The magnitude of nocebo effects in pain: A meta-analysis

Pain

Volumn 155, Issue 8, 2014, Pages 1426-1434

  Petersen, Gitte Laue ^a,b   Finnerup, Nanna Brix ^b   Colloca, Luana ^c   Amanzio, Martina ^d   Price, Donald D ^e   Jensen, Troels Staehelin ^b   Vase, Lene ^a,b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d UNIVERSITY OF TURIN   (Italy)

^e UNIVERSITY OF FLORIDA   (United States)

Author keywords

Conditioning; Magnitude; Nocebo; Pain; Placebo; Verbal suggestion

Indexed keywords

ANALGESIA; CONDITIONING; EFFECT SIZE; HUMAN; META ANALYSIS; NOCEBO EFFECT; PAIN; PAIN ASSESSMENT; PLACEBO EFFECT; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; HYPERALGESIA; PAIN MEASUREMENT; PATHOPHYSIOLOGY;

HUMANS; HYPERALGESIA; NOCEBO EFFECT; PAIN; PAIN MEASUREMENT;

EID: 84904639591     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2014.04.016     Document Type: Review

References (66)

1. M. Amanzio Do we need a new procedure for the assessment of adverse events in anti-migraine clinical trials Recent Pat CNS Drug Disc 6 2011 41 47
2. M. Amanzio, L.L. Corazzini, L. Vase, and F. Benedetti A systematic review of adverse effects in placebo groups of anti-migraine clinical trials PAIN® 146 2009 261 269
3. A.J. Barsky, R. Saintfort, M.P. Rogers, and J.F. Borus Nonspecific medication side effects and the nocebo phenomenon JAMA 287 2002 622 627
4. H.K. Beecher The powerful placebo J Am Med Assoc 159 1955 1602 1606
5. C.J. Beedie, D.A. Coleman, and A.J. Foad Positive and negative placebo effects resulting from the deceptive administration of an ergogenic aid Int J Sport Nutr Exerc Metab 17 2007 259 269
6. F. Benedetti Mechanisms of placebo and placebo-related effects across diseases and treatments Annu Rev Pharmacol Toxicol 48 2008 33 60
7. F. Benedetti Placebo effects. Understanding the mechanisms in health and disease 2009 Oxford University Press Oxford
8. F. Benedetti, M. Amanzio, O. Casadio, A. Oliaro, and G. Maggi Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide PAIN® 71 1997 135 140
9. F. Benedetti, M. Amanzio, S. Vighetti, and G. Asteggiano The biochemical and neuroendocrine basis of the hyperalgesic nocebo effect J Neurosci 26 2006 12014 12022
10. F. Benedetti, M. Lanotte, L. Lopiano, and L. Colloca When words are painful: unraveling the mechanisms of the nocebo effect Neuroscience 147 2007 260 271
11. F. Benedetti, A. Pollo, L. Lopiano, M. Lanotte, S. Vighetti, and I. Rainero Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses J Neurosci 23 2003 4315 4323
12. U. Bingel, V. Wanigasekera, K. Wiech, R.N. Mhuircheartaigh, M.C. Lee, M. Ploner, and I. Tracey The effect of treatment expectation on drug efficacy: Imaging the analgesic benefit of the opioid remifentanil Sci Trans Med 3 2011 70ra14
13. E. Bjørkedal, and M.A. Flaten Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females J Pain Res 5 2012 289 300
14. M. Borenstein, L.V. Hedges, J.P.T. Higgens, and H.R. Rothstein Introduction to meta-analysis 2009 John Wiley & Sons West Sussex, UK
15. C.S.L. Chooi, R. Nerlekar, A. Raju, and A.M. Cyna Placebo vs. nocebo questioning for pain evaluation following caesarean section Anaesth Intens Care 38 2010 762 763
16. W.G. Cochran The combination of estimates from different experiments Biometrics 10 1954 101 129
17. J. Cohen Statistical power analysis for the behavioral sciences 2nd ed. 1988 Lawrence Erlbaum Associates Mahwaw, NJ
18. L. Colloca, and F. Benedetti Nocebo hyperalgesia: how anxiety is turned into pain Curr Opin Anaesthesiol 5 2007 435 439
19. L. Colloca, L. Lopiano, M. Lanotte, and F. Benedetti Overt versus covert treatment for pain, anxiety, and Parkinson's disease Lancet Neurol 3 2004 679 684
20. L. Colloca, M. Sigaudo, and F. Benedetti The role of learning in nocebo and placebo effects PAIN® 136 2008 211 218
21. L. Colloca, P. Petrovic, T.D. Wager, M. Ingvar, and F. Benedetti How the number of learning trials affects placebo and nocebo responses PAIN® 151 2010 430 439
