Neuroprotective effects of Citrus reticulata in scopolamine-induced dementia oxidative stress in rats

CNS and Neurological Disorders - Drug Targets

Volumn 13, Issue 4, 2014, Pages 684-690

  El Khadragy, Manal F ^a,b   Al Olayan, Ebtesam M ^a   Abdel Moneim, Ahmed E ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b HELWAN UNIVERSITY   (Egypt)

Author keywords

Citrus reticulate; Dementia; Neuroprotection; Scopolamine

Indexed keywords

ACETYLCHOLINESTERASE; CITRUS RETICULATE EXTRACT; FLAVONOID; GLUTATHIONE; NITRIC OXIDE; NORADRENALIN; PLANT EXTRACT; POLYPHENOL; SCOPOLAMINE; SEROTONIN; UNCLASSIFIED DRUG; DOPAMINE; NEUROPROTECTIVE AGENT; SCOPOLAMINE BROMIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; CORPUS STRIATUM; DEMENTIA; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; MEMORY DISORDER; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; ANIMAL; CITRUS; DISEASE MODEL; DRUG EFFECTS; FRUIT; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PHYTOTHERAPY; WISTAR RAT;

ACETYLCHOLINESTERASE; ANIMALS; CEREBRAL CORTEX; CITRUS; CORPUS STRIATUM; DEMENTIA; DISEASE MODELS, ANIMAL; DOPAMINE; FRUIT; GLUTATHIONE; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; NOREPINEPHRINE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; RATS, WISTAR; SCOPOLAMINE HYDROBROMIDE; SEROTONIN;

EID: 84904488855     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/1871527313666140618105404     Document Type: Article

References (49)

