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Volumn , Issue , 2009, Pages

Regulation of bile acid and cholesterol metabolism by PPARs

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; ATORVASTATIN; BEZAFIBRATE; BILE ACID; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CLOFIBRATE; FENOFIBRATE; FIBRIC ACID DERIVATIVE; GEMFIBROZIL; GW 610742; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PIRINIXIC ACID; ROSIGLITAZONE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TORCETRAPIB; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

EID: 68949122515     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2009/501739     Document Type: Review
Times cited : (161)

References (149)
  • 1
    • 1942518840 scopus 로고    scopus 로고
    • PPARs and the complex journey to obesity
    • Evans R. M., Barish G. D., Wang Y.-X., PPARs and the complex journey to obesity Nature Medicine 2004 10 4 355 361
    • (2004) Nature Medicine , vol.10 , Issue.4 , pp. 355-361
    • Evans, R.M.1    Barish, G.D.2    Wang, Y.-X.3
  • 2
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann I., Green S., Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators Nature 1990 347 6294 645 650
    • (1990) Nature , vol.347 , Issue.6294 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 3
    • 0026517010 scopus 로고
    • Control of the peroxisomal -oxidation pathway by a novel family of nuclear hormone receptors
    • Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W., Control of the peroxisomal -oxidation pathway by a novel family of nuclear hormone receptors Cell 1992 68 5 879 887
    • (1992) Cell , vol.68 , Issue.5 , pp. 879-887
    • Dreyer, C.1    Krey, G.2    Keller, H.3    Givel, F.4    Helftenbein, G.5    Wahli, W.6
  • 5
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor activates fat metabolism to prevent obesity
    • Wang Y.-X., Lee C.-H., Tiep S., Peroxisome-proliferator-activated receptor activates fat metabolism to prevent obesity Cell 2003 113 2 159 170
    • (2003) Cell , vol.113 , Issue.2 , pp. 159-170
    • Wang, Y.-X.1    Lee, C.-H.2    Tiep, S.3
  • 7
    • 0026778193 scopus 로고
    • Bile acid biosynthesis
    • Russell D. W., Setchell K. D. R., Bile acid biosynthesis Biochemistry 1992 31 20 4737 4749
    • (1992) Biochemistry , vol.31 , Issue.20 , pp. 4737-4749
    • Russell, D.W.1    Setchell, K.D.R.2
  • 8
    • 0000778664 scopus 로고    scopus 로고
    • Regulation of bile acid synthesis
    • Chiang J. Y., Regulation of bile acid synthesis Frontiers in Bioscience 1998 3 D176 D193
    • (1998) Frontiers in Bioscience , vol.3
    • Chiang, J.Y.1
  • 9
    • 0036668184 scopus 로고    scopus 로고
    • Bile acid regulation of gene expression: Roles of nuclear hormone receptors
    • Chiang J. Y., Bile acid regulation of gene expression: roles of nuclear hormone receptors Endocrine Reviews 2002 23 4 443 463
    • (2002) Endocrine Reviews , vol.23 , Issue.4 , pp. 443-463
    • Chiang, J.Y.1
  • 11
    • 0026551710 scopus 로고
    • Mechanism of degradation of the steroid side chain in the formation of bile acids
    • Bjorkhem I., Mechanism of degradation of the steroid side chain in the formation of bile acids Journal of Lipid Research 1992 33 4 455 471
    • (1992) Journal of Lipid Research , vol.33 , Issue.4 , pp. 455-471
    • Bjorkhem, I.1
  • 12
    • 0025045782 scopus 로고
    • Potential bile acid precursors in plasmapossible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man
    • Axelson M., Sjovall J., Potential bile acid precursors in plasmapossible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man Journal of Steroid Biochemistry 1990 36 6 631 640
    • (1990) Journal of Steroid Biochemistry , vol.36 , Issue.6 , pp. 631-640
    • Axelson, M.1    Sjovall, J.2
  • 13
    • 0023933622 scopus 로고
    • Occurrence of 3 -hydroxy-5-cholestenoic acid, 3 ,7 -dihydroxy-5- cholestenoic acid, and 7 -hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood
    • Axelson M., Mork B., Sjovall J., Occurrence of 3 -hydroxy-5-cholestenoic acid, 3,7 -dihydroxy-5-cholestenoic acid, and 7 -hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood Journal of Lipid Research 1988 29 5 629 641
    • (1988) Journal of Lipid Research , vol.29 , Issue.5 , pp. 629-641
    • Axelson, M.1    Mork, B.2    Sjovall, J.3
  • 14
    • 0032541028 scopus 로고    scopus 로고
    • Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways
    • Pikuleva I. A., Babiker A., Waterman M. R., Bjrkhem I., Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways Journal of Biological Chemistry 1998 273 29 18153 18160
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.29 , pp. 18153-18160
    • Pikuleva, I.A.1    Babiker, A.2    Waterman, M.R.3    Bjrkhem, I.4
  • 15
    • 0037379362 scopus 로고    scopus 로고
    • Bile salt transporters: Molecular characterization, function, and regulation
    • Trauner M., Boyer J. L., Bile salt transporters: molecular characterization, function, and regulation Physiological Reviews 2003 83 2 633 671
    • (2003) Physiological Reviews , vol.83 , Issue.2 , pp. 633-671
    • Trauner, M.1    Boyer, J.L.2
  • 16
    • 0019224595 scopus 로고
    • New concepts of mechanisms of hepatocyte bile formation
    • Boyer J. L., New concepts of mechanisms of hepatocyte bile formation Physiological Reviews 1980 60 2 303 326
    • (1980) Physiological Reviews , vol.60 , Issue.2 , pp. 303-326
    • Boyer, J.L.1
  • 17
    • 0029615982 scopus 로고
    • Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile
    • Meier P. J., Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile American Journal of Physiology 1995 269 6 G801 G812
    • (1995) American Journal of Physiology , vol.269 , Issue.6
    • Meier, P.J.1
  • 20
    • 0030725999 scopus 로고    scopus 로고
    • Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
    • Meier P. J., Eckhardt U., Schroeder A., Hagenbuch B., Stieger B., Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver Hepatology 1997 26 6 1667 1677
    • (1997) Hepatology , vol.26 , Issue.6 , pp. 1667-1677
    • Meier, P.J.1    Eckhardt, U.2    Schroeder, A.3    Hagenbuch, B.4    Stieger, B.5
  • 23
    • 0034595593 scopus 로고    scopus 로고
    • Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver
    • Cattori V., Hagenbuch B., Hagenbuch N., Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver FEBS Letters 2000 474 2-3 242 245
    • (2000) FEBS Letters , vol.474 , Issue.2-3 , pp. 242-245
    • Cattori, V.1    Hagenbuch, B.2    Hagenbuch, N.3
  • 24
    • 0040368659 scopus 로고    scopus 로고
    • Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
    • Abe T., Kakyo M., Tokui T., Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 Journal of Biological Chemistry 1999 274 24 17159 17163
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.24 , pp. 17159-17163
    • Abe, T.1    Kakyo, M.2    Tokui, T.3
  • 25
    • 0029022589 scopus 로고
    • Identification of a sister gene to P-glycoprotein
    • Childs S., Yeh R. L., Georges E., Ling V., Identification of a sister gene to P-glycoprotein Cancer Research 1995 55 10 2029 2034
    • (1995) Cancer Research , vol.55 , Issue.10 , pp. 2029-2034
