Cocrystal structures of glycyl-tRNA synthetase in complex with tRNA suggest multiple conformational states in glycylation

Journal of Biological Chemistry

Volumn 289, Issue 29, 2014, Pages 20359-20369

  Qin, Xiangjing ^a   Hao, Zhitai ^a   Tian, Qingnan ^a   Zhang, Zhemin ^a   Zhou, Chun ^b   Xie, Wei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYMES; MOLECULES; SUBSTRATES;

AMINOACYL-TRNA SYNTHETASES; BIOCHEMICAL STUDIES; CHARCOT-MARIE-TOOTH DISEASE; COCRYSTAL STRUCTURE; CONFORMATIONAL CHANGE; CONFORMATIONAL STATE; MULTIPLE CONFORMATIONS; QUATERNARY STRUCTURE;

CONFORMATIONS;

GLYCINE TRANSFER RNA LIGASE; TRANSFER RNA;

ACYLATION; ANTICODON; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; GLYCYLATION; MOLECULAR RECOGNITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA BINDING;

AMINOACYL TRNA SYNTHETASE; COCRYSTAL; CRYSTAL STRUCTURE; NEUROLOGICAL DISEASE; PROTEIN CONFORMATION; RNA-PROTEIN INTERACTION; TRANSFER RNA (TRNA);

BACTERIAL PROTEINS; CATALYTIC DOMAIN; CHARCOT-MARIE-TOOTH DISEASE; CRYSTALLOGRAPHY, X-RAY; GLYCINE-TRNA LIGASE; GLYCOSYLATION; HELA CELLS; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MUTAGENESIS, INSERTIONAL; MUTANT PROTEINS; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; RNA, TRANSFER, GLY; THERMUS THERMOPHILUS;

EID: 84904479728     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.557249     Document Type: Article

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