1. Agrawal R, Tyagi E, Saxena G, Nath C. Cholinergic influence on memory stages: A study on scopolamine amnesic mice. Ind J Pharmacol 2009; 41(4): 192-6.
2. Kasa P, Rakonczay Z, Gulya K. The cholinergic system in Alzheimer's disease. Prog Neurobiol 1997; 52(6): 511-35.
3. Hake AM. Use of cholinesterase inhibitors for treatment of Alzheimer disease. Clev Clin J Med 2001; 68(7): 608-9.
4. Jahanshahi M, Azami NS, Nickmahzar E. Effect of Scopolaminebased Amnesia on the Number of Astrocytes in the Rat's Hippocampus. Int J Morphol 2012; 30: 388-93.
5. Azami NS, Piri M, Oryan S, et al. Involvement of dorsal hippocampal alpha-adrenergic receptors in the effect of scopolamine on memory retrieval in inhibitory avoidance task. Neurobiol Learn Mem 2010; 93(4): 455-62.
6. Dringenberg HC. Alzheimer's disease: more than a 'cholinergic disorder'-evidence that cholinergic-monoaminergic interactions contribute to EEG slowing and dementia. Behav Brain Res 2000; 115(2): 235-49.
7. Fan Y, Hu J, Li J, et al. Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms. Neurosci Lett 2005; 374(3): 222-6.
8. Chen J, Long Y, Han M, et al. Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice. Pharmacol Biochem Behav 2008; 90(3): 441-6.
9. Goverdhan P, Sravanthi A, Mamatha T. Neuroprotective effects of meloxicam and selegiline in scopolamine-induced cognitive impairment and oxidative stress. Int J Alzheimer Dis 2012; 2012: 974013.
10. El-Sherbiny DA, Khalifa AE, Attia AS, Eldenshary D. Hypericum perforatum extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine. Pharmacol Biochem Behav 2003; 76(3-4): 525-33.
11. Jimenez-Jimenez FJ, Alonso-Navarro H, Ayuso-Peralta L, Jabbour-Wadih T. Oxidative stress and Alzheimer's disease. Rev Neurol 2006; 42(7): 419-27.
12. Cruz R, Almaguer Melian W, Bergado Rosado JA. Glutathione in cognitive function and neurodegeneration. Rev Neurol 2003; 36(9): 877-86.
13. Abdel Moneim AE. The Neuroprotective Effects of Purslane (Portulaca oleracea) on Rotenone-Induced Biochemical Changes and Apoptosis in Brain of Rat. CNS Neurol Disord Drug Targets 2013; 12(6): 830-41.
14. Ding Q, Dimayuga E, Keller JN. Oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease. Cur Alzheimer Res 2007; 4(1): 73-9.
15. Onozuka H, Nakajima A, Matsuzaki K, et al. Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease. J Pharmacol Exp Ther 2008; 326(3): 739-44.
16. Sood S, Bansal S, Muthuraman A, Gill NS, Bali M. Therapeutic Potential of Citrus medica L. Peel extract in carrageenan induced inflammatory pain in rat. Res J Med Plant 2009; 3, 123-33.
17. Avula B, Joshi VC, Weerasooriya A, Khan IA. Liquid chromatography for separation and quantitative determination of adrenergic amines and flavonoids from poncirus trifoliatus raf. Fruits at different stages of growth. Chroma 2005; 62(7-8): 379-83.
18. Xu G, Ye X, Chen J, Liu D. Effect of heat treatment on the phenolic compounds and antioxidant capacity of citrus peel extract. J Agric Food Chem 2007; 55(2): 330-5.
19. Abdel Moneim AE. Citrus peel extract attenuates acute cyanide poisoning-induced seizures and oxidative stress in rats. CNS Neurol Disord Drug Targets 2014; 13(4): 638-46.
20. Xu GH, Chen JC, Liu DH, et al. Minerals, phenolic compounds, and antioxidant capacity of citrus peel extract by hot water. J Food Sci 2008; 73(1): C11-8.
21. Soković M, Griensven LLD. Antimicrobial activity of essential oils and their components against the three major pathogens of the cultivated button mushroom, Agaricus bisporus. Eur J Plant Pathol 2006; 116(3): 211-24.
22. Glowinski J, Axelrod J, Iversen LL. Regional studies of catecholamines in the rat brain. IV. Effects of drugs on the disposition and metabolism of H3-norepinephrine and H3-dopamine. J Pharmacol Exp Ther 1966; 153(1): 30-41.
23. Ellman GL, Courtney KD, Andres V, Feather-Stone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961; 7: 88-95.
24. Ohkawa H.; Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95(2): 351-8.
25. Green LC, Wagner DA, Glogowski J, et al. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 1982; 126(1): 131-8.
26. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82(1): 70-7.
27. Jeong EJ, Lee KY, Kim SH, Sung SH, Kim YC. Cognitiveenhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice. Eur J Pharmacol 2008; 588(1): 78-84.
28. Nade VS, Kanhere SV, Kawale LA, Yadav AV. Cognitive enhancing and antioxidant activity of ethyl acetate soluble fraction of the methanol extract of Hibiscus rosa sinensis in scopolamineinduced amnesia. Ind J Pharmacol 2011; 43(2): 137-42.
29. Lee MR, Yun BS, Zhang DL, et al. Effect of aqueous antler extract on scopolamine-induced memory impairment in mice and antioxidant activities. Food Sci Biotechnol 2010; 19(3): 655-61.
30. Al-Hazmi MA, Rawi SM, Arafa NM, Wagas A, Montasser AO. The potent effects of ginseng root extract and memantine on cognitive dysfunction in male albino rats. Toxicol Ind Health 2014; Epub ahead of print.
31. Hasselmo ME. The role of acetylcholine in learning and memory. Curr Opin Neurobiol 2006; 16(6): 710-5.
32. Ballard CG, Greig NH, Guillozet-Bongaarts AL, Enz A, Darvesh S. Cholinesterases: roles in the brain during health and disease. Curr Alzheimer Res 2005; 2(3): 307-18.
33. Brouillette J, Young D, During MJ, Quirion R. Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia. J Neurochem 2007; 102(6): 1978-89.
34. Falsafi SK, Deli A, Hoger H, Pollak A, Lubec G. Scopolamine administration modulates muscarinic, nicotinic and NMDA receptor systems. PLoS One 2012; 7(2): e32082.
35. Garcia-Alloza M, Gil-Bea FJ, Diez-Ariza M, et al. Cholinergicserotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease. Neuropsychologia 2005; 43(3): 442-9.
36. Mesulam M. The cholinergic lesion of Alzheimer's disease: pivotal factor or side show? Learn Mem 2004; 11(1): 43-9.
37. White NM, McDonald RJ. Multiple parallel memory systems in the brain of the rat. Neurobiol Learn Mem 2002; 77(2): 125-84.
38. Chapman CA, Yeomans JS, Blaha CD, Blackburn JR. Increased striatal dopamine efflux follows scopolamine administered systemically or to the tegmental pedunculopontine nucleus. Neuroscience 1997; 76(1): 177-86.
39. Furey ML, Drevets WC. Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebocontrolled clinical trial. Arch Gen psychiatry 2006; 63(10): 1121-9.
40. Lester DB, Rogers TD, Blaha CD. Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS Neurosci Ther 2010; 16(3): 137-62.
41. Furey ML, Khanna A, Hoffman EM, Drevets WC. Scopolamine produces larger antidepressant and antianxiety effects in women than in men. Neuropsychopharmacology 2010; 35(12): 2479-88.
42. Meneses A, Perez-Garcia G, Ponce-Lopez T, Tellez R, Castillo C. Serotonin transporter and memory. Neuropharmacol 2011; 61(3): 355-63.
43. Shankar GM, Walsh DM. Alzheimer's disease: synaptic dysfunction and Abeta. Mol Neurodegener 2009; 4: 48.
44. Shepherd CE, Grace EM, Mann DMA, Halliday GM. Relationship between neuronal loss and 'inflammatory plaques' in early onset Alzheimer's disease. Neuropathol Appl Neurobiol 2007; 33(3): 328-33.
45. Maiti P, Singh SB, Mallick B, Muthuraju S, Ilavazhagan G. High altitude memory impairment is due to neuronal apoptosis in hippocampus, cortex and striatum. J Chem Neuroanat 2008; 36(3-4): 227-38.
46. Marcus DL, Thomas C, Rodriguez C, et al. Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease. Exp Neurol 1998; 150(1): 40-4.
47. Nijveldt RJ, van Nood E, van Hoorn DE, et al. Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 2001; 74(4): 418-25.
48. Maher P, Hanneken A. Flavonoids Protect Retinal Ganglion Cells from Oxidative Stress-Induced Death. Invest Ophthalmol Vis Sci 2005; 46(12): 4796-803.
49. Ishige K, Schubert D, Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 2001; 30(4): 433-46.