Altered cytological parameters in buccal cells from individuals with mild cognitive impairment and Alzheimer's disease

Cytometry Part A

Volumn 85, Issue 8, 2014, Pages 698-708

  François, Maxime ^a,b   Leifert, Wayne ^a   Hecker, Jane ^c   Faunt, Jeffrey ^c   Martins, Ralph ^b   Thomas, Philip ^a   Fenech, Michael ^a  

^a CSIRO   (Australia)

^b EDITH COWAN UNIVERSITY   (Australia)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Alzheimer's disease; Biomarkers; Cell imaging; Cognitive impairment; Hyperdiploidy; Laser scanning cytometry; Neutral lipids; Oral epithelium

Indexed keywords

AZO COMPOUND; BIOLOGICAL MARKER; DNA; OIL RED O;

AGED; ALZHEIMER DISEASE; FEMALE; HUMAN; MALE; METABOLISM; MILD COGNITIVE IMPAIRMENT; MOUTH MUCOSA; PATHOLOGY; PLOIDY; RECEIVER OPERATING CHARACTERISTIC;

AGED; ALZHEIMER DISEASE; AZO COMPOUNDS; BIOLOGICAL MARKERS; DNA; FEMALE; HUMANS; MALE; MILD COGNITIVE IMPAIRMENT; MOUTH MUCOSA; PLOIDIES; ROC CURVE;

EID: 84904687940     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.22453     Document Type: Article

References (41)

