Weight loss herbal intervention therapy (W-LHIT) a non-appetite suppressing natural product controls weight and lowers cholesterol and glucose levels in a murine model

BMC Complementary and Alternative Medicine

Volumn 14, Issue , 2014, Pages

  Yang, Nan ^a   Chung, Danna ^a   Liu, Changda ^a   Liang, Banghao ^a   Li, Xiu Min ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

C57BL 6 J; Cholesterol; High fat diet; Obesity; PPAR ; Serum glucose; W LHIT natural product; Weight loss

Indexed keywords

ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; ANTIOBESITY AGENT; ASTRAGALUS EXTRACT; CHAENOMELES SPECIOSA ETRACT; CHINESE DRUG; CHOLESTEROL; COPTIS CHINENSIS EXTRACT; FATTY ACID BINDING PROTEIN 4; FRUCTUS AURANTII EXTRACT; GANODERMA LUCIDUM EXTRACT; GLUCOSE; NELUMBO NUCIFERA EXTRACT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; UNCLASSIFIED DRUG; HERBACEOUS AGENT; NATURAL PRODUCT; WEIGHT LOSS HERBAL INTERVENTION THERAPY;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BLOOD TOXICITY; CALORIC RESTRICTION; CHAENOMELES SPECIOSA; CHINESE MEDICINE; CHOLESTEROL BLOOD LEVEL; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG SAFETY; EPIDIDYMIS FAT; FOOD INTAKE; FRUCTUS AURANTII; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; KIDNEY FUNCTION; LIPID DIET; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; OBESITY; SHAM PROCEDURE; TOXICITY TESTING; WEIGHT GAIN; WEIGHT REDUCTION; BODY WEIGHT; GENE EXPRESSION; WEIGHT CONTROL;

ADIPOSE TISSUE; ANIMALS; ANTI-OBESITY AGENTS; BLOOD GLUCOSE; BODY WEIGHT; CHOLESTEROL; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; MALE; MICE; MICE, INBRED C57BL; OBESITY; PHYTOTHERAPY; PLANT EXTRACTS; PPAR GAMMA;

EID: 84904534397     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-261     Document Type: Article

References (36)