    • Childs, S.1    Yeh, R.L.2    Georges, E.3    Ling, V.4
  • 26
    • 0030869696 scopus 로고    scopus 로고
    • Identification of a locus for progressive familial intrahepatic cholestasis PFIC2 on chromosome 2q24
    • Strautnieks S. S., Kagalwalla A. F., Tanner M. S., Identification of a locus for progressive familial intrahepatic cholestasis PFIC2 on chromosome 2q24 American Journal of Human Genetics 1997 61 3 630 633
    • (1997) American Journal of Human Genetics , vol.61 , Issue.3 , pp. 630-633
    • Strautnieks, S.S.1    Kagalwalla, A.F.2    Tanner, M.S.3
  • 27
    • 0033736679 scopus 로고    scopus 로고
    • Mechanisms of biliary lipid secretion and their role in lipid homeostasis
    • Oude Elferink R. P. J., Groen A. K., Mechanisms of biliary lipid secretion and their role in lipid homeostasis Seminars in Liver Disease 2000 20 3 293 305
    • (2000) Seminars in Liver Disease , vol.20 , Issue.3 , pp. 293-305
    • Oude Elferink, R.P.J.1    Groen, A.K.2
  • 28
    • 0027363563 scopus 로고
    • Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
    • Smit J. J. M., Schinkel A. H., Elferink R. P., Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease Cell 1993 75 3 451 462
    • (1993) Cell , vol.75 , Issue.3 , pp. 451-462
    • Smit, J.J.M.1    Schinkel, A.H.2    Elferink, R.P.3
  • 29
    • 23244450463 scopus 로고    scopus 로고
    • ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile
    • Langheim S., Yu L., von Bergmann K., ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile Journal of Lipid Research 2005 46 8 1732 1738
    • (2005) Journal of Lipid Research , vol.46 , Issue.8 , pp. 1732-1738
    • Langheim, S.1    Yu, L.2    Von Bergmann, K.3
  • 32
    • 0030944084 scopus 로고    scopus 로고
    • Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)
    • Oelkers P., Kirby L. C., Heubi J. E., Dawson P. A., Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2) Journal of Clinical Investigation 1997 99 8 1880 1887
    • (1997) Journal of Clinical Investigation , vol.99 , Issue.8 , pp. 1880-1887
    • Oelkers, P.1    Kirby, L.C.2    Heubi, J.E.3    Dawson, P.A.4
  • 34
    • 14844291348 scopus 로고    scopus 로고
    • The heteromeric organic solute transporter - , Ost -Ost , is an ileal basolateral bile acid transporter
    • Dawson P. A., Hubbert M., Haywood J., The heteromeric organic solute transporter -, Ost -Ost, is an ileal basolateral bile acid transporter Journal of Biological Chemistry 2005 280 8 6960 6968
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.8 , pp. 6960-6968
    • Dawson, P.A.1    Hubbert, M.2    Haywood, J.3
  • 35
    • 51149089559 scopus 로고    scopus 로고
    • Ost -Ost is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver
    • Ballatori N., Fang F., Christian W. V., Li N., Hammond C. L., Ost -Ost is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver American Journal of Physiology 2008 295 1 G179 G186
    • (2008) American Journal of Physiology , vol.295 , Issue.1
    • Ballatori, N.1    Fang, F.2    Christian, W.V.3    Li, N.4    Hammond, C.L.5
  • 36
    • 0015472014 scopus 로고
    • Mechanisms of action of clofibrate on cholesterol metabolism in patients with hyperlipidemia
    • Grundy S. M., Ahrens E. H. Jr., Salen G., Mechanisms of action of clofibrate on cholesterol metabolism in patients with hyperlipidemia Journal of Lipid Research 1972 13 4 531 551
    • (1972) Journal of Lipid Research , vol.13 , Issue.4 , pp. 531-551
    • Grundy, S.M.1    Ahrens Jr., E.H.2    Salen, G.3
  • 37
    • 0021276830 scopus 로고
    • Influence of gemfibrozil and clofibrate on metabolism of cholesterol and plasma triglycerides in man
    • Kesaniemi Y. A., Grundy S. M., Influence of gemfibrozil and clofibrate on metabolism of cholesterol and plasma triglycerides in man Journal of the American Medical Association 1984 251 17 2241 2246
    • (1984) Journal of the American Medical Association , vol.251 , Issue.17 , pp. 2241-2246
    • Kesaniemi, Y.A.1    Grundy, S.M.2
  • 39
    • 0022525548 scopus 로고
    • Biliary lipid secretion in patients with heterozygous familial hypercholesterolemia and combined hyperlipidemia. Influence of bezafibrate and fenofibrate
    • Leiss O., Meyer-Krahmer K., von Bergmann K., Biliary lipid secretion in patients with heterozygous familial hypercholesterolemia and combined hyperlipidemia. Influence of bezafibrate and fenofibrate Journal of Lipid Research 1986 27 7 713 723
    • (1986) Journal of Lipid Research , vol.27 , Issue.7 , pp. 713-723
    • Leiss, O.1    Meyer-Krahmer, K.2    Von Bergmann, K.3
  • 40
    • 84991145406 scopus 로고
    • Influence of bezafibrate on hepatic cholesterol metabolism in gallstone patients: Reduced activity of cholesterol 7 -hydroxylase
    • Stahlberg D., Reihnr E., Rudling M., Berglund L., Einarsson K., Angelin B. O., Influence of bezafibrate on hepatic cholesterol metabolism in gallstone patients: reduced activity of cholesterol 7 -hydroxylase Hepatology 1995 21 4 1025 1030
    • (1995) Hepatology , vol.21 , Issue.4 , pp. 1025-1030
    • Stahlberg, D.1    Reihnr, E.2    Rudling, M.3    Berglund, L.4    Einarsson, K.5    Angelin, B.O.6
  • 41
    • 0029143455 scopus 로고
    • Effects of different phenotypes of hyperlipoproteinemia and of treatment with fibric acid derivatives on the rates of cholesterol 7 -hydroxylation in humans
    • Bertolotti M., Concari M., Loria P., Effects of different phenotypes of hyperlipoproteinemia and of treatment with fibric acid derivatives on the rates of cholesterol 7 -hydroxylation in humans Arteriosclerosis, Thrombosis, and Vascular Biology 1995 15 8 1064 1069
    • (1995) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.15 , Issue.8 , pp. 1064-1069
    • Bertolotti, M.1    Concari, M.2    Loria, P.3
  • 42
    • 85047684249 scopus 로고    scopus 로고
    • Human cholesterol 7 -hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype
    • Pullinger C. R., Eng C., Salen G., Human cholesterol 7 -hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype Journal of Clinical Investigation 2002 110 1 109 117
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.1 , pp. 109-117
    • Pullinger, C.R.1    Eng, C.2    Salen, G.3
  • 43
    • 0033999108 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR ) and agonist inhibit cholesterol 7 -hydroxylase gene (CYP7A1) transcription
    • Marrapodi M., Chiang J. Y. L., Peroxisome proliferator-activated receptor (PPAR ) and agonist inhibit cholesterol 7 -hydroxylase gene (CYP7A1) transcription Journal of Lipid Research 2000 41 4 514 520
    • (2000) Journal of Lipid Research , vol.41 , Issue.4 , pp. 514-520
    • Marrapodi, M.1    Chiang, J.Y.L.2
  • 44
    • 0034331437 scopus 로고    scopus 로고
    • The effect of peroxisome-proliferator-activated receptor- on the activity of the cholesterol 7 -hydroxylase gene
    • Patel D. D., Knight B. L., Soutar A. K., Gibbons G. F., Wade D. P., The effect of peroxisome-proliferator-activated receptor- on the activity of the cholesterol 7 -hydroxylase gene Biochemical Journal 2000 351 3 747 753
    • (2000) Biochemical Journal , vol.351 , Issue.3 , pp. 747-753
