15-Deoxy- γ 12,14-prostaglandin J2 reduces liver impairment in a model of ConA-induced acute hepatic inflammation by activation of PPAR γ and reduction in NF- B activity

PPAR Research

Volumn 2014, Issue , 2014, Pages

  Chen, Kan ^a   Li, Jingjing ^a   Wang, Junshan ^a   Xia, Yujing ^a   Dai, Weiqi ^a   Wang, Fan ^a   Shen, Miao ^a   Cheng, Ping ^a   Zhang, Yan ^a   Wang, Chengfen ^a   Yang, Jing ^a   Zhu, Rong ^a   Zhang, Huawei ^a   Zheng, Yuanyuan ^a   Lu, Jie ^a   Fan, Zhuoyi ^a   Zhou, Yingqun ^a   Guo, Chuanyong ^a  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; BETA ACTIN; CONCANAVALIN A; CYTOPLASM PROTEIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 6; LAMIN A; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TUMOR NECROSIS FACTOR ALPHA;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE HEPATITIS; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER INJURY; LIVER PROTECTION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

EID: 84904600213     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2014/215631     Document Type: Article

References (37)

1. Eggink H. F., Houthoff H. J., Huitema S., Gips C. H., Poppema S., Cellular and humoral immune reactions in chronic active liver disease. I. Lymphocyte subsets in liver biopsies of patients with untreated idiopathic autoimmune hepatitis, chronic active hepatitis B and primary biliary cirrhosis. Clinical & Experimental Immunology 1982 50 17 24 (Pubitemid 12037531)
2. Mizuhara H., O'Neill E., Seki N., Ogawa T., Kusunoki C., Otsuka K., Satoh S., Niwa M., Senoh H., Fujiwara H., T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6. The Journal of Experimental Medicine 1994 179 1529 1537 (Pubitemid 24129570)
3. Nakaya M., Hashimoto M., Nakagawa R., Wakabayashi Y., Ishizaki T., Takada I., Komai K., Yoshida H., Yoshimura A., SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis. The Journal of Immunology 2009 183 11 7047 7053 10.4049/jimmunol.0900547
4. Tiegs G., Hentschel J., Wendel A., A T cell-dependent experimental liver injury in mice inducible by concanavalin A. Journal of Clinical Investigation 1992 90 196 203 10.1172/JCI115836
5. Zhang X., Wei H. X., Rui S., Wei H., Tian Z., Opposite effects of high and low doses of interleukin-2 on T cell-mediated hepatitis in mice (interleukin-2 on hepatitis). Hepatology International 2010 4 3 641 648 10.1007/s12072-010-9196-0
6. Fitzpatrick F. A., Wynalda M. A., Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. The Journal of Biological Chemistry 1983 258 11713 11718 (Pubitemid 13019315)
7. Funk C. D., Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001 294 1871 1875 10.1126/science.294.5548.1871 (Pubitemid 33101574)
8. Shibata T., Kondo M., Osawa T., Shibata N., Kobayashi M., Uchida K., 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes. The Journal of Biological Chemistry 2002 277 12 10459 10466 10.1074/jbc.M110314200 (Pubitemid 34968167)
9. Gilroy D. W., Colville-Nash P. R., Willis D., Inducible cyclooxygenase may have anti-inflammatory properties. Nature Medicine 1999 5 6 698 701 (Pubitemid 29289435)
10. Yoshikai Y., Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection. Current Opinion in Infectious Diseases 2001 14 3 257 263 10.1097/00001432-200106000-00003 (Pubitemid 32493535)
11. Liu X., Yu H., Yang L., Li C., Li L., 15-Deoxy-Delta(12, 14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines. European Journal of Cell Biology 2012 91 654 661 10.1016/j.ejcb.2012.03.004
12. Jiang C., Ting A. T., Seed B., PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998 391 6662 82 86 (Pubitemid 28079219)
13. 2 reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury in mice. Hepatology 2012 56 1 350 360 10.1002/hep.25672
14. Alves C., de Melo N., Fraceto L., de Araujo D., Napimoga M., Effects of 15d-PGJ(2)-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation. British Journal of Pharmacology 2011 162 3 623 632
15. Zingarelli B., Sheehan M., Hake P. W., O'Connor M., Denenberg A., Cook J. A., Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways. The Journal of Immunology 2003 171 12 6827 6837 10.4049/jimmunol.171. 12.6827 (Pubitemid 37532118)
16. Dugo L., Collin M., Cuzzocrea S., Thiemermann C., 15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria. European Journal of Pharmacology 2004 498 295 301 (Pubitemid 39208092)
