메뉴 건너뛰기




Volumn 50, Issue 8, 2014, Pages 355-361

Future biologic therapies in asthma;Futuras terapias biológicas en el asma

Author keywords

Asthma; Biological agents; Monoclonal antibodies; Therapy

Indexed keywords

DULIPUMAB; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 4; INTERLEUKIN 5; LEBRIKIZUMAB; MEPOLIZUMAB; MONOCLONAL ANTIBODY; OMALIZUMAB; UNCLASSIFIED DRUG; ANTI-IGE ANTIBODIES; ANTIASTHMATIC AGENT; ANTIIDIOTYPIC ANTIBODY; BIOLOGICAL FACTOR; CYTOKINE; IMMUNOGLOBULIN E; INTERLEUKIN DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84904515808     PISSN: 03002896     EISSN: 15792129     Source Type: Journal    
DOI: 10.1016/j.arbres.2014.02.002     Document Type: Short Survey
Times cited : (15)

References (56)
  • 1
    • 85028123864 scopus 로고    scopus 로고
    • Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention: NHLBI/WHO workshop report. Bethesda: National Institutes of Health, National Heart, Lung and Blood Institute. Updated [consultado 1 Oct 2013]. Disponible en:
    • Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention: NHLBI/WHO workshop report. Bethesda: National Institutes of Health, National Heart, Lung and Blood Institute. Updated 2010 [consultado 1 Oct 2013]. Disponible en:. http://www.ginasthma.com/.
    • (2010)
  • 2
    • 77956444329 scopus 로고    scopus 로고
    • GEMA (Guía Española del Manejo del Asma)
    • GEMA (Guía Española del Manejo del Asma). Arch Bronconeumol 2009, 45(Supl 7):1-35.
    • (2009) Arch Bronconeumol , vol.45 , Issue.SUPL 7 , pp. 1-35
  • 3
    • 84857834051 scopus 로고    scopus 로고
    • Repeated cross-sectional survey of patient-reported asthma control in Europe in the past 5 years
    • Demoly P., Annunziata K., Gubba E., Adamek L. Repeated cross-sectional survey of patient-reported asthma control in Europe in the past 5 years. Eur Respir Rev 2012, 21:66-74.
    • (2012) Eur Respir Rev , vol.21 , pp. 66-74
    • Demoly, P.1    Annunziata, K.2    Gubba, E.3    Adamek, L.4
  • 4
    • 84867099171 scopus 로고    scopus 로고
    • Measurement of asthma control according to Global Initiative for Asthma guidelines: A comparison with the Asthma Control Questionnaire
    • MAGIC Study Group
    • Olaguibel J.M., Quirce S., Juliá B., Fernández C., Fortuna A.M., Molina J., et al. Measurement of asthma control according to Global Initiative for Asthma guidelines: A comparison with the Asthma Control Questionnaire. Respir Res 2012, 13:50. MAGIC Study Group.
    • (2012) Respir Res , vol.13 , pp. 50
    • Olaguibel, J.M.1    Quirce, S.2    Juliá, B.3    Fernández, C.4    Fortuna, A.M.5    Molina, J.6
  • 5
    • 33745596102 scopus 로고    scopus 로고
    • Attitudes and actions of asthma patients on regular maintenance therapy: The INSPIRE study
    • Partridge M.R., van der Molen T., Myrseth S.E., Busse W.W. Attitudes and actions of asthma patients on regular maintenance therapy: The INSPIRE study. BMC Pulm Med 2006, 6:13.
    • (2006) BMC Pulm Med , vol.6 , pp. 13
    • Partridge, M.R.1    van der Molen, T.2    Myrseth, S.E.3    Busse, W.W.4
  • 7
    • 84860679595 scopus 로고    scopus 로고
    • Asthma phenotypes: The evolution from clinical to molecular approaches
    • Wenzel S.E. Asthma phenotypes: The evolution from clinical to molecular approaches. Nat Med 2012, 18:716-725.
    • (2012) Nat Med , vol.18 , pp. 716-725
    • Wenzel, S.E.1
  • 10
    • 84871716411 scopus 로고    scopus 로고
    • Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma
    • Gevaert P., Calus L., van Zele T., Blomme K., de Ruyck N., Bauters W., et al. Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma. J Allergy Clin Immunol 2013, 131:110-116.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 110-116
    • Gevaert, P.1    Calus, L.2    van Zele, T.3    Blomme, K.4    de Ruyck, N.5    Bauters, W.6
  • 12
    • 84874914555 scopus 로고    scopus 로고
    • Spanish Registry. Effects of omalizumab in non-atopic asthma: Results from a Spanish multicenter registry
    • De Llano L.P., Vennera M.C., Álvarez F.J., Medina J.F., Borderías L., Pellicer C., et al. Spanish Registry. Effects of omalizumab in non-atopic asthma: Results from a Spanish multicenter registry. J Asthma 2013, 50:296-301.