    • Patel, D.D.1    Knight, B.L.2    Soutar, A.K.3    Gibbons, G.F.4    Wade, D.P.5
  • 45
    • 0035570381 scopus 로고    scopus 로고
    • Fibrates suppress bile acid synthesis via peroxisome proliferator- activated receptor- -mediated downregulation of cholesterol 7 -hydroxylase and sterol 27-hydroxylase expression
    • Post S. M., Duez H., Gervois P. P., Staels B., Kuipers F., Princen H. M. G., Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor- -mediated downregulation of cholesterol 7 -hydroxylase and sterol 27-hydroxylase expression Arteriosclerosis, Thrombosis, and Vascular Biology 2001 21 11 1840 1845
    • (2001) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.21 , Issue.11 , pp. 1840-1845
    • Post, S.M.1    Duez, H.2    Gervois, P.P.3    Staels, B.4    Kuipers, F.5    Princen, H.M.G.6
  • 47
    • 0032892176 scopus 로고    scopus 로고
    • Removal of cholesterol from extrahepatic sources by oxidative mechanisms
    • Bjorkhem I., Diczfalusy U., Lutjohann D., Removal of cholesterol from extrahepatic sources by oxidative mechanisms Current Opinion in Lipidology 1999 10 2 161 165
    • (1999) Current Opinion in Lipidology , vol.10 , Issue.2 , pp. 161-165
    • Bjorkhem, I.1    Diczfalusy, U.2    Lutjohann, D.3
  • 48
    • 4444337443 scopus 로고    scopus 로고
    • Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages
    • Szanto A., Benko S., Szatmari I., Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages Molecular and Cellular Biology 2004 24 18 8154 8166
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.18 , pp. 8154-8166
    • Szanto, A.1    Benko, S.2    Szatmari, I.3
  • 49
    • 13444266129 scopus 로고    scopus 로고
    • Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: A role for RXR and PPAR ligands
    • Quinn C. M., Jessup W., Wong J., Kritharides L., Brown A. J., Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPAR ligands Biochemical Journal 2005 385 3 823 830
    • (2005) Biochemical Journal , vol.385 , Issue.3 , pp. 823-830
    • Quinn, C.M.1    Jessup, W.2    Wong, J.3    Kritharides, L.4    Brown, A.J.5
  • 50
    • 0028826623 scopus 로고
    • Bile acids as drugs: Principles, mechanisms of action and formulations
    • Hofmann A. F., Bile acids as drugs: principles, mechanisms of action and formulations Italian Journal of Gastroenterology 1995 27 2 106 113
    • (1995) Italian Journal of Gastroenterology , vol.27 , Issue.2 , pp. 106-113
    • Hofmann, A.F.1
  • 51
    • 0032866276 scopus 로고    scopus 로고
    • Structure, evolution, and liver-specific expression of sterol 12 -hydroxylase P450 (CYP8B)
    • Ishida H., Kuruta Y., Gotoh O., Yamashita C., Yoshida Y., Noshiro M., Structure, evolution, and liver-specific expression of sterol 12 -hydroxylase P450 (CYP8B) Journal of Biochemistry 1999 126 1 19 25
    • (1999) Journal of Biochemistry , vol.126 , Issue.1 , pp. 19-25
    • Ishida, H.1    Kuruta, Y.2    Gotoh, O.3    Yamashita, C.4    Yoshida, Y.5    Noshiro, M.6
  • 52
    • 0034666324 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor (PPAR ) regulates bile acid biosynthesis
    • Hunt M. C., Yang Y.-Z., Eggertsen G., The peroxisome proliferator- activated receptor (PPAR ) regulates bile acid biosynthesis Journal of Biological Chemistry 2000 275 37 28947 28953
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.37 , pp. 28947-28953
    • Hunt, M.C.1    Yang, Y.-Z.2    Eggertsen, G.3
  • 53
    • 0037325403 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR )-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice
    • Kok T., Bloks V. W., Wolters H., Peroxisome proliferator-activated receptor (PPAR )-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice Biochemical Journal 2003 369 3 539 547
    • (2003) Biochemical Journal , vol.369 , Issue.3 , pp. 539-547
    • Kok, T.1    Bloks, V.W.2    Wolters, H.3
  • 54
    • 54349084084 scopus 로고    scopus 로고
    • Critical role of PPAR- in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of oatp uptake transporters in mouse livers
    • Cheng X., Klaassen C. D., Critical role of PPAR- in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of oatp uptake transporters in mouse livers Toxicological Sciences 2008 106 1 37 45
    • (2008) Toxicological Sciences , vol.106 , Issue.1 , pp. 37-45
    • Cheng, X.1    Klaassen, C.D.2
  • 55
    • 0037163053 scopus 로고    scopus 로고
    • Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor α
    • Jung D., Fried M., Kullak-Ublick G. A., Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor α Journal of Biological Chemistry 2002 277 34 30559 30566
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.34 , pp. 30559-30566
    • Jung, D.1    Fried, M.2    Kullak-Ublick, G.A.3
  • 56
    • 20444491581 scopus 로고    scopus 로고
    • The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors
    • Landrier J. F., Thomas C., Grober J., The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors Biochimica et Biophysica Acta 2005 1735 1 41 49
    • (2005) Biochimica et Biophysica Acta , vol.1735 , Issue.1 , pp. 41-49
    • Landrier, J.F.1    Thomas, C.2    Grober, J.3
  • 57
    • 11144318237 scopus 로고    scopus 로고
    • Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
    • Moschetta A., Bookout A. L., Mangelsdorf D. J., Prevention of cholesterol gallstone disease by FXR agonists in a mouse model Nature Medicine 2004 10 12 1352 1358
    • (2004) Nature Medicine , vol.10 , Issue.12 , pp. 1352-1358
    • Moschetta, A.1    Bookout, A.L.2    Mangelsdorf, D.J.3
  • 59
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • Shepherd J., Cobbe S. M., Ford I., Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia The New England Journal of Medicine 1995 333 20 1301 1307
    • (1995) The New England Journal of Medicine , vol.333 , Issue.20 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 60
    • 0032572086 scopus 로고    scopus 로고
    • Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS
    • Downs J. R., Clearfield M., Weis S., Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS Journal of the American Medical Association 1998 279 20 1615 1622
    • (1998) Journal of the American Medical Association , vol.279 , Issue.20 , pp. 1615-1622
    • Downs, J.R.1    Clearfield, M.2    Weis, S.3
  • 61
    • 0037420492 scopus 로고    scopus 로고
    • Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes TrialLipid Lowering Arm (ASCOT-LLA): A multicentre randomised controlled trial
    • Sever P. S., Dahlf B., Poulter N. R., Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes TrialLipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial The Lancet 2003 361 9364 1149 1158
    • (2003) The Lancet , vol.361 , Issue.9364 , pp. 1149-1158
    • Sever, P.S.1    Dahlf, B.2    Poulter, N.R.3
  • 62
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Baigent C., Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins The Lancet 2005 366 9493 1267 1278
    • (2005) The Lancet , vol.366 , Issue.9493 , pp. 1267-1278
    • Baigent, C.1
  • 63
    • 0037109085 scopus 로고    scopus 로고
    • Low-density lipoprotein lowering and atherosclerosis progression: Does more mean less?
