A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification

Nature Chemical Biology

Volumn 10, Issue 8, 2014, Pages 629-631

  Nolte, Whitney M ^a   Fortin, Jean Philippe ^a   Stevens, Benjamin D ^a   Aspnes, Gary E ^a   Griffith, David A ^a   Hoth, Lise R ^a   Ruggeri, Roger B ^a   Mathiowetz, Alan M ^a   Limberakis, Chris ^a   Hepworth, David ^a   Carpino, Philip A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; BETA ARRESTIN; CYCLIC AMP; CYSTEINE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; OXYNTOMODULIN; PHENYLALANINE; PYRIMIDINE DERIVATIVE;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM MOBILIZATION; CLICK CHEMISTRY; CONFORMATIONAL TRANSITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INSULIN RELEASE; INTRACELLULAR SIGNALING; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTEIN PROCESSING; WILD TYPE;

ANIMALS; CHO CELLS; CRICETULUS; CYSTEINE; GLUCAGON-LIKE PEPTIDE 1; HUMANS; LIGANDS; PYRIMIDINES; RECEPTORS, GLUCAGON;

EID: 84904667847     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1581     Document Type: Article

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