CPT1α over-expression increases long-chain fatty acid oxidation and reduces cell viability with incremental palmitic acid concentration in 293T cells

Biochemical and Biophysical Research Communications

Volumn 338, Issue 2, 2005, Pages 757-761

  Jambor De Sousa, Ulrike L ^a   Koss, Michael D ^a   Fillies, Marion ^b   Gahl, Anja ^b   Scheeder, Martin R L ^a   Cardoso, M Cristina ^b   Leonhardt, Heinrich ^b,c   Geary, Nori ^a   Langhans, Wolfgang ^a   Leonhardt, Monika ^a  

^a ETH ZURICH   (Switzerland)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

CPT1 ; Lipotoxicity; Long chain fatty acids; Mitochondria

Indexed keywords

ACYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE 1 ALPHA; DOXYCYCLINE; PALMITIC ACID; UNCLASSIFIED DRUG; CARNITINE PALMITOYLTRANSFERASE; FATTY ACID; RECOMBINANT PROTEIN;

ARTICLE; CELL COUNT; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; FATTY ACID OXIDATION; GENE TRANSLOCATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN EMBRYO; KIDNEY CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENE; CELL LINE; CELL SURVIVAL; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; LIPID PEROXIDATION; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

CARNITINE O-PALMITOYLTRANSFERASE; CELL LINE; CELL SURVIVAL; FATTY ACIDS; GENE EXPRESSION REGULATION; HUMANS; KIDNEY; LIPID PEROXIDATION; OXIDATION-REDUCTION; PALMITIC ACID; RECOMBINANT PROTEINS;

EID: 27744510003     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.10.016     Document Type: Article

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