Biclonal and biallelic deletions occur in 20% of B-ALL cases with IKZF1 mutations

Leukemia

Volumn 27, Issue 2, 2013, Pages 503-507

  Dupuis, A ^a,b   Gaub, M P ^a,b,c   Legrain, M ^a,b,c   Drenou, B ^c,d   Mauvieux, L ^a,b,c   Lutz, P ^a,b   Herbrecht, R ^a,b   Chan, S ^a   Kastner, P ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b HÔPITAL DE HAUTEPIERRE   (France)

^c Plate forme Régionale INCa de Génétique Moléculaire des Cancers d'Alsace   (France)

^d Hôpitaux Universitaires de Strasbourg   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; COMPARATIVE GENOMIC HYBRIDIZATION; EXON; GENE; GENE DELETION; HAPLOINSUFFICIENCY; HUMAN; IKZF1 GENE; LETTER; LEUKEMOGENESIS; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MULTIPLEX POLYMERASE CHAIN REACTION; OVERALL SURVIVAL; POINT MUTATION; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; CHILD; HAPLOINSUFFICIENCY; HUMANS; IKAROS TRANSCRIPTION FACTOR; MUTATION; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS;

EID: 84873571191     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.204     Document Type: Letter

References (13)

1. Sellars M, Kastner P, Chan S. Ikaros in B cell development and function. World J Biol Chem 2011; 2: 132-139.
2. Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J et al. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 2008; 453: 110-114.
3. Iacobucci I, Storlazzi CT, Cilloni D, Lonetti A, Ottaviani E, Soverini S et al. Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP). Blood 2009; 114: 2159-2167.
4. Kuiper RP, Waanders E, Van der Velden VH, Van Reijmersdal SV, Venkatachalam R, Scheijen B et al. IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. Leukemia 2010; 24: 1258-1264.
5. Mullighan CG, Su X, Zhang J, Radtke I, Phillips LA, Miller CB et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009; 360: 470-480.
6. Martinelli G, Iacobucci I, Storlazzi CT, Vignetti M, Paoloni F, Cilloni D et al. IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report. J Clin Oncol 2009; 27: 5202-5207.
7. Waanders E, Van der Velden VH, Van der Schoot CE, Van Leeuwen FN, Van Reijmersdal SV, de Haas V et al. Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia. Leukemia 2011; 25: 254-258.
8. Yang YL, Hung CC, Chen JS, Lin KH, Jou ST, Hsiao CC et al. IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: a multicenter analysis in Taiwan. Cancer Sci 2011; 102: 1874-1881.
9. Mi JQ, Wang X, Yao Y, Lu HJ, Jiang XX, Zhou JF et al. Newly diagnosed acute lymphoblastic leukemia in China (II): prognosis related to genetic abnormalities in a series of 1091 cases. Leukemia 2012; 26: 1507-1516.
10. Krentz S, Hof J, Mendioroz A, Vaggopoulou R, Dörge P, Lottaz C et al. Prognostic valueof genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia. Leukemia; e-pub ahead of print 13 June 2012; doi: 10.1038/leu.2012.155.
11. Schwab CJ, Jones LR, Morrison H, Ryan SL, Yigittop H, Schouten JP et al. Evaluation of multiplex ligation-dependent probe amplification as a method for the detection of copy number abnormalities in B-cell precursor acute lymphoblastic leukemia. Genes Chromosomes Cancer 2010; 49: 1104-1113.
12. Cazzaniga G, Van Delft FW, Lo Nigro L, Ford AM, Score J, Iacobucci I et al. Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph\+ acute lymphoblastic leukemia. Blood 2011; 118: 5559-5564.
13. Venn NC, Van der Velden VH, de Bie M, Waanders E, Giles JE, Law T et al. Highly sensitive MRD tests for ALL based on the IKZF1 D3-6 microdeletion. Leukemia 2011; 26: 1414-1416.