22. L. Colloca, and F.G. Miller The nocebo effect and its relevance for clinical practice Psychosom Med 73 2011 598 603
23. M. De La Cruz, D. Hui, H.A. Parsons, and E. Bruera Placebo and nocebo effects in randomized double-blind clinical trials of agents for the therapy for fatigue in patients with advanced cancer Cancer 116 2010 766 774
24. M.-D. Drici, F. Raybaud, C. De Lunardo, P. Iacono, and P. Gustovic Influence of the behaviour pattern on the nocebo response of healthy volunteers Br J Clin Pharmacol 39 1995 204 206
25. R.H. Dworkin, D.C. Turk, N.P. Katz, M.C. Rowbotham, S. Peirce-Sandner, I. Cerny, C.S. Clingman, B.C. Eloff, J.T. Farrar, C. Kamp, M.P. McDermott, B.A. Rappaport, and W.R. Sanhai Evidence-based clinical trial design for chronic pain pharmacotherapy: a blueprint for ACTION PAIN® 152 2011 107 115
26. S. Elsenbruch, J. Schmid, M. Bäsler, E. Ceso, M. Schedlowski, and S. Benson How positive and negative expectations shape the experience of visceral pain: an experimental pilot study in healthy women Neurogastroenterol Motil 24 2012 10.1111/j.1365-2982.2012.01950.x 914-e460
27. H.L. Fields, and J.D. Levine Pain - mechanics and management West J Med 141 1984 347 357
28. M.A. Flaten, T. Simonsen, and H. Olsen Drug-related information generates placebo and nocebo responses that modify the drug response Psychosom Med 61 1999 250 255
29. R.A. Hahn The nocebo phenomenon: concept, evidence, and implications for public health Prev Med 26 1997 607 611
30. L.V. Hedges Distribution theory for Glass' estimator of effect size and related estimators J Educ Stat 6 1981 107 128
31. L.V. Hedges Estimation of effect size from a series of independent experiments Psychol Bull 92 1982 489 490
32. J.P.T. Higgins, and S.G. Thompson Quantifying heterogeneity in a meta-analysis Stat Med 21 2002 1539 1558
33. A. Hróbjartsson The uncontrollable placebo effect Eur J Clin Pharmacol 50 1996 345 348
34. A. Hróbjartsson Placeboeffekten i lægevidenskab og klinik O.K. Andersen, M.H. Claësson, A Hjóbjartsson, A.N. Sørensen, Placebo. Historie, biologi, og effekt 1997 Akademisk Forlag A/S Denmark, Copenhagen 11 67
35. A. Hrobjartsson, and P.C. Gotzsche Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment N Engl J Med 344 2001 1594 1602
36. A. Hrobjartsson, and P.C. Gotzsche Placebo interventions for all clinical conditions Cochrane Database Syst Rev 3 2004 CD003974
37. A. Hrobjartsson, and P.C. Gotzsche Placebo interventions for all clinical conditions Cochrane Database Syst Rev 1 2010 CD003974
38. K.B. Jensen, T.J. Kaptchuk, I. Kirsch, J. Raicek, K.M. Lindstrom, C. Berna, R.L. Gollub, M. Ingvar, and J. Kong Nonconscious activation of placebo and nocebo pain responses Proc Natl Acad Sci U S A 109 2012 15959 15964
39. O. Johansen, J. Brox, and M.A. Flaten Placebo and nocebo responses, cortisol, and circulating beta-endorphin Psychosom Med 65 2003 786 790
40. A. Keitel, L. Wojtecki, J. Hirschmann, C.J. Hartmann, S. Ferrea, M. Südmeyer, and A. Schnitzler Motor and cognitive placebo-/nocebo responses in Parkinson's disease patients with deep brain stimulation Behav Brain Res 250 2013 199 205
41. W.P. Kennedy The nocebo reaction Med World 95 1961 203 205
42. S. Kessner, K. Wiech, K. Forkmann, M. Ploner, and U. Bingel The effect of treatment history on therapeutic outcome: an experimental approach JAMA Intern Med 173 2013 1468 1469
43. P. Kissel, and D. Barrucand Placebos et effet placebo en medicine 1964 Masson Paris, France
44. S. Klosterhalfen, S. Kellerman, S. Brain, A. Kowalski, M. Schrauth, S. Zipfel, and P. Enck Gender and the nocebo response following conditioning and expectancy J Psychosom Res 66 2009 323 328
45. J. Kong, R.L. Gollub, G. Polich, I. Kirsch, P. LaViolette, M. Vangel, B. Rosen, and T.J. Kaptchuk A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect J Neurosci 28 2008 13354 13362
