup P, Berglund M, Bremme K & Vahter M 1998 Serum transferrin receptor: a specific marker of iron deficiency in pregnancy. American Journal of Clinical Nutrition 68 1241-1246. (Pubitemid 28550955)
2. Bastin J, Drakesmith H, Rees M, Sargent I & Townsend A 2006 Localisation of proteins of iron metabolism in the human placenta and liver. British Journal of Haematology 134 532-543. (doi:10.1111/j.1365-2141.2006.06216. x)
3. Brugnara C 2009 Reference values in infancy and childhood. In Nathan & Oski's Hematology of Infancy and Childhood, edn 7, pp 1769-1796. Eds Fisher DE, Ginsburg D, Look AT, Lux SE, Nathan DG, and Orkin SH. Philadelphia: Saunders/Elsevier.
4. Cao C & O'Brien KO 2013 Pregnancy and iron homeostasis: an update. Nutrition Reviews 71 35-51. (doi:10.1111/j.1753-4887.2012.00550.x)
5. Cook JD, Flowers CH & Skikne BS 2003 The quantitative assessment of body iron. Blood 101 3359-3364. (doi:10.1182/blood-2002-10-3071)
6. Cornock R, Gambling L, Langley-Evans SC, McArdle HJ & McMullen S 2013 The effect of feeding a low iron diet prior to and during gestation on fetal and maternal iron homeostasis in two strains of rat. Reproductive Biology and Endocrinology 11 32. (doi:10.1186/1477-7827-11-32)
7. Delanghe JR & Langlois MR 2001 Hemopexin: a review of biological aspects and the role in laboratory medicine. Clinica Chimica Acta 312 13-23. (doi:10.1016/S0009-8981(01)00586-1)
8. van Dijk JP 1988 Regulatory aspects of placental iron transfer - a comparative study. Placenta 9 215-226. (doi:10.1016/0143-4004(88)90018-5)
9. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A et al. 2000 Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403 776-781. (doi:10.1038/35001596)
10. Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S & Andrews NC 2005 The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metabolism 1 191-200. (doi:10.1016/j.cmet.2005.01.003)
11. Gafvels ME, Coukos G, Sayegh R, Coutifaris C, Strickland DK & Strauss JF III 1992 Regulated expression of the trophoblast a 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Differentiation and cAMP modulate protein and mRNA levels. Journal of Biological Chemistry 267 21230-21234.
12. Gambling L, Danzeisen R, Gair S, Lea RG, Charania Z, Solanky N, Joory KD, Srai SK & McArdle HJ 2001 Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro. Biochemical Journal 356 883-889. (doi:10.1042/0264-6021:3560883)
13. Gambling L, Czopek A, Andersen HS, Holtrop G, Srai SK, Krejpcio Z & McArdle HJ 2009 Fetal iron status regulates maternal iron metabolism during pregnancy in the rat. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 296 R1063-R1070. (doi:10.1152/ajpregu.90793.2008)
14. Gitlin D & Biasucci A 1969 Development of gamma G, gamma A, gamma M, beta IC-beta IA, C 1 esterase inhibitor, ceruloplasmin, transferrin, hemopexin, haptoglobin, fibrinogen, plasminogen, alpha 1-antitrypsin, orosomucoid, beta-lipoprotein, alpha 2-macroglobulin, and prealbumin in the human conceptus. Journal of Clinical Investigation 48 1433-1446. (doi:10.1172/JCI106109)
15. Hvidberg V, Maniecki MB, Jacobsen C, Hojrup P, Moller HJ & Moestrup SK 2005 Identification of the receptor scavenging hemopexin-heme complexes. Blood 106 2572-2579. (doi:10.1182/blood-2005-03-1185)
16. Institute of Medicine 1993 Recommended guidelines for preventing and treating iron deficiency anemia in pregnant women. Iron deficiency anemia: a synthesis of current scientific knowledge and U.S. recommendations for prevention and treatment. In Iron Deficiency Anemia: Recommended Guidelines for Prevention, Detection and Management Among U.S. Children and Women of Childbearing Age, pp 24-25. Eds Earl R and Woteki CE. Washington, DC: National Academies Press.
17. Jaacks LM, Young MF, Essley BV, McNanley TJ, Cooper EM, Pressman EK, McIntyre AW, Orlando MS, Abkowitz JL, Guillet R et al. 2011 Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents. Journal of Nutrition 141 1267-1272. (doi:10.3945/jn.110.135798)
18. Jensen PH, Moestrup SK, Sottrup-Jensen L, Petersen CM & Gliemann J 1988 Receptors for α2-macroglobulin- and pregnancy zone protein-proteinase complexes in the human placental syncytiotrophoblast. Placenta 9 463-477. (doi:10.1016/0143-4004(88)90019-7)
19. Jensen PH, Moestrup SK & Gliemann J 1989 Purification of the human placental α2-macroglobulin receptor. FEBS Letters 255 275-280. (doi:10.1016/0014-5793(89)81105-6)
20. Kanakoudi F, Drossou V, Tzimouli V, Diamanti E, Konstantinidis T, Germenis A & Kremenopoulos G 1995 Serum concentrations of 10 acute-phase proteins in healthy term and preterm infants from birth to age 6 months. Clinical Chemistry 41 605-608.
21. Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J et al. 2008 A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 319 825-828. (doi:10.1126/science.1151133)
22. Kristensen T, Moestrup SK, Gliemann J, Bendtsen L, Sand O & Sottrup-Jensen L 1990 Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the α2-macroglobulin receptor. FEBS Letters 276 151-155. (doi:10.1016/0014-5793(90)80530-V)
23. Li YQ, Yan H & Bai B 2008 Change in iron transporter expression in human term placenta with different maternal iron status. European Journal of Obstetrics, Gynecology, and Reproductive Biology 140 48-54. (doi:10.1016/j. ejogrb.2008.02.012)
24. Li RC, Saleem S, Zhen G, Cao W, Zhuang H, Lee J, Smith A, Altruda F, Tolosano E & Dore S 2009 Heme-hemopexin complex attenuates neuronal cell death and stroke damage. Journal of Cerebral Blood Flow and Metabolism 29 953-964. (doi:10.1038/jcbfm.2009.19)
25. Loh TT, Higuchi DA, van Bockxmeer FM, Smith CH & Brown EB 1980 Transferrin receptors on the human placental microvillous membrane. Journal of Clinical Investigation 65 1182-1191. (doi:10.1172/JCI109773)
26. Lundh B, Oski FA & Gardner FH 1970 Plasma hemopexin and haptoglobin in hemolytic diseases of the newborn. Acta Paediatrica Scandinavica 59 121-126. (doi:10.1111/j.1651-2227.1970.tb08975.x)
27. May P, Bock HH, Nimpf J & Herz J 2003 Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase. Journal of Biological Chemistry 278 37386-37392. (doi:10.1074/jbc.M305858200)
28. McArdle HJ, Lang C, Hayes H & Gambling L 2011 Role of the placenta in regulation of fetal iron status. Nutrition Reviews 69 (Suppl 1) S17-S22. (doi:10.1111/j.1753-4887.2011.00428.x)
29. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F et al. 2000 A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Molecular Cell 5 299-309. (doi:10.1016/S1097-2765(00)80425-6)
30. Mei Z, Cogswell ME, Looker AC, Pfeiffer CM, Cusick SE, Lacher DA & Grummer-Strawn LM 2011 Assessment of iron status in US pregnant women from the National Health and Nutrition Examination Survey (NHANES), 1999-2006. American Journal of Clinical Nutrition 93 1312-1320. (doi:10.3945/ajcn.110.007195)
31. Moestrup SK, Gliemann J & Pallesen G 1992 Distribution of the α2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell and Tissue Research 269 375-382. (doi:10.1007/ BF00353892)
32. Muller-Eberhard U, Javid J, Liem HH, Hanstein A & Hanna M 1968 Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases. Blood 32 811-815.
33. O'Brien KO, Li S, Cao C, Kent T, Young BV, Queenan R, Pressman EK & Cooper EM 2014 Placental cyp27b1 and cyp24a1 expression in human placental tissue and their association with maternal and neonatal calcitropic hormones. Journal of Clinical Endocrinology and Metabolism 99 1348-1356. (doi:10.1210/jc.2013-1366)
34. Smith A & Ledford BE 1988 Expression of the haemopexin-transport system in cultured mouse hepatoma cells. Links between haemopexin and iron metabolism. Biochemical Journal 256 941-950. (Pubitemid 19021726)
35. Tolosano E, Hirsch E, Patrucco E, Camaschella C, Navone R, Silengo L & Altruda F 1999 Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice. Blood 94 3906-3914.
36. Tolosano E, Fagoonee S, Morello N, Vinchi F & Fiorito V 2010 Heme scavenging and the other facets of hemopexin. Antioxidants & Redox Signaling 12 305-320. (doi:10.1089/ars.2009.2787)
37. Van Campenhout A, Van Campenhout C, Lagrou AR, Abrams P, Moorkens G, Van Gaal L & Manuel-y-Keenoy B 2006 Impact of diabetes mellitus on the relationships between iron-, inflammatory- and oxidative stress status. Diabetes/Metabolism Research and Reviews 22 444-454. (doi:10.1002/dmrr.635)
38. Vinchi F, Gastaldi S, Silengo L, Altruda F & Tolosano E 2008 Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload. American Journal of Pathology 173 289-299. (doi:10.2353/ajpath. 2008.071130)
39. Viteri FE 1994 The concurrences of iron deficiency and anemia in pregnancy. In Nutrient Regulation During Pregnancy, Lactation, and Infant Growth, pp 127-139. Eds Allen L, King J, Lönnerdal B. New York: Plenum Press.
40. Yang Z, Philips JD, Doty RT, Giraudi P, Ostrow JD, Tiribelli C, Smith A & Abkowitz JL 2010 Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. Journal of Biological Chemistry 285 28874-28882. (doi:10.1074/jbc.M110.119131)
41. Young MF, Pressman E, Foehr ML, McNanley T, Cooper E, Guillet R, Orlando M, McIntyre AW, Lafond J & O'Brien KO 2010 Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents. Placenta 31 1010-1014. (doi:10.1016/j.placenta.2010.08.009)
42. Young BE, McNanley TJ, Cooper EM, McIntyre AW, Witter F, Harris ZL & O'Brien KO 2012 Vitamin D insufficiency is prevalent and vitamin D is inversely associated with PTH and calcitriol in pregnant adolescents. Journal of Bone andMineral Research 27 177-186. (doi:10.1002/jbmr.526)
43. Young BE, McNanley TJ, Cooper EM, McIntyre AW, Witter F, Harris ZL & O'Brien KO 2012a Maternal vitamin D status and calcium intake interact to affect fetal skeletal growth in utero in pregnant adolescents. American Journal of Clinical Nutrition 95 1103-1112. (doi:10.3945/ajcn.111.023861)
44. Young MF, Griffin I, Pressman E, McIntyre AW, Cooper E, McNanley T, Harris ZL, Westerman M & O'Brien KO 2012 b Maternal hepcidin is associated with placental transfer of iron derived from dietary heme and nonheme sources. Journal of Nutrition 142 33-39. (doi:10.3945/jn.111.145961)