Development and validation of a LC-MS/MS assay for quantitation of plasma citrulline for application to animal models of the acute radiation syndrome across multiple species

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 19, 2014, Pages 4663-4675

  Jones, Jace W ^a   Tudor, Gregory ^b   Bennett, Alexander ^c   Farese, Ann M ^c   Moroni, Maria ^d   Booth, Catherine ^b   MacVittie, Thomas J ^c   Kane, Maureen A ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b Epistem Ltd   (United Kingdom)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Acute radiation syndrome; Biomarker validation; Citrulline; LC MS MS; Plasma biomarkers; Radiation animal models

Indexed keywords

BIOMARKERS; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMAS;

ACUTE RADIATION SYNDROME; ANIMAL MODEL; CITRULLINE; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY ASSAYS; LOWER LIMIT OF QUANTITATIONS; TIME-DEPENDENT RESPONSE; US FOOD AND DRUG ADMINISTRATION;

RADIATION EFFECTS;

ANIMALIA; PRIMATES;

BIOLOGICAL MARKER; CITRULLINE;

ACUTE RADIATION SYNDROME; ANIMAL; ANIMAL MODEL; BLOOD; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; GASTROINTESTINAL TRACT; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MALE; MINIPIG; MOUSE; PIG; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; TANDEM MASS SPECTROMETRY; UNITED STATES; VALIDATION STUDY;

ACUTE RADIATION SYNDROME; ANIMALS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; CITRULLINE; GASTROINTESTINAL TRACT; LIMIT OF DETECTION; LINEAR MODELS; MALE; MICE; MODELS, ANIMAL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SWINE; SWINE, MINIATURE; TANDEM MASS SPECTROMETRY; UNITED STATES;

EID: 84904515205     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-014-7870-0     Document Type: Article

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