    • Shah P. K., Low-density lipoprotein lowering and atherosclerosis progression: does more mean less? Circulation 2002 106 16 2039 2040
    • (2002) Circulation , vol.106 , Issue.16 , pp. 2039-2040
    • Shah, P.K.1
  • 64
    • 0026572204 scopus 로고
    • Lipoprotein cholesterol, apolipoprotein A-I and B and lipoprotein (a) abnormality in men with premature coronary heart disease
    • Genest J. Jr., McNamara J. R., Ordovas J. M., Lipoprotein cholesterol, apolipoprotein A-I and B and lipoprotein (a) abnormality in men with premature coronary heart disease Journal of the American College of Cardiology 1992 19 792 802
    • (1992) Journal of the American College of Cardiology , vol.19 , pp. 792-802
    • Genest Jr., J.1    McNamara, J.R.2    Ordovas, J.M.3
  • 65
    • 0017384270 scopus 로고
    • High density lipoprotein as a protective factor against coronary heart disease. the Framingham study
    • Gordon T., Castelli W. P., Hjortland M. C., Kannel W. B., Dawber T. R., High density lipoprotein as a protective factor against coronary heart disease. The Framingham study American Journal of Medicine 1977 62 5 707 714
    • (1977) American Journal of Medicine , vol.62 , Issue.5 , pp. 707-714
    • Gordon, T.1    Castelli, W.P.2    Hjortland, M.C.3    Kannel, W.B.4    Dawber, T.R.5
  • 66
    • 0019431602 scopus 로고
    • Associations of serum high density lipoprotein and total cholesterol with total, cardiovascular, and cancer mortality in a 7-year prospective study of 10 000 men
    • Yaari S., Goldbourt U., Even-Zohar S., Neufeld H. N., Associations of serum high density lipoprotein and total cholesterol with total, cardiovascular, and cancer mortality in a 7-year prospective study of 10 000 men The Lancet 1981 1 8228 1011 1015
    • (1981) The Lancet , vol.1 , Issue.8228 , pp. 1011-1015
    • Yaari, S.1    Goldbourt, U.2    Even-Zohar, S.3    Neufeld, H.N.4
  • 67
    • 0035924636 scopus 로고    scopus 로고
    • Increasing high-density lipoprotein cholesterol: An update on fenofibrate
    • Desprs J.-P., Increasing high-density lipoprotein cholesterol: an update on fenofibrate American Journal of Cardiology 2001 88 12A 30N 36N
    • (2001) American Journal of Cardiology , vol.88 , Issue.12 A
    • Desprs, J.-P.1
  • 68
    • 11844296800 scopus 로고    scopus 로고
    • Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: A meta-analysis of randomized controlled trials
    • Birjmohun R. S., Hutten B. A., Kastelein J. J. P., Stroes E. S. G., Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials Journal of the American College of Cardiology 2005 45 2 185 197
    • (2005) Journal of the American College of Cardiology , vol.45 , Issue.2 , pp. 185-197
    • Birjmohun, R.S.1    Hutten, B.A.2    Kastelein, J.J.P.3    Stroes, E.S.G.4
  • 69
    • 33748194146 scopus 로고    scopus 로고
    • Determinants of plasma HDL concentrations and reverse cholesterol transport
    • Lewis G. F., Determinants of plasma HDL concentrations and reverse cholesterol transport Current Opinion in Cardiology 2006 21 4 345 352
    • (2006) Current Opinion in Cardiology , vol.21 , Issue.4 , pp. 345-352
    • Lewis, G.F.1
  • 70
    • 0025322265 scopus 로고
    • Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit
    • Badimon J. J., Badimon L., Fuster V., Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit Journal of Clinical Investigation 1990 85 4 1234 1241
    • (1990) Journal of Clinical Investigation , vol.85 , Issue.4 , pp. 1234-1241
    • Badimon, J.J.1    Badimon, L.2    Fuster, V.3
  • 71
    • 9544221670 scopus 로고    scopus 로고
    • Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein A-I-transgenic rabbits
    • Duverger N., Kruth H., Emmanuel F., Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein A-I-transgenic rabbits Circulation 1996 94 4 713 717
    • (1996) Circulation , vol.94 , Issue.4 , pp. 713-717
    • Duverger, N.1    Kruth, H.2    Emmanuel, F.3
  • 72
    • 0033595686 scopus 로고    scopus 로고
    • Reconstituted HDL containing human apolipoprotein A-1 reduces VCAM-1 expression and neointima formation following periadventitial cuff-induced carotid injury in apoE null mice
    • Dimayuga P., Zhu J., Oguchi S., Reconstituted HDL containing human apolipoprotein A-1 reduces VCAM-1 expression and neointima formation following periadventitial cuff-induced carotid injury in apoE null mice Biochemical and Biophysical Research Communications 1999 264 2 465 468
    • (1999) Biochemical and Biophysical Research Communications , vol.264 , Issue.2 , pp. 465-468
    • Dimayuga, P.1    Zhu, J.2    Oguchi, S.3
  • 73
    • 8944252340 scopus 로고    scopus 로고
    • Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice
    • Berthou L., Duverger N., Emmanuel F., Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice Journal of Clinical Investigation 1996 97 11 2408 2416
    • (1996) Journal of Clinical Investigation , vol.97 , Issue.11 , pp. 2408-2416
    • Berthou, L.1    Duverger, N.2    Emmanuel, F.3
  • 74
    • 0032475854 scopus 로고    scopus 로고
    • The nuclear receptors peroxisome proliferator-activated receptor and rev-erb mediate the species-specific regulation of apolipoprotein A-I expression by fibrates
    • Vu-Dac N., Chopin-Delannoy S., Gervois P., The nuclear receptors peroxisome proliferator-activated receptor and rev-erb mediate the species-specific regulation of apolipoprotein A-I expression by fibrates Journal of Biological Chemistry 1998 273 40 25713 25720
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.40 , pp. 25713-25720
    • Vu-Dac, N.1    Chopin-Delannoy, S.2    Gervois, P.3
  • 75
    • 0026577411 scopus 로고
    • Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat
    • Staels B., van Tol A., Andreu T., Auwerx J., Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat Arteriosclerosis and Thrombosis 1992 12 3 286 294
    • (1992) Arteriosclerosis and Thrombosis , vol.12 , Issue.3 , pp. 286-294
    • Staels, B.1    Van Tol, A.2    Andreu, T.3    Auwerx, J.4
  • 76
    • 0030766476 scopus 로고    scopus 로고
    • Alterations in lipoprotein metabolism in peroxisome proliferator- activated receptor -deficient mice
    • Peters J. M., Hennuyer N., Staels B., Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor -deficient mice Journal of Biological Chemistry 1997 272 43 27307 27312
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.43 , pp. 27307-27312
    • Peters, J.M.1    Hennuyer, N.2    Staels, B.3
  • 77
    • 33750127491 scopus 로고    scopus 로고
    • Variations on a gene: Rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis
    • Brunham L. R., Singaraja R. R., Hayden M. R., Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis Annual Review of Nutrition 2006 26 105 129
    • (2006) Annual Review of Nutrition , vol.26 , pp. 105-129
    • Brunham, L.R.1    Singaraja, R.R.2    Hayden, M.R.3
  • 78
    • 0343717914 scopus 로고    scopus 로고
    • High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATp-binding cassette transporter-1
    • McNeish J., Aiello R. J., Guyot D., High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATp-binding cassette transporter-1 Proceedings of the National Academy of Sciences of the United States of America 2000 97 8 4245 4250
    • (2000) Proceedings of the National Academy of Sciences of the United States of America , vol.97 , Issue.8 , pp. 4245-4250
    • McNeish, J.1    Aiello, R.J.2    Guyot, D.3
  • 79
    • 0035138625 scopus 로고    scopus 로고
    • PPAR- and PPAR- activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
    • Chinetti G., Lestavel S., Bocher V., PPAR- and PPAR- activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway Nature Medicine 2001 7 1 53 58
    • (2001) Nature Medicine , vol.7 , Issue.1 , pp. 53-58
    • Chinetti, G.1    Lestavel, S.2    Bocher, V.3
  • 80
    • 0036205326 scopus 로고    scopus 로고
    • Conditional disruption of the peroxisome proliferator-activated receptor gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux
    • Akiyama T. E., Sakai S., Lambert G., Conditional disruption of the peroxisome proliferator-activated receptor gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux Molecular and Cellular Biology 2002 22 8 2607 2619
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.8 , pp. 2607-2619
    • Akiyama, T.E.1    Sakai, S.2    Lambert, G.3
  • 82
    • 17744376173 scopus 로고    scopus 로고
    • A PPAR -LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
    • Chawla A., Boisvert W. A., Lee C.-H., A PPAR -LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis Molecular Cell 2001 7 1 161 171
    • (2001) Molecular Cell , vol.7 , Issue.1 , pp. 161-171
    • Chawla, A.1    Boisvert, W.A.2    Lee, C.-H.3
  • 84
    • 33645502340 scopus 로고    scopus 로고
    • Intestinal ABCA1 directly contributes to HDL biogenesis in vivo
    • Brunham L. R., Kruit J. K., Iqbal J., Intestinal ABCA1 directly contributes to HDL biogenesis in vivo Journal of Clinical Investigation 2006 116 4 1052 1062
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.4 , pp. 1052-1062
    • Brunham, L.R.1    Kruit, J.K.2    Iqbal, J.3
  • 85
    • 20944435724 scopus 로고    scopus 로고
    • Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I
    • Timmins J. M., Lee J.-Y., Boudyguina E., Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I Journal of Clinical Investigation 2005 115 5 1333 1342
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.5 , pp. 1333-1342
    • Timmins, J.M.1    Lee, J.-Y.2    Boudyguina, E.3
  • 86
    • 0344236149 scopus 로고    scopus 로고
    • Inhibition of cholesterol absorption associated with a PPAR -dependent increase in ABC binding cassette transporter A1 in mice
    • Knight B. L., Patel D. D., Humphreys S. M., Wiggins D., Gibbons G. F., Inhibition of cholesterol absorption associated with a PPAR -dependent increase in ABC binding cassette transporter A1 in mice Journal of Lipid Research 2003 44 11 2049 2058
    • (2003) Journal of Lipid Research , vol.44 , Issue.11 , pp. 2049-2058
    • Knight, B.L.1    Patel, D.D.2    Humphreys, S.M.3    Wiggins, D.4    Gibbons, G.F.5
  • 87
    • 0025104275 scopus 로고
    • Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation
    • Inazu A., Brown M. L., Hesler C. B., Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation The New England Journal of Medicine 1990 323 18 1234 1238
    • (1990) The New England Journal of Medicine , vol.323 , Issue.18 , pp. 1234-1238
    • Inazu, A.1    Brown, M.L.2    Hesler, C.B.3
  • 88
    • 34548157559 scopus 로고    scopus 로고
    • Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression
    • van der Hoogt C. C., De Haan W., Westerterp M., Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression Journal of Lipid Research 2007 48 8 1763 1771
    • (2007) Journal of Lipid Research , vol.48 , Issue.8 , pp. 1763-1771
    • Van Der Hoogt, C.C.1    De Haan, W.2    Westerterp, M.3
  • 89
    • 34247241088 scopus 로고    scopus 로고
    • Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia
    • Kastelein J. J. P., van Leuven S. I., Burgess L., Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia The New England Journal of Medicine 2007 356 16 1620 1630
    • (2007) The New England Journal of Medicine , vol.356 , Issue.16 , pp. 1620-1630
    • Kastelein, J.J.P.1    Van Leuven, S.I.2    Burgess, L.3
  • 90
  • 92
    • 0032568095 scopus 로고    scopus 로고
    • Long-term efficacy and safety of fenofibrate and a statin in the treatment of combined hyperlipidemia
    • Ellen R. L. B., McPherson R., Long-term efficacy and safety of fenofibrate and a statin in the treatment of combined hyperlipidemia American Journal of Cardiology 1998 81 4A 60B 65B
    • (1998) American Journal of Cardiology , vol.81 , Issue.4 A
    • Ellen, R.L.B.1    McPherson, R.2
  • 93
    • 0037446467 scopus 로고    scopus 로고
    • Effects of adding fenofibrate (200mg/day) to simvastatin (10mg/day) in patients with combined hyperlipidemia and metabolic syndrome
    • Vega G. L., Ma P. T. S., Cater N. B., Effects of adding fenofibrate (200mg/day) to simvastatin (10mg/day) in patients with combined hyperlipidemia and metabolic syndrome American Journal of Cardiology 2003 91 8 956 960
    • (2003) American Journal of Cardiology , vol.91 , Issue.8 , pp. 956-960
    • Vega, G.L.1    Ma, P.T.S.2    Cater, N.B.3
  • 94
    • 22544473888 scopus 로고    scopus 로고
    • A role for PPAR in the control of SREBP activity and lipid synthesis in the liver
    • Knight B. L., Hebbach A., Hauton D., A role for PPAR in the control of SREBP activity and lipid synthesis in the liver Biochemical Journal 2005 389 2 413 421
    • (2005) Biochemical Journal , vol.389 , Issue.2 , pp. 413-421
    • Knight, B.L.1    Hebbach, A.2    Hauton, D.3
  • 95
    • 0018184704 scopus 로고
    • Mode of action of the lipid-lowering agents, elofibrate and BM 15075, on cholesterol biosynthesis in rat liver
    • Berndt J., Gaumert R., Still J., Mode of action of the lipid-lowering agents, elofibrate and BM 15075, on cholesterol biosynthesis in rat liver Atherosclerosis 1978 30 2 147 152
    • (1978) Atherosclerosis , vol.30 , Issue.2 , pp. 147-152
    • Berndt, J.1    Gaumert, R.2    Still, J.3
