Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne)

British Journal of Nutrition

Volumn 78, Issue 2, 1997, Pages 325-334

  Gray, Alison M ^a,b   Flatt, Peter R ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Diabetes mellitus; Insulin; Lucerne

Indexed keywords

ALANINE; DIAZOXIDE; DRINKING WATER; GLUCOSE; GLYCOGEN; INSULIN; ISOBUTYLMETHYLXANTHINE; PLANT EXTRACT; POTASSIUM CHLORIDE;

ABDOMINAL WALL MUSCULATURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DIALYSIS; DIET; GLUCOSE OXIDATION; HYPERGLYCEMIA; INSULIN RELEASE; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PANCREAS; PANCREAS FUNCTION; PLANT LEAF; REACTION TIME; TRADITIONAL MEDICINE;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL TRANSPORT; CULTURE TECHNIQUES; DEOXYGLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIAZOXIDE; GLUCOSE; GLYCOGEN; INSULIN; ISLETS OF LANGERHANS; MALE; MEDICAGO SATIVA; MEDICINE, TRADITIONAL; MICE; MUSCLE, SKELETAL; PHOSPHODIESTERASE INHIBITORS; PHYTOTHERAPY; PLANT EXTRACTS; STIMULATION, CHEMICAL;

ANIMALIA; MEDICAGO SATIVA;

EID: 0030768048     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN19970150     Document Type: Article

References (17)

1. Bailey, C. J. & Day, C. (1989). Traditional treatments for diabetes. Diabetes Care 12, 553-564.
2. Bailey, C. J. & Puah, J. A. (1986). Effect of metformin on glucose metabolism in mouse soleus muscle. Diabète et Metabolisme 12, 212-218.
3. Flatt, P. R. & Bailey, C. J. (1981). Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice. Diabetologia 20, 573-577.
4. Hunt, S. M., Chrzanowska, C., Barnett, C. R., Brand, H. N. & Fawell, J. K. (1987). A comparison of in vitro cytotoxicity assays and their application to water samples. Alternatives to Laboratory Animals 15, 20-29.
5. Lewis, J. J. (1949). Diabetes and the insulin administration problem. Physiological Reviews 29, 75-90.
6. Lust, J. (1986). The Herb Book. London: Bantam Books.
7. McClenaghan, N. H., Barnett, C. R., Ah-Sing, E., Abdelwahab, Y. H. A., O'Harte, F. P. M., Yoon, T.-W., Swanston-Flatt, S. K. & Flatt, P. R. (1996). Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion. Diabetes 45, 1132-1140.
8. Prager, R., Schernthaser, G. & Graf, H. (1986). Effect of metformin on peripheral insulin sensitivity in non-insulin dependent diabetes mellitus. Diabète et Metabolisme 12, 346-350.
9. Rubenstein, A. H., Levin, N. W. & Elliott, G. A. (1962a). Manganese-induced hypoglycaemia. Lancet ii, 1348-1351.
10. Rubenstein, A. H., Levin, N. W. & Elliott, G. A. (1962b). Hypoglycaemia induced by manganese. Nature 194, 188-199.
11. + channel in pancreatic B-cells. In Frontiers of Insulin Secretion and Pancreatic B-cell Research, pp. 161-166 [P. R. Flatt and S. Lenzen, editors]. London: Smith-Gordon.
12. Sharp, G. W. G. (1979). The adenylate cyclase-cylic AMP system in islets of Langerhans and its role in the control of insulin releases. Diabetologia 16, 287-297.
13. Stevens, J. F. (1971). Determination of glucose by automatic analyser. Clinica Chimica Acta 32, 199-201.
14. Swanston-Flatt, S. K., Day, C., Bailey, C. J. & Flatt, P. R. (1990). Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 33, 462-464.
15. + channel in mouse pancreatic B-cells. Pflugers Archives 407, 493-499.
16. World Health Organization (1980). Second Report of the WHO Expert Committee on Diabetes Mellitus. Technical Report Series 646, p. 66. Geneva: World Health Organization.
17. Yada, T. (1994). Action mechanisms of amino acids in pancreatic B-cells. In Frontiers of Insulin Secretion and Pancreatic B-cell Research, pp. 129-135 [P. R. Flatt and S. Lenzen, editors]. London: Smith-Gordon.