1. World Health Organization Obesity and overweight 2008, http://www.who.int/mediacentre/factsheets/fs311/en/ (updated 2013), World Health Organization.
2. Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010, 303:235-241. 10.1001/jama.2009.2014, 20071471.
3. Kopelman PG. Obesity as a medical problem. Nature 2000, 404:635-643.
4. Bardou M, Barkun AN, Martel M. Obesity and colorectal cancer. Gut 2013, 62:933-947. 10.1136/gutjnl-2013-304701, 23481261.
5. Maynard LM, Serdula MK, Galuska DA, Gillespie C, Mokdad AH. Secular trends in desired weight of adults. Int J Obes (Lond) 2006, 30:1375-1381. 10.1038/sj.ijo.0803297, 16552407.
6. Maahs D, de Serna DG, Kolotkin RL, Ralston S, Sandate J, Qualls C, Schade DS. Randomized, double-blind, placebo-controlled trial of orlistat for weight loss in adolescents. Endocr Pract 2006, 12:18-28. 10.4158/EP.12.1.18, 16524859.
7. Manore MM. Dietary supplements for improving body composition and reducing body weight: where is the evidence?. Int J Sport Nutr Exerc Metab 2012, 22:139-154.
8. U.S.Food and Drug Administration (FDA) FDA warns consumers about Brazilian diet pills found to contain active drug ingredients 2006, http://www.fda.gov/newsevents/newsroom/pressannouncements/2006/ucm108578.htm, U.S.Food and Drug Administration (FDA).
9. NCCAM/NIH NCCAM Strategic Plan 2005-2009: Expanding Horizons of Health Care http://nccam.nih.gov/sites/nccam.nih.gov/files/about/plans/2005/strategicplan.pdf. Accessed on 2011, NCCAM/NIH.
10. Lenon GB, Li KX, Chang YH, Yang AW, Da Costa C, Li CG, Cohen M, Mann N, Xue CC. Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial. Evid Based Complement Alternat Med 2012, 2012:435702. 3328918, 22550541.
11. Xiong Y, Shen L, Liu KJ, Tso P, Xiong Y, Wang G, Woods SC, Liu M. Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes 2010, 59:2505-2512. 10.2337/db10-0315, 3279544, 20682695.
12. Hariri N, Thibault L. High-fat diet-induced obesity in animal models. Nutr Res Rev 2010, 23:270-299. 10.1017/S0954422410000168, 20977819.
13. Ko SG, Jang HJ, Lee BC, Lee KT, Lee KM, Lee H, Kim SH, Kim SJ, Hong SH, Um JY. Corni Fructus Containing Formulation Attenuates Weight Gain in Mice with Diet-Induced Obesity and Regulates Adipogenesis through AMPK. Evid Based Complement Alternat Med 2013, 2013:423741. 3792538, 24171041.
14. Xie W, Gu D, Li J, Cui K, Zhang Y. Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice. PLoS One 2011, 6:e24520. 10.1371/journal.pone.0024520, 3167861, 21915347.
15. You JS, Lee YJ, Kim KS, Kim SH, Chang KJ. Anti-obesity and hypolipidaemic effects of Nelumbo nucifera seed ethanol extract in human pre-adipocytes and rats fed a high-fat diet. J Sci Food Agric 2013, 94:568-575.
16. Wang CD, Teng BS, He YM, Wu JS, Pan D, Pan LF, Zhang D, Fan ZH, Yang HJ, Zhou P. Effect of a novel proteoglycan PTP1B inhibitor from Ganoderma lucidum on the amelioration of hyperglycaemia and dyslipidaemia in db/db mice. Br J Nutr 2012, 108:2014-2025. 10.1017/S0007114512000153, 22453054.
17. Hoo RL, Wong JY, Qiao C, Xu A, Xu H, Lam KS. The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity. Nutr Metab (Lond) 2010, 7:67. 10.1186/1743-7075-7-67, 2936435, 20735814.
18. Institute of Laboratory Animal Resources Commission of Life Sciences NRC Guide for the Care and Use of Laboratory Animals 1996, Washington D.C.: National Academy Press, Institute of Laboratory Animal Resources Commission of Life Sciences NRC.
19. Kelly-Pieper K, Patil SP, Busse P, Yang N, Sampson H, Li XM, Wisnivesky JP, Kattan M. Safety and tolerability of an antiasthma herbal Formula (ASHMI) in adult subjects with asthma: a randomized, double-blinded, placebo-controlled, dose-escalation phase I study. J Altern Complement Med 2009, 15:735-743. 10.1089/acm.2008.0543, 2830609,2830609, 19586409.
20. Dolan SP, Nortrup DA, Bolger PM, Capar SG. Analysis of dietary supplements for arsenic, cadmium, mercury, and lead using inductively coupled plasma mass spectrometry. J Agric Food Chem 2003, 51:1307-1312. 10.1021/jf026055x, 12590474.
21. Caldas ED, Machado LL. Cadmium, mercury and lead in medicinal herbs in Brazil. Food Chem Toxicol 2004, 42:599-603. 10.1016/j.fct.2003.11.004, 15019183.
22. Raman P, Patino LC, Nair MG. Evaluation of metal and microbial contamination in botanical supplements. J Agric Food Chem 2004, 52:7822-7827. 10.1021/jf049150+, 15612762.
23. The State Pharmacopoeia Commission of The People's Republic of China Pharmacopoeia of the People's Republic of China 2005, Beijing: People's Medical Publishing House, 6, The State Pharmacopoeia Commission of The People's Republic of China.
24. The state of administration of Traditional Chinese Medicine of the People's Republic of China Standards of Import and Export of Green Medicinal Plants and Their Preparations 2001, Ministry of Foreign Trade and Economic Cooperation, People's Republic of China, The state of administration of Traditional Chinese Medicine of the People's Republic of China.
25. Xiu SY. The Experimental Method of Pharmacology 1986, Beijing: The People's Public Health Publisher.
26. Alexander J, Chang GQ, Dourmashkin JT, Leibowitz SF. Distinct phenotypes of obesity-prone AKR/J, DBA2J and C57BL/6 J mice compared to control strains. Int J Obes (Lond) 2006, 30:50-59. 10.1038/sj.ijo.0803110, 16231032.
27. Clemente-Postigo M, Queipo-Ortuno MI, Fernandez-Garcia D, Gomez-Huelgas R, Tinahones FJ, Cardona F. Adipose tissue gene expression of factors related to lipid processing in obesity. PLoS One 2011, 6:e24783. 10.1371/journal.pone.0024783, 3178563, 21966368.
28. Queipo-Ortuno MI, Escote X, Ceperuelo-Mallafre V, Garrido-Sanchez L, Miranda M, Clemente-Postigo M, Perez-Perez R, Peral B, Cardona F, Fernandez-Real JM, Tinahones FJ, Vendrell J. FABP4 dynamics in obesity: discrepancies in adipose tissue and liver expression regarding circulating plasma levels. PLoS One 2012, 7:e48605. 10.1371/journal.pone.0048605, 3489666, 23139800.
29. Boss O, Hagen T, Lowell BB. Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. Diabetes 2000, 49:143-156. 10.2337/diabetes.49.2.143, 10868929.
30. Jambor de Sousa UL, Koss MD, Fillies M, Gahl A, Scheeder MR, Cardoso MC, Leonhardt H, Geary N, Langhans W, Leonhardt M. CPT1alpha over-expression increases long-chain fatty acid oxidation and reduces cell viability with incremental palmitic acid concentration in 293T cells. Biochem Biophys Res Commun 2005, 338:757-761. 10.1016/j.bbrc.2005.10.016, 16246309.
31. Canto C, Auwerx J. AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci 2010, 67:3407-3423. 10.1007/s00018-010-0454-z, 3622821, 20640476.
32. Monsalve FA, Pyarasani RD, Delgado-Lopez F, Moore-Carrasco R. Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases. Mediators Inflamm 2013, 2013:549627. 3678499, 23781121.
33. Klopotek A, Hirche F, Eder K. PPAR gamma ligand troglitazone lowers cholesterol synthesis in HepG2 and Caco-2 cells via a reduced concentration of nuclear SREBP-2. Exp Biol Med (Maywood) 2006, 231:1365-1372.
34. Li T, Chiang JY. Regulation of bile acid and cholesterol metabolism by PPARs. PPAR Res 2009, 2009:501739. 2712638, 19636418.
35. Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002, 13:84-89. 10.1016/S1043-2760(01)00524-0, 11854024.
36. Bensky DCS, Stoger E. Chinese Herbal Medicine: Material and Meidica 2004, Seattle: Eastland Press, Inc, 3.