메뉴 건너뛰기




Volumn 4 JUN, Issue , 2014, Pages

Nestin(+) tissue-resident multipotent stem cells contribute to tumor progression by differentiating into pericytes and smooth muscle cells resulting in blood vessel remodeling

Author keywords

mesenchymal stem cell; Nestin; Pericytes; Vascular remodeling; Vessel maturation

Indexed keywords

NESTIN; VASCULOTROPIN;

EID: 84904633643     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00169     Document Type: Article
Times cited : (50)

References (39)
  • 1
    • 65249173169 scopus 로고    scopus 로고
    • Endothelial-mural cell signaling in vascular development and angiogenesis
    • doi: 10.1161/ATVBAHA.107.161521
    • Gaengel K, Genove G, Armulik A, Betsholtz C. Endothelial-mural cell signaling in vascular development and angiogenesis. Arterioscler Thromb Vasc Biol (2009) 29:630-8. doi: 10.1161/ATVBAHA.107.161521
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 630-638
    • Gaengel, K.1    Genove, G.2    Armulik, A.3    Betsholtz, C.4
  • 2
    • 36049043759 scopus 로고    scopus 로고
    • Zone-specific remodeling of tumor blood vessels affects tumor growth
    • doi:10.1002/cncr.23024
    • Tilki D, Kilic N, Sevinc S, Zywietz F, Stief CG, Ergun S. Zone-specific remodeling of tumor blood vessels affects tumor growth. Cancer (2007) 110:2347-62. doi:10.1002/cncr.23024
    • (2007) Cancer , vol.110 , pp. 2347-2362
    • Tilki, D.1    Kilic, N.2    Sevinc, S.3    Zywietz, F.4    Stief, C.G.5    Ergun, S.6
  • 3
    • 0037223555 scopus 로고    scopus 로고
    • Tumor vessel development and maturation impose limits on the effectiveness of anti-vascular therapy
    • doi:10.1016/S0002-9440(10)63809-6
    • Gee MS, Procopio WN, Makonnen S, Feldman MD, Yeilding NM, Lee WM. Tumor vessel development and maturation impose limits on the effectiveness of anti-vascular therapy. Am J Pathol (2003) 162:183-93. doi:10.1016/S0002-9440(10)63809-6
    • (2003) Am J Pathol , vol.162 , pp. 183-193
    • Gee, M.S.1    Procopio, W.N.2    Makonnen, S.3    Feldman, M.D.4    Yeilding, N.M.5    Lee, W.M.6
  • 4
    • 27644557532 scopus 로고    scopus 로고
    • The role of pericytes in blood-vessel formation and maintenance
    • doi:10.1215/S1152851705000232
    • Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol (2005) 7:452-64. doi:10.1215/S1152851705000232
    • (2005) Neuro Oncol , vol.7 , pp. 452-464
    • Bergers, G.1    Song, S.2
  • 5
    • 79957562794 scopus 로고    scopus 로고
    • Vascular wall-resident CD44+ multipotent stem cells give rise to pericytes and smooth muscle cells and contribute to new vessel maturation
    • doi:10.1371/journal.pone.0020540
    • Klein D, Weisshardt P, Kleff V, Jastrow H, Jakob HG, Ergun S. Vascular wall-resident CD44+ multipotent stem cells give rise to pericytes and smooth muscle cells and contribute to new vessel maturation. PLoS One (2011) 6:e20540. doi:10.1371/journal.pone.0020540
    • (2011) PLoS One , vol.6
    • Klein, D.1    Weisshardt, P.2    Kleff, V.3    Jastrow, H.4    Jakob, H.G.5    Ergun, S.6
  • 6
    • 84871235918 scopus 로고    scopus 로고
    • Adventitial pericyte progenitor/mesenchymal stem cells participate in the restenotic response to arterial injury
    • doi:10.1159/000345524
    • Tigges U, Komatsu M, Stallcup WB. Adventitial pericyte progenitor/mesenchymal stem cells participate in the restenotic response to arterial injury. J Vasc Res (2013) 50:134-44. doi:10.1159/000345524
    • (2013) J Vasc Res , vol.50 , pp. 134-144
    • Tigges, U.1    Komatsu, M.2    Stallcup, W.B.3
  • 7
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
    • Gerber HP, Ferrara N. Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res (2005) 65:671-80.