46. M.E. Levine, R.M. Stern, and K.L. Koch The effects of manipulating expectations through placebo and nocebo administration on gastric tachyarrhythmia and motion-induced nausea Psychosom Med 68 2006 478 486
47. G. Liccardi, G. Senna, M. Russo, P. Bonadonna, M. Crivellaro, A. Dama, M. D'Amato, G.W. Canonica, and G. Passalacqua Evaluation of the nocebo effect during oral challenge in patients with adverse drug reactions J Invest Allergy Clin Immunol 14 2004 104 107
48. J. Link, R. Haggard, K. Kelly, and D. Forrer Placebo/nocebo symptom reporting in a sham herbal supplement trial Eval Health Prof 29 2006 394 406
49. C. Lombardi, S. Gargioni, G.W. Canonica, and G. Passalacqua The nocebo effect during oral challenge in subjects with adverse drug reactions Eur Ann Allergy Clin Immunol 40 2008 138 141
50. J. Lorenz, M. Hauck, R.C. Paur, Y. Nakamura, R. Zimmermann, B. Bromm, and A.K. Engel Cortical correlates of false expectations during pain intensity judgments - a possible manifestation of placebo/nocebo cognitions Brain Behav Immun 19 2005 283 295
51. L. Manchikanti, V. Pampati, and K. Damron The role of placebo and nocebo effects of perioperative administration of sedatives and opioids in interventional pain management Pain Phys 8 2005 349 355
52. D. Moher, A. Liberati, J. Tetzlaff, D.G. Altman PRISMA group Preferred reporting items for systematic reviews and meta-analysis: the PRISMA statement J Clin Epidemiol 62 2009 1006 1012
53. M. Nicolodi, and A. Torrini From nocebo effect to the hypothesis of nocebo and psychometric tests as entry criteria in headache trials Cephalalgia 29 2009 39
54. A. Pollo, E. Carlino, L. Vase, and F. Benedetti Preventing motor training through nocebo suggestions Eur J Appl Physiol 112 2012 3893 3903
55. D.D. Price, J.L. Riley 3rd, and L. Vase Reliable differences in placebo effects between clinical analgesic trials and studies of placebo analgesia mechanisms PAIN® 104 2003 715 716
56. D.D. Price, D.G. Finniss, and F. Benedetti A comprehensive review of the placebo effect: recent advances and current thought Annu Rev Psychol 59 2008 565 590
57. D.J. Scott, C.S. Stohler, C.M. Egnatuk, H. Wang, R.A. Koeppe, and J.-A. Zubieta Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses Arch Gen Psychiatry 65 2008 220 231
58. L.J. Stovner, G. Oftedal, A. Straume, and A. Johnsson Nocebo as headache trigger: evidence from a sham-controlled provocation study with RF fields Acta Neurol Scand 117 2008 67 71
59. K. Swider, and P. Babel The effect of the sex of a model on nocebo hyperalgesia induced by social observational learning PAIN® 154 2013 1312 1317 pii:S0304-3959
60. A.I.M. Van Laarhoven, M.K. Vogelaar, O.H. Wilder-Smith, P.I.C.M. van Riel, P.C.M. van der Kerkhof, F.W. Kraaimaat, and A.W.M. Evers Induction of nocebo and placebo effects on itch and pain by verbal suggestions PAIN® 152 2011 1486 1494
61. D. Varelmann, C. Pancaro, E.C. Cappiello, and W.R. Camann Nocebo-induced hyperalgesia during local anesthetic injection Anesth Analg 110 2010 868 870
62. L. Vase, M.E. Robinson, G.N. Verne, and D.D. Price The contribution of suggestion, desire, and expectation to placebo effects in irritable bowel syndrome patients. An empirical investigation PAIN® 105 2003 17 25
63. L. Vase, J.L. Riley III, and D.D. Price A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia PAIN® 99 2002 443 452
64. L. Vase, G.L. Petersen, J.L. Riley 3rd, and D.D. Price Factors contributing to large analgesic effects in placebo mechanism studies conducted between 2002 and 2007 PAIN® 145 2009 36 44
65. P. Vernia, M. Di Camillo, T. Foglietta, V.E. Avallone, and A. De Carolis Diagnosis of lactose intolerance and the "nocebo" effect: the role of negative expectations Digest Liver Dis 42 2010 616 619
66. E. Vögtle, A. Barke, and B. Kröner-Herwig Nocebo hyperalgesia induced by social observational learning PAIN® 154 2013 1427 1433 10.1016/j.pain.2013.04.041