Myristoylated Alanine Rich C Kinase Substrate (MARCKS) is essential to β2-integrin dependent responses of equine neutrophils

Veterinary Immunology and Immunopathology

Volumn 160, Issue 3-4, 2014, Pages 167-176

  Sheats, Mary K ^a   Pescosolido, Kimberly C ^a   Hefner, Ethan M ^a   Sung, Eui Jae ^a   Adler, Kenneth B ^a   Jones, Samuel L ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Adhesion; Beta2 integrin; Inflammation; Migration; Neutrophil; Respiratory burst

Indexed keywords

CD18 ANTIGEN; CHEMOATTRACTANT; MARCKS PROTEIN; ANTIGEN ANTIBODY COMPLEX; MARCKS-RELATED PEPTIDE; MEMBRANE PROTEIN; MYRISTOYLATED ALANINE-RICH C KINASE SUBSTRATE; PEPTIDE FRAGMENT; PHORBOL 13 ACETATE 12 MYRISTATE; SIGNAL PEPTIDE;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL ADHESION; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; EQUIDAE; IN VITRO STUDY; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MOTION; DRUG EFFECTS; GENETICS; HORSE; IMMUNOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; RESPIRATORY BURST; SEQUENCE HOMOLOGY;

EQUIDAE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, CD18; CELL ADHESION; CELL MOVEMENT; CONSERVED SEQUENCE; HORSES; IN VITRO TECHNIQUES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NEUTROPHIL INFILTRATION; PEPTIDE FRAGMENTS; RESPIRATORY BURST; SEQUENCE HOMOLOGY, AMINO ACID; TETRADECANOYLPHORBOL ACETATE;

EID: 84904647187     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2014.04.009     Document Type: Article

References (47)