    • (2005) Cancer Res , vol.65 , pp. 671-680
    • Gerber, H.P.1    Ferrara, N.2
  • 8
    • 33745738260 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: from the biology to the clinic
    • doi:10.2174/092986706777585059
    • Ranieri G, Patruno R, Ruggieri E, Montemurro S, Valerio P, Ribatti D. Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: from the biology to the clinic. Curr Med Chem (2006) 13:1845-57. doi:10.2174/092986706777585059
    • (2006) Curr Med Chem , vol.13 , pp. 1845-1857
    • Ranieri, G.1    Patruno, R.2    Ruggieri, E.3    Montemurro, S.4    Valerio, P.5    Ribatti, D.6
  • 9
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • doi:10.1126/science.1104819
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science (2005) 307:58-62. doi:10.1126/science.1104819
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 10
    • 79960096827 scopus 로고    scopus 로고
    • Normalization of the vasculature for treatment of cancer and other diseases
    • doi:10.1152/physrev.00038.2010
    • Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, et al. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev (2011) 91:1071-121. doi:10.1152/physrev.00038.2010
    • (2011) Physiol Rev , vol.91 , pp. 1071-1121
    • Goel, S.1    Duda, D.G.2    Xu, L.3    Munn, L.L.4    Boucher, Y.5    Fukumura, D.6
  • 11
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • doi:10.1172/JCI5028
    • Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest (1999) 103:159-65. doi:10.1172/JCI5028
    • (1999) J Clin Invest , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 12
    • 33745009983 scopus 로고    scopus 로고
    • Significance of vascular stabilization for tumor growth and metastasis
    • doi:10.1016/j.canlet.2005.06.033
    • Ergun S, Tilki D, Oliveira-Ferrer L, Schuch G, Kilic N. Significance of vascular stabilization for tumor growth and metastasis. Cancer Lett (2006) 238:180-7. doi:10.1016/j.canlet.2005.06.033
    • (2006) Cancer Lett , vol.238 , pp. 180-187
    • Ergun, S.1    Tilki, D.2    Oliveira-Ferrer, L.3    Schuch, G.4    Kilic, N.5
  • 13
    • 58149284060 scopus 로고    scopus 로고
    • Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-beta receptor inhibitor on extravasation of nanoparticles from neovasculature
    • doi:10.1111/j.1349-7006.2008.01003.x
    • Kano MR, Komuta Y, Iwata C, Oka M, Shirai YT, Morishita Y, et al. Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-beta receptor inhibitor on extravasation of nanoparticles from neovasculature. Cancer Sci (2009) 100:173-80. doi:10.1111/j.1349-7006.2008.01003.x
    • (2009) Cancer Sci , vol.100 , pp. 173-180
    • Kano, M.R.1    Komuta, Y.2    Iwata, C.3    Oka, M.4    Shirai, Y.T.5    Morishita, Y.6
  • 14
    • 84857630253 scopus 로고    scopus 로고
    • Tumor vessel stabilization and remodeling by anti-angiogenic therapy with bevacizumab
    • doi:10.1007/s00418-011-0898-8
    • Weisshardt P, Trarbach T, Durig J, Paul A, Reis H, Tilki D, et al. Tumor vessel stabilization and remodeling by anti-angiogenic therapy with bevacizumab. Histochem Cell Biol (2012) 137:391-401. doi:10.1007/s00418-011-0898-8
    • (2012) Histochem Cell Biol , vol.137 , pp. 391-401
    • Weisshardt, P.1    Trarbach, T.2    Durig, J.3    Paul, A.4    Reis, H.5    Tilki, D.6
  • 15
    • 84884170348 scopus 로고    scopus 로고
    • Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes
    • doi:10.1182/blood-2013-03-490763
