Assessment of total-and partial-body irradiation in a baboon model: Preliminary results of a kinetic study including clinical, physical, and biological parameters

Health Physics

Volumn 103, Issue 2, 2012, Pages 143-149

  Hérodin, Francis ^a   Richard, Sandrine ^a   Grenier, Nancy ^a   Arvers, Philippe ^a   Gérome, Patrick ^b   Baugé, Stéphane ^a   Denis, Josiane ^a   Chaussard, Hervé ^a   Gouard, Stéphane ^a   Mayol, Jean François ^a   Agay, Diane ^a   Drouet, Michel ^a  

^a INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES   (France)

^b HIA Desgenettes   (France)

Author keywords

biological dosimetry; dose assessment; dosimetry; gamma radiation

Indexed keywords

ANIMAL; ANIMAL MODEL; BABOON; BLOOD; BLOOD CELL; CONFERENCE PAPER; ENVIRONMENTAL EXPOSURE; GAMMA RADIATION; KINETICS; MALE; METABOLISM; METHODOLOGY; PHYSICAL PHENOMENA; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; RADIOMETRY; TIME; WHOLE BODY RADIATION;

ANIMALS; BLOOD CELLS; ENVIRONMENTAL EXPOSURE; GAMMA RAYS; KINETICS; MALE; MODELS, ANIMAL; PAPIO; PHYSICAL PROCESSES; RADIATION DOSAGE; RADIATION INJURIES, EXPERIMENTAL; RADIOMETRY; TIME FACTORS; WHOLE-BODY IRRADIATION;

ANIMALIA; PAPIO;

EID: 84863303197     PISSN: 00179078     EISSN: None     Source Type: Journal    
DOI: 10.1097/HP.0b013e3182475e54     Document Type: Conference Paper

References (16)

1. Bajerska A, Liniecki J. The yield of chromosomal aberrations in rabbit lymphocytes after irradiation in vitro and in vivo. Mutation Res 27:271-284; 1975.
2. Bertho JM, Demarquay C, Frick J, Joubert C, Arenales S, Jacquet N, Sorokine-Durm I, Quang-Chau, Lopez M, Aigueperse J, Gorin NC, Gourmelon P. Level of Flt-3 ligand in plasma: a possible new bio-indicator for radiation-induced aplasia. Int J Radiat Biol 77:703-712; 2001. (Pubitemid 32531887)
3. Blakely WF, Ossetrova NI, Whitnall MH, Sandgren DJ, Krivokrysenko VI, Shakhov A, Feinstein E. Multiple parameter radiation injury assessment using a nonhuman primate radiation modelVbiodosimetry applications. Health Phys 98: 153-159; 2010a.
4. Blakely WF, Sandgren DJ, Nagy V, Kim SY, Ossetrova NI. Murine partial-body radiation exposure model for biodosimetry studies. La Napoule, France EPRBioDose 2010 2010b.
5. Darroudi F, NatarajanAT, Bentvelzen PA, Heidt PJ,Van Rotterdam A, Zoetelief J, Broerse JJ. Detection of total-and partialbody irradiation in a monkey model: a comparative study of chromosomal aberration, micronucleus and premature chromosome condensation assays. Int J Radiat Biol 74: 207-215; 1998. (Pubitemid 28372547)
6. Herodin F, Mestries JC, Janodet D, Martin S, Mathieu J, Gascon MP, Pernin MO, Ythier A. Recombinant glycosylated human interleukin-6 accelerates peripheral blood platelet count recovery in radiation-induced bone marrow depression in baboons. Blood 80:688-695; 1992.
7. HeÄ'Ấrodin F, Drouet M. Cytokine-based treatment of accidentally irradiated victims and new approaches. Exp Hematol 33: 1071-1080; 2005. (Pubitemid 41416954)
8. HeÄ'Ấrodin F, Roy L, Grenier N, Delaunay C, BaugeÄ'Ấ S, Vaurijoux A, GreÄ'Ấgoire E, Martin C, Alonso A, Mayol JF, Drouet M. Antiapoptotic cytokines in combination with pegfilgrastim soon after irradiation mitigates myelosuppression in nonhuman primates exposed to high irradiation dose. Exp Hematol 35: 1172-1181; 2007. (Pubitemid 47088776)
9. International Atomic Energy Agency. Cytogenetic analysis for radiation dose assessment. Vienna: IAEA; Technical Reports Series No 405; 2001.
10. Liniecki J, Bajerska A, Wyszynska K. Dose relationships for chromosome aberrations in peripheral blood lymphocytes after whole-and partial-body irradiations. I. Effects immediately after irradiation. Mutation Res 110:83-101; 1983a. (Pubitemid 13054262)
11. Liniecki J, Bajerska A, Wyszynska K. Dose relationships for chromosome aberrations in peripheral blood lymphocytes after whole-and partial-body irradiations. II. Decline of aberration-carrying cells in blood with time post-exposure. Mutation Res 110:103-110; 1983b.
12. Mahmud N, Pang W, Cobbs C, Alur P, Borneman J, Dodds R, Archambault M, Devine S, Turian J, Bartholomew A, Vanguri P, Mackay A, Young R, Hoffman R. Studies of the route of administration and role of conditioning with radiation on unrelated allogeneic mismatched mesenchymal stem cell engraftment in a nonhuman primate model. Exp Hematol 32: 494-501; 2004. (Pubitemid 38624334)
13. Meadows SK, Dressman HK, Daher P, Himburg H, Russell JL, Doan P, Chao NJ, Lucas J, Nevins JR, Chute JP. Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. PLoS One 12:e11535; 2010.
14. Prasanna PGS, Blakely WF, Bertho JM, Chute JP, Cohen EP, Goans RE, Grace MB, Lillis-Hearne PK, Lloyd DC, Lutgens LC, Meineke V, Ossetrova NI, Romanyukha A, Saba JD, Weisdorf DJ, Wocjik A, Yukihara EG, Pellmar TC. Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop. Radiat Res 173: 245-253; 2010a.
15. Prasanna PGS, Moroni M Pellmar TC. Triage dose assessment for partial-body exposure: dicentric analysis. Health Phys 98: 244-251; 2010b.
16. Riecke A, Ruf CG, Meineke V. Assessment of radiation damageVthe need for a multiparametric and integrative approach with the help of both clinical and biological dosimetry. Health Phys 98:160-167; 2010.