1. Burns A, Byrne EJ, Maurer K. Alzheimer's disease. Lancet 2002;360:163-165.
2. Alzheimer's Association, Thies W, Bleiler L. 2011 Alzheimer's disease facts and figures. Alzheimers Dement 2011;7:208-244.
3. Kalaria RN, Maestre GE, Arizaga R, Friedland RP, Galasko D, Hall K, Luchsinger JA, Ogunniyi A, Perry EK, Potocnik F, et al. Alzheimer's disease and vascular dementia in developing countries: Prevalence, management, and risk factors. Lancet Neurol 2008;7:812-826.
4. Sloane PD, Zimmerman S, Suchindran C, Reed P, Wang L, Boustani M, Sudha S. The public health impact of Alzheimer's disease, 2000-2050: Potential implication of treatment advances. Annu Rev Public Health 2002;23:213-231.
5. Smith AD. The worldwide challenge of the dementias: A role for B vitamins and homocysteine? Food Nutr Bull 2008;29:S143-72.
6. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M, Alzheimer's Disease International. Global prevalence of dementia: A Delphi consensus study. Lancet 2005;366:2112-2117.
7. Thomas P, O'Callaghan NJ, Fenech M. Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease. Mech Ageing Dev 2008;129:183-190.
8. Thomas P, Hecker J, Faunt J, Fenech M. Buccal micronucleus cytome biomarkers may be associated with Alzheimer's disease. Mutagenesis 2007;22:371-379.
9. Thomas P, Holland N, Bolognesi C, Kirsch-Volders M, Bonassi S, Zeiger E, Knasmueller S, Fenech M. Buccal micronucleus cytome assay. Nat Protoc 2009;4:825-837.
10. Thomas P, Harvey S, Gruner T, Fenech M. The buccal cytome and micronucleus frequency is substantially altered in Down's syndrome and normal ageing compared to young healthy controls. Mutat Res 2008;638:37-47.
11. Thomas P, Fenech M. Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease. Mutagenesis 2008;23:57-65.
12. Fischer HG, Morawski M, Bruckner MK, Mittag A, Tarnok A, Arendt T. Changes in neuronal DNA content variation in the human brain during aging. Aging Cell 2012;11:628-633.
13. Mosch B, Morawski M, Mittag A, Lenz D, Tarnok A, Arendt T. Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease. J Neurosci 2007;27:6859-6867.
14. Han X. Lipid alterations in the earliest clinically recognizable stage of Alzheimer's disease: Implication of the role of lipids in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res 2005;2:65-77.
15. Han X, Holtzman DM, McKeel DW Jr. Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: Molecular characterization using electrospray ionization mass spectrometry. J Neurochem 2001;77:1168-1180.
16. Gupta VB, Laws SM, Villemagne VL, Ames D, Bush AI, Ellis KA, Lui JK, Masters C, Rowe CC, Szoeke C, et al. Plasma apolipoprotein E and Alzheimer disease risk: The AIBL study of aging. Neurology 2011;76:1091-1098.
17. Taddei K, Clarnette R, Gandy SE, Martins RN. Increased plasma apolipoprotein E (apoE) levels in Alzheimer's disease. Neurosci Lett 1997;223:29-32.
18. Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: The cholesterol connection. Nat Neurosci 2003;6:345-351.
19. Pani A, Dessi S, Diaz G, La Colla P, Abete C, Mulas C, Angius F, Cannas MD, Orru CD, Cocco PL, et al. Altered cholesterol ester cycle in skin fibroblasts from patients with Alzheimer's disease. J Alzheimers Dis 2009;18:829-841.
20. Pani A, Mandas A, Diaz G, Abete C, Cocco PL, Angius F, Brundu A, Mucaka N, Pais ME, Saba A, et al. Accumulation of neutral lipids in peripheral blood mononuclear cells as a distinctive trait of Alzheimer patients and asymptomatic subjects at risk of disease. BMC Med 2009;7:66.
21. Leifert WR, Francois M, Thomas P, Luther E, Holden E, Fenech M. Automation of the buccal micronucleus cytome assay using laser scanning cytometry. Methods Cell Biol 2011;102:321-339.
22. Reinert A, Mittag A, Reinert T, Tarnok A, Arendt T, Morawski M. On the quantification of intracellular proteins in multifluorescence-labeled rat brain slices using slide-based cytometry. Cytometry A 2011;79A:485-491.
23. Mosch B, Mittag A, Lenz D, Arendt T, Tarnok A. Laser scanning cytometry in human brain slices. Cytometry A 2006;69A:135-138.
24. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
25. de Oliveira RM, Lia EN, Guimaraes RM, Bocca AL, Cavalcante Neto FF, da Silva TA. Cytologic and cytometric analysis of oral mucosa in Alzheimer's disease. Anal Quant Cytol Histol 2008;30:113-118.
26. Pozarowski P, Huang X, Gong RW, Priebe W, Darzynkiewicz Z. Simple, semiautomatic assay of cytostatic and cytotoxic effects of antitumor drugs by laser scanning cytometry: Effects of the bis-intercalator WP631 on growth and cell cycle of T-24 cells. Cytometry A 2004;57A:113-119.
27. Kirsch-Volders M, Fenech M. Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes. Mutagenesis 2001;16:51-58.
28. Migliore L, Testa A, Scarpato R, Pavese N, Petrozzi L, Bonuccelli U. Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease. Hum Genet 1997;101:299-305.
29. Trippi F, Botto N, Scarpato R, Petrozzi L, Bonuccelli U, Latorraca S, Sorbi S, Migliore L. Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer's disease patients. Mutagenesis 2001;16:323-327.
30. Myung NH, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee HG. Evidence of DNA damage in Alzheimer disease: Phosphorylation of histone H2AX in astrocytes. Age (Dordr) 2008;30:209-215.
31. Migliore L, Fontana I, Trippi F, Colognato R, Coppede F, Tognoni G, Nucciarone B, Siciliano G. Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients. Neurobiol Aging 2005;26:567-573.
32. Perry G, Castellani RJ, Smith MA, Harris PL, Kubat Z, Ghanbari K, Jones PK, Cordone G, Tabaton M, Wolozin B, Ghanbari H. Oxidative damage in the olfactory system in Alzheimer's disease. Acta Neuropathol 2003;106:552-556.
33. Gonzalez JE, Roch-Lefevre SH, Mandina T, Garcia O, Roy L. Induction of gamma-H2AX foci in human exfoliated buccal cells after in vitro exposure to ionising radiation. Int J Radiat Biol 2010;86:752-759.
34. Borthakur G, Butryee C, Stacewicz-Sapuntzakis M, Bowen PE. Exfoliated buccal mucosa cells as a source of DNA to study oxidative stress. Cancer Epidemiol Biomarkers Prev 2008;17:212-219.
35. Yao JK, Wengenack TM, Curran GL, Poduslo JF. Reduced membrane lipids in the cortex of Alzheimer's disease transgenic mice. Neurochem Res 2009;34:102-108.
36. Soderberg M, Edlund C, Alafuzoff I, Kristensson K, Dallner G. Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type. J Neurochem 1992;59:1646-1653.
37. Soderberg M, Edlund C, Kristensson K, Dallner G. Lipid compositions of different regions of the human brain during aging. J Neurochem 1990;54:415-423.
38. Natter K, Kohlwein SD. Yeast and cancer cells-Common principles in lipid metabolism. Biochim Biophys Acta 2013;1831:314-326.
39. Thambisetty M, Lovestone S. Blood-based biomarkers of Alzheimer's disease: Challenging but feasible. Biomark Med 2010;4:65-79.
40. Hampel H, Prvulovic D. Are biomarkers harmful to recruitment and retention in Alzheimer's disease clinical trials? An international perspective. J Nutr Health Aging 2012;16:346-348.
41. Blennow K, Zetterberg H. Cerebrospinal fluid biomarkers for Alzheimer's disease. J Alzheimers Dis 2009;18:413-417.