  • 96
    • 33748294205 scopus 로고    scopus 로고
    • PPAR gamma ligand troglitazone lowers cholesterol synthesis in HepG2 and Caco-2 cells via a reduced concentration of nuclear SREBP-2
    • Klopotek A., Hirche F., Eder K., PPAR gamma ligand troglitazone lowers cholesterol synthesis in HepG2 and Caco-2 cells via a reduced concentration of nuclear SREBP-2 Experimental Biology and Medicine 2006 231 8 1365 1372
    • (2006) Experimental Biology and Medicine , vol.231 , Issue.8 , pp. 1365-1372
    • Klopotek, A.1    Hirche, F.2    Eder, K.3
  • 98
    • 0037162719 scopus 로고    scopus 로고
    • Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
    • Yang T., Espenshade P. J., Wright M. E., Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER Cell 2002 110 4 489 500
    • (2002) Cell , vol.110 , Issue.4 , pp. 489-500
    • Yang, T.1    Espenshade, P.J.2    Wright, M.E.3
  • 99
    • 0036792050 scopus 로고    scopus 로고
    • Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
    • Yabe D., Brown M. S., Goldstein J. L., Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins Proceedings of the National Academy of Sciences of the United States of America 2002 99 20 12753 12758
    • (2002) Proceedings of the National Academy of Sciences of the United States of America , vol.99 , Issue.20 , pp. 12753-12758
    • Yabe, D.1    Brown, M.S.2    Goldstein, J.L.3
  • 100
    • 2642546601 scopus 로고    scopus 로고
    • Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor and sterol regulatory element-binding protein in the regulation of adipogenesis
    • Kast-Woelbern H. R., Dana S. L., Cesario R. M., Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor and sterol regulatory element-binding protein in the regulation of adipogenesis Journal of Biological Chemistry 2004 279 23 23908 23915
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.23 , pp. 23908-23915
    • Kast-Woelbern, H.R.1    Dana, S.L.2    Cesario, R.M.3
  • 101
    • 33845955966 scopus 로고    scopus 로고
    • Activation of PPAR lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2
    • Knig B., Koch A., Spielmann J., Hilgenfeld C., Stangl G. I., Eder K., Activation of PPAR lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2 Biochemical Pharmacology 2007 73 4 574 585
    • (2007) Biochemical Pharmacology , vol.73 , Issue.4 , pp. 574-585
    • Knig, B.1    Koch, A.2    Spielmann, J.3    Hilgenfeld, C.4    Stangl, G.I.5    Eder, K.6
  • 102
    • 49649129066 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor- induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice
    • Qin X., Xie X., Fan Y., Peroxisome proliferator-activated receptor- induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice Hepatology 2008 48 2 432 441
    • (2008) Hepatology , vol.48 , Issue.2 , pp. 432-441
    • Qin, X.1    Xie, X.2    Fan, Y.3
  • 103
    • 0034655917 scopus 로고    scopus 로고
    • Evidence for a niemann-pick C (NPC) gene family: Identification and characterization of NPC1L1
    • Davies J. P., Levy B., Ioannou Y. A., Evidence for a niemann-pick C (NPC) gene family: identification and characterization of NPC1L1 Genomics 2000 65 2 137 145
    • (2000) Genomics , vol.65 , Issue.2 , pp. 137-145
    • Davies, J.P.1    Levy, B.2    Ioannou, Y.A.3
  • 104
    • 10744221008 scopus 로고    scopus 로고
    • Niemann-pick C1 like 1 protein is critical for intestinal cholesterol absorption
    • Altmann S. W., Davis H. R. Jr., Zhu L.-J., Niemann-pick C1 like 1 protein is critical for intestinal cholesterol absorption Science 2004 303 5661 1201 1204
    • (2004) Science , vol.303 , Issue.5661 , pp. 1201-1204
    • Altmann, S.W.1    Davis Jr., H.R.2    Zhu, L.-J.3
  • 105
    • 17744390348 scopus 로고    scopus 로고
    • Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
    • Berge K. E., Tian H., Graf G. A., Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters Science 2000 290 5497 1771 1775
    • (2000) Science , vol.290 , Issue.5497 , pp. 1771-1775
    • Berge, K.E.1    Tian, H.2    Graf, G.A.3
  • 106
    • 0036733630 scopus 로고    scopus 로고
    • Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol
    • Yu L., Li-Hawkins J., Hammer R. E., Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol Journal of Clinical Investigation 2002 110 5 671 680
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.5 , pp. 671-680
    • Yu, L.1    Li-Hawkins, J.2    Hammer, R.E.3
  • 107
    • 0034889279 scopus 로고    scopus 로고
    • Inhibitory action of gemfibrozil on cholesterol absorption in rat intestine
    • Umeda Y., Kako Y., Mizutani K., Inhibitory action of gemfibrozil on cholesterol absorption in rat intestine Journal of Lipid Research 2001 42 8 1214 1219
    • (2001) Journal of Lipid Research , vol.42 , Issue.8 , pp. 1214-1219
    • Umeda, Y.1    Kako, Y.2    Mizutani, K.3
  • 108
    • 22344449773 scopus 로고    scopus 로고
    • Reduced cholesterol absorption upon PPAR activation coincides with decreased intestinal expression of NPC1L1
    • van der Veen J. N., Kruit J. K., Havinga R., Reduced cholesterol absorption upon PPAR activation coincides with decreased intestinal expression of NPC1L1 Journal of Lipid Research 2005 46 3 526 534
    • (2005) Journal of Lipid Research , vol.46 , Issue.3 , pp. 526-534
    • Van Der Veen, J.N.1    Kruit, J.K.2    Havinga, R.3
  • 109
    • 37249042184 scopus 로고    scopus 로고
    • Fenofibrate reduces intestinal cholesterol absorption via PPAR -dependent modulation of NPC1L1 expression in mouse
    • Valasek M. A., Clarke S. L., Repa J. J., Fenofibrate reduces intestinal cholesterol absorption via PPAR -dependent modulation of NPC1L1 expression in mouse Journal of Lipid Research 2007 48 12 2725 2735
    • (2007) Journal of Lipid Research , vol.48 , Issue.12 , pp. 2725-2735
    • Valasek, M.A.1    Clarke, S.L.2    Repa, J.J.3
  • 110
    • 0037219280 scopus 로고    scopus 로고
    • Induction of hepatic ABC transporter expression is part of the PPAR -mediated fasting response in the mouse
    • Kok T., Wolters H., Bloks V. W., Induction of hepatic ABC transporter expression is part of the PPAR -mediated fasting response in the mouse Gastroenterology 2003 124 1 160 171
    • (2003) Gastroenterology , vol.124 , Issue.1 , pp. 160-171
    • Kok, T.1    Wolters, H.2    Bloks, V.W.3
  • 112
    • 0035914330 scopus 로고    scopus 로고
    • 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells
    • Fu X., Menke J. G., Chen Y., 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells Journal of Biological Chemistry 2001 276 42 38378 38387
