Synthesis, pharmacological characterization, and structure - Activity relationship studies of small molecular agonists for the orphan GPR88 receptor

ACS Chemical Neuroscience

Volumn 5, Issue 7, 2014, Pages 576-587

  Jin, Chunyang ^a   Decker, Ann M ^a   Huang, Xi Ping ^b   Gilmour, Brian P ^a   Blough, Bruce E ^a   Roth, Bryan L ^b   Hu, Yang ^c   Gill, Joseph B ^c   Zhang, X Peter ^c  

^a RTI INTERNATIONAL   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

2 PCCA; agonists; Orphan GPR88

Indexed keywords

2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLIC ACID HYDROCHLORIDE; 2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLIC ACID [ 2 AMINO 3 METHYLPENTYL] (4' ACETYLBIPHENYL 4 YL)AMIDE DIHYDROCHLORIDE; 2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLIC ACID [ 2 AMINO 3 METHYLPENTYL] (4' CHLOROBIPHENYL 4 YL)AMIDE DIHYDROCHLORIDE; 2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLIC ACID [ 2 AMINO 3 METHYLPENTYL] (4' CYCLOHEXYLBIPHENYL 4 YL)AMIDE DIHYDROCHLORIDE; 2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLIC ACID [ 2 AMINO 3 METHYLPENTYL] (4' ETHYLBIPHENYL 4 YL)AMIDE DIHYDROCHLORIDE; 2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLIC ACID [ 2 AMINO 3 METHYLPENTYL] (4' FLUOROBIPHENYL 4 YL)AMIDE DIHYDROCHLORIDE; 2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLIC ACID [ 2 AMINO 3 METHYLPENTYL] (4' ISOBUTYLBIPHENYL 4 YL)AMIDE DIHYDROCHLORIDE; 2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLIC ACID [ 2 AMINO 3 METHYLPENTYL] (4' METHYLBIPHENYL 4 YL)AMIDE DIHYDROCHLORIDE; 2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLIC ACID [ 2 AMINO 3 METHYLPENTYL] (4' PROPYLBIPHENYL 4 YL)AMIDE DIHYDROCHLORIDE; 2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLIC ACID [ 2 AMINO 3 METHYLPENTYL] (4' TRIFLUOROMETHYLBIPHENYL 4 YL)AMIDE DIHYDROCHLORIDE; 2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLIC ACID [ 2 AMINO 3 METHYLPENTYL] (BIPHENYL 4 YL)AMIDE DIHYDROCHLORIDE; BETA 2 ADRENERGIC RECEPTOR; CENTRAL NERVOUS SYSTEM AGENTS; CHEMOKINE RECEPTOR AGONIST; G PROTEIN COUPLED RECEPTOR 88 AGONIST; ISOPRENALINE; ORPHAN DRUG; TERT BUTYL 2 (PYRIDIN 2 YL)CYCLOPROPANECARBOXYLATE; TERT BUTYL [1 [(4 BROMOPHENYL)AMINO] 3 METHYLPENTAN 2YL]CARBAMATE; TERT BUTYL [1 [(4' ACETYLBIPHENYL 4 YL) [2 (PYRIDIN 2 YL)CYCLOPROPANECARBONYL]AMINO] 3 METHYLPENTAN 2 YL]CARBAMATE; TERT BUTYL [1 [(4' CHLOROBIPHENYL 4 YL) [2 (PYRIDIN 2 YL)CYCLOPROPANECARBONYL]AMINO] 3 METHYLPENTAN 2 YL]CARBAMATE; TERT BUTYL [1 [(4' CYCLOHEXYBIPHENYL 4 YL) [2 (PYRIDIN 2 YL)CYCLOPROPANECARBONYL]AMINO] 3 METHYLPENTAN 2 YL]CARBAMATE; TERT BUTYL [1 [(4' ETHYLBIPHENYL 4 YL) [2 (PYRIDIN 2 YL)CYCLOPROPANECARBONYL]AMINO] 3 METHYLPENTAN 2 YL]CARBAMATE; TERT BUTYL [1 [(4' FLUOROBIPHENYL 4 YL) [2 (PYRIDIN 2 YL)CYCLOPROPANECARBONYL]AMINO] 3 METHYLPENTAN 2 YL]CARBAMATE; TERT BUTYL [1 [(4' ISOBIPHENYL 4 YL) [2 (PYRIDIN 2 YL)CYCLOPROPANECARBONYL]AMINO] 3 METHYLPENTAN 2 YL]CARBAMATE; TERT BUTYL [1 [(4' METHYLBIPHENYL 4 YL) [2 (PYRIDIN 2 YL)CYCLOPROPANECARBONYL]AMINO] 3 METHYLPENTAN 2 YL]CARBAMATE; TERT BUTYL [1 [(4' PROPYLBIPHENYL 4 YL) [2 (PYRIDIN 2 YL)CYCLOPROPANECARBONYL]AMINO] 3 METHYLPENTAN 2 YL]CARBAMATE; TERT BUTYL [1 [(4' TRIFLUOROMETHYLBIPHENYL 4 YL) [2 (PYRIDIN 2 YL)CYCLOPROPANECARBONYL]AMINO] 3 METHYLPENTAN 2 YL]CARBAMATE; TERT BUTYL [1 [(BIPHENYL 4 YL) [2 (PYRIDIN 2 YL)CYCLOPROPANECARBONYL]AMINO] 3 METHYLPENTAN 2 YL]CARBAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 2-(4-CHLOROPHENYL)CYCLOPROPYLAMINE; CALCIUM; CHLORAMPHETAMINE; CHROMAN DERIVATIVE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GPR88 PROTEIN, HUMAN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM MOBILIZATION; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYCLOPROPANATION; DIASTEREOISOMER; DRUG SYNTHESIS; ENANTIOMER; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; THIN LAYER CHROMATOGRAPHY; AGONISTS; ANALOGS AND DERIVATIVES; CHEMISTRY; DOSE RESPONSE; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; SYNTHESIS;

CALCIUM; CHROMANS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEK293 CELLS; HUMANS; ISOPROTERENOL; P-CHLOROAMPHETAMINE; RECEPTORS, G-PROTEIN-COUPLED; TRANSFECTION;

EID: 84904440198     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn500082p     Document Type: Article

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