    • (2013) J Asthma , vol.50 , pp. 296-301
    • De Llano, L.P.1    Vennera, M.C.2    Álvarez, F.J.3    Medina, J.F.4    Borderías, L.5    Pellicer, C.6
  • 13
    • 84880851544 scopus 로고    scopus 로고
    • A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma
    • Garcia G., Magnan A., Chiron R., Contin-Bordes C., Berger P., Taillé C., et al. A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma. Chest 2013, 144:411-419.
    • (2013) Chest , vol.144 , pp. 411-419
    • Garcia, G.1    Magnan, A.2    Chiron, R.3    Contin-Bordes, C.4    Berger, P.5    Taillé, C.6
  • 14
    • 84861195053 scopus 로고    scopus 로고
    • An anti-IgE monoclonal antibody that binds to IgE on CD23 but not on high-affinity IgE Fc receptors
    • Shiung Y.Y., Chiang C.Y., Chen J.B., Wu P.C., Hung A.F., Lu D.C., et al. An anti-IgE monoclonal antibody that binds to IgE on CD23 but not on high-affinity IgE Fc receptors. Immunobiology 2012, 217:676-683.
    • (2012) Immunobiology , vol.217 , pp. 676-683
    • Shiung, Y.Y.1    Chiang, C.Y.2    Chen, J.B.3    Wu, P.C.4    Hung, A.F.5    Lu, D.C.6
  • 15
    • 84881517741 scopus 로고    scopus 로고
    • Development of small molecules to target the IgE: Fc(RI protein-protein interaction in allergies
    • Smith L.D., Leatherbarrow R.J., Spivey A.C. Development of small molecules to target the IgE: Fc(RI protein-protein interaction in allergies. Future Med Chem 2013, 5:1423-1435.
    • (2013) Future Med Chem , vol.5 , pp. 1423-1435
    • Smith, L.D.1    Leatherbarrow, R.J.2    Spivey, A.C.3
  • 16
    • 84885177716 scopus 로고    scopus 로고
    • Rationale and clinical results of inhibiting interleukin-5 for the treatment of severe asthma
    • Berair R., Pavord I.D. Rationale and clinical results of inhibiting interleukin-5 for the treatment of severe asthma. Curr Allergy Asthma Resp 2013, 13:469-476.
    • (2013) Curr Allergy Asthma Resp , vol.13 , pp. 469-476
    • Berair, R.1    Pavord, I.D.2
  • 18
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie M.J., ten Brinke A., Khan J., Diamant Z., O'Connor B.J., Walls C.M., et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000, 356:2144-2148.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    ten Brinke, A.2    Khan, J.3    Diamant, Z.4    O'Connor, B.J.5    Walls, C.M.6
  • 19
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    • Flood-Page P.T., Menzies-Grow A.N., Kay A.B., Robinson D.S. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003, 167:199-204.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Grow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 20
    • 36749065556 scopus 로고    scopus 로고
    • A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
    • International Mepolizumab Study Group
    • Flood-Page P., Swenson C., Faiferman I., Matthews J., Williams M., Brannick L., et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 2007, 176:1062-1071. International Mepolizumab Study Group.
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1062-1071
    • Flood-Page, P.1    Swenson, C.2    Faiferman, I.3    Matthews, J.4    Williams, M.5    Brannick, L.6
  • 23
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
    • Pavord I.D., Korn S., Howarth P., Bleecker E.R., Buhl R., Keene O.N., et al. Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial. Lancet 2012, 380:651-699.
    • (2012) Lancet , vol.380 , pp. 651-699
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3    Bleecker, E.R.4    Buhl, R.5    Keene, O.N.6
  • 24
    • 84875467652 scopus 로고    scopus 로고
    • Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: A meta-analysis of randomized placebo-controlled trials
    • Liu Y., Zhang S., Li D.W., Jiang S.J. Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: A meta-analysis of randomized placebo-controlled trials. PLos One 2013, 8:e59872.
    • (2013) PLos One , vol.8
    • Liu, Y.1    Zhang, S.2    Li, D.W.3    Jiang, S.J.4
  • 25
    • 81455155725 scopus 로고    scopus 로고
    • Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study
    • Res-5-0010 Study Group
