The potential role of GLUT4 transporters and insulin receptors in the hypoglycaemic activity of Ficus lutea acetone leaf extract

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  Olaokun, Oyinlola O ^a,b   McGaw, Lyndy J ^a   Awouafack, Maurice D ^a,c   Eloff, Jacobus N ^a   Naidoo, Vinny ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b FEDERAL INSTITUTE OF INDUSTRIAL RESEARCH   (Nigeria)

^c UNIVERSITY OF DSCHANG   (Cameroon)

Author keywords

African Ficus species; Diabetes; Ficus lutea; Glucose uptake; Insulin secretion

Indexed keywords

ACETONE; DIMETHYL SULFOXIDE; FAT; FICUS LUTEA LEAF EXTRACT; GLIBENCLAMIDE; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; METFORMIN; PLANT EXTRACT; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; SLC2A4 PROTEIN, RAT;

ADIPOCYTE; ANIMAL CELL; ANTIDIABETIC ACTIVITY; ARTICLE; CELL SURFACE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HEPATOCELLULAR CARCINOMA CELL LINE; INSULIN RELEASE; LIVER CELL; MOUSE; MUSCLE CELL; NONHUMAN; PANCREAS CELL; PROTEIN FUNCTION; RAT; ANIMAL; CHEMISTRY; FICUS; MALE; METABOLISM; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; FICUS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HYPOGLYCEMIC AGENTS; INSULIN; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, INSULIN;

EID: 84904770772     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-269     Document Type: Article

References (48)