1. Aderem A. The MARCKS brothers: a family of protein kinase C substrates. Cell 1992, 71:713-716.
2. Arbuzova A., Schmitz A.A., Vergeres G. Cross-talk unfolded: MARCKS proteins. Biochem. J 2002, 362:1-12.
3. Baggiolini M. Chemokines and leukocyte traffic. Nature 1998, 392:565-568.
4. Berger C., Rossaint J., Van Aken H., Westphal M., Hahnenkamp K., Zarbock A. Lidocaine reduces neutrophil recruitment by abolishing chemokine-induced arrest and transendothelial migration in septic patients. J. Immunol. 2014, 192:367-376.
5. Blackshear P.J. The MARCKS family of cellular protein kinase C substrates. J. Biol. Chem. 1993, 268:1501-1504.
6. Cazzola M., Page C.P., Calzetta L., Matera M.G. Emerging anti-inflammatory strategies for COPD. Eur. Respir. J. 2012, 40:724-741.
7. Cicchetti G., Allen P.G., Glogauer M. Chemotactic signaling pathways in neutrophils: from receptor to actin assembly. Crit. Rev. Oral Biol. Med. 2002, 13:220-228.
8. Clark E.A., Brugge J.S. Integrins and signal transduction pathways: the road taken. Science 1995, 268:233-239.
9. Colditz I.G. Margination and emigration of leucocytes. Surv. Synth. Pathol. Res. 1985, 4:44-68.
10. de la Rebiere de Pouyade G., Serteyn D. The role of activated neutrophils in the early stage of equine laminitis. Vet. J. 2011, 189:27-33.
11. Dillon S.B., Verghese M.W., Snyderman R. Signal transduction in cells following binding of chemoattractants to membrane receptors. Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol. 1988, 55:65-80.
12. Disatnik M.H., Boutet S.C., Pacio W., Chan A.Y., Ross L.B., Lee C.H., Rando T.A. The bi-directional translocation of MARCKS between membrane and cytosol regulates integrin-mediated muscle cell spreading. J. Cell Sci. 2004, 117:4469-4479.
13. Eckert R.E., Neuder L.E., Park J., Adler K.B., Jones S.L. Myristoylated alanine-rich C-kinase substrate (MARCKS) protein regulation of human neutrophil migration. Am. J. Respir. Cell Mol. Biol. 2009, 42:586-594.
14. Foxman E.F., Campbell J.J., Butcher E.C. Multistep navigation and the combinatorial control of leukocyte chemotaxis. J. Cell Biol. 1997, 139:1349-1360.
15. Frevert C.W., Wong V.A., Goodman R.B., Goodwin R., Martin T.R. Rapid fluorescence-based measurement of neutrophil migration in vitro. J. Immunol. Methods 1998, 213:41-52.
16. Fujishima S., Aikawa N. Neutrophil-mediated tissue injury and its modulation. Intensive Care Med. 1995, 21:277-285.
17. Gerard M.P., Blikslager A.T., Roberts M.C., Tate L.P., Argenzio R.A. The characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine. Equine Vet. J. 1999, 31:331-335.
18. Hartwig J.H., Thelen M., Rosen A., Janmey P.A., Nairn A.C., Aderem A. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature 1992, 356:618-622.
19. Hurley D.J., Parks R.J., Reber A.J., Donovan D.C., Okinaga T., Vandenplas M.L., Peroni J.F., Moore J.N. Dynamic changes in circulating leukocytes during the induction of equine laminitis with black walnut extract. Vet. Immunol. Immunopathol. 2006, 110:195-206.
20. Hynes R.O. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992, 69:11-25.
21. Jones S.L., Knaus U.G., Bokoch G.M., Brown E.J. Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils. J. Biol. Chem. 1998, 273:10556-10566.
22. Jones S.L., Sharief Y., Chilcoat C.D. Signaling mechanism for equine neutrophil activation by immune complexes. Vet. Immunol. Immunopathol. 2001, 82:87-100.
23. Kraan M.C., de Koster B.M., Elferink J.G., Post W.J., Breedveld F.C., Tak P.P. Inhibition of neutrophil migration soon after initiation of treatment with leflunomide or methotrexate in patients with rheumatoid arthritis: findings in a prospective, randomized, double-blind clinical trial in fifteen patients. Arthritis Rheum. 2000, 43:1488-1495.
24. Kurtel H., Tso P., Granger D.N. Granulocyte accumulation in postischemic intestine: role of leukocyte adhesion glycoprotein CD11/CD18. Am. J. Physiol. 1992, 262:G878-G882.
25. Larsson C. Protein kinase C and the regulation of the actin cytoskeleton. Cell. Signal. 2006, 18:276-284.
26. Lehmeyer J.E., Snyderman R., Johnston R.B. Stimulation of neutrophil oxidative metabolism by chemotactic peptides: influence of calcium ion concentration and cytochalasin B and comparison with stimulation by phorbol myristate acetate. Blood 1979, 54:35-45.
27. Ley K., Laudanna C., Cybulsky M.I., Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat. Rev. Immunol. 2007, 7:678-689.
28. Li J., D'Annibale-Tolhurst M.A., Adler K.B., Fang S., Yin Q., Birkenheuer A.J., Levy M.G., Jones S.L., Sung E.J., Hawkins E.C., Yoder J.A., Nordone S.K. A myristoylated alanine-rich C kinase substrate-related peptide suppresses cytokine mRNA and protein expression in LPS-activated canine neutrophils. Am. J. Respir. Cell Mol. Biol. 2013, 48:314-321.
29. Little D., Tomlinson J.E., Blikslager A.T. Post operative neutrophilic inflammation in equine small intestine after manipulation and ischaemia. Equine Vet. J. 2005, 37:329-335.
30. Luo B.H., Carman C.V., Springer T.A. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 2007, 25:619-647.
31. Marinkovic D., Aleksic-Kovacevic S., Plamenac P. Cellular basis of chronic obstructive pulmonary disease in horses. Int. Rev. Cytol. 2007, 257:213-247.
32. Moore R.M., Muir W.W., Granger D.N. Mechanisms of gastrointestinal ischemia-reperfusion injury and potential therapeutic interventions: a review and its implications in the horse. J. Vet. Intern. Med. 1995, 9:115-132.
33. Nauseef W.M. Isolation of human neutrophils from venous blood. Methods Mol. Biol. 2007, 412:15-20.
34. Nishida N., Xie C., Shimaoka M., Cheng Y., Walz T., Springer T.A. Activation of leukocyte beta2 integrins by conversion from bent to extended conformations. Immunity 2006, 25:583-594.
35. Ott L.E., Sung E.J., Melvin A.T., Sheats M.K., Haugh J.M., Adler K.B., Jones S.L. Fibroblast migration is regulated by myristoylated alanine-rich C-kinase substrate (MARCKS) protein. PLoS ONE 2013, 8:e66512.
36. Rosales C., Juliano R.L. Signal transduction by cell adhesion receptors in leukocytes. J. Leukoc. Biol. 1995, 57:189-198.
37. Schmidt S., Moser M., Sperandio M. The molecular basis of leukocyte recruitment and its deficiencies. Mol. Immunol. 2013, 55:49-58.
38. Schymeinsky J., Mocsai A., Walzog B. Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications. Thromb. Haemost. 2007, 98:262-273.
39. Singer M., Martin L.D., Vargaftig B.B., Park J., Gruber A.D., Li Y., Adler K.B. A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma. Nat. Med. 2004, 10:193-196.
40. Siskova Z., Baron W., de Vries H., Hoekstra D. Fibronectin impedes myelin sheet-directed flow in oligodendrocytes: a role for a beta 1 integrin-mediated PKC signaling pathway in vesicular trafficking. Mol. Cell. Neurosci. 2006, 33:150-159.
41. Springer T.A. Adhesion receptors of the immune system. Nature 1990, 346:425-434.
42. Takashi S., Park J., Fang S., Koyama S., Parikh I., Adler K.B. A peptide against the N-terminus of myristoylated alanine-rich C kinase substrate inhibits degranulation of human leukocytes in vitro. Am. J. Respir. Cell Mol. Biol. 2006, 34:647-652.
43. Thelen M., Rosen A., Nairn A.C., Aderem A. Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane. Nature 1991, 351:320-322.
44. Uriarte S.M., Rane M.J., Merchant M.L., Jin S., Lentsch A.B., Ward R.A., McLeish K.R. Inhibition of neutrophil exocytosis ameliorates acute lung injury in rats. Shock 2013, 39:286-292.
45. Williams M.A., Solomkin J.S. Integrin-mediated signaling in human neutrophil functioning. J. Leukoc. Biol. 1999, 65:725-736.
46. Wong D.M., Moore R.M., Brockus C.W. Mechanisms of oxidative injury in equine disease. Compend. Contin. Educ. Vet. 2012, 34:E6.
47. Zhou X., Li J. Macrophage-enriched myristoylated alanine-rich C kinase substrate and its phosphorylation is required for the phorbol ester-stimulated diffusion of beta 2 integrin molecules. J. Biol. Chem. 2000, 275:20217-20222.