    • Ruan J, Luo M, Wang C, Fan L, Yang SN, Cardenas M, et al. Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes. Blood (2013) 121:5192-202. doi:10.1182/blood-2013-03-490763
    • (2013) Blood , vol.121 , pp. 5192-5202
    • Ruan, J.1    Luo, M.2    Wang, C.3    Fan, L.4    Yang, S.N.5    Cardenas, M.6
  • 16
    • 79960395669 scopus 로고    scopus 로고
    • Vascular wall as a reservoir for different types of stem and progenitor cells
    • doi:10.1089/ars.2010.3507
    • Ergun S, Tilki D, Klein D. Vascular wall as a reservoir for different types of stem and progenitor cells. Antioxid Redox Signal (2011) 15:981-95. doi:10.1089/ars.2010.3507
    • (2011) Antioxid Redox Signal , vol.15 , pp. 981-995
    • Ergun, S.1    Tilki, D.2    Klein, D.3
  • 18
    • 41149139870 scopus 로고    scopus 로고
    • Gene therapy of beta(c)-deficient pulmonary alveolar proteinosis (beta(c)-PAP): studies in a murine in vivo model
    • doi:10.1038/mt.2008.7
    • Kleff V, Sorg UR, Bury C, Suzuki T, Rattmann I, Jerabek-Willemsen M, et al. Gene therapy of beta(c)-deficient pulmonary alveolar proteinosis (beta(c)-PAP): studies in a murine in vivo model. Mol Ther (2008) 16:757-64. doi:10.1038/mt.2008.7
    • (2008) Mol Ther , vol.16 , pp. 757-764
    • Kleff, V.1    Sorg, U.R.2    Bury, C.3    Suzuki, T.4    Rattmann, I.5    Jerabek-Willemsen, M.6
  • 19
    • 33644526967 scopus 로고    scopus 로고
    • Analysis of neurogenesis using transgenic mice expressing GFP with nestin gene regulatory regions
    • doi:10.1093/chemse/bjh142
    • Yamaguchi M. Analysis of neurogenesis using transgenic mice expressing GFP with nestin gene regulatory regions. Chem Senses (2005) 30(Suppl 1):i117-8. doi:10.1093/chemse/bjh142
    • (2005) Chem Senses , vol.30 , Issue.SUPPL 1
    • Yamaguchi, M.1
  • 20
    • 40949117599 scopus 로고    scopus 로고
    • Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway
    • doi:10.1002/hep.22084
    • Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, et al. Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology (2008) 47:1018-31. doi:10.1002/hep.22084
    • (2008) Hepatology , vol.47 , pp. 1018-1031
    • Klein, D.1    Demory, A.2    Peyre, F.3    Kroll, J.4    Augustin, H.G.5    Helfrich, W.6
  • 21
    • 84873622320 scopus 로고    scopus 로고
    • Nestin: a novel angiogenesis marker and possible target for tumor angiogenesis
    • doi:10.3748/wjg.v19.i1.42
    • Matsuda Y, Hagio M, Ishiwata T. Nestin: a novel angiogenesis marker and possible target for tumor angiogenesis. World J Gastroenterol (2013) 19:42-8. doi:10.3748/wjg.v19.i1.42
    • (2013) World J Gastroenterol , vol.19 , pp. 42-48
    • Matsuda, Y.1    Hagio, M.2    Ishiwata, T.3
  • 22
    • 77649186478 scopus 로고    scopus 로고
    • Expression profiles of nestin in vascular smooth muscle cells in vivo and in vitro
    • doi:10.1016/j.yexcr.2009.10.025
    • Oikawa H, Hayashi K, Maesawa C, Masuda T, Sobue K. Expression profiles of nestin in vascular smooth muscle cells in vivo and in vitro. Exp Cell Res (2010) 316:940-50. doi:10.1016/j.yexcr.2009.10.025
    • (2010) Exp Cell Res , vol.316 , pp. 940-950
    • Oikawa, H.1    Hayashi, K.2    Maesawa, C.3    Masuda, T.4    Sobue, K.5
  • 23
    • 47149102903 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature
    • doi:10.1182/blood-2007-10-118273
    • Au P, Tam J, Fukumura D, Jain RK. Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood (2008) 111:4551-8. doi:10.1182/blood-2007-10-118273
    • (2008) Blood , vol.111 , pp. 4551-4558
