The effect of treatment expectation on drug efficacy: Imaging the analgesic benefit of the opioid remifentanil

Science Translational Medicine

Volumn 3, Issue 70, 2011, Pages

  Bingel, Ulrike ^a,b   Wanigasekera, Vishvarani ^a   Wiech, Katja ^a   Mhuircheartaigh, Roisin Ni ^a   Lee, Michael C ^c   Ploner, Markus ^d   Tracey, Irene ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

REMIFENTANIL; NARCOTIC ANALGESIC AGENT; PIPERIDINE DERIVATIVE;

ADULT; ANALGESIA; ANXIETY; ARTICLE; BOLD SIGNAL; BRAIN FUNCTION; BRAIN REGION; BRAIN STEM; CINGULATE GYRUS; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFICACY; EXPECTATION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEAT STRESS; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; INSULA; MALE; NERVE CELL NETWORK; NEUROIMAGING; NEUROMODULATION; NOCICEPTION; NORMAL HUMAN; PAIN THRESHOLD; PATIENT ATTITUDE; PATIENT EDUCATION; PREFRONTAL CORTEX; PRIORITY JOURNAL; RESPONSE TIME; SOMATOSENSORY CORTEX; THALAMUS; VISUAL ANALOG SCALE; BRAIN; CLINICAL TRIAL; DRUG EFFECT; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN; PSYCHOLOGICAL ASPECT;

ADULT; ANALGESICS, OPIOID; BRAIN; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PAIN; PIPERIDINES; YOUNG ADULT;

EID: 79951883846     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3001244     Document Type: Article

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43. Acknowledgments: We thank I. Wilson and R. Rogers for substantial technical and medical support and C. Eccleston for valuable comments on the manuscript. Funding: This work was supported by the Federal Ministry of Education and Research, German Research Foundation (FOR-1328), local University funding from the University of Hamburg (U.B.), and the Medical Research Council (Oxford Centre of Functional Magnetic Resonance Imaging of the Brain Centre). Author contributions: All authors designed the study. U.B., M.C.L., R.M., K.W., and V.W. performed the experiments and/or analyzed the data. U.B., M.C.L., M.P., I.T., K.W., and V.W. wrote the manuscript. Competing interests: The authors declare that they have no competing interests.