1. Kamboj VP. Herbal medicine. Curr Sci-Bangalore 2000, 78(1):35-38.
2. Hart BL. Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 1988, 12(2):123-137.
3. Cousins D, Huffman MA. Medicinal properties in the diet of gorillas: An ethno- pharmacological evaluation. Afr Stud Monogr 2002, 23:65-89.
4. Reiter CE, Gardner TW. Functions of insulin and insulin receptor signaling in retina: possible implications for diabetic retinopathy. Prog Retin Eye Res 2003, 22(4):545-562.
5. Hou JC, Min L, Pessin JE. Insulin granule biogenesis, trafficking and exocytosis. Vitam Horm 2009, 80:473-506.
6. Kaneto H, Katakami N, Kawamori D, Miyatsuka T, Sakamota K, Matsuoka T-A, Matsuhisa M, Yamasaki Y. Involvement of oxidative stress in the pathogenesis of diabetes. Antioxid Redox Signal 2007, 9(3):355-366.
7. Jain S, Saraf S. Review on Type 2 diabetes mellitus-its global prevalence and therapeutic strategies. Diab Metab Syndr: Clin Res Rev 2010, 4:48-56.
8. Ducorps M, Ndong W, Jupkwo B, Belmejdoub G, Thiolet C, Mayaudon H, Bauduceau B. Diabetes in Cameroon. Classification difficulties in Africa. Med Trop (Mars) 1996, 56(3):264-270.
9. Venkatesh S, Dayanand Reddy G, Reddy YSR, Sathyavathy D, Madhava Reddy B. Effect of Helicteres isora root extracts on glucose tolerance in glucose-induced hyperglycemic rats. Fitoterapia 2004, 75(3):364-367.
10. Watt JM, Breyer-Brandwijk MG. Medicinal and Poisonous Plants of Southern and Eastern Africa 1962, 773-780. London: Livingstone Ltd.
11. Trivedi P, Hind S, Sharma RC. Preliminary phytochemical and pharmacological studies on Ficus racemosa. J Med Res 1969, 56:1070-1074.
12. Singh RK, Mehta S, Jaiswal D, Rai PK, Watal G. Antidiabetic effect of Ficus bengalensis aerial roots in experimental animals. J Ethnopharmacol 2009, 123:110-114.
13. Perez C, Dominguez E, Ramiro JM, Romero A, Campillo JE, Torres MD. A study on the glycaemic balance in streptozotocin-diabetic rats treated with an aqueous extract of Ficus carica (fig tree) leaves. Phytother Res 1996, 10:82-83.
14. Rao RB, Murugesan T, Sinha S, Saha BP, Pal M, Mandal SC. Glucose lowering efficacy of Ficus racemosa bark extract in normal and alloxan diabetic rats. Phytother Res 2002, 16:590-592.
15. Ghosh R, Sharatchandra KH, Rita S, Thokchom IS. Hypoglycaemic activity of Ficus hispida (bark) in normal and diabetic albino rats. Indian J Pharmacol 2004, 36:222-225.
16. Kumar KA, Maheshwari MU, Sivashanmugam AT, Devi VS, Prasanth NV, Ravi TK. Hypoglycemic effect of Ficus microcarpa leaves (Chinese banyan) on alloxan-induced diabetic rats. J Biol Sci 2007, 7(2):321-326.
17. Pandit R, Phahke A, Jagtap A. Antidiabetic effects of Ficus religiosa extract in streptozotocin-induced diabetic rats. J Ethnopharmacol 2010, 128:462-466.
18. Musabayane CT, Gondwe M, Kamadyaapa DR, Chuturgoon AA, Ojewole JAO. Effects of Ficus thonningii (Blume) [Morarceae] stem-bark ethanolic extract on blood glucose, cardiovascular and kidney functions of rats, and on kidney cell lines of the proximal (LLC-PK1) and distal tubules (MDBK). Ren Fail 2007, 29:389-397.
19. Madubunyi II, Onoja SO, Asuzu IU. In vitro antioxidant and in vivo antidiabetic potential of the methanolic extract of Ficus glumosa Del (Moraceae) stem bark in alloxan-induced diabetic mice. Comp Clin Pathol 2012, 21:389-394.
20. Mazumder PM, Farswan M, Parcha V. Hypoglycaemic effect of Ficus arnottiana Miq. bark extracts on streptozotocin induced diabetes in rats. Nat Prod Radiance 2009, 8:478-482.
21. Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 2003, 84:105-108.
22. Adoum OA, Michael BO, Mohammad IS. Phytochemicals and hypoglycaemic effect of methanol stem-bark extract of Ficus sycomorus Linn (Moraceae) on allozan induced diabetic Wistar albino rats. Afr J Biotechnol 2012, 11(17):4095-4097.
23. Adam Z, Khamis S, Ismail A, Hamid M. Ficus deltoidea: A potential alternative medicine for diabetes mellitus. Evid Based Complement Alternat Med 2012, doi: 10.1155/2012/632763.
24. Olaokun OO, McGaw LJ, Eloff JN, Naidoo V. Evaluation of the inhibition of carbohydrate hydrolysing enzymes, antioxidant activity and polyphenolic content of extracts of then African Ficus species (Moraceae) used traditionally to treat diabetes. BMC Complement Altern Med 2013, 13:94.
25. Eloff JN. Conservation of Medicinal Plants: Selecting Medicinal Plants for research and gene banking. Monographs in Systematic Botany from the Missouri Garden. Conservation of Plants Genes III: Conservation and Utilisation of African Plants 1998a, 71:209-222. St. Louis, USA: Missouri Botanical Garden Press, Adams RP, Adams JE.
26. Eloff JN. A sensitive and quick microplate method to determine the minimal inhibitory concentration of plants extracts for bacteria. Planta Med 1998, 64:711-713.
27. Suffness M, Douros J. Drugs of plant origin. Methods Cancer Res 1979, 26:73-126.
28. Yin J, Gao Z, Liu D, Liu Z, Ye J. Berberine improves glucose metabolism through induction of glycolysis. Am J Physiol Endocrinol Metab 2008, 294(1):E148-E156.
29. Deutschländer MS, van de Venter M, Roux S, Louw J, Lall N. Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes. J Ethnopharmacol 2009, 124(3):619-624.
30. Gray AM, Flatt PR. Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, medicago sativa (lucerne). Br J Nutr 1997, 78(2):325-334.
31. Rodbell M. The metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem 1964, 239:375-380.
32. Martz A, Mookerjee BK, Jung CH. Insulin and phorbol esters affect the maximum velocity rather than the half-saturation constant of 3-O-methylglucose transport in rat adipocytes. J Biol Chem 1986, 261(29):13606-13609.
33. Persaud SJ, Al-Majed H, Raman A, Jones PM. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrinol 1999, 163(2):207-212.
34. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65(1-2):55-63.
35. Kpegba K, Agbonon A, Petrovic AG, Amouzou E, Gbeassor M, Proni G, Nesnas N. Epiafzelechin from the root bark of cassia sieberiana: Detection by DART mass spectrometry, spectroscopic characterization, and antioxidant properties. J Nat Prod 2010, 74(3):455-459.
36. Kuete V, Ngameni B, Fotso Simo CC, Tankeu RK, Ngadjui BT, Meyer JJM, Lall N, Kuiate JR. Antimicrobial activity of the crude extract and compounds from Ficus chlamydocarp and Ficus cordata (Moraceae). J Ethnopharmacol 2008, 120(1):17-24.
37. Ariga M, Nedachi T, Katagiri H, Kanzaki M. Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes. J Biol Chem 2008, 283(15):10208-10220.
38. Scheepers A, Joost HG, Schurmann A. The glucose transporter families SGLT and GLUT: Molecular basis of normal and aberrant function. J Parenter Enter Nutr 2004, 28(5):364-371.
39. Guo X, Liao K. Analysis of gene expression profile during 3T3-L1 preadipocyte differentiation. Gene 2000, 251:45-53.
40. Kaestner KH, Christy RJ, McLenithan JC, Braiterman LT, Cornelius P, Pekala PH, Lane MD. Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 1989, 86:3150-3154.
41. Garcia de Herreros A, Birnbaum MJ. The acquisition of increased insulin responsive hexose transport in 3T3-L1 adipocytes correlates with expression of a novel transporter gene. J Biol Chem 1989, 264:19994-19999.
42. Richardson JM, Pessin JE. Identification of a skeletal muscle- specific regulatory domain in the rat GLUT 4/muscle-fat gene. J Biol Chem 1993, 268:21021-21027.
43. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414(6865):799-806.
44. Liu F, Kim J, Yunsheng L, Xue-qing L, Jing L, Xiaozhuo C. An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake stimulatory and adipocyte differentiation-inhibitory activities in 3TC-L1 cells. J Nutr 2001, 131:2242-2247.
45. Schäffer L, Brand CL, Hansen BF, Ribel U, Shaw AC, Slaaby R, Sturis J. A novel high-affinity peptide antagonist to the insulin receptor. Biochem Biophys Res Commun 2008, 376:380-383.
46. Deng JY, Hsieh PS, Huang JP, Lu LS, Hung LM. Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathways. Diabetes 2008, 57(7):1814-1823.
47. Cazarolli LH, Zanatta L, Alberton EH, Figueiredo MS, Folador P, Damazio RG, Pizzolatti MG, Silva FR. Flavonoids: Cellular and molecular mechanism of action in glucose homeostasis. Mini Rev Med Chem 2008, 8(10):1032-1038.
48. Ueda M, Nishiumi S, Nagayasu H, Fukuda I, Yoshida K, Ashida H. Epigallocatechin gallate promotes GLUT4 translocation in skeletal muscle. Biochem Biophys Res Commun 2008, 377(1):286-290.