A quantitative HPLC-MS/MS method for studying internal concentrations and toxicokinetics of 34 polar analytes in zebrafish (Danio rerio) embryos

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 20, 2014, Pages 4831-4840

  Brox, Stephan ^a   Ritter, Axel P ^a   Küster, Eberhard ^a   Reemtsma, Thorsten ^a  

^a HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

Author keywords

Absorption, distribution, metabolism and excretion; Bioconcentration; Electrospray; Larvae; Toxicity; Toxicodynamic

Indexed keywords

HERBICIDES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; TOXICITY;

2 ,4-DICHLOROPHENOXYACETIC ACID; BIOCONCENTRATION; DEVELOPMENTAL STAGE; ELECTROSPRAYS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LARVAE; MULTIPLE-REACTION MONITORING MODES; TOXICODYNAMIC;

PHYSIOLOGY;

DANIO RERIO;

2,4-DICHLOROPHENOXYACETIC ACID; ATROPINE; CIMETIDINE; METOPROLOL; PESTICIDES; PHARMACEUTICAL PREPARATIONS; PHENYTOIN; WATER POLLUTANTS, CHEMICAL;

ANALYSIS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOLOGY; DRUG EFFECTS; EMBRYO, NONMAMMALIAN; GROWTH AND DEVELOPMENT; METABOLISM; METHODS; TANDEM MASS SPECTROMETRY; TOXICOKINETICS; WATER POLLUTANTS, CHEMICAL; ZEBRAFISH;

2,4-DICHLOROPHENOXYACETIC ACID; ANIMALS; ATROPINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIMETIDINE; EMBRYO, NONMAMMALIAN; METOPROLOL; PESTICIDES; PHARMACEUTICAL PREPARATIONS; PHENYTOIN; TANDEM MASS SPECTROMETRY; TOXICOKINETICS; WATER POLLUTANTS, CHEMICAL; ZEBRAFISH;

EID: 84904459483     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-014-7929-y     Document Type: Article

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