    • Castro M., Mathur s, Hargreave F., Boulet L.P., Xie F., Young J., et al. Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study. Am J Respir Crit Care Med 2011, 184:1125-1132. Res-5-0010 Study Group.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 1125-1132
    • Castro, M.1    Mathur, S.2    Hargreave, F.3    Boulet, L.P.4    Xie, F.5    Young, J.6
  • 26
    • 77952683218 scopus 로고    scopus 로고
    • Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma
    • Busse W.W., Katial R., Gossage D., Sari S., Wang B., Kolbeck R., et al. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol 2010, 125:1237-1244.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1237-1244
    • Busse, W.W.1    Katial, R.2    Gossage, D.3    Sari, S.4    Wang, B.5    Kolbeck, R.6
  • 28
    • 0036528907 scopus 로고    scopus 로고
    • Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma
    • Allakhverdi Z., Allam M., Renzi P.M. Inhibition of antigen-induced eosinophilia and airway hyperresponsiveness by antisense oligonucleotides directed against the common beta chain of IL-3, IL-5, GM-CSF receptors in a rat model of allergic asthma. Am J Respir Crit Care Med 2002, 165:1015-1021.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 1015-1021
    • Allakhverdi, Z.1    Allam, M.2    Renzi, P.M.3
  • 29
  • 32
    • 42149136164 scopus 로고    scopus 로고
    • Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness
    • Huang H., Lee C., Chiang B. Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness. Gene Ther 2008, 15:660-667.
    • (2008) Gene Ther , vol.15 , pp. 660-667
    • Huang, H.1    Lee, C.2    Chiang, B.3
  • 33
    • 77649198441 scopus 로고    scopus 로고
    • Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma
    • Oh C.K., Geba G.P., Molfino N. Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma. Eur Respir Rev 2010, 19:46-54.
    • (2010) Eur Respir Rev , vol.19 , pp. 46-54
    • Oh, C.K.1    Geba, G.P.2    Molfino, N.3
  • 34
    • 0036379740 scopus 로고    scopus 로고
    • Preclinical efficacy and safety of pascolizumab (SB 240683): A humanized anti-interleukin-4 antibody with therapeutic potential in asthma
    • Hart T.K., Blackburn M.N., Brigham-Burke M., Dede K., al-Mahdi N., Zia-Amirhosseini P., et al. Preclinical efficacy and safety of pascolizumab (SB 240683): A humanized anti-interleukin-4 antibody with therapeutic potential in asthma. Clin Exp Immunol 2002, 130:93-100.
    • (2002) Clin Exp Immunol , vol.130 , pp. 93-100
    • Hart, T.K.1    Blackburn, M.N.2    Brigham-Burke, M.3    Dede, K.4    al-Mahdi, N.5    Zia-Amirhosseini, P.6
  • 35
    • 85028101024 scopus 로고    scopus 로고
    • PDL Biopharma, Inc. Pilot study in patients with symptomatic steroid-naïve asthma; 2012. [consultado Dic 2011]. Disponible en:
    • PDL Biopharma, Inc. Pilot study in patients with symptomatic steroid-naïve asthma; 2012. [consultado Dic 2011]. Disponible en:. http://clinicaltrials.gov/ct2/show/NCT00024544.
  • 37
    • 0034995872 scopus 로고    scopus 로고
    • Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
    • IL-4R Asthma Study Group
    • Borish L.C., Nelson H.S., Corren J., Bensch G., Busse W.W., Whitmore J.B., et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol 2001, 107:963-970. IL-4R Asthma Study Group.
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 963-970
    • Borish, L.C.1    Nelson, H.S.2    Corren, J.3    Bensch, G.4    Busse, W.W.5    Whitmore, J.B.6
  • 38
    • 85028094578 scopus 로고    scopus 로고
    • NIAID. Phase II efficacy study of aerosolized recombinant human IL-4 receptor in asthma; 1999. [consultado Dic 2011]. Disponible en:
    • NIAID. Phase II efficacy study of aerosolized recombinant human IL-4 receptor in asthma; 1999. [consultado Dic 2011]. Disponible en:. http://clinicaltrials.gov/ct2/show/NCT00001909.
  • 40
    • 85028093503 scopus 로고    scopus 로고
    • Wyeth (Pfizer). Study evaluating the effect of IMA-638 in subjects with persistent asthma; 2007. [consultado Feb 2012]. Disponible en:
    • Wyeth (Pfizer). Study evaluating the effect of IMA-638 in subjects with persistent asthma; 2007. [consultado Feb 2012]. Disponible en:. http://clinicaltrials.gov/ct2/show/NCT00425061.
  • 43
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies
    • Wenzel S., Wilbraham D., Fuller R., Getz E.B., Longphre M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies. Lancet 2007, 370:1422-1431.
    • (2007) Lancet , vol.370 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3    Getz, E.B.4    Longphre, M.5
  • 44
    • 85028126369 scopus 로고    scopus 로고
    • Aerovance Inc. Press release. Phase 2b clinical trial results show Aerovance's Aerovant™ is effective in patients with eosinophilic asthma: Statistically significant results support novel inhaled IL-4/IL-13 inhibitor's continued clinical development. Bekerley: Aerovance; [consultado 15 Abr 2012]. Disponible en:
    • Aerovance Inc. Press release. Phase 2b clinical trial results show Aerovance's Aerovant™ is effective in patients with eosinophilic asthma: Statistically significant results support novel inhaled IL-4/IL-13 inhibitor's continued clinical development. Bekerley: Aerovance; 2010 [consultado 15 Abr 2012]. Disponible en:. http://www.aerovance.com/news/press-releases/.
    • (2010)
  • 46
    • 79952049626 scopus 로고    scopus 로고
    • Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma
    • MEDI-528 Clinical Trials Group
    • Parker J.M., Oh C.K., LaForce C., Miller S.D., Pearlman D.S., Le C. Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma. BMC Pulm Med 2011, 11:14. MEDI-528 Clinical Trials Group.
    • (2011) BMC Pulm Med , vol.11 , pp. 14
    • Parker, J.M.1    Oh, C.K.2    LaForce, C.3    Miller, S.D.4    Pearlman, D.S.5    Le, C.6
  • 47
    • 84884504092 scopus 로고    scopus 로고
    • A randomized, controlled trial to evaluate the effect of an anti-interleukin-9 monoclonal antibody in adults with uncontrolled asthma
    • Oh C.K., Leigh R., Mc Laurin K.K., Kim K., Hultquist M., Molfino N.A. A randomized, controlled trial to evaluate the effect of an anti-interleukin-9 monoclonal antibody in adults with uncontrolled asthma. Respir Res 2013, 14:93.
    • (2013) Respir Res , vol.14 , pp. 93
    • Oh, C.K.1    Leigh, R.2    Mc Laurin, K.K.3    Kim, K.4    Hultquist, M.5    Molfino, N.A.6
  • 48
    • 79957987328 scopus 로고    scopus 로고
    • Efficacy/safety of etanercept in moderate-to-severe asthma: A randomised, controlled trial
    • Holgate S.T., Noonan M., Chanez P., Busse W., Dupont L., Pavord I., et al. Efficacy/safety of etanercept in moderate-to-severe asthma: A randomised, controlled trial. Eur Respir J 2011, 37:1352-1359.
    • (2011) Eur Respir J , vol.37 , pp. 1352-1359
    • Holgate, S.T.1    Noonan, M.2    Chanez, P.3    Busse, W.4    Dupont, L.5    Pavord, I.6
  • 50
    • 67650895323 scopus 로고    scopus 로고
    • TNFα inhibitors may improve asthma symptoms: A case series of 12 patients with rheumatoid arthritis and asthma
    • Stoll M.L., Solomon D.H., Batra K.L., Simard J.F., Karison E.W., Dellaripa P.F., et al. TNFα inhibitors may improve asthma symptoms: A case series of 12 patients with rheumatoid arthritis and asthma. J Clin Rheumatol 2009, 15:198-200.
    • (2009) J Clin Rheumatol , vol.15 , pp. 198-200
    • Stoll, M.L.1    Solomon, D.H.2    Batra, K.L.3    Simard, J.F.4    Karison, E.W.5    Dellaripa, P.F.6
  • 53
    • 62549084077 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of tumor necrosis factor alpha blockade in severe persistent asthma
    • Wenzel S.E., Barnes P.J., Bleecker E.R., Bousquet J., Busse W., Dahlén S.E., et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor alpha blockade in severe persistent asthma. Am J Respir Crit Care Med 2009, 179:549-558.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 549-558
    • Wenzel, S.E.1    Barnes, P.J.2    Bleecker, E.R.3    Bousquet, J.4    Busse, W.5    Dahlén, S.E.6
  • 55
    • 0034906753 scopus 로고    scopus 로고
    • The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4zT-cells in asthma
    • Kon O.M., Sihra B.S., Loh L.C., Barkans J., Compton C.H., Bernes N.C., et al. The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4zT-cells in asthma. Eur Respir J 2001, 18:45-52.
    • (2001) Eur Respir J , vol.18 , pp. 45-52
    • Kon, O.M.1    Sihra, B.S.2    Loh, L.C.3    Barkans, J.4    Compton, C.H.5    Bernes, N.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.