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.42 , pp. 38378-38387
    • Fu, X.1    Menke, J.G.2    Chen, Y.3
  • 113
    • 14444285707 scopus 로고    scopus 로고
    • Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
    • Lehmann J. M., Kliewer S. A., Moore L. B., Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway Journal of Biological Chemistry 1997 272 6 3137 3140
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.6 , pp. 3137-3140
    • Lehmann, J.M.1    Kliewer, S.A.2    Moore, L.B.3
  • 115
    • 0347034082 scopus 로고    scopus 로고
    • Characterization of the human ABCG1 gene. Liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein
    • DOI 10.1074/jbc.M105863200
    • Kennedy M. A., Venkateswaran A., Tarr P. T., Characterization of the human ABCG1 gene. Liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein Journal of Biological Chemistry 2001 276 42 39438 39447 (Pubitemid 37371322)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.42 , pp. 39438-39447
    • Kennedy, M.A.1    Venkateswaran, A.2    Tarr, P.T.3    Xenarios, I.4    Kudoh, J.5    Shimizu, N.6    Edwards, P.A.7
  • 116
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
    • Peet D. J., Turley S. D., Ma W., Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα Cell 1998 93 5 693 704
    • (1998) Cell , vol.93 , Issue.5 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3
  • 119
    • 0034669171 scopus 로고    scopus 로고
    • Role of LXRs in control of lipogenesis
    • Schultz J. R., Tu H., Luk A., Role of LXRs in control of lipogenesis Genes and Development 2000 14 22 2831 2838
    • (2000) Genes and Development , vol.14 , Issue.22 , pp. 2831-2838
    • Schultz, J.R.1    Tu, H.2    Luk, A.3
  • 121
    • 0035047709 scopus 로고    scopus 로고
    • Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter
    • Yoshikawa T., Shimano H., Amemiya-Kudo M., Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter Molecular and Cellular Biology 2001 21 9 2991 3000
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.9 , pp. 2991-3000
    • Yoshikawa, T.1    Shimano, H.2    Amemiya-Kudo, M.3
  • 122
    • 0034669025 scopus 로고    scopus 로고
    • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
    • Repa J. J., Liang G., Ou J., Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR and LXR Genes and Development 2000 14 22 2819 2830
    • (2000) Genes and Development , vol.14 , Issue.22 , pp. 2819-2830
    • Repa, J.J.1    Liang, G.2    Ou, J.3
  • 123
    • 0029931972 scopus 로고    scopus 로고
    • The orphan nuclear hormone receptor LXR interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling
    • Miyata K. S., McCaw S. E., Patel H. V., Rachubinski R. A., Capone J. P., The orphan nuclear hormone receptor LXR interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling Journal of Biological Chemistry 1996 271 16 9189 9192
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.16 , pp. 9189-9192
    • Miyata, K.S.1    McCaw, S.E.2    Patel, H.V.3    Rachubinski, R.A.4    Capone, J.P.5
  • 125
    • 44149085369 scopus 로고    scopus 로고
    • PPAR gene expression is up-regulated by LXR and PXR activators in the small intestine
    • Inoue J., Satoh S., Kita M., PPAR gene expression is up-regulated by LXR and PXR activators in the small intestine Biochemical and Biophysical Research Communications 2008 371 4 675 678
    • (2008) Biochemical and Biophysical Research Communications , vol.371 , Issue.4 , pp. 675-678
    • Inoue, J.1    Satoh, S.2    Kita, M.3
  • 126
    • 53249093992 scopus 로고    scopus 로고
    • Intestine-specific regulation of PPAR gene transcription by liver X receptors
    • Colin S., Bourguignon E., Boullay A.-B., Intestine-specific regulation of PPAR gene transcription by liver X receptors Endocrinology 2008 149 10 5128 5135
    • (2008) Endocrinology , vol.149 , Issue.10 , pp. 5128-5135
    • Colin, S.1    Bourguignon, E.2    Boullay, A.-B.3
  • 127
    • 0033544869 scopus 로고    scopus 로고
    • A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
    • Yahagi N., Shimano H., Hasty A. H., A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids Journal of Biological Chemistry 1999 274 50 35840 35844
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.50 , pp. 35840-35844
    • Yahagi, N.1    Shimano, H.2    Hasty, A.H.3
  • 128
    • 0033551846 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats
    • Xu J., Nakamura M. T., Cho H. P., Clarke S. D., Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats Journal of Biological Chemistry 1999 274 33 23577 23583
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.33 , pp. 23577-23583
    • Xu, J.1    Nakamura, M.T.2    Cho, H.P.3    Clarke, S.D.4
  • 129
    • 18544388579 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
    • Yoshikawa T., Shimano H., Yahagi N., Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements Journal of Biological Chemistry 2002 277 3 1705 1711
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.3 , pp. 1705-1711
    • Yoshikawa, T.1    Shimano, H.2    Yahagi, N.3
  • 130
    • 33746905103 scopus 로고    scopus 로고
    • Ligand-activated PPAR efficiently represses the induction of LXR-dependent promoter activity through competition with RXR
    • Matsusue K., Miyoshi A., Yamano S., Gonzalez F. J., Ligand-activated PPAR efficiently represses the induction of LXR-dependent promoter activity through competition with RXR Molecular and Cellular Endocrinology 2006 256 1-2 23 33
    • (2006) Molecular and Cellular Endocrinology , vol.256 , Issue.1-2 , pp. 23-33
    • Matsusue, K.1    Miyoshi, A.2    Yamano, S.3    Gonzalez, F.J.4
  • 131
    • 85047693466 scopus 로고    scopus 로고
    • Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, and γ
    • Li A. C., Binder C. J., Gutierrez A., Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPAR, /, and Journal of Clinical Investigation 2004 114 11 1564 1576
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.11 , pp. 1564-1576
    • Li, A.C.1    Binder, C.J.2    Gutierrez, A.3
  • 133
    • 2242436246 scopus 로고    scopus 로고
    • Reduction of atherosclerosis by the peroxisome proliferator-activated receptor agonist fenofibrate in mice
    • Duezt H., Chao Y.-S., Hernandez M., Reduction of atherosclerosis by the peroxisome proliferator-activated receptor agonist fenofibrate in mice Journal of Biological Chemistry 2002 277 50 48051 48057
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.50 , pp. 48051-48057
    • Duezt, H.1    Chao, Y.-S.2    Hernandez, M.3
  • 134
    • 0034744590 scopus 로고    scopus 로고