    • Au, P.1    Tam, J.2    Fukumura, D.3    Jain, R.K.4
  • 24
    • 84886541582 scopus 로고    scopus 로고
    • Hox genes are involved in vascular wall-resident multipotent stem cell differentiation into smooth muscle cells
    • doi:10.1038/srep02178
    • Klein D, Benchellal M, Kleff V, Jakob HG, Ergun S. Hox genes are involved in vascular wall-resident multipotent stem cell differentiation into smooth muscle cells. Sci Rep (2013) 3:2178. doi:10.1038/srep02178
    • (2013) Sci Rep , vol.3 , pp. 2178
    • Klein, D.1    Benchellal, M.2    Kleff, V.3    Jakob, H.G.4    Ergun, S.5
  • 26
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • doi:10.1096/fj.03-0271fje
    • Erber R, Thurnher A, Katsen AD, Groth G, Kerger H, Hammes HP, et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J (2004) 18:338-40. doi:10.1096/fj.03-0271fje
    • (2004) FASEB J , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3    Groth, G.4    Kerger, H.5    Hammes, H.P.6
  • 27
    • 57649135172 scopus 로고    scopus 로고
    • A role for VEGF as a negative regulator of pericyte function and vessel maturation
    • doi:10.1038/nature07424
    • Greenberg JI, Shields DJ, Barillas SG, Acevedo LM, Murphy E, Huang J, et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature (2008) 456:809-13. doi:10.1038/nature07424
    • (2008) Nature , vol.456 , pp. 809-813
    • Greenberg, J.I.1    Shields, D.J.2    Barillas, S.G.3    Acevedo, L.M.4    Murphy, E.5    Huang, J.6
  • 28
    • 10944242667 scopus 로고    scopus 로고
    • Antiangiogenic therapy: creating a unique "window" of opportunity
    • doi:10.1016/S1535-6108(04)00340-X
    • Lin MI, Sessa WC. Antiangiogenic therapy: creating a unique "window" of opportunity. Cancer Cell (2004) 6:529-31. doi:10.1016/S1535-6108(04)00340-X
    • (2004) Cancer Cell , vol.6 , pp. 529-531
    • Lin, M.I.1    Sessa, W.C.2
  • 29
    • 79959400230 scopus 로고    scopus 로고
    • The role of pericytes in angiogenesis
    • doi:10.1387/ijdb.103167dr
    • Ribatti D, Nico B, Crivellato E. The role of pericytes in angiogenesis. Int J Dev Biol (2011) 55:261-8. doi:10.1387/ijdb.103167dr
    • (2011) Int J Dev Biol , vol.55 , pp. 261-268
    • Ribatti, D.1    Nico, B.2    Crivellato, E.3
  • 30
    • 26944437515 scopus 로고    scopus 로고
    • PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
    • doi:10.1038/ncb1288
    • Song S, Ewald AJ, Stallcup W, Werb Z, Bergers G. PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol (2005) 7:870-9. doi:10.1038/ncb1288
    • (2005) Nat Cell Biol , vol.7 , pp. 870-879
    • Song, S.1    Ewald, A.J.2    Stallcup, W.3    Werb, Z.4    Bergers, G.5
  • 31
    • 0033565540 scopus 로고    scopus 로고
    • VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
    • doi:10.1093/emboj/18.14.3964
    • Asahara T, Takahashi T, Masuda H, Kalka C, Chen D, Iwaguro H, et al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J (1999) 18:3964-72. doi:10.1093/emboj/18.14.3964
    • (1999) EMBO J , vol.18 , pp. 3964-3972
    • Asahara, T.1    Takahashi, T.2    Masuda, H.3    Kalka, C.4    Chen, D.5    Iwaguro, H.6
  • 32
    • 33749005405 scopus 로고    scopus 로고
    • Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
    • doi:10.1126/science.1127592
    • Shaked Y, Ciarrocchi A, Franco M, Lee CR, Man S, Cheung AM, et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science (2006) 313:1785-7. doi:10.1126/science.1127592
    • (2006) Science , vol.313 , pp. 1785-1787
