Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity

ACS Chemical Biology

Volumn 9, Issue 7, 2014, Pages 1451-1459

  Pavic, Karolina ^a   Rios, Pablo ^a   Dzeyk, Kristina ^a   Koehler, Christine ^a   Lemke, Edward A ^a   Köhn, Maja ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMBER; AMINO ACID; HOMODIMER; PHOSPHATASE; UNCLASSIFIED DRUG; VACCINIA H1 RELATED PHOSPHATASE; 4-BENZOYLPHENYLALANINE; BENZOPHENONE DERIVATIVE; CROSS LINKING REAGENT; DUAL SPECIFICITY PHOSPHATASE 3; PHENYLALANINE;

AMINO ACID SEQUENCE; ARTICLE; CIRCULAR DICHROISM; CROSS LINKING; DIMERIZATION; ENZYME ACTIVITY; GEL PERMEATION CHROMATOGRAPHY; HYDROGEN BOND; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MUTAGENESIS; MUTATIONAL ANALYSIS; OLIGOMERIZATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; REGULATORY MECHANISM; STOP CODON; TANDEM MASS SPECTROMETRY; ULTRAVIOLET IRRADIATION; ULTRAVIOLET RADIATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; GENETICS; HUMAN; METABOLISM; MUTATION; PHOTOCHEMISTRY; PROTEIN MULTIMERIZATION;

ANIMALS; BENZOPHENONES; CATALYTIC DOMAIN; CERCOPITHECUS AETHIOPS; COS CELLS; CROSS-LINKING REAGENTS; DUAL SPECIFICITY PHOSPHATASE 3; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; PHENYLALANINE; PHOTOCHEMICAL PROCESSES; PROTEIN MULTIMERIZATION;

EID: 84904567394     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500240n     Document Type: Article

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