Th2-like chemokine levels are increased in allergic children and influenced by maternal immunity during pregnancy

Pediatric Allergy and Immunology

Volumn 25, Issue 4, 2014, Pages 387-393

  Abelius, Martina S ^a   Lempinen, Esma ^a   Lindblad, Karin ^a   Ernerudh, Jan ^a   Berg, Göran ^a   Matthiesen, Leif ^a,b   Nilsson, Lennart J ^a   Jenmalm, Maria C ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b HELSINGBORG HOSPITAL   (Sweden)

Author keywords

Allergy; CCL17; CCL22; Chemokines; Pregnancy; Th2

Indexed keywords

CCL18 CHEMOKINE; CHEMOKINE; CXCL11 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROPHAGE DERIVED CHEMOKINE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG; IMMUNOGLOBULIN E;

ALLERGY; ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNITY; MATERNAL IMMUNITY; PREGNANCY; PRIORITY JOURNAL; SENSITIZATION; TH2 CELL; BLOOD; DOWN REGULATION; FETOMATERNAL TRANSFUSION; FOLLOW UP; HYPERSENSITIVITY; IMMUNOLOGY; INFANT; MALE; NEWBORN; PASSIVE IMMUNIZATION; PREGNANCY COMPLICATION; PRESCHOOL CHILD; TH1 TH2 BALANCE; UTERUS;

CHEMOKINES; CHILD; CHILD, PRESCHOOL; DOWN-REGULATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERSENSITIVITY; IMMUNITY, MATERNALLY-ACQUIRED; IMMUNOGLOBULIN E; INFANT; INFANT, NEWBORN; MALE; MATERNAL-FETAL EXCHANGE; PREGNANCY; PREGNANCY COMPLICATIONS; TH1-TH2 BALANCE; TH2 CELLS; UTERUS;

EID: 84904620750     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12235     Document Type: Article

References (34)