    • Shaked, Y.1    Ciarrocchi, A.2    Franco, M.3    Lee, C.R.4    Man, S.5    Cheung, A.M.6
  • 33
    • 70349248272 scopus 로고    scopus 로고
    • Endothelial progenitor cells do not contribute to tumor endothelium in primary and metastatic tumors
    • doi:10.1002/ijc.24605
    • Wickersheim A, Kerber M, de Miguel LS, Plate KH, Machein MR. Endothelial progenitor cells do not contribute to tumor endothelium in primary and metastatic tumors. Int J Cancer (2009) 125:1771-7. doi:10.1002/ijc.24605
    • (2009) Int J Cancer , vol.125 , pp. 1771-1777
    • Wickersheim, A.1    Kerber, M.2    de Miguel, L.S.3    Plate, K.H.4    Machein, M.R.5
  • 34
    • 20144386931 scopus 로고    scopus 로고
    • Contribution of bone marrow-derived endothelial cells to human tumor vasculature
    • doi:10.1038/nm1200
    • Peters BA, Diaz LA, Polyak K, Meszler L, Romans K, Guinan EC, et al. Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med (2005) 11:261-2. doi:10.1038/nm1200
    • (2005) Nat Med , vol.11 , pp. 261-262
    • Peters, B.A.1    Diaz, L.A.2    Polyak, K.3    Meszler, L.4    Romans, K.5    Guinan, E.C.6
  • 35
    • 44349143198 scopus 로고    scopus 로고
    • Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
    • doi:10.1073/pnas.0710516105
    • Purhonen S, Palm J, Rossi D, Kaskenpaa N, Rajantie I, Yla-Herttuala S, et al. Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A (2008) 105:6620-5. doi:10.1073/pnas.0710516105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 6620-6625
    • Purhonen, S.1    Palm, J.2    Rossi, D.3    Kaskenpaa, N.4    Rajantie, I.5    Yla-Herttuala, S.6
  • 36
    • 84881092225 scopus 로고    scopus 로고
    • Immunological characterization of multipotent mesenchymal stromal cells - The International Society for Cellular Therapy (ISCT) working proposal
    • doi:10.1016/j.jcyt.2013.02.010
    • Krampera M, Galipeau J, Shi Y, Tarte K, Sensebe L. Immunological characterization of multipotent mesenchymal stromal cells - The International Society for Cellular Therapy (ISCT) working proposal. Cytotherapy (2013) 15:1054-61. doi:10.1016/j.jcyt.2013.02.010
    • (2013) Cytotherapy , vol.15 , pp. 1054-1061
    • Krampera, M.1    Galipeau, J.2    Shi, Y.3    Tarte, K.4    Sensebe, L.5
  • 37
    • 77955646193 scopus 로고    scopus 로고
    • Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    • doi:10.1038/nature09262
    • Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature (2010) 466:829-34. doi:10.1038/nature09262
    • (2010) Nature , vol.466 , pp. 829-834
    • Mendez-Ferrer, S.1    Michurina, T.V.2    Ferraro, F.3    Mazloom, A.R.4    Macarthur, B.D.5    Lira, S.A.6
  • 38
    • 50849139576 scopus 로고    scopus 로고
    • A perivascular origin for mesenchymal stem cells in multiple human organs
    • doi:10.1016/j.stem.2008.07.003
    • Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell (2008) 3:301-13. doi:10.1016/j.stem.2008.07.003
    • (2008) Cell Stem Cell , vol.3 , pp. 301-313
    • Crisan, M.1    Yap, S.2    Casteilla, L.3    Chen, C.W.4    Corselli, M.5    Park, T.S.6
  • 39
    • 34249289023 scopus 로고    scopus 로고
    • Developmental basis of vascular smooth muscle diversity
    • doi:10.1161/ATVBAHA.107.141069
    • Majesky MW. Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol (2007) 27:1248-58. doi:10.1161/ATVBAHA.107.141069
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1248-1258
    • Majesky, M.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.