Plasma citrulline concentration: A reliable marker of small bowel absorptive capacity independent of intestinal inflammation

American Journal of Gastroenterology

Volumn 102, Issue 7, 2007, Pages 1474-1482

  Papadia, Cinzia ^a,b   Sherwood, Roy A ^c   Kalantzis, Chrysostomos ^a   Wallis, Katharina ^d   Volta, Umberto ^e   Fiorini, Erica ^e   Forbes, Alastair ^a  

^a UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c KING S COLLEGE HOSPITAL   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CITRULLINE; LACTULOSE; RHAMNOSE; XYLOSE;

ADULT; AGED; ARTICLE; CELIAC DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROHN DISEASE; DISEASE ACTIVITY; ENTERITIS; FEMALE; HUMAN; INTESTINE ABSORPTION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MESENTERY; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEDIMENTATION RATE; SMALL INTESTINE; SMALL INTESTINE RESECTION; STATISTICAL SIGNIFICANCE; THROMBOCYTE COUNT;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALBUMINS; BIOLOGICAL MARKERS; BLOOD SEDIMENTATION; C-REACTIVE PROTEIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRULLINE; DRUG COMBINATIONS; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL ABSORPTION; LACTULOSE; LAPAROTOMY; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PLATELET COUNT; PROGNOSIS; RETROSPECTIVE STUDIES; RHAMNOSE; ROC CURVE; SEVERITY OF ILLNESS INDEX; XYLOSE;

EID: 34250799303     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2007.01239.x     Document Type: Article

References (45)