1. Liu CA, Wang CL, Chuang H, Ou CY, Hsu TY, Yang KD. Prenatal prediction of infant atopy by maternal but not paternal total IgE levels. J Allergy Clin Immunol 2003: 112: 899-904.
2. Lim RH, Kobzik L, Dahl M. Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis. PLoS ONE 2010: 5: e10134.
3. Jenmalm MC. Childhood immune maturation and allergy development: regulation by maternal immunity and microbial exposure. Am J Reprod Immunol 2011: 66(Suppl 1): 75-80.
4. Ege MJ, Bieli C, Frei R, et al. Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol 2006: 117: 817-23.
5. Douwes J, Cheng S, Travier N, et al. Farm exposure in utero may protect against asthma, hay fever and eczema. Eur Respir J 2008: 32: 603-11.
6. Roduit C, Wohlgensinger J, Frei R, et al. Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis. J Allergy Clin Immunol. 2011: 127: 179-85, 85 e1.
7. Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 1993: 14: 353-6.
8. Makhseed M, Raghupathy R, Azizieh F, Omu A, Al-Shamali E, Ashkanani L. Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions. Hum Reprod 2001: 16: 2219-26.
9. Boij R, Svensson J, Nilsson-Ekdahl K, et al. Biomarkers of coagulation, inflammation, and angiogenesis are independently associated with preeclampsia. Am J Reprod Immunol 2012: 68: 258-70.
10. Sykes L, MacIntyre DA, Yap XJ, Teoh TG, Bennett PR. The Th1:Th2 dichotomy of pregnancy and preterm labour. Mediators Inflamm 2012: 2012: 967629.
11. Ernerudh J, Berg G, Mjösberg J. Regulatory T helper cells in pregnancy and their roles in systemic versus local immune tolerance. Am J Reprod Immunol 2011: 66(Suppl 1): 31-43.
12. Wang WJ, Hao CF, Yi L, et al. Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients. J Reprod Immunol 2010: 84: 164-70.
13. Sandberg M, Frykman A, Jonsson Y, et al. Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy. J Reprod Immunol 2009: 81: 82-8.
14. Sandberg M, Frykman A, Ernerudh J, et al. Cord blood cytokines and chemokines and development of allergic disease. Pediatr Allergy Immunol 2009: 20: 519-27.
15. Abelius MS, Ernerudh J, Berg G, Matthiesen L, Nilsson LJ, Jenmalm MC. High cord blood levels of the T-helper 2-associated chemokines CCL17 and CCL22 precede allergy development during the first 6 years of life. Pediatr Res 2011: 70: 495-500.
16. Pease JE, Williams TJ. Chemokines and their receptors in allergic disease. J Allergy Clin Immunol 2006: 118: 305-18; quiz 19-20.
17. Gunther C, Bello-Fernandez C, Kopp T, et al. CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells. J Immunol 2005: 174: 1723-8.
18. Nakazato J, Kishida M, Kuroiwa R, Fujiwara J, Shimoda M, Shinomiya N. Serum levels of Th2 chemokines, CCL17, CCL22, and CCL27, were the important markers of severity in infantile atopic dermatitis. Pediatr Allergy Immunol 2008: 19: 605-13.
19. Abrahamsson TR, Sandberg Abelius M, Forsberg A, Björksten B, Jenmalm MC. A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization. Clin Exp Allergy 2011: 41: 1729-39.
20. Kelly RW, King AE, Critchley HOD. Cytokine control in human endometrium. Reproduction 2001: 121: 3-19.
21. Komine M, Kakinuma T, Kagami S, Hanakawa Y, Hashimoto K, Tamaki K. Mechanism of Thymus- and Activation-Regulated Chemokine (TARC)/CCL17 Production and its Modulation by Roxithromycin. J Invest Dermatol 2005: 125: 491-8.
22. Berin CM, Dwinell MB, Eckmann L, Kagnoff MF. Production of MDC/CCL22 by human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2001: 280: G1217-26.
23. Halonen M, Lohman IC, Stern DA, et al. Th1/Th2 patterns and balance in cytokine production in the parents and infants of a large birth cohort. J Immunol 2009: 182: 3285-93.
24. Herberth G, Hinz D, Roder S, et al. Maternal immune status in pregnancy is related to offspring's immune responses and atopy risk. Allergy 2011: 66: 1065-74.
25. Walter J, Fraga L, Orin MJ, et al. Immunomodulatory factors in cervicovaginal secretions from pregnant and non-pregnant women: a cross-sectional study. BMC Infect Dis 2011: 11: 263.
26. Aminzadeh F, Ghorashi Z, Nabati S, et al. Differential expression of CXC chemokines CXCL10 and CXCL12 in term and pre-term neonates and their mothers. Am J Reprod Immunol 2012: 68: 338-44.
27. Gomez-Lopez N, Hernandez-Santiago S, Lobb AP, Olson DM, Vadillo-Ortega F. Normal and premature rupture of fetal membranes at term delivery differ in regional chemotactic activity and related chemokine/cytokine production. Reprod Sci 2013: 20: 276-84.
28. Malamitsi-Puchner A, Vrachnis N, Samoli E, et al. Possible early prediction of preterm birth by determination of novel proinflammatory factors in midtrimester amniotic fluid. Ann N Y Acad Sci 2006: 1092: 440-9.
29. Campbell JD, Stinson MJ, Simons FE, HayGlass KT. Systemic chemokine and chemokine receptor responses are divergent in allergic versus non-allergic humans. Int Immunol 2002: 14: 1255-62.
30. Hijnen D, De Bruin-Weller M, Oosting B, et al. Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis. J Allergy Clin Immunol 2004: 113: 334-40.
31. Leung TF, Wong GW, Ko FW, Lam CW, Fok TF. Increased macrophage-derived chemokine in exhaled breath condensate and plasma from children with asthma. Clin Exp Allergy 2004: 34: 786-91.
32. Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Holt PG. Development of allergen-specific T-cell memory in atopic and normal children. Lancet 1999: 353: 196-200.
33. Kulig M, Tacke U, Forster J, et al. Serum IgE levels during the first 6 years of life. J Pediatr 1999: 134: 453-8.
34. Barker DJ. The origins of the developmental origins theory. J Intern Med 2007: 261: 412-7.