17. Cloutier A., Marois I., Cloutier D., The prostanoid 15-deoxy-Delta12, 14-prostaglandin-j2 reduces lung inflammation and protects mice against lethal influenza infection. The Journal of Infectious Diseases 2012 205 621 630
18. Rossi A., Kapahi P., Natoli G., Takahashi T., Chen Y., Karin M., Santoro M. G., Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of I B kinase. Nature 2000 403 6765 103 108 10.1038/47520 2-s2.0-0034610759 (Pubitemid 30038530)
19. Shiraki T., Kamiya N., Shiki S., Alpha, beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma. The Journal of Biological Chemistry 2005 280 14145 14153 (Pubitemid 40517317)
20. Ogawa Y., Yoneda M., Tomeno W., Imajo K., Shinohara Y., Peroxisome proliferator-activated receptor gamma exacerbates concanavalin a-induced liver injury via suppressing the translocation of NF- B into the nucleus. PPAR Research 2012 2012 5 940384 10.1155/2012/940384
21. Li C. C., Yang H. T., Hou Y. C., Chiu Y. S., Chiu W. C., Dietary fish oil reduces systemic inflammation and ameliorates sepsis-induced liver injury by up-regulating the peroxisome proliferator-activated receptor gamma-mediated pathway in septic mice. Journal of Nutritional Biochemistry 2014 25 19 25 10.1016/j.jnutbio.2013.08.010
22. Ricote M., Huang J., Fajas L., Li A., Welch J., Najib J., Witztum J. L., Auwerx J., Palinski W., Glass C. K., Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proceedings of the National Academy of Sciences of the United States of America 1998 95 7614 7619
23. Sasaguri T., Miwa Y., Prostaglandin J2 family and the cardiovascular system. Current Vascular Pharmacology 2004 2 2 103 114 10.2174/1570161043476384 (Pubitemid 38855018)
24. Hashimoto K., Ethridge R. T., Saito H., Rajaraman S., Evers B. M., The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. Pancreas 2003 27 1 58 66 (Pubitemid 36775980)
25. Baregamian N., Mourot J. M., Ballard A. R., Evers B. M., Chung D. H., PPAR- γ agonist protects against intestinal injury during necrotizing enterocolitis. Biochemical and Biophysical Research Communications 2009 379 2 423 427 10.1016/j.bbrc.2008.11.155 2-s2.0-58149488639
26. Xu F., Li J., Ni W., Shen Y. W., Zhang X. P., Peroxisome proliferator-activated receptor- γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury. PLoS ONE 2013 8 1 e55080 10.1371/journal.pone.0055080
27. 2 inhibits macrophage colonization by Salmonella enterica serovar Typhimurium. PLoS ONE 2013 8 e69759 10.1371/journal.pone.0069759
28. Nozaki Y., Harada K., Sanzen T., Nakanuma Y., PPAR γ ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis. Medical Molecular Morphology 2013 46 3 153 159 10.1007/s00795-013-0017-0 2-s2.0-84873342272
29. 12,14-PGJ2, but not troglitazone, modulates IL-1 β effects in human chondrocytes by inhibiting NF- B and AP-1 activation pathways. FEBS Letters 2001 501 24 30 10.1016/S0014-5793(01)02614-X (Pubitemid 33712481)
30. Giri S., Rattan R., Singh A. K., Singh I., The 15-deoxy-delta12, 14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF- kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. The Journal of Immunology 2004 173 5196 5208 10.4049/jimmunol.173.8.5196 (Pubitemid 39387803)
31. Raikwar H. P., Muthian G., Rajasingh J., Johnson C. N., Bright J. J., PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2. Journal of Neuroimmunology 2006 178 1-2 76 86 (Pubitemid 44307334)
32. Natarajan C., Bright J. J., Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation. Genes and Immunity 2002 3 2 59 70 10.1038/sj.gene.6363832 (Pubitemid 38961111)
33. Uchida K., Shibata T., 15-Deoxy-Δ12,14-prostaglandin J2: an electrophilic trigger of cellular responses. Chemical Research in Toxicology 2008 21 1 138 144 10.1021/tx700177j 2-s2.0-38949126129 (Pubitemid 351219715)
34. Jung W. K., Park I. S., Park S. J., The 15-deoxy-Delta12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF- kappaB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1. Life Sciences 2009 85 46 53 10.1016/j.lfs.2009.04.010
35. Ackerman W. T., Zhang X. L., Rovin B. H., Kniss D. A., Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells. Biology of Reproduction 2005 73 527 535 10.1095/biolreprod.104.039032 (Pubitemid 41170208)
36. Ciucci A., Gianferretti P., Piva R., Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway. Molecular Pharmacology 2006 70 5 1812 1821
37. Kostadinova R., Wahli W., Michalik L., PPARs in diseases: Control mechanisms of inflammation. Current Medicinal Chemistry 2005 12 25 2995 3009 10.2174/092986705774462905 2-s2.0-27944505915 (Pubitemid 41672488)