1. Wakabayashi Y, Jones ME. Pyrroline-5-carboxylate synthesis from glutamate by rat intestinal mucosa. J Biol Chem 1983 258 : 3865 72.
2. Pita AM, Fernandez-Bustos A, Rodes M, et al. Orotic aciduria and plasma urea cycle-related amino acid alteration in short bowel syndrome, evoked by an arginine-free diet. JPEN J Parenter Enteral Nutr 2004 28 : 315 23.
3. Wu G, Knabe DA, Flynn NE. Synthesis of citrulline from glutamine in pig enterocytes. Biochem J 1994 299 : 115 21.
4. Crenn P, Coudray-Lucas C, Thuillier F, et al. Postabsorptive plasma citrulline concentration is a marker of enterocite mass and intestinal failure in humans. Gastroenterology 2000 119 : 1496 505.
5. Ziegler TR, Fernandez-Estivariz C, Gu LH, et al. Distribution of the H+/peptide transporter PepT1 in human intestine: Up-regulated expression in the colonic mucosa of patients with short-bowel syndrome. Am J Clin Nutr 2002 75 : 922 30.
6. Bernal NP, Stehr W, Coyle R, et al. Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice. Gastroenterology 2006 130 : 412 23.
7. Chiarla C, Giovannini I, Sieghel JH. Plasma arginine correlations in trauma and sepsis. Amino Acids 2006 30 : 81 6.
8. Sandstrom P, Gasslader T, Sundqvist T, et al. Depletion of serum l-arginine in patients with acute pancreatitis. Pancreas 2003 27 : 261 6.
9. Luiking YC, Poeze M, Ramsay G, et al. The role of arginine in infection and sepsis. JPEN J Parenter Enteral Nutr, 2005 29 : S70 4.
10. Crenn P, Kouroche V, Lavergne-Slove A, et al. Plasma citrulline: A marker of enterocyte mass in villous atrophy-associated small bowel disease. Gastroenterology 2003 124 : 1210 9.
11. Garcia-Martinez C, Liovera M, Lopez Soriano FJ, et al. The effects of endotoxin administration on blood amino acid concentrations: Similarities with sepsis. Cell Mol Biol 1993 39 : 537 42.
12. Bruins MJ, Lamers WH, Meijers AJ, et al. In vivo measurement of nitric oxide production in porcine gut, liver and muscle during hyperdynamic endotoxaemia. Br J Pharmacol 2002 137 : 1225 36.
13. Cerra FB, Siegel JH, Coleman B, et al. Septic autocannibalism. A failure of exogenous nutritional support. Ann Surg 1992 192 : 570 80.
14. Castillo L, Beaumier L, Ajami AM, et al. Whole body nitric oxide synthesis in healthy men determined from [15N] arginine-to-[15N] citrulline labeling. Proc Natl Acad Sci U S A 1996 93 : 11460 5.
15. Castillo L, Sanchez M, Vogt J, et al. Plasma arginine, citrulline and ornithine in adults, with observation on nitric oxide synthesis. Am J Physiol 1995 268 : E360 7.
16. Moncada S, Palmer RM, Higgs EA. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991 43 : 109 42.
17. McCafferty DM, Mudgett JS, Swain MG, et al. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology 1997 112 : 1022 7.
18. Weber FL, Reiser BJ. Relationship of plasma amino acids to nitrogen balance and portal-systemic encephalopathy in alcoholic liver disease. Dig Dis Sci 1982 27 : 103 9.
19. Nightingale JMD, Lennard-Jones JE, Walker ER, et al. Jejunal efflux in short bowel syndrome. Lancet 1990 336 : 765 8.
20. Nightingale JMD, Bartram CI, Lennard Jones JE. Length of residual small bowel after partial resection: Correlation between radiographic and surgical measurements. Gastrointest Radiol 1991 16 : 305 6.
21. Nightingale JMD. Introduction. Definition and classification of intestinal failure. Intestinal failure. London : Greenwich Medical Media Limited, 2001.
22. Nightingale JMD. The medical management of intestinal failure: Methods to reduce the severity. Proc Nutrition Soc 2003 62 : 703 10.
23. Rossi TM, Lee PC, Young C, et al. Small intestinal mucosa changes, including epithelial cell proliferative activity, of children receiving total parenteral nutrition. Dig Dis Sci 1993 38 : 1608 13.
24. Jeppesen PB, Hartmann B, Hansen BS, et al. Impaired meal stimulated glucagon-like peptide 2 response in ileal resected short bowel patients with intestinal failure. Gut 1999 45 : 559 63.
25. Jeppesen PB, Hartmann B, Thulesenb J, et al. Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon. Gut 2000 47 : 370 6.
26. Jeppesen PB, Sanguinetti EL, Buchman A, et al. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients. Gut 2005 54 : 1224 31.
27. Seguy D, Vahedi K, Kapel N, et al. Low dose growth hormon in adult home parenteral nutrition dependent short bowel syndrome patients: A positive study. Gastroenterology 2003 124 : 239 302.
28. Booth C, Booth D, Williamson S, et al. Teduglutide ([Gly2]GLP-2) protects small intestinal stem cells from radiation damage. Cell Prolif 2004 37 : 385 400.
29. Wakabayashi Y, Yamada E, Yoshida T, et al. Arginine becomes an essential amino acid after massive resection of rat small intestine. J Biol Chem 1994 269 : 32667 71.
30. Wakabayashi Y, Yamada E, Yoshida T, et al. Effect of intestinal resection and arginine-free diet on rat physiology. Am J Physiol 1995 269 : G313 8.
31. Dejjong CHC, Welters CFM, Deutz NEP, et al. Renal arginine metabolism in fasted rats with subacute short bowel syndrome. Clin Sci 1998 95 : 409 18.
32. Chen K, Nezu R, Sando K, et al. Influence of glutamine-supplemented parenteral nutrition on intestinal amino acid metabolism in rats after small bowel resection. Surg Today 1996 26 : 618 23.
33. Lutgens LC, Deutz NE, Guleulette J, et al. Citrulline: A physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage. Int J Radiat Oncol Biol Phys 2003 57 : 1067 74.
34. Lutgens LC, Blijlevens NM, Deutz NE, et al. Monitoring myeloablative therapy induced small bowel toxicity by serum citrulline concentration. A comparison with sugar permeability tests. Cancer 2005 103 : 191 9.
35. Tizianello A, de Ferrari G, Garibotto G, et al. Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest 1980 65 : 1162 73.
36. Windmueller HG, Spaeth AE. Source and fate of circulating citrulline. Am J Physiol 1981 241 : E473 80.
37. Weber FI, Reiser BJ. Relationship of plasma amino acids to nitrogen balance and portal-systemic encephalopathy in alcoholic liver disease. Dig Dis Sci 1982 27 : 103 9.
38. Rabier D, Kamoun P. Metabolism of citrulline in man. Amino Acids 1995 9 : 299 316.
39. Gondolesi G, Fishbein T, Chehade M, et al. Serum citrulline is a potential marker for rejection of intestinal allografts. Transplant Proc 2002 34 : 918 20.
40. Pappas PA, Saudubray JM, Tzakis AG, et al. Serum citrulline and rejection in small bowel trasplantation: A preliminary report. Transplantation 2001 72 : 1212.
41. Pappas PA, Saudubray JM, Tzakis AG, et al. Serum citrulline as a marker of acute cellular rejection for intestinal transplantation. Transplant Proc 2002 34 : 915 7.
42. Pappas PA, Tzakis G, Gaynor JJ, et al. An analysis of the association between serun citrulline and acute rejection among 26 recipients of intestinal transplant. Am J Transplant 2004 4 : 1124 32.
43. Gondolesi GE, Kauffman SS, Sansaricq C, et al. Defining normal plasma citrulline in intestinal transplant recipients. Am J Transplant 2004 4 : 414 8.
44. Sherwood RA. Amino acid measurement by high performance liquid chromatography using electrochemical detection. J Neuroscience Methods 1990 34 : 17 22.
45. Wasa M, Takagi Y, Sando K, et al. A long term outcome of short bowel syndrome in adult and paediatric patients. JPEN J Parenter Enteral Nutr 1999 23 : S110 2.