    • PPAR deficiency reduces insulin resistance and atherosclerosis in apoE-null mice
    • Tordjman K., Bernal-Mizrachi C., Zemany L., PPAR deficiency reduces insulin resistance and atherosclerosis in apoE-null mice Journal of Clinical Investigation 2001 107 8 1025 1034
    • (2001) Journal of Clinical Investigation , vol.107 , Issue.8 , pp. 1025-1034
    • Tordjman, K.1    Bernal-Mizrachi, C.2    Zemany, L.3
  • 135
    • 0042568979 scopus 로고    scopus 로고
    • The peroxisome-proliferator-activated receptor agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein e
    • Fu T., Kashireddy P., Borensztajn J., The peroxisome-proliferator- activated receptor agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E Biochemical Journal 2003 373 3 941 947
    • (2003) Biochemical Journal , vol.373 , Issue.3 , pp. 941-947
    • Fu, T.1    Kashireddy, P.2    Borensztajn, J.3
  • 136
    • 0037315190 scopus 로고    scopus 로고
    • Bile acids induce the expression of the human peroxisome proliferator-activated receptor gene via activation of the farnesoid X receptor
    • Torra I. P., Claudel T., Duval C., Kosykh V., Fruchart J.-C., Staels B., Bile acids induce the expression of the human peroxisome proliferator-activated receptor gene via activation of the farnesoid X receptor Molecular Endocrinology 2003 17 2 259 272
    • (2003) Molecular Endocrinology , vol.17 , Issue.2 , pp. 259-272
    • Torra, I.P.1    Claudel, T.2    Duval, C.3    Kosykh, V.4    Fruchart, J.-C.5    Staels, B.6
  • 137
    • 85047694456 scopus 로고    scopus 로고
    • Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
    • Watanabe M., Houten S. M., Wang L., Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c Journal of Clinical Investigation 2004 113 10 1408 1418
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.10 , pp. 1408-1418
    • Watanabe, M.1    Houten, S.M.2    Wang, L.3
  • 138
    • 0035861625 scopus 로고    scopus 로고
    • Antagonism of the actions of peroxisome proliferator-activated receptor- by Bile Acids
    • Sinal C. J., Yoon M., Gonzalez F. J., Antagonism of the actions of peroxisome proliferator-activated receptor- by Bile Acids Journal of Biological Chemistry 2001 276 50 47154 47162
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.50 , pp. 47154-47162
    • Sinal, C.J.1    Yoon, M.2    Gonzalez, F.J.3
  • 139
    • 0035947087 scopus 로고    scopus 로고
    • The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor -mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal -oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase
    • Kassam A., Capone J. P., Rachubinski R. A., The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor -mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal -oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase Molecular and Cellular Endocrinology 2001 176 1-2 49 56
    • (2001) Molecular and Cellular Endocrinology , vol.176 , Issue.12 , pp. 49-56
    • Kassam, A.1    Capone, J.P.2    Rachubinski, R.A.3
  • 140
    • 0037059762 scopus 로고    scopus 로고
    • Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor transactivation
    • Nishizawa H., Yamagata K., Shimomura I., Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor transactivation Journal of Biological Chemistry 2002 277 2 1586 1592
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.2 , pp. 1586-1592
    • Nishizawa, H.1    Yamagata, K.2    Shimomura, I.3
  • 141
    • 39649096642 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Pathogenesis and potential for nuclear receptors as therapeutic targets
    • George J., Liddle C., Nonalcoholic fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets Molecular Pharmaceutics 2008 5 1 49 59
    • (2008) Molecular Pharmaceutics , vol.5 , Issue.1 , pp. 49-59
    • George, J.1    Liddle, C.2
  • 142
    • 39849099238 scopus 로고    scopus 로고
    • Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease
    • Kallwitz E. R., McLachlan A., Cotler S. J., Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease World Journal of Gastroenterology 2008 14 1 22 28
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.1 , pp. 22-28
    • Kallwitz, E.R.1    McLachlan, A.2    Cotler, S.J.3
  • 143
    • 0033962940 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells
    • Galli A., Crabb D., Price D., Peroxisome proliferator-activated receptor transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells Hepatology 2000 31 1 101 108
    • (2000) Hepatology , vol.31 , Issue.1 , pp. 101-108
    • Galli, A.1    Crabb, D.2    Price, D.3
  • 144
    • 0036082703 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
    • Galli A., Crabb D. W., Ceni E., Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro Gastroenterology 2002 122 7 1924 1940
    • (2002) Gastroenterology , vol.122 , Issue.7 , pp. 1924-1940
    • Galli, A.1    Crabb, D.W.2    Ceni, E.3
  • 145
    • 0034680787 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and hepatic stellate cell activation
    • Miyahara T., Schrum L., Rippe R., Peroxisome proliferator-activated receptors and hepatic stellate cell activation Journal of Biological Chemistry 2000 275 46 35715 35722
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.46 , pp. 35715-35722
    • Miyahara, T.1    Schrum, L.2    Rippe, R.3
  • 146
    • 33847421803 scopus 로고    scopus 로고
    • Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor activation
    • Senekeo-Effenberger K., Chen S., Brace-Sinnokrak E., Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2- pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor activation Drug Metabolism and Disposition 2007 35 3 419 427
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.3 , pp. 419-427
    • Senekeo-Effenberger, K.1    Chen, S.2    Brace-Sinnokrak, E.3
  • 147
    • 24144496168 scopus 로고    scopus 로고
    • Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis
    • Marra F., DeFranco R., Robino G., Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis World Journal of Gastroenterology 2005 11 32 4931 4938
    • (2005) World Journal of Gastroenterology , vol.11 , Issue.32 , pp. 4931-4938
    • Marra, F.1    Defranco, R.2    Robino, G.3
  • 148
    • 38849137817 scopus 로고    scopus 로고
    • Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: An experimental study
    • Cindoruk M., Kerem M., Karakan T., Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study BMC Gastroenterology 2007 7, article 44
    • (2007) BMC Gastroenterology , vol.744
    • Cindoruk, M.1    Kerem, M.2    Karakan, T.3


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