메뉴 건너뛰기




Volumn 6, Issue JUN, 2014, Pages

Multimodal approaches for regenerative stroke therapies: Combination of granulocyte colony-stimulating factor with bone marrow mesenchymal stem cells is not superior to G-CSF alone

Author keywords

Aging; Angiogenesis; BM MSC; Cell therapy; G CSF; Stroke; Translational medicine

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ENDOGLIN; GRANULOCYTE COLONY STIMULATING FACTOR; NEURON SPECIFIC NUCLEAR PROTEIN;

EID: 84904551002     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2014.00130     Document Type: Article
Times cited : (70)

References (75)
  • 1
    • 79957814267 scopus 로고    scopus 로고
    • Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain
    • doi: 10.1093/brain/awr094
    • Andres, R. H., Horie, N., Slikker, W., Keren-Gill, H., Zhan, K., Sun, G., et al. (2011). Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain. Brain 134(Pt 6), 1777-1789. doi: 10.1093/brain/awr094
    • (2011) Brain , vol.134 , Issue.Pt 6 , pp. 1777-1789
    • Andres, R.H.1    Horie, N.2    Slikker, W.3    Keren-Gill, H.4    Zhan, K.5    Sun, G.6
  • 2
    • 5044220530 scopus 로고    scopus 로고
    • Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats
    • doi:10.1016/j.expneurol.2004.05.045
    • Ankeny, D. P., McTigue, D. M., and Jakeman, L. B. (2004). Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats. Exp. Neurol. 190, 17-31. doi:10.1016/j.expneurol.2004.05.045
    • (2004) Exp. Neurol. , vol.190 , pp. 17-31
    • Ankeny, D.P.1    McTigue, D.M.2    Jakeman, L.B.3
  • 3
    • 0036735672 scopus 로고    scopus 로고
    • Neuronal replacement from endogenous precursors in the adult brain after stroke
    • doi:10.1038/nm747
    • Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., and Lindvall, O. (2002). Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 8, 963-970. doi:10.1038/nm747
    • (2002) Nat. Med. , vol.8 , pp. 963-970
    • Arvidsson, A.1    Collin, T.2    Kirik, D.3    Kokaia, Z.4    Lindvall, O.5
  • 4
    • 67749143855 scopus 로고    scopus 로고
    • Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms
    • doi:10.1093/brain/awp174
    • Bacigaluppi, M., Pluchino, S., Peruzzotti-Jametti, L., Kilic, E., Kilic, U., Salani, G., et al. (2009). Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain 132(Pt 8), 2239-2251. doi:10.1093/brain/awp174
    • (2009) Brain , vol.132 , Issue.PT 8 , pp. 2239-2251
    • Bacigaluppi, M.1    Pluchino, S.2    Peruzzotti-Jametti, L.3    Kilic, E.4    Kilic, U.5    Salani, G.6
  • 5
    • 0344394955 scopus 로고    scopus 로고
    • Temporal dynamics of degenerative and regenerative events associated with cerebral ischemia in aged rats
    • doi:10.1159/000073763
    • Badan, I., Platt, D., Kessler, C., and Popa-Wagner, A. (2003). Temporal dynamics of degenerative and regenerative events associated with cerebral ischemia in aged rats. Gerontology 49, 356-365. doi:10.1159/000073763
    • (2003) Gerontology , vol.49 , pp. 356-365
    • Badan, I.1    Platt, D.2    Kessler, C.3    Popa-Wagner, A.4
  • 6
    • 78650517407 scopus 로고    scopus 로고
    • Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats
    • doi:10.1016/j.brainres.2010.10.063
    • Bao, X., Wei, J., Feng, M., Lu, S., Li, G., Dou, W., et al. (2011). Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats. Brain Res. 1367, 103-113. doi:10.1016/j.brainres.2010.10.063
    • (2011) Brain Res , vol.1367 , pp. 103-113
    • Bao, X.1    Wei, J.2    Feng, M.3    Lu, S.4    Li, G.5    Dou, W.6
  • 7
    • 79960733740 scopus 로고    scopus 로고
    • Prestroke proteomic changes in cerebral microvessels in stroke-prone, transgenic[hCETP]-hyperlipidemic Dahl salt-sensitive hypertensive rats
    • doi:10.2119/molmed.2010.00228
    • Bergerat, A., Decano, J., Wu, C. J., Choi, H., Nesvizhskii, A. I., Moran, A. M., et al. (2011). Prestroke proteomic changes in cerebral microvessels in stroke-prone, transgenic[hCETP]-hyperlipidemic, Dahl salt-sensitive hypertensive rats. Mol. Med. 17, 588-598. doi:10.2119/molmed.2010.00228
    • (2011) Mol. Med. , vol.17 , pp. 588-598
    • Bergerat, A.1    Decano, J.2    Wu, C.J.3    Choi, H.4    Nesvizhskii, A.I.5    Moran, A.M.6
  • 8
    • 84861889719 scopus 로고    scopus 로고
    • Watermaze performance after middle cerebral artery occlusion in the rat: the role of sensorimotor versus memory impairments
    • doi:10.1038/jcbfm.2012.16
    • Bingham, D., Martin, S. J., Macrae, I. M., and Carswell, H. V. (2012). Watermaze performance after middle cerebral artery occlusion in the rat: the role of sensorimotor versus memory impairments. J. Cereb. Blood Flow Metab. 32, 989-999. doi:10.1038/jcbfm.2012.16
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 989-999
    • Bingham, D.1    Martin, S.J.2    Macrae, I.M.3    Carswell, H.V.4
  • 9
    • 84866335471 scopus 로고    scopus 로고
    • Kinematic analysis of motor recovery with human adult bone marrow-derived somatic cell therapy in a rat model of stroke
    • doi:10.1177/1545968312446004
    • Braun, R. G., Andrews, E. M., and Kartje, G. L. (2012). Kinematic analysis of motor recovery with human adult bone marrow-derived somatic cell therapy in a rat model of stroke. Neurorehabil. Neural Repair 26, 898-906. doi:10.1177/1545968312446004
    • (2012) Neurorehabil. Neural Repair , vol.26 , pp. 898-906
    • Braun, R.G.1    Andrews, E.M.2    Kartje, G.L.3
  • 10
    • 0034531907 scopus 로고    scopus 로고
    • From marrow to brain: expression of neuronal phenotypes in adult mice
    • doi:10.1126/science.290.5497.1775
    • Brazelton, T. R., Rossi, F. M., Keshet, G. I., and Blau, H. M. (2000). From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290, 1775-1779. doi:10.1126/science.290.5497.1775
    • (2000) Science , vol.290 , pp. 1775-1779
    • Brazelton, T.R.1    Rossi, F.M.2    Keshet, G.I.3    Blau, H.M.4
  • 11
    • 84902537549 scopus 로고    scopus 로고
    • Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis
    • doi:10.1016/j.pharmthera.2014.02.013
    • Bronckaers, A., Hilkens, P., Martens, W., Gervois, P., Ratajczak, J., Struys, T., et al. (2014). Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis. Pharmacol. Ther. 143, 181-196. doi:10.1016/j.pharmthera.2014.02.013
    • (2014) Pharmacol. Ther. , vol.143 , pp. 181-196
    • Bronckaers, A.1    Hilkens, P.2    Martens, W.3    Gervois, P.4    Ratajczak, J.5    Struys, T.6
  • 12
    • 42149145248 scopus 로고    scopus 로고
    • Environmental enrichment improves functional and neuropathological indices following stroke in young and aged rats
    • Buchhold, B., Mogoanta, L., Suofu, Y., Hamm, A., Walker, L., and Popa-Wagner, A. (2007). Environmental enrichment improves functional and neuropathological indices following stroke in young and aged rats. Restor. Neurol. Neurosci. 25, 1-18.
    • (2007) Restor. Neurol. Neurosci. , vol.25 , pp. 1-18
    • Buchhold, B.1    Mogoanta, L.2    Suofu, Y.3    Hamm, A.4    Walker, L.5    Popa-Wagner, A.6
  • 13
    • 84890488095 scopus 로고    scopus 로고
    • Preclinical models of stroke in aged animals with or without comorbidities: role of neuroinflammation
    • doi:10.1007/s10522-013-9465-0
    • Buga, A. M., Di Napoli, M., and Popa-Wagner, A. (2013). Preclinical models of stroke in aged animals with or without comorbidities: role of neuroinflammation. Biogerontology 14, 651-662. doi:10.1007/s10522-013-9465-0
    • (2013) Biogerontology , vol.14 , pp. 651-662
    • Buga, A.M.1    Di Napoli, M.2    Popa-Wagner, A.3
  • 15
    • 36248932643 scopus 로고    scopus 로고
    • Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing
    • doi:10.1634/stemcells.2007-0197
    • Chamberlain, G., Fox, J., Ashton, B., and Middleton, J. (2007). Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25, 2739-2749. doi:10.1634/stemcells.2007-0197
    • (2007) Stem Cells , vol.25 , pp. 2739-2749
    • Chamberlain, G.1    Fox, J.2    Ashton, B.3    Middleton, J.4
  • 16
    • 0033974706 scopus 로고    scopus 로고
    • Intracerebral transplantation of bone marrow with BDNF after MCAo in rat
    • doi:10.1016/S0028-3908(00)00006-X
    • Chen, J., Li, Y., and Chopp, M. (2000). Intracerebral transplantation of bone marrow with BDNF after MCAo in rat. Neuropharmacology 39, 711-716. doi:10.1016/S0028-3908(00)00006-X
    • (2000) Neuropharmacology , vol.39 , pp. 711-716
    • Chen, J.1    Li, Y.2    Chopp, M.3
  • 17
    • 1642319466 scopus 로고    scopus 로고
    • Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis
    • doi:10.1016/j.brainres.2003.11.080
    • Chen, J., Li, Y., Zhang, R., Katakowski, M., Gautam, S. C., Xu, Y., et al. (2004). Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis. Brain Res. 1005, 21-28. doi:10.1016/j.brainres.2003.11.080
    • (2004) Brain Res , vol.1005 , pp. 21-28
    • Chen, J.1    Li, Y.2    Zhang, R.3    Katakowski, M.4    Gautam, S.C.5    Xu, Y.6
  • 18
    • 0037418936 scopus 로고    scopus 로고
    • Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats
    • doi:10.1161/01.RES.0000063425.51108.8D
    • Chen, J., Zhang, Z. G., Li, Y., Wang, L., Xu, Y. X., Gautam, S. C., et al. (2003). Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ. Res. 92, 692-699. doi:10.1161/01.RES.0000063425.51108.8D
    • (2003) Circ. Res. , vol.92 , pp. 692-699
    • Chen, J.1    Zhang, Z.G.2    Li, Y.3    Wang, L.4    Xu, Y.X.5    Gautam, S.C.6
  • 19
    • 26244445972 scopus 로고    scopus 로고
    • Progenitor proliferation in the adult hippocampus and substantia nigra induced by glial cell line-derived neurotrophic factor
    • doi:10.1016/j.expneurol.2005.07.010
    • Chen, Y., Ai, Y., Slevin, J. R., Maley, B. E., and Gash, D. M. (2005). Progenitor proliferation in the adult hippocampus and substantia nigra induced by glial cell line-derived neurotrophic factor. Exp. Neurol. 196, 87-95. doi:10.1016/j.expneurol.2005.07.010
    • (2005) Exp. Neurol. , vol.196 , pp. 87-95
    • Chen, Y.1    Ai, Y.2    Slevin, J.R.3    Maley, B.E.4    Gash, D.M.5
  • 20
    • 84917674645 scopus 로고    scopus 로고
    • Aging of the subventricular zone neural stem cell niche
    • Conover, J. C., and Shook, B. A. (2011). Aging of the subventricular zone neural stem cell niche. Aging Dis. 2, 49-63.
    • (2011) Aging Dis , vol.2 , pp. 49-63
    • Conover, J.C.1    Shook, B.A.2
  • 21
    • 32644434557 scopus 로고    scopus 로고
    • Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis
    • doi:10.1016/j.expneurol.2005.10.029
    • Crigler, L., Robey, R. C., Asawachaicharn, A., Gaupp, D., and Phinney, D. G. (2006). Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis. Exp. Neurol. 198, 54-64. doi:10.1016/j.expneurol.2005.10.029
    • (2006) Exp. Neurol. , vol.198 , pp. 54-64
    • Crigler, L.1    Robey, R.C.2    Asawachaicharn, A.3    Gaupp, D.4    Phinney, D.G.5
  • 22
    • 33745499805 scopus 로고    scopus 로고
    • Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation
    • doi:10.1634/stemcells.2005-0370
    • Deng, J., Petersen, B. E., Steindler, D. A., Jorgensen, M. L., and Laywell, E. D. (2006). Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation. Stem Cells 24, 1054-1064. doi:10.1634/stemcells.2005-0370
    • (2006) Stem Cells , vol.24 , pp. 1054-1064
    • Deng, J.1    Petersen, B.E.2    Steindler, D.A.3    Jorgensen, M.L.4    Laywell, E.D.5
  • 23
    • 40849113545 scopus 로고    scopus 로고
    • Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats
    • doi:10.1016/j.neurobiolaging.2006.12.007
    • DiNapoli, V. A., Huber, J. D., Houser, K., Li, X., and Rosen, C. L. (2008). Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats. Neurobiol. Aging 29, 753-764. doi:10.1016/j.neurobiolaging.2006.12.007
    • (2008) Neurobiol. Aging , vol.29 , pp. 753-764
    • DiNapoli, V.A.1    Huber, J.D.2    Houser, K.3    Li, X.4    Rosen, C.L.5
  • 24
    • 84856410426 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor for mobilizing bone marrow stem cells in subacute stroke: the stem cell trial of recovery enhancement after stroke 2 randomized controlled trial
    • doi:10.1161/STROKEAHA.111.636449
    • England, T. J., Abaei, M., Auer, D. P., Lowe, J., Jones, D. R., Sare, G., et al. (2012). Granulocyte-colony stimulating factor for mobilizing bone marrow stem cells in subacute stroke: the stem cell trial of recovery enhancement after stroke 2 randomized controlled trial. Stroke 43, 405-411. doi:10.1161/STROKEAHA.111.636449
    • (2012) Stroke , vol.43 , pp. 405-411
    • England, T.J.1    Abaei, M.2    Auer, D.P.3    Lowe, J.4    Jones, D.R.5    Sare, G.6
  • 25
    • 41949089365 scopus 로고    scopus 로고
    • Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice
    • doi:10.1161/CIRCULATIONAHA.107.746008
    • Foteinos, G., Hu, Y., Xiao, Q., Metzler, B., and Xu, Q. (2008). Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice. Circulation 117, 1856-1863. doi:10.1161/CIRCULATIONAHA.107.746008
    • (2008) Circulation , vol.117 , pp. 1856-1863
    • Foteinos, G.1    Hu, Y.2    Xiao, Q.3    Metzler, B.4    Xu, Q.5
  • 27
    • 79954784811 scopus 로고    scopus 로고
    • Age-dependent susceptibility to infarct growth in women
    • doi:10.1161/STROKEAHA.110.603902
    • Gokcay, F., Arsava, E. M., Baykaner, T., Vangel, M., Garg, P., Wu, O., et al. (2011). Age-dependent susceptibility to infarct growth in women. Stroke 42, 947-951. doi:10.1161/STROKEAHA.110.603902
    • (2011) Stroke , vol.42 , pp. 947-951
    • Gokcay, F.1    Arsava, E.M.2    Baykaner, T.3    Vangel, M.4    Garg, P.5    Wu, O.6
  • 28
    • 68249088090 scopus 로고    scopus 로고
    • Committed neural progenitor cells derived from genetically modified bone marrow stromal cells ameliorate deficits in a rat model of stroke
    • doi:10.1038/jcbfm.2009.62
    • Hayase, M., Kitada, M., Wakao, S., Itokazu, Y., Nozaki, K., Hashimoto, N., et al. (2009). Committed neural progenitor cells derived from genetically modified bone marrow stromal cells ameliorate deficits in a rat model of stroke. J. Cereb. Blood Flow Metab. 29, 1409-1420. doi:10.1038/jcbfm.2009.62
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 1409-1420
    • Hayase, M.1    Kitada, M.2    Wakao, S.3    Itokazu, Y.4    Nozaki, K.5    Hashimoto, N.6
  • 29
    • 84858601983 scopus 로고    scopus 로고
    • Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation
    • doi:10.1016/S1474-4422(12)70039-X
    • Hermann, D., and Chopp, M. (2012). Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation. Lancet Neurol. 11, 369-380. doi:10.1016/S1474-4422(12)70039-X
    • (2012) Lancet Neurol , vol.11 , pp. 369-380
    • Hermann, D.1    Chopp, M.2
  • 30
    • 70349675503 scopus 로고    scopus 로고
    • Implications of vascular endothelial growth factor for postischemic neurovascular remodeling
    • doi:10.1038/jcbfm.2009.100
    • Hermann, D. K., and Zechariah, A. (2009). Implications of vascular endothelial growth factor for postischemic neurovascular remodeling. J. Cereb. Blood Flow Metab. 29, 1620-1643. doi:10.1038/jcbfm.2009.100
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 1620-1643
    • Hermann, D.K.1    Zechariah, A.2
  • 31
    • 0036093023 scopus 로고    scopus 로고
    • Bone marrow as a source of endothelial cells and NeuN-expressing cells after stroke
    • doi:10.1161/01.STR.0000014925.09415.C3
    • Hess, D. C., Hill, W. D., Martin-Studdard, A., Carroll, J., Brailer, J., and Carothers, J. (2002). Bone marrow as a source of endothelial cells and NeuN-expressing cells after stroke. Stroke 33, 1362-1368. doi:10.1161/01.STR.0000014925.09415.C3
    • (2002) Stroke , vol.33 , pp. 1362-1368
    • Hess, D.C.1    Hill, W.D.2    Martin-Studdard, A.3    Carroll, J.4    Brailer, J.5    Carothers, J.6
  • 32
    • 0037133174 scopus 로고    scopus 로고
    • Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery
    • doi:10.1073/pnas.042678299
    • Hofstetter, C. P., Schwarz, E. J., Hess, D., Widenfalk, J., El Manira, A., Prockop, D. J., et al. (2002). Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc. Natl. Acad. Sci. U.S.A. 99, 2199-2204. doi:10.1073/pnas.042678299
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 2199-2204
    • Hofstetter, C.P.1    Schwarz, E.J.2    Hess, D.3    Widenfalk, J.4    El Manira, A.5    Prockop, D.J.6
  • 33
    • 84860539878 scopus 로고    scopus 로고
    • Mesenchymal stem cells: therapeutic outlook for stroke
    • doi:10.1016/j.molmed.2012.02.003
    • Honmou, O., Onodera, R., Sasaki, M., Waxman, S. G., and Kocsis, J. D. (2012). Mesenchymal stem cells: therapeutic outlook for stroke. Trends Mol. Med. 18, 292-297. doi:10.1016/j.molmed.2012.02.003
    • (2012) Trends Mol. Med. , vol.18 , pp. 292-297
    • Honmou, O.1    Onodera, R.2    Sasaki, M.3    Waxman, S.G.4    Kocsis, J.D.5
  • 34
    • 79952164901 scopus 로고    scopus 로고
    • Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair
    • doi:10.1002/stem.584
    • Horie, N., Pereira, M. P., Niizuma, K., Sun, G., Keren-Gill, H., Encarnacion, A., et al. (2011). Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair. Stem Cells 29, 274-285. doi:10.1002/stem.584
    • (2011) Stem Cells , vol.29 , pp. 274-285
    • Horie, N.1    Pereira, M.P.2    Niizuma, K.3    Sun, G.4    Keren-Gill, H.5    Encarnacion, A.6
  • 35
    • 84882789442 scopus 로고    scopus 로고
    • Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and angiogenesis
    • doi:10.1371/journal.pone.0072604
    • Hsieh, J. Y., Wang, H. W., Chang, S. J., Liao, K. H., Lee, I. H., Lin, W. S., et al. (2013). Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and angiogenesis. PLoS ONE 8:e72604. doi:10.1371/journal.pone.0072604
    • (2013) PLoS ONE , vol.8
    • Hsieh, J.Y.1    Wang, H.W.2    Chang, S.J.3    Liao, K.H.4    Lee, I.H.5    Lin, W.S.6
  • 36
    • 84865004727 scopus 로고    scopus 로고
    • MRI detects brain reorganization after human umbilical tissue-derived cells (hUTC) treatment of stroke in rat
    • doi:10.1371/journal.pone.0042845
    • Jiang, Q., Thiffault, C., Kramer, B. C., Ding, G. L., Zhang, L., Nejad-Davarani, S. P., et al. (2012). MRI detects brain reorganization after human umbilical tissue-derived cells (hUTC) treatment of stroke in rat. PLoS ONE 7:e42845. doi:10.1371/journal.pone.0042845
    • (2012) PLoS ONE , vol.7
    • Jiang, Q.1    Thiffault, C.2    Kramer, B.C.3    Ding, G.L.4    Zhang, L.5    Nejad-Davarani, S.P.6
  • 37
    • 33845666847 scopus 로고    scopus 로고
    • The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia
    • doi:10.1096/fj.05-4829fje
    • Kilic, E., Kilic, U., Wang, Y., Bassetti, C. L., Marti, H. H., and Hermann, D. M. (2006). The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J. 20, 1185-1187. doi:10.1096/fj.05-4829fje
    • (2006) FASEB J , vol.20 , pp. 1185-1187
    • Kilic, E.1    Kilic, U.2    Wang, Y.3    Bassetti, C.L.4    Marti, H.H.5    Hermann, D.M.6
  • 38
    • 0032874061 scopus 로고    scopus 로고
    • Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains
    • doi:10.1073/pnas.96.19.10711
    • Kopen, G. C., Prockop, D. J., and Phinney, D. G. (1999). Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc. Natl. Acad. Sci. U.S.A. 96, 10711-10716. doi:10.1073/pnas.96.19.10711
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 10711-10716
    • Kopen, G.C.1    Prockop, D.J.2    Phinney, D.G.3
  • 39
    • 39749109431 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke
    • doi:10.1093/brain/awm306
    • Lee, S. T., Chu, K., Jung, K. H., Kim, S. J., Kim, D. H., Kang, K. M., et al. (2008). Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain 131(Pt 3), 616-629. doi:10.1093/brain/awm306
    • (2008) Brain , vol.131 , Issue.Pt 3 , pp. 616-629
    • Lee, S.T.1    Chu, K.2    Jung, K.H.3    Kim, S.J.4    Kim, D.H.5    Kang, K.M.6
  • 40
    • 56149124382 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling controls development of the blood-brain barrier
    • doi:10.1083/jcb.200806024
    • Liebner, S., Corada, M., Bangsow, T., Babbage, J., Taddei, A., Czupalla, C. J., et al. (2008). Wnt/beta-catenin signaling controls development of the blood-brain barrier. J. Cell Biol. 183, 409-417. doi:10.1083/jcb.200806024
    • (2008) J. Cell Biol. , vol.183 , pp. 409-417
    • Liebner, S.1    Corada, M.2    Bangsow, T.3    Babbage, J.4    Taddei, A.5    Czupalla, C.J.6
  • 41
    • 7944219604 scopus 로고    scopus 로고
    • Lesion-induced and training-induced brain reorganization
    • Liepert, J., Hamzei, F., and Weiller, C. (2004). Lesion-induced and training-induced brain reorganization. Restor. Neurol. Neurosci. 22, 269-277.
    • (2004) Restor. Neurol. Neurosci. , vol.22 , pp. 269-277
    • Liepert, J.1    Hamzei, F.2    Weiller, C.3
  • 42
    • 84863012210 scopus 로고    scopus 로고
    • Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia
    • doi:10.1186/scrt79
    • Lim, J. Y., Jeong, C. H., Jun, J. A., Kim, S. M., Ryu, C. H., Hou, Y., et al. (2011). Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia. Stem Cell Res. Ther. 2, 38. doi:10.1186/scrt79
    • (2011) Stem Cell Res. Ther. , vol.2 , pp. 38
    • Lim, J.Y.1    Jeong, C.H.2    Jun, J.A.3    Kim, S.M.4    Ryu, C.H.5    Hou, Y.6
  • 43
    • 0031281862 scopus 로고    scopus 로고
    • Reliability, distribution, and validity of age-related cognitive deficits in the Morris water maze
    • doi:10.1006/nlme.1997.3782
    • Lindner, M. D. (1997). Reliability, distribution, and validity of age-related cognitive deficits in the Morris water maze. Neurobiol. Learn. Mem. 68, 203-220. doi:10.1006/nlme.1997.3782
    • (1997) Neurobiol. Learn. Mem. , vol.68 , pp. 203-220
    • Lindner, M.D.1
  • 44
    • 0345060355 scopus 로고    scopus 로고
    • Long-lasting functional disabilities in middle-aged rats with small cerebral infarcts
    • Lindner, M. D., Gribkoff, V. K., Donlan, N. A., and Jones, T. A. (2003). Long-lasting functional disabilities in middle-aged rats with small cerebral infarcts. J. Neurosci. 23, 10913-10922.
    • (2003) J. Neurosci. , vol.23 , pp. 10913-10922
    • Lindner, M.D.1    Gribkoff, V.K.2    Donlan, N.A.3    Jones, T.A.4
  • 45
    • 52449112648 scopus 로고    scopus 로고
    • Contralesional axonal remodeling of the corticospinal system in adult rats after stroke and bone marrow stromal cell treatment
    • doi:10.1161/STROKEAHA.107.511659
    • Liu, Z., Li, Y., Zhang, X., Savant-Bhonsale, S., and Chopp, M. (2008). Contralesional axonal remodeling of the corticospinal system in adult rats after stroke and bone marrow stromal cell treatment. Stroke 39, 2571-2577. doi:10.1161/STROKEAHA.107.511659
    • (2008) Stroke , vol.39 , pp. 2571-2577
    • Liu, Z.1    Li, Y.2    Zhang, X.3    Savant-Bhonsale, S.4    Chopp, M.5
  • 46
    • 34248644341 scopus 로고    scopus 로고
    • G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia
    • doi:10.1042/BST0341327
    • Lu, C. Z., and Xiao, B. G. (2006). G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia. Biochem. Soc. Trans. 34(Pt 6), 1327-1333. doi:10.1042/BST0341327
    • (2006) Biochem. Soc. Trans. , vol.34 , Issue.PT 6 , pp. 1327-1333
    • Lu, C.Z.1    Xiao, B.G.2
  • 47
    • 40949134167 scopus 로고    scopus 로고
    • Morphological and functional characterization of predifferentiation of myelinating glia-like cells from human bone marrow stromal cells through activation of F3/Notch signaling in mouse retina
    • doi:10.1634/stemcells.2007-0106
    • Lu, L., Chen, X., Zhang, C. W., Yang, W. L., Wu, Y. J., and Sun, L. (2008). Morphological and functional characterization of predifferentiation of myelinating glia-like cells from human bone marrow stromal cells through activation of F3/Notch signaling in mouse retina. Stem Cells 26, 580-590. doi:10.1634/stemcells.2007-0106
    • (2008) Stem Cells , vol.26 , pp. 580-590
    • Lu, L.1    Chen, X.2    Zhang, C.W.3    Yang, W.L.4    Wu, Y.J.5    Sun, L.6
  • 48
    • 11844273931 scopus 로고    scopus 로고
    • BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury
    • doi:10.1016/j.expneurol.2004.09.018
    • Lu, P., Jones, L. L., and Tuszynski, M. H. (2005). BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp. Neurol. 191, 344-360. doi:10.1016/j.expneurol.2004.09.018
    • (2005) Exp. Neurol. , vol.191 , pp. 344-360
    • Lu, P.1    Jones, L.L.2    Tuszynski, M.H.3
  • 49
    • 0041854545 scopus 로고    scopus 로고
    • Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells
    • doi:10.1227/01.NEU.0000079333.61863.AA
    • Mahmood, A., Lu, D., Lu, M., and Chopp, M. (2003). Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells. Neurosurgery 53, 697-702. doi:10.1227/01.NEU.0000079333.61863.AA
    • (2003) Neurosurgery , vol.53 , pp. 697-702
    • Mahmood, A.1    Lu, D.2    Lu, M.3    Chopp, M.4
  • 50
    • 70349849517 scopus 로고    scopus 로고
    • Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy
    • doi:10.1002/stem.136
    • Menon, L. G., Kelly, K., Yang, H. W., Kim, S. K., Black, P. M., and Carroll, R. S. (2009). Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy. Stem Cells 27, 2320-2330. doi:10.1002/stem.136
    • (2009) Stem Cells , vol.27 , pp. 2320-2330
    • Menon, L.G.1    Kelly, K.2    Yang, H.W.3    Kim, S.K.4    Black, P.M.5    Carroll, R.S.6
  • 51
    • 84868151948 scopus 로고    scopus 로고
    • Intracerebral injection of human mesenchymal stem cells impacts cerebral microvasculature after experimental stroke: MRI study
    • doi:10.1002/nbm.2806
    • Moisan, A., Pannetier, N., Grillon, E., Richard, M. J., de Fraipont, F., Rémy, C., et al. (2012). Intracerebral injection of human mesenchymal stem cells impacts cerebral microvasculature after experimental stroke: MRI study. NMR Biomed. 25, 1340-1348. doi:10.1002/nbm.2806
    • (2012) NMR Biomed , vol.25 , pp. 1340-1348
    • Moisan, A.1    Pannetier, N.2    Grillon, E.3    Richard, M.J.4    de Fraipont, F.5    Rémy, C.6
  • 52
    • 84864284648 scopus 로고    scopus 로고
    • Intra-arterial bone marrow mononuclear cells in ischemic stroke: a pilot clinical trial
    • doi:10.1161/STROKEAHA.112.659409
    • Moniche, F., Gonzalez, A., Gonzalez-Marcos, J. R., Carmona, M., Piñero, P., Espigado, I., et al. (2012). Intra-arterial bone marrow mononuclear cells in ischemic stroke: a pilot clinical trial. Stroke 43, 2242-2244. doi:10.1161/STROKEAHA.112.659409
    • (2012) Stroke , vol.43 , pp. 2242-2244
    • Moniche, F.1    Gonzalez, A.2    Gonzalez-Marcos, J.R.3    Carmona, M.4    Piñero, P.5    Espigado, I.6
  • 53
    • 84878552183 scopus 로고    scopus 로고
    • The role of DNA damage and repair in aging through the prism of Koch-like criteria
    • doi:10.1016/j.arr.2012.02.001
    • Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., et al. (2013). The role of DNA damage and repair in aging through the prism of Koch-like criteria. Ageing Res. Rev. 12, 661-684. doi:10.1016/j.arr.2012.02.001
    • (2013) Ageing Res. Rev. , vol.12 , pp. 661-684
    • Moskalev, A.A.1    Shaposhnikov, M.V.2    Plyusnina, E.N.3    Zhavoronkov, A.4    Budovsky, A.5    Yanai, H.6
  • 54
    • 17944371854 scopus 로고    scopus 로고
    • Mobilized bone marrow cells repair the infarcted heart, improving function and survival
    • doi:10.1073/pnas.181177898
    • Orlic, D., Kajstura, J., Chimenti, S., Limana, F., Jakoniuk, I., Quaini, F., et al. (2001). Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. U.S.A. 98, 10344-10349. doi:10.1073/pnas.181177898
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 10344-10349
    • Orlic, D.1    Kajstura, J.2    Chimenti, S.3    Limana, F.4    Jakoniuk, I.5    Quaini, F.6
  • 55
    • 0036895463 scopus 로고    scopus 로고
    • Rat forebrain neurogenesis and striatal neuron replacement after focal stroke
    • doi:10.1002/ana.10393
    • Parent, J. M., Vexler, Z. S., Gong, C., Derugin, N., and Ferriero, D. M. (2002). Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann. Neurol. 52, 802-813. doi:10.1002/ana.10393
    • (2002) Ann. Neurol. , vol.52 , pp. 802-813
    • Parent, J.M.1    Vexler, Z.S.2    Gong, C.3    Derugin, N.4    Ferriero, D.M.5
  • 56
    • 51649129232 scopus 로고    scopus 로고
    • Mesenchymal stem cells transplantation could be beneficial for treatment of experimental ischemic stroke in rats
    • doi:10.1016/j.brainres.2008.06.123
    • Pavlichenko, N., Sokolova, I., Vijde, S., Shvedova, E., Alexandrov, G., Krouglyakov, P., et al. (2008). Mesenchymal stem cells transplantation could be beneficial for treatment of experimental ischemic stroke in rats. Brain Res. 1233, 203-213. doi:10.1016/j.brainres.2008.06.123
    • (2008) Brain Res , vol.1233 , pp. 203-213
    • Pavlichenko, N.1    Sokolova, I.2    Vijde, S.3    Shvedova, E.4    Alexandrov, G.5    Krouglyakov, P.6
  • 57
    • 78650230589 scopus 로고    scopus 로고
    • Perturbed cellular response to brain injury during aging
    • doi:10.1016/j.arr.2009.10.008
    • Popa-Wagner, A., Buga, A. M., and Kokaia, Z. (2011). Perturbed cellular response to brain injury during aging. Ageing Res. Rev. 10, 71-79. doi:10.1016/j.arr.2009.10.008
    • (2011) Ageing Res. Rev. , vol.10 , pp. 71-79
    • Popa-Wagner, A.1    Buga, A.M.2    Kokaia, Z.3
  • 58
    • 77951764744 scopus 로고    scopus 로고
    • Effects of granulocyte-colony stimulating factor after stroke in aged rats
    • doi:10.1161/STROKEAHA.109.575621
    • Popa-Wagner, A., Stocker, K., Balseanu, A., Rogalewski, A., Diederich, K., Minnerup, J., et al. (2010). Effects of granulocyte-colony stimulating factor after stroke in aged rats. Stroke 41, 1027-1031. doi:10.1161/STROKEAHA.109.575621
    • (2010) Stroke , vol.41 , pp. 1027-1031
    • Popa-Wagner, A.1    Stocker, K.2    Balseanu, A.3    Rogalewski, A.4    Diederich, K.5    Minnerup, J.6
  • 59
    • 0035956418 scopus 로고    scopus 로고
    • Neogenesis of cerebellar Purkinje neurons from genemarked bone marrow cells in vivo
    • doi:10.1083/jcb.200105103
    • Priller, J., Persons, D. A., Klett, F. F., Kempermann, G., Kreutzberg, G. W., and Dirnagl, U. (2001). Neogenesis of cerebellar Purkinje neurons from genemarked bone marrow cells in vivo. J. Cell Biol. 155, 733-738. doi:10.1083/jcb.200105103
    • (2001) J. Cell Biol. , vol.155 , pp. 733-738
    • Priller, J.1    Persons, D.A.2    Klett, F.F.3    Kempermann, G.4    Kreutzberg, G.W.5    Dirnagl, U.6
  • 60
    • 77958466892 scopus 로고    scopus 로고
    • Stem cell mediation of functional recovery after stroke in the rat
    • doi:10.1371/journal.pone.0012779
    • Ramos-Cabrer, P., Justicia, C., Wiedermann, D., and Hoehn, M. (2010). Stem cell mediation of functional recovery after stroke in the rat. PLoS ONE 5:e12779. doi:10.1371/journal.pone.0012779
    • (2010) PLoS ONE , vol.5
    • Ramos-Cabrer, P.1    Justicia, C.2    Wiedermann, D.3    Hoehn, M.4
  • 61
    • 84888309505 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for ischemic stroke trial
    • doi:10.1161/STROKEAHA.113.001531
    • Ringelstein, E. B., Thijs, V., Norrving, B., Chamorro, A., Aichner, F., Grond, M., et al. (2013). Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for ischemic stroke trial. Stroke 44, 2681-2687. doi:10.1161/STROKEAHA.113.001531
    • (2013) Stroke , vol.44 , pp. 2681-2687
    • Ringelstein, E.B.1    Thijs, V.2    Norrving, B.3    Chamorro, A.4    Aichner, F.5    Grond, M.6
  • 62
    • 57049136556 scopus 로고    scopus 로고
    • A population of serum deprivation-induced bone marrow stem cells (SD-BMSC) expresses marker typical for embryonic and neural stem cells
    • doi:10.1016/j.yexcr.2008.10.007
    • Sauerzweig, S., Munsch, T., Lessmann, V., Reymann, K. G., and Braun, H. (2009). A population of serum deprivation-induced bone marrow stem cells (SD-BMSC) expresses marker typical for embryonic and neural stem cells. Exp. Cell Res. 315, 50-66. doi:10.1016/j.yexcr.2008.10.007
    • (2009) Exp. Cell Res. , vol.315 , pp. 50-66
    • Sauerzweig, S.1    Munsch, T.2    Lessmann, V.3    Reymann, K.G.4    Braun, H.5
  • 63
    • 37549052559 scopus 로고    scopus 로고
    • A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF)
    • doi:10.1038/sj.jcbfm.9600496
    • Schäbitz, W. R., Krüger, C., Pitzer, C., Weber, D., Laage, R., Gassler, N., et al. (2008). A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF). J. Cereb. Blood Flow Metab. 28, 29-43. doi:10.1038/sj.jcbfm.9600496
    • (2008) J. Cereb. Blood Flow Metab. , vol.28 , pp. 29-43
    • Schäbitz, W.R.1    Krüger, C.2    Pitzer, C.3    Weber, D.4    Laage, R.5    Gassler, N.6
  • 64
    • 33947605748 scopus 로고    scopus 로고
    • New targets for established proteins: exploring G-CSF for the treatment of stroke
    • doi:10.1016/j.tips.2007.02.007
    • Schäbitz, W. R., and Schneider, A. (2007). New targets for established proteins: exploring G-CSF for the treatment of stroke. Trends Pharmacol. Sci. 28, 157-161. doi:10.1016/j.tips.2007.02.007
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 157-161
    • Schäbitz, W.R.1    Schneider, A.2
  • 65
    • 23644445498 scopus 로고    scopus 로고
    • The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    • doi:10.1172/JCI23559
    • Schneider, A., Krüger, C., Steigleder, T., Weber, D., Pitzer, C., Laage, R., et al. (2005). The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J. Clin. Invest. 115, 2083-2098. doi:10.1172/JCI23559
    • (2005) J. Clin. Invest. , vol.115 , pp. 2083-2098
    • Schneider, A.1    Krüger, C.2    Steigleder, T.3    Weber, D.4    Pitzer, C.5    Laage, R.6
  • 66
    • 33744819984 scopus 로고    scopus 로고
    • Reply: GDNF poses troubling questions for doctors, drug maker
    • doi:10.1002/ana.20880
    • Slevin, J. T., Gerhardt, G. A., Smith, C. D., Gash, D. M., and Young, A. B. (2006). Reply: GDNF poses troubling questions for doctors, drug maker. Ann. Neurol. 59, 989-990. doi:10.1002/ana.20880
    • (2006) Ann. Neurol. , vol.59 , pp. 989-990
    • Slevin, J.T.1    Gerhardt, G.A.2    Smith, C.D.3    Gash, D.M.4    Young, A.B.5
  • 67
    • 43049139914 scopus 로고    scopus 로고
    • Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells
    • doi:10.1038/gt.2008.39
    • Spaeth, E., Klopp, A., Dembinski, J., Andreeff, M., and Marini, F. (2008). Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells. Gene Ther. 15, 730-738. doi:10.1038/gt.2008.39
    • (2008) Gene Ther , vol.15 , pp. 730-738
    • Spaeth, E.1    Klopp, A.2    Dembinski, J.3    Andreeff, M.4    Marini, F.5
  • 68
    • 84858152974 scopus 로고    scopus 로고
    • Systemically administered human bone marrow-derived mesenchymal stem home into peripheral organs but do not induce neuroprotective effects in the MCAo-mouse model for cerebral ischemia
    • doi:10.1016/j.neulet.2012.01.078
    • Steiner, B., Roch, M., Holtkamp, N., and Kurtz, A. (2012). Systemically administered human bone marrow-derived mesenchymal stem home into peripheral organs but do not induce neuroprotective effects in the MCAo-mouse model for cerebral ischemia. Neurosci. Lett. 513, 25-30. doi:10.1016/j.neulet.2012.01.078
    • (2012) Neurosci. Lett. , vol.513 , pp. 25-30
    • Steiner, B.1    Roch, M.2    Holtkamp, N.3    Kurtz, A.4
  • 69
    • 84873100398 scopus 로고    scopus 로고
    • Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model
    • doi:10.1016/j.brainres.2012.12.028
    • Suzuki, J., Sasaki, M., Harada, K., Bando, M., Kataoka, Y., Onodera, R., et al. (2013). Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model. Brain Res. 1497, 15-22. doi:10.1016/j.brainres.2012.12.028
    • (2013) Brain Res , vol.1497 , pp. 15-22
    • Suzuki, J.1    Sasaki, M.2    Harada, K.3    Bando, M.4    Kataoka, Y.5    Onodera, R.6
  • 70
    • 78650254124 scopus 로고    scopus 로고
    • Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior
    • doi:10.1038/mp.2009.110
    • Tfilin, M., Sudai, E., Merenlender, A., Gispan, I., Yadid, G., and Turgeman, G. (2010). Mesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior. Mol. Psychiatry 15, 1164-1175. doi:10.1038/mp.2009.110
    • (2010) Mol. Psychiatry , vol.15 , pp. 1164-1175
    • Tfilin, M.1    Sudai, E.2    Merenlender, A.3    Gispan, I.4    Yadid, G.5    Turgeman, G.6
  • 71
    • 0036196175 scopus 로고    scopus 로고
    • Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine(1A) receptor agonist OPC-14523(1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3 4-dihydro-2[1H]-quinolinone monomethanesulfonate)
    • doi:10.1124/jpet.301.1.249
    • Tottori, K., Nakai, M., Uwahodo, Y., Miwa, T., Yamada, S., Oshiro, Y., et al. (2002). Attenuation of scopolamine-induced and age-associated memory impairments by the sigma and 5-hydroxytryptamine(1A) receptor agonist OPC-14523(1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate). J. Pharmacol. Exp. Ther. 301, 249-257. doi:10.1124/jpet.301.1.249
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 249-257
    • Tottori, K.1    Nakai, M.2    Uwahodo, Y.3    Miwa, T.4    Yamada, S.5    Oshiro, Y.6
  • 72
    • 11244276997 scopus 로고    scopus 로고
    • VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena
    • doi:10.1093/brain/awh325
    • Wang, Y., Kilic, E., Kilic, U., Weber, B., Bassetti, C. L., Marti, H. H., et al. (2005). VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena. Brain 128(Pt 1), 52-63. doi:10.1093/brain/awh325
    • (2005) Brain , vol.128 , Issue.Pt 1 , pp. 52-63
    • Wang, Y.1    Kilic, E.2    Kilic, U.3    Weber, B.4    Bassetti, C.L.5    Marti, H.H.6
  • 73
    • 84880155067 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes pericyte coverage of brain capillaries, improves cerebral blood flow during subsequent focal cerebral ischemia, and preserves the metabolic penumbra
    • doi:10.1161/STROKEAHA.111.000240
    • Zechariah, A., ElAli, A., Doeppner, T. R., Jin, F., Hasan, M. R., Helfrich, I., et al. (2013). Vascular endothelial growth factor promotes pericyte coverage of brain capillaries, improves cerebral blood flow during subsequent focal cerebral ischemia, and preserves the metabolic penumbra. Stroke 44, 1690-1697. doi:10.1161/STROKEAHA.111.000240
    • (2013) Stroke , vol.44 , pp. 1690-1697
    • Zechariah, A.1    ElAli, A.2    Doeppner, T.R.3    Jin, F.4    Hasan, M.R.5    Helfrich, I.6
  • 74
    • 0036901546 scopus 로고    scopus 로고
    • Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic acid
    • doi:10.1161/01.STR.0000037787.07479.9A
    • Zhang, C., and Harder, D. R. (2002). Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic acid. Stroke 33, 2957-2964. doi:10.1161/01.STR.0000037787.07479.9A
    • (2002) Stroke , vol.33 , pp. 2957-2964
    • Zhang, C.1    Harder, D.R.2
  • 75
    • 0036118625 scopus 로고    scopus 로고
    • Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats
    • doi:10.1006/exnr.2001.7853
    • Zhao, L. R., Duan, W. M., Reyes, M., Keene, C. D., Verfaillie, C. M., and Low, W. C. (2002). Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp. Neurol. 174, 11-20. doi:10.1006/exnr.2001.7853
    • (2002) Exp. Neurol. , vol.174 , pp. 11-20
    • Zhao, L.R.1    Duan, W.M.2    Reyes, M.3    Keene, C.D.4    Verfaillie